Abstract: An aspect of an embodiment of the invention relates to providing treatment of disease, in particular age-related disease, through increasing or decreasing the activity of SIRT6 protein. This may be accomplished through upregulation and downregulation of expression of SIRT6 in mammals. It has been found by the inventors that mice over-expressing SIRT6 have a longer lifespan in comparison to control mice, indicating that increasing SIRT6 expression can lengthen lifespan of mammals. Agents which modulate SIRT6 expression through, for example binding to 3?UTR region of human mRNA encoding SIRT6 or by blocking binding of agents to 3?UTR region of human mRNA encoding SIRT6, have been identified.

Abstract: Disclosed are an apparatus and a method for encryption. The apparatus includes a key table generator configured to generate random values based on a seed value and generate a key table including the generated random values; and an encryptor configured to apply the generated key table to a round function, generate a block encryption algorithm having a Feistel structure based on the round function, and encrypt a plaintext data block based on the generated block encryption algorithm.

Abstract: Disclosed are an apparatus and a method for encryption. The apparatus includes, a key table generation unit configured to generate random values derived from a seed value and generate a key table including the generated random values, and an encryption unit configured to encrypt a plain text data block by generating an encryption algorithm by repeatedly combining the generated key table with a permutation function in a crossing manner, and using the generated encryption algorithm.

Abstract: A system and method monitoring conditions of a subject's body including a control unit receiving image data and data indicative of an external stimulation applied to the body during collection of the image data therefrom, a memory utility, and a processor utility. The image data is indicative of a sequence of speckle patterns generated by the body according to a certain sampling time pattern.

Abstract: The present invention discloses plural planar Hall-effect sensors each having a magnetic sensing region of an elongated shape, the magnetic sensing regions having plural orientations, wherein, for a ratio of long axis length to short axis length greater than a predetermined number, effective single magnetic domain behavior is exhibited in the sensing region, the sensing having shape-induced uniaxial magnetic anisotropy with the easy axis parallel to the long axis of the magnetic sensing region; further wherein the magnitude of the uniaxial magnetic anisotropy depends on the ratio of the thickness of the sensing region to the length of the short axis, and method of operating the same to measure plural magnetic field components.

Abstract: The invention relates to inhibitors of a bacterial biofilm formation that target the N? loop extension of the periplasmic subunit of a bacterial Phosphate Specific Transfer system (PstS), specifically, of P. aeruginosa. The inhibitors of the invention may be either derived from the N? loop extension of PstS or directed against the N? loop extension. The invention further provides compositions and methods using said inhibitors in inhibiting biofilm formation and in treating pathologic conditions associated therewith.

Abstract: The present disclosure provides systems and methods for improving the resolution of a spectrometer configured to provide a frequency spectrum of a radiation incoming from a sample. The system comprises an optical medium configured so that the radiation incoming from the sample be transferred through the optical medium, the optical medium having a predetermined tunable spectral transmission curve; an operating unit connectable to the optical medium and configured to operate the optical medium so as to shift the spectral transmission curve of the optical medium over a predetermined spectral range; and a processing unit connectable to the spectrometer and configured to process a set of shifted frequency spectra provided by the spectrometer and obtainable by transferring the radiation incoming from the sample through the optical medium while shifting the spectral transmission curve of the optical medium so as to obtain a super resolved frequency spectrum of improved spectral resolution.

Abstract: An aspect of embodiments of the invention relates to surface modified proteinaceous spherical particles (SMOP). SMOPs according to an embodiment of the invention may comprise a protein layer and an amyloid-binding moiety bound to the protein. In an embodiment, the protein layer is spherical in shape and comprises proteins linked to each other by disulfide bonds. It is suggested that SMOPs are effective in preventing formation of amyloid and aggregation of A? when administered to a patient in need thereof.

Abstract: A nanoparticle, which has a metal oxide core and a cerium shell is provided. The weight ratio of the cerium within the shell to the metal oxide in the core is at least 1%. Additionally a method for delivering a ligand into a cell with the nanoparticle is provided.

Abstract: A method for designing a dual-mode logic circuit which is selectably operational in static and dynamic modes is performed as follows. A basis library with a DML inverter and dual-mode logic (DML) bicells is provided. Each DML bicell includes a type-A DML logic gate with a clock input and a type-B DML logic gate with an inverted clock input. A pseudo-static library is formed from the basis library by modifying each bicell of the basis library and specifying at least one dynamic timing parameter. A dynamic library is formed from the basis library by specifying dynamic timing parameters for the basis library DML inverter and bicells. Logic behavior of the required logic circuit is defined. An initial logic circuit design synthesized from the pseudo-static library and the defined logic behavior. Finally, a dynamic circuit design is formed by replacing modified bicells with corresponding bicells from the dynamic library.

