Patents Assigned to Bar-Ilan University
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Patent number: 5569675Abstract: This invention relates to novel methods of increasing the level of fetal hemoglobin (HbF) in a subject and methods of treating, preventing or ameliorating .beta.-globin or other HbF-related disorders by increasing the level of HbF in a subject in need of such treatment comprising administering one or more compounds of the Formulae (I), (II), or (III):(I) XCH.sub.2 --CHX--CHX--C(.dbd.O)--O--Z(II) CH.sub.3 --CO--CH.sub.2 --C(.dbd.O)--O--Z(III) CH.sub.3 --CH.sub.2 --CO--C(.dbd.O)--O--Zwherein:X is H, or one of X only may be OH;Z is --CHR--O--C(.dbd.O)R', --CHR--O--C(.dbd.Type: GrantFiled: March 7, 1994Date of Patent: October 29, 1996Assignees: Bar Ilan University, Mor Research Applications Ltd.Inventors: Ada Rephaeli, Abraham Nudelman, Matityahu Shaklai
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Patent number: 5552307Abstract: A method for culturing fungal and plant cells in a culture medium containing an elicitor to increase production of a metabolite produced by the cells. For example, tobacco leaves produce the metabolite nicotine and the nicotine is produced in significantly greater amounts when the tobacco is cultured in a elicitor-containing medium. The elicitor is an oxidized Bovine Serum Albumin (BSA), or a glycosylated BSA, or an oxidized lysozyme, or glycosylated lysozyme or azetidine-2-carboxylic acid. Further, metabolite production is increased 1000% over the production of the metabolite when an elicitor is not added during the culturing method.Type: GrantFiled: November 4, 1994Date of Patent: September 3, 1996Assignees: Bar-Ilan University, Rutgers, The State University of New JerseyInventors: Bezalel Kessler, Chaim Frenkel, Daphna Frenkel, Abraham Kessler
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Patent number: 5539761Abstract: A phase-controlled oscillator using a resonant tunneling diode (RTD), which is included in a self-oscillating biasing circuit. A biasing voltage controls the phase of the pulsating output relative to a pulsating input signal. If the output modulates a laser, the pulse position of the laser output can be varied in time. If the output modulates a microwave or other emitter have an electromagnetic frequency equal to that of the RTD biasing circuit, the electromagnetic phase of the emission is controlled, thereby allowing phase-array radars using multiple RTD biasing circuits. Also, multiple RTD biasing circuits can have self-oscillation frequencies which are rational fractions of a single master clock frequency driving all of them. The outputs then have different frequencies but are phase locked.Type: GrantFiled: May 24, 1994Date of Patent: July 23, 1996Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Bar Ilan UniversityInventors: John Golub, Michael Rosenbluh, Edith Grumann, Michael Matusovsky
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Patent number: 5516673Abstract: Polymers containing a plurality of free hydroxy groups, such as cellulose, agarose or polyvinyl alcohol, are contacted in absence of reactants for hydroxy groups, with at least one N-heterocyclic compound, e.g. pyridine, pyrrole, pyridazine, their partially or fully hydrogenated analogs and any of these which may be substituted, in a pre-activation step prior to reaction with reactant for free hydroxy groups in the polymer, the polymer-bound residue of which reactant may be thereafter reacted in turn with amino compounds containing at least one unsubstituted N-attached hydrogen atom, e.g. proteins, thereby to form amine-polymer conjugates. The invention further relates to a powder, bandage, patch or like cover for application to wounds which has been manufactured from polymer containing a plurality of hydroxy groups by a process which includes the step of providing an amine conjugated to the polymer; the amine may be, e.g., trypsin, chymotrypsin, lysozyme, collagenase, albumin and hyaluronidase.Type: GrantFiled: February 10, 1994Date of Patent: May 14, 1996Assignee: Bar Ilan UniversityInventors: Shlomo Margel, Sophia Sturchak
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Patent number: 5506141Abstract: An apertured cell carrier defines first and second outer surfaces and comprises an ordered array of holes therethrough, the holes being in identifiable positions on the carrier and sized to contain individual living cells, the cross sections of the holes at the first outer surface and at a level spaced from the first outer surface, as well as the height between the first outer surface and the level of the second cross section, being defined. Preferably, the ordered array comprises at least one sub-group of uniformly shaped holes sized to accommodate individual living cells of the same size. The carrier may contain entire living cells or substantially entire living cells, held within individual holes. The carrier may be supported on a holder, in which case the carrier is preferably constructed to include a device for aligning it with a complementary device on the holder, whereby the individual addresses of holes in the carrier are identifiable by a set of x and y coordinates.Type: GrantFiled: May 9, 1994Date of Patent: April 9, 1996Assignee: Bar-Ilan UniversityInventors: Arye Weinreb, Mordechai Deutsch
