Abstract: A lithography apparatus includes: a projection system configured to project a desired image onto a substrate; an active module that generates a time-varying heat load; a temperature conditioning system configured to maintain a component of the lithography apparatus at a predetermined target temperature; and a heat buffer including a phase change material in thermal contact with the active module, the phase change material having a phase change temperature such that the phase change material is caused to undergo a phase change by the time-varying heat load, and wherein the phase change material is stationary relative to the projection system during critical operations of the lithography apparatus.

Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein X1, X2, X3, X4, X5, W1, W2, W3, and W4 are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. In one aspect, the invention relates to selective HDAC3 inhibitors useful for protecting ?-cells and improving insulin resistence. The selective HDAC3 inhibitors are also useful for promoting cognitive function and enhancing learning and memory formation.

Abstract: A new and distinct cultivar of Rudbeckia plant named ‘ET RDB 410’, characterized by its compact, upright to outwardly spreading and mounded plant habit; freely branching growth habit; relatively small leaves; freely flowering habit; single-type inflorescences with yellow and greyed orange bi-colored ray florets positioned above the foliar plane on strong peduncles; and good postproduction longevity.

Abstract: Disclosed is a method for the integrated production of two different urea products. One is an aqueous urea solution suitable for use in NOx abatement (generally indicated as Diesel Exhaust Fluid—DEF). The other is a solution used as a fertilizer, viz. Urea Ammonium Nitrate (UAN). The production of DEF and UAN are integrated as follows: ammonia recovered from the production of urea is used as a feed to the production of ammonium nitrate. At least part of an aqueous urea stream from urea prodution, is mixed with ammonium nitrate so as to obtain UAN.

Abstract: A picktool manipulator device collects a specimen from a culture medium. In a first mode of operation, a picktool is allowed to move in an axial direction relative to support structure of the device. A detector may generate a signal in response to movement of the body in the axial direction so as to determine a height at which the picktool contacts the medium. The device may operate in the first mode when collecting a specimen from a culture medium. A second mode of operation constrains or precludes axial movement of the picktool. In some cases, the device may operate in the second mode when receiving a new picktool or discarding a used picktool.

Abstract: Disclosed is an inspection apparatus and associated method for measuring a target structure on a substrate. The inspection apparatus comprises an illumination source for generating measurement radiation; an optical arrangement for focusing the measurement radiation onto said target structure; and a compensatory optical device. The compensatory optical device may comprise an SLM operable to spatially modulate the wavefront of the measurement radiation so as to compensate for a non-uniform manufacturing defect in said optical arrangement. In alternative embodiments, the compensatory optical device may be located in the beam of measurement radiation, or in the beam of pump radiation used to generate high harmonic radiation in a HHG source. Where located in in the beam of pump radiation, the compensatory optical device may be used to correct pointing errors, or impart a desired profile or varying illumination pattern in a beam of the measurement radiation.

Abstract: An amusement ride such as a roller coaster, more in particular to booster drives mounted on a track of such a ride, are disclosed. The booster drives each include at least one booster drive motor for driving booster wheels, and for engaging a drive fin of a passenger vehicle to propel that vehicle along the track. The booster drive further includes a base mounted to the track structure, a frame that supports the at least one booster drive motor and the two booster wheels, and a mobile carrier that connects the frame to the base via a left and a right carrier arm. These carrier arms are non-flexible arms pivotably connected to the base and the frame or they are flexible arms, such that in use they enable movement of the frame relative to the base. A biasing device resiliently forces the frame towards a predetermined position.

Abstract: A brachytherapy system includes a brachytherapy applicator. The brachytherapy applicator includes an applicator tube and a radiation source configured to deliver radiation to a tumor. At least a portion of the applicator tube is configured to conform to at least a portion of a patient's anatomy. At least one ultrasound element or probe is coupled to or embedded with the applicator tube.

Abstract: Described are proteinaceous molecules comprising at least a domain that comprises an amino acid sequence that specifically binds to an MHC-peptide complex on an aberrant cell, functionally connected with a substance that induces apoptosis in aberrant cells, but not in normal cells. These proteinaceous molecules are preferably used in selectively modulating biological processes. The provided proteinaceous molecules are of particular use in pharmaceutical compositions for the treatment of diseases related to cellular aberrancies, such as cancers.

Abstract: A new and distinct cultivar of Rudbeckia plant named ‘ET RDB 402’, characterized by its compact, upright to outwardly spreading and mounded plant habit; freely branching growth habit; relatively small leaves; freely flowering habit; single-type inflorescences with dark reddish brown-colored ray florets positioned above the foliar plane on strong peduncles; and good postproduction longevity.

