Abstract: The invention relates to new anti-hCTLA-4 antibodies that bind to a different epitope than prior art anti-CTLA4 antibodies, methods to produce these antibodies and therapeutic and diagnostic uses of these antibodies. These antibodies show a similar affinity for the CTLA4 antigen and they are also able to block the binding of CTLA4 to CD80 and/or CD86.

Abstract: A method of reducing perspiration comprising the topical application of a composition comprising an siRNA that is capable of reducing levels of a specified protein or its mRNA or the function or formation of calcium channel associated therewith; wherein the specified protein is Orai1, Stim1, Orai3, TRPC1 or Stim2.

Abstract: A lithographic apparatus is disclosed including a liquid supply system configured to at least partly fill a space between the projection system and the substrate with a liquid, an outlet configured to remove a mixture of liquid and gas passing through a gap between a liquid confinement structure of the liquid supply system and the substrate, and an evacuation system configured to draw the mixture through the outlet, the evacuation system having a separator tank arranged to separate liquid from gas in the mixture and a separator tank pressure controller, connected to a non-liquid-filled region of the separator tank, configured to maintain a stable pressure within the non-liquid-filled region.

Abstract: A method of correcting an optical image formed by an optical system, the method including obtaining a map indicative of a polarization dependent property of the optical system across a pupil plane of the optical system for each spatial position in an image plane of the optical system, combining the map indicative of the polarization dependent property of the optical system with a radiation map of the intensity and polarization of an input radiation beam to form an image map, and using the image map to correct an optical image formed by directing the input radiation beam through the optical system.

Abstract: A system and method of conducting a drone race or game in a contained area is disclosed herein. The system may also include cameras attached to the drones and the video feed from the camera is transmitted to a computing device used to control the drone and to display the video feed. The system may also use computing devices and monitors to display the video feeds from the cameras attached to the drones. The system may also be configured as a game with information points.

Abstract: An ostomy appliance comprising an adaptor having a distal end adapted to be coupled to an ostomy wafer and a proximal end adapted to be coupled to a cap, said distal end having an opening in fluid communication with an opening in said proximal end.

Abstract: The present invention relates to compounds according to Formula (I) or a pharmaceutically acceptable salt or solvate thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or condition.

Abstract: Disclosed are systems and methods for identifying a user of a smart object inside a moving vehicle and as well as automatic detection and calculation of a time and a location when and where the vehicle has been parked. The systems and methods are capable to enable the identification of the user of an object inside a moving entity based on the orientation of the object to be localized as well as the movement direction of the moving entity.

Abstract: A self-propelled agricultural application machine includes a chassis which carries a storage tank for the material to be applied. The chassis has a central longitudinal beam from which at least a pair of wheels is suspended. A transversely-extending boom assembly is suspended from the longitudinal beam. An engine is located to one side of the longitudinal beam and has an output drive shaft connected through the longitudinal beam to hydraulic pumps. The narrow chassis allows steerable wheels to be positioned at tolerable track widths while permitting a large steering angle and thus small turning radii.

Abstract: A film forming apparatus includes a susceptor, and a shower head provided above the susceptor and having a first passage and a second passage independent of the first passage formed therein, wherein the first passage is formed through the shower head by being provided with a first cavity surrounded by a first upper wall and a first lower wall, a first thin hole formed in the first upper wall, and a plurality of second thin holes formed in the first lower wall, the height of the first upper wall in the vertical direction is reduced with increase in distance from the first thin hole, and the second passage is formed in the same manner as the first passage.

Abstract: A pacifier strap for connecting a pacifier to a fastening clip. The pacifier strap forms a loop at at least one end and includes a loop adjuster configured to adjust the length of the loop so that the length of the pacifier strap itself can be adjusted between a first length, in which the loop has a maximum length, and a second length, in which the loop has a minimum length. In addition, the pacifier strap has a container configured to receive at least one nipple of the pacifier, which container can be connected, at least temporarily, to the loop adjuster.

Abstract: A lithographic projection apparatus includes a support structure configured to hold a patterning device, the patterning device configured to pattern a beam of radiation according to a desired pattern; a substrate table configured to hold a substrate; a projection system configured to project the patterned beam onto a target portion of the substrate; a liquid supply system configured to provide liquid to a space between the projection system and the substrate; and a shutter configured to isolate the space from the substrate or a space to be occupied by a substrate.