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Patent number: 5494684Abstract: A composition for protecting a crop against fungal diseases which includes one or more fish oils used in association with an agriculturally acceptable diluent and, preferably, with a metal salt. Also provided is a method for protecting a crop against fungal diseases which includes applying to the seed, tuber or foliage of a crop or its locus, a fish oil in an amount sufficient to induce the local and/or systemic resistance of the crop to control the fungal disease. Preferably, the fish oil is used to protect a potato or tomato crop against infection by the late blight fungus Phytophthora infestans.Type: GrantFiled: February 23, 1994Date of Patent: February 27, 1996Assignee: Bar-Ilan UniversityInventor: Yigal Cohen
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Patent number: 5468776Abstract: A composition of matter which consists of (a) from about 16.7 to about 22.2% by weight of at least one compound selected from the group consisting of linolenic acid and derivatives thereof, calculated as the free acid, said derivatives of linolenic acid being both physiologically hydrolyzable and pharmacologically acceptable, and (b) about 77.8 to about 83.3% by weight of at least one compound selected from the group consisting of linoleic acid and derivatives thereof, calculated as the free acid, said derivatives of linoleic acid being both physiologically hydrolyzable and pharmacologically acceptable, is utilized e.g. as a pharmaceutical formulation or nutritional composition, in absence of an oily carrier or diluent which comprises at least one member of the group consisting of C.sub.Type: GrantFiled: July 20, 1993Date of Patent: November 21, 1995Assignee: Bar Ilan UniversityInventor: Shlomo Yehuda
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Patent number: 5465372Abstract: A dataflow machine for generally following data dependent path processes, the machine including an instruction store, an operand store, a plurality of data dependent path process executors, each process executor including an instruction queue and a queue loader associated with the instruction queue and operative to load the instruction queue with instructions selected from the instruction store, wherein the instructions with which the instruction queue is loaded are associated with a dynamically determined data dependent path process and are selected based, at least in part, on an active operand associated with each instruction, the active operand including a result of a previous instruction, and wherein at least some of the instructions are selected based, at least in part, on availability of an outside operand, and wherein the queue loader is operative to read the outside operand from the operand store, execution apparatus operative to sequentially apply each instruction in each instruction queue to at leasType: GrantFiled: January 6, 1993Date of Patent: November 7, 1995Assignee: Bar Ilan UniversityInventors: Israel Gottlieb, Yehuda Singer
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Patent number: 5416114Abstract: A composition of matter which consists of (a) from about 13.0 to about 27.5% by weight of at least one compound selected from the group consisting of linolenic acid and derivatives thereof, calculated as the free acid, said derivatives or linolenic acid being both physiologically hydrolyzable and pharmacologically acceptable, and (b) about 87.0 to about 72.5% by weight of at least one compound selected from the group consisting of linoleic acid and derivatives thereof, calculated as the free acid, said derivatives of linoleic acid being both physiologically hydrolyzable and pharmacologically acceptable, is utilized e.g. as a pharmaceutical formulation or nutritional composition, in absence of an oily carrier or diluent which comprises at least one member of the group consisting of C.sub.Type: GrantFiled: July 20, 1993Date of Patent: May 16, 1995Assignee: Bar Ilan UniversityInventor: Shlomo Yehuda
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Patent number: 5310674Abstract: An apertured cell carrier has a configuration defining first and second outer surfaces and comprising an ordered array of holes therethrough, the positions on the carrier of the holes being identifiable and the holes being sized to have the ability to contain individual living cells having a generally spherical shape therewithin, one cell only per hole, in that the holes have (i) a first cross section at the first outer surface of the carrier of such dimensions that living cells can pass through the first cross section without suffering substantial damage, (ii) a second cross section at a level intermediate between said first and second outer surfaces and of such dimensions that said living cells cannot pass through the second cross section, and (iii) a height between the first outer surface and the level of the second cross section such that either such an entire living cell or substantially such an entire living cell is containable within the hole.Type: GrantFiled: July 29, 1991Date of Patent: May 10, 1994Assignee: Bar-Ilan UniversityInventors: Arye Weinreb, Mordechai Deutsch