Abstract: An aspect of an embodiment of the invention relates to providing treatment of disease, in particular age-related disease, through increasing or decreasing the activity of SIRT6 protein. This may be accomplished through upregulation and downregulation of expression of SIRT6 in mammals. It has been found by the inventors that mice over-expressing SIRT6 have a longer lifespan in comparison to control mice, indicating that increasing SIRT6 expression can lengthen lifespan of mammals. Agents which modulate SIRT6 expression through, for example binding to 3?UTR region of human mRNA encoding SIRT6 or by blocking binding of agents to 3?UTR region of human mRNA encoding SIRT6, have been identified.

Abstract: Provided is a composite including lead oxide particles (PbO2) and functionalized carbon nanotubes (CNTs).

Abstract: The present invention is directed to compounds such as: formula wherein linker is independently selected from the group consisting of —S—, —S—S—, —S—(CH2)n-, —NH—, —NH—(CH2)n-, —O—, —SO2-, arylene, heteroarylene; R1 is selected from the group consisting of straight or branched C4-C20 alkyl, straight or branched C4-C20 alkenyl, straight or branched C4-C20 alkynyl, each optionally interrupted with at least one NH, C5-C7 saturated cycloalkyl or heteroalkyl ring, C5-C12 aromatic or heteroaromatic ring, each optionally substituted with at least one group selected from —COOH, —NH2, C1-C8 alkoxy, C1-C5 amidyle, C1-C5 carboxyl, halogen; and R2 is independently selected from the group consisting of H, OH, SH, NH2, NO2, halogen, CN, C1-C8 alkoxy, C1-C5 carboxylic acid, straight or branched C1-C8 alkyl, straight or branched C2-C10 alkenyl, straight or branched C2-C12 alkynyl each optionally substituted by at least one substituent selected from the group consisting of C1-C5 alkoxy, C1-C5 carboxylic acid, OH, SH, NH2, hal

Abstract: An imaging system is provided, configured for providing three-dimensional data of a region of interest. The system comprising: an optical unit and a control unit. The optical unit comprises a radiation collection unit and a detection unit. The radiation collection unit comprises at least two mask arrangement defining at least two radiation collection regions respectively, the mask arrangements are configured to sequentially apply a plurality of a predetermined number of spatial filtering patterns formed by a predetermined arrangement of apertures applied on radiation collected thereby generating at least two elemental image data pieces corresponding to the collected radiation from said at least two collection regions. The control unit comprising is configured for receiving and processing said at least two elemental image data pieces and determining a plurality of at least two restored elemental images respectively being together indicative of a three dimensional arrangement of the region being imaged.

Abstract: Novel N-acylated, O-acylated and (bis or tris)-N,O-acylated derivatives of purinic and pyrimidinic nucleoside analogs, pharmaceutical compositions containing same, and uses thereof for treating proliferative diseases or disorders are disclosed.

Abstract: We disclose a system for preparing antimicrobial fabrics, coated with metal oxide nanoparticles by means of a novel sonochemical method. These antibacterial fabrics are widely used for production of outdoor clothes, under-wear, bed-linen, bandages, etc. The deposition of metal oxides known to possess antimicrobial activity, namely ZnO, MgO and CuO, can significantly extent the applications of textile fabrics and prolong the period of their use. By means of the novel sonochemical method disclosed here, uniform deposition of metal oxide nanoparticles is achieved simply.

Abstract: The invention provides nanoparticles consisting of a polymer which is a metal chelating agent coated with a magnetic metal oxide, wherein at least one active agent is covalently bound to the polymer, said nanoparticles may optionally further comprise at least one active agent physically or covalently bound to the outer surface of the magnetic metal oxide. Pharmaceutical compositions comprising these nanoparticles may be used, inter alia, for detection and treatment of tumors and inflammations.

Abstract: A method for providing spectral and temporal stealthy information transmitted over an optical communication channel, according to which, at the transmitting side, the power spectral density of a pulse sequence bearing the information is reduced by encrypting the temporal phase of the pulse sequence. The power of the pulse sequence is spread in the frequency domain, to be below the noise level, by sampling the pulse sequence. Spectral phase encoding is used to temporally spread the pulse sequence and to prevent coherent addition of its spectral replicas in frequency domain. The resulting signal, encrypted both in time and frequency domains, is then transmitted. Spectral phase decoding is performed at the receiving side by performing coherent detection and folding all the spectral replicas of the transmitted signal to the baseband by means of sampling. The temporal phase of the signal is decrypted and the information which is delivered by the pulse sequence is decoded.

Abstract: The present invention relates to animal model systems comprising a chimera between an avian embryo and a mammalian organism. Specifically, chimeric model systems comprising normal, diseased or genetically transformed mammalian cells and tissues transplanted into avian embryos, and uses thereof for in vivo testing of drugs and therapeutic modalities are disclosed.

Abstract: The disclosure provides particular uridine di- and tri-phosphate compounds of Formula I, and pharmaceutical compositions thereof. The definitions of variables such as R, Y, B, m, Z1, Z2, and Z3 are as provided in the disclosure. These compounds are useful for treatment of diseases, disorders and conditions modulated by P2Y6 receptors, and particularly for lowering intraocular pressure and thereby treating ocular hypertension and/or glaucoma.