Abstract: The invention pertains to a method for processing a defeathered whole leg poultry product, wherein the method comprises the following steps: —providing a leg product which comprises: —a thigh, —a drumstick, —a knee joint, —while the leg product is suspended from a carrier of a conveyor, making a transverse cut at the knee joint, which transverse cut is made from the rear side of the leg product towards the knee cap, said cut having a cut end which is located adjacent to the rear of the knee cap so that the thigh and the drumstick remain connected to each other and the knee cap remains intact, by which cut a drumstick side cut plane and a thigh side cut plane are created, —while keeping the thigh meat and the drumstick connected to each other, removing the thigh bone from the thigh meat via the thigh side cut plane of the transverse cut, —while keeping the thigh meat and the drumstick connected to each other, severing the knee meat from the knee cap while keeping the knee meat and the thigh meat connected to e

Abstract: The present invention provides an orally disintegrating solid pharmaceutical dosage unit having a weight of 50-1,000 mg and containing at least 0.1 mg of an estetrol component selected from estetrol, estetrol esters and combinations thereof. This solid dosage unit consists of: 4-95 wt. % of granules consisting of: 3-80 wt. % of an estetrol component selected from estetrol, estetrol esters and combinations thereof; 20-97 wt. % C4-C12 sugar alcohol; 0-45 wt. % of one or more other pharmaceutically acceptable ingredients; and 5-96 wt. % of one or more pharmaceutically acceptable excipients. The solid dosage units of the present invention are particularly suited for sublingual, buccal or sublabial administration of the estetrol component.

Abstract: There is disclosed a portable security device for securing a data exchange between a host device and a remote device, said portable security device comprising a processing unit, a secure element and a data interface, wherein: the secure element is arranged to store an encryption key and a decryption key; the processing unit is arranged to control the encryption of data to be transmitted from the host device to the remote device, wherein said encryption is performed using said encryption key; the processing unit is further arranged to control the decryption of data transmitted from the remote device to the host device, wherein said decryption is performed using said decryption key. Furthermore, a corresponding method for securing a data exchange between a host device and a remote device using a portable security device is disclosed, as well as a corresponding computer program product.

Abstract: A system and method of removing target material debris deposits simultaneously with generating EUV light includes generating hydrogen radicals in situ in the EUV vessel, proximate to the target material debris deposits and volatilizing the target material debris deposits and purging the volatilized target material debris deposits from the EUV vessel without the need of an oxygen containing species in the EUV vessel.

Abstract: Optical wave guide panel for visualization of an image, wherein the panel has an image interface surface for interfacing with an image to be visually presented and a viewing interface surface opposite the image interface surface for reviewing the image located at the image interface surface. The panel has at least one boundary, and is fabricated from a transparent solid material. The panel is provided with a pattern of grooves and to the image interface surface, extending at lease partially into the panel between image interface surface and the viewing interface surface of the panel. The pattern of grooves comprises at least one groove following a contour of the at least one boundary of the panel.

Abstract: A device for collecting vehicle on-board diagnostics (OBO) data is disclosed, together with an associated method of collecting OBD data in such devices. In embodiments, the OBO data collection device includes a connector for connecting the device to a vehicle OBO port to receive OBO data and power and a processor for controlling collection of the OBO data. The processor is arranged to determine a vehicle engine state by monitoring a voltage at the connector, taken in combination with OBO data relating to vehicle speed and/or engine revolutions. Such devices are able to reliably detect both engine ‘on’ and ‘off’ states in modern vehicles that use “smart charging” technology.

Abstract: A new and distinct Aloe aristata cultivar named ‘AMIAL1619’ which is characterized by erect foliage that is arranged in a spreading basal rosette, with foliage in the innermost whorls held very tightly. The large deltoid foliage exhibits a soft mucronulate apex, dark green general coloration, and is densely covered with prominent papillae, many of which bear spines. Papillae on the abaxial leaf surface are arranged in distinct transverse rows. The new variety has shown to be uniform and stable in the resulting generations from asexual propagation.