Patents Assigned to Auspex Pharmaceuticals, Inc.
  • INDOLONE MODULATORS OF 5-HT3 RECEPTOR
    Publication number: 20100113478
    Abstract: The present invention relates to new indolone modulators of 5-HT3 receptor, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: September 11, 2009
    Publication date: May 6, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • DIMETHYLPHENOXY MODULATORS OF VIRAL PROTEASE ACTIVITY AND/OR PARASITIC ENZYME ACTIVITY
    Publication number: 20100113359
    Abstract: The present invention relates to new dimethylphenoxy inhibitors of viral protease or parasitic enzymes, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: November 5, 2009
    Publication date: May 6, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • N-METHYL PIPERAZINE MODULATORS OF H1 RECEPTOR
    Publication number: 20100113431
    Abstract: The present invention relates to new N-methyl piperazine modulators of H1 receptor activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: November 4, 2009
    Publication date: May 6, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Manouchehr M. Shahbaz
  • AMINOPROPANOL MODULATORS OF BETA-1 ADRENERGIC RECEPTOR
    Publication number: 20100113606
    Abstract: The present invention relates to new aminopropanol modulators of beta-1 adrenergic receptor activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: November 3, 2009
    Publication date: May 6, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • SUBSTITUTED BENZAMIDE MODULATORS OF DOPAMINE RECEPTOR
    Publication number: 20100105755
    Abstract: The present invention relates to new substituted benzamide modulators of dopamine receptor, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: September 11, 2009
    Publication date: April 29, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • PREPARATION AND UTILITY OF SUBSTITUTED IMIDAZOPYRIDINE COMPOUNDS WITH HYPNOTIC EFFECTS
    Publication number: 20100105720
    Abstract: The present disclosure is directed to modulators of GABAA receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of sleep disorders and/or for providing a patient in need with a hypnotic, anxiolytic or anti-convulsive effect are described.
    Type: Application
    Filed: September 1, 2009
    Publication date: April 29, 2010
    Applicant: Auspex Pharmaceuticals, Inc.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • ISOQUINOLINONE MODULATORS OF 5-HT3 RECEPTORS
    Publication number: 20100099701
    Abstract: The present invention relates to new isoquinolinone modulators of 5-HT3 receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: October 19, 2009
    Publication date: April 22, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventor: Thomas G. Gant
  • PHENOTHIAZINE MODULATORS OF H1 RECEPTOR AND D2 RECEPTOR
    Publication number: 20100099666
    Abstract: The present invention relates to new phenothiazine modulators of H1 receptors and/or D2 receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: October 20, 2009
    Publication date: April 22, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • PYRIDINE SULFONAMIDE MODULATORS OF ENDOTHELIN-A RECEPTOR
    Publication number: 20100093758
    Abstract: The present invention relates to new pyridine sulfonamide modulators of endothelin-A receptor, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: July 23, 2009
    Publication date: April 15, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • TROPINE MODULATORS OF 5-HT3 RECEPTOR
    Publication number: 20100087364
    Abstract: The present invention relates to new tropine modulators of 5-HT3 receptor, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: October 7, 2009
    Publication date: April 8, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventor: Thomas G. Gant
  • SUBSTITUTED XANTHINE COMPOUNDS
    Publication number: 20100087455
    Abstract: The present invention relates to new substituted xanthine-based agents, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: October 6, 2009
    Publication date: April 8, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventor: Thomas G. Gant
  • pH sensitive prodrugs of 2,6-diisopropylphenol
    Patent number: 7691904
    Abstract: The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby providing an alternative to the water-insoluble 2,6-diisopropylphenol. Pharmaceutical compositions comprising these compounds, methods of induction and maintenance of anesthesia or sedation as well as methods of treating neurodegenerative diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
    Type: Grant
    Filed: July 24, 2007
    Date of Patent: April 6, 2010
    Assignee: Auspex Pharmaceuticals, Inc
    Inventors: Subramanian Marappan, Cris Davenport, Sepehr Sarshar
  • THIOXANTHENE MODULATORS OF DOPAMINE D2 RECEPTORS
    Publication number: 20100074973
    Abstract: The present invention relates to new thioxanthene modulators of dopamine D2 receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: August 21, 2009
    Publication date: March 25, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Manouchehr M. Shahbaz, Sepehr Sarshar
  • XANTHINE MODULATORS OF ADENOSINE A1 RECEPTOR
    Publication number: 20100075935
    Abstract: The present invention relates to new xanthine modulators of adenosine A1 receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: August 24, 2009
    Publication date: March 25, 2010
    Applicant: Auspex Pharmaceuticals, Inc.
    Inventors: Thomas G. Gant, Manouchehr M. Shahbaz
  • METHODS OF REDUCTION OF INTERPATIENT VARIABILITY
    Publication number: 20100076087
    Abstract: Disclosed herein are methods for the reduction of inter-patient variability of a drug, such as in one or more parameters including half-life (t1/2), maximum plasma concentration (Cmax), time at maximal plasma concentration (Tmax), area under the time-versus-concentration curve (AUC). Also provided are methods of reducing side effects associated with drugs.
    Type: Application
    Filed: April 13, 2009
    Publication date: March 25, 2010
    Applicant: Auspex Pharmaceuticals, Inc.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • PHENYLPROPANONE MODULATORS OF DOPAMINE RECEPTOR
    Publication number: 20100075950
    Abstract: The present invention relates to new phenylpropanone modulators of dopamine receptors, serotonin receptors, and/or nicotinic acetylcholine receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: August 19, 2009
    Publication date: March 25, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Manouchehr M. Shahbaz, Sepehr Sarshar
  • CARBAMATE REDUCERS OF SKELETAL MUSCLE TENSION
    Publication number: 20100076074
    Abstract: The present invention relates to new carbamate skeletal muscle relaxants, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: August 20, 2009
    Publication date: March 25, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Manouchehr M. Shahbaz
  • SUBSTITUTED QUINAZOLINE INHIBITORS OF GROWTH FACTOR RECEPTOR TYROSINE KINASES
    Publication number: 20100075916
    Abstract: The present invention relates to new substituted quinazoline inhibitors of vascular endothelial growth factor receptor tyrosine kinase, epidermal growth factor receptor tyrosine kinase, and/or REarranged during Transfection tyrosine kinase, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: September 4, 2009
    Publication date: March 25, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar, Manouchehr M. Shahbaz
  • DIBENZOTHIAZEPINE MODULATORS OF DOPAMINE, ALPHA ADRENERGIC, AND SEROTONIN RECEPTORS
    Publication number: 20100069356
    Abstract: The present invention relates to new dibenzothiazepine modulators of D1 receptors, D2 receptors, alpha-1 adrenergic receptors, alpha-2 adrenergic receptors, H1 receptors, 5-HT1A receptors, and/or 5-HT2 receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: May 15, 2009
    Publication date: March 18, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar
  • ARYLPIPERAZINE MODULATORS OF D2 RECEPTORS, 5-HT1A RECEPTORS, AND/OR 5-HT2A RECEPTORS
    Publication number: 20100069399
    Abstract: The present invention relates to new arylpiperazine modulators of D2 receptors, 5-HT1A receptors, and/or 5-HT2A receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: February 27, 2009
    Publication date: March 18, 2010
    Applicant: AUSPEX PHARMACEUTICAL, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar, Chengzhi Zhang