Abstract: A new and distinct cultivar of Rudbeckia plant named ‘ET RDB 401’, characterized by its compact, upright to outwardly spreading and mounded plant habit; freely branching growth habit; relatively small leaves; freely flowering habit; single-type inflorescences with yellow and dark reddish brown bi-colored ray florets positioned above the foliar plane on strong peduncles; and good postproduction longevity.

Abstract: A new and distinct cultivar of Rudbeckia plant named ‘ET RDB 404’, characterized by its compact, upright to somewhat outwardly spreading and mounded plant habit; freely branching growth habit; relatively small leaves; freely flowering habit; single-type inflorescences with quilled yellow and dark reddish brown-colored ray florets positioned above the foliar plane on strong peduncles; and good postproduction longevity.

Abstract: Disclosed is a method of determining a characteristic of a target on a substrate and corresponding metrology apparatus and computer program. The method comprises determining a plurality of intensity asymmetry measurements from pairs of complementary pixels comprising a first image pixel in a first image of the target and a second image pixel in a second image of the target. The first image is obtained from first radiation scattered by the target and the second image is obtained from second radiation scattered by the target, the first radiation and second radiation comprising complementary non-zero diffraction orders. The characteristic of the target is then determined from said plurality of intensity asymmetry measurements.

Abstract: A substrate table to support a substrate on a substrate supporting area, the substrate table having a heat transfer fluid channel at least under the substrate supporting area, and a plurality of heaters and/or coolers to thermally control the heat transfer fluid in the channel at a location under the substrate supporting area.

Abstract: According to a first aspect of the present disclosure, a signal processing system is provided, comprising: a receiving unit configured to receive at least one signal that comprises a plurality of multipath components; a verification unit configured to correlate at least one multipath component under test with a reference signal derived from one or more of said plurality of multipath components. According to a second aspect of the present disclosure, a corresponding signal processing method is conceived. According to a third aspect of the present disclosure, a corresponding computer program is provided.

Abstract: Aspects of the disclosure are directed to communications between respective power domains (circuitry) that may operate in a stacked arrangement in which the each domain operates over a different voltage range. A first circuit provides differential outputs that vary between first and second voltage levels, based on transitions of an input signal received from a first one of the power domains. First and second driver circuits are respectively coupled to the first and second differential outputs. A third driver circuit operates with the first and second circuits to level-shift the input signal from the first power domain to an output signal on a second power domain by driving an output circuit at the second voltage level in response to the input signal being at the first voltage level, and driving the output circuit at a third voltage level in response to the input signal being at the second voltage level.

Abstract: A multi-staged lighting device (1) for generating a polarized multi-colored light beam (25) is disclosed. The multi-staged lighting device (1) comprises two or more light concentrators (5, 15), each light concentrator (5, 15) having a wavelength converter (8, 19) configured to convert light entering the light concentrator (5, 15) to light having a longer wavelength, and at least one polarizing beam splitter (10) configured to split converted light coupled out from a light concentrator (5, 15) into two light beams having different polarizations, one of the light beams being transmitted to a different light concentrator (5, 15) and the other light beam forming a color component of the polarized multi-colored light beam (25).

Abstract: A pattern from a patterning device is applied to a substrate by a lithographic apparatus. The applied pattern includes product features and metrology targets. The metrology targets include large targets which are for measuring overlay using X-ray scattering and small targets which are for measuring overlay by diffraction of visible radiation. Some of the smaller targets are distributed at locations between the larger targets, while other small targets are placed at the same locations as a large target. By comparing values measured using a small target and large target at the same location, parameter values measured using all the small targets can be corrected for better accuracy. The large targets can be located primarily within scribe lanes while the small targets are distributed within product areas.

Abstract: Needle hub assembly (200) for a syringe (100), said assembly having a longitudinal axis (L1) comprising:—a needle hub body (210) having a syringe connector (212) for receiving an attachment member (110) of a syringe (100) at a first end (210a) of the body (210) and a needle receiving portion (214) at a second opposing end (210b) of the body (210),—a needle (216) extending from the needle receiving portion (214), wherein the syringe connector (212) comprises a substantially conical receiving opening (218) for receiving a syringe attachment member (110), at least a distal end (110b) thereof, wherein a length (A) of said opening (218), measured along the longitudinal axis (L1), is approximately 6.1+0.05 mm.

Abstract: A new cultivar of Hydrangea macrophylla plant named, ‘Hort 10-087-07’, that is characterized by its compact plant habit, its double flowers with a large number of sepals that are pink in color, and its star-shaped sterile flowers comprised of elongated shaped sepals (ovate-elliptic) with pointed tips.