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Patent number: 5288755Abstract: A composition of matter which consists of (a) from about 13.0 to about 27.5% by weight of at least one compound selected from the group consisting of linolenic acid and derivatives thereof, calculated as the free acid, said derivatives of linolenic acid being both physiologically hydrolyzable and pharmacologically acceptable, and (b) about 87.0 to about 72.5% by weight of at least one compound selected from the group consisting of linoleic acid and derivatives thereof, calculated as the free acid, said derivatives of linoleic acid being both physiologically hydrolyzable and pharmacologically acceptable is utilized in a nutritional composition, in absence of an oily carrier or diluent which comprises at least one member of the group consisting of C-.sub.8-18 saturated fatty acids, oleic acid and derivatives of these acids, in order to induce in a mammal (including humans) at least one physiological effect selected from memory enhancement, analgesia, sleep regulation and inhibition of the symptoms of senility.Type: GrantFiled: January 14, 1992Date of Patent: February 22, 1994Assignee: Bar Ilan UniversityInventor: Shlomo Yehuda
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Patent number: 5272081Abstract: A method for producing cells having at least one common optical property, electromagnetic property, or biological property. The cells derived from selected living cells located at particular hole positions on an apertured carrier. The selected living cells are separated from all other cells on the carrier either by removing the selected cells from the carrier, or by removing undesired living cells from the carrier, or by killing undesired living cells on the carrier. The selected cells are growing either on the carrier or after having been removed therefrom.Type: GrantFiled: February 4, 1991Date of Patent: December 21, 1993Assignee: Bar-Ilan UniversityInventors: Arye Weinreb, Mordechai Deutsch
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Patent number: 5242692Abstract: A factor isolable from muscle tissue or muscle cell culture inhibits proliferation of tumor cells, such as ESB, HT-29 and B-16 F1 cell lines, as well as the peripheral white blood cells of a patient with chronic myeloid leukemia. The active fraction has a molecular weight in the range of 25-30,000 daltons.Type: GrantFiled: July 10, 1990Date of Patent: September 7, 1993Assignee: Bar Ilan UniversityInventors: Meir Djaldetti, Pnina Fishman, Benjamin Sredni
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Patent number: 5194282Abstract: At least part of the fat in fat-containing manufactured food products is replaced by gelatin in an amount by weight which is generally no more than 10% of the weight of the original fat content which has been replaced. Suitable gelatin for this purpose may be made from fish waste comprising fish skins by an aqueous extraction process, such as e.g. a stepwise process including separate alkaline, mineral acid and organic acid treatment steps. The gelatin is said to mimic the sensation experienced by the consumer of the creaminess or richness of foodstuffs containing regular fat levels. Exemplary products to which the invention may be applied are baked goods, dressings, whipped toppings, frostings, cream fillings and spreads. In Examples, the fat content is thus reduced substantially, to give food products which closely resemble in quality the higher fat-containing analogs.Type: GrantFiled: November 26, 1990Date of Patent: March 16, 1993Assignee: Bar Ilan UniversityInventors: Shlomo Grossman, Margalit Bergman, Abraham I. Bakal, Penny A. Cash
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Patent number: 5126149Abstract: The present invention provides a method for the stimulation of the production of lymphokines which comprises the administration of an effective amount of a tellurium tetrahalide.Type: GrantFiled: January 26, 1989Date of Patent: June 30, 1992Assignee: Bar-Ilan UniversityInventors: Benjamin Sredni, Michael Albeck
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Patent number: 5124167Abstract: Antioxidant compositions and methods are disclosed that are prepared by the extraction of natural antioxidants from plant substrates.Type: GrantFiled: July 25, 1990Date of Patent: June 23, 1992Assignee: Bar-Ilan UniversityInventors: Michael Albeck, Shlomo Grossman
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Patent number: 5120763Abstract: A composition of matter which consists of (a) from about 13.0 to about 27.5% by weight of at least one compound selected from the group consisting of linolenic acid and derivatives thereof, calculated as the free acid, said derivatives of linolenic acid being both physiologically hydrolyzable and pharmacologically acceptable, and (b) about 87.0 to about 72.5% by weight of at least one compound selected from the group consisting of linoleic acid and derivatives thereof, calculated as the free acid, said derivatives of linoleic acid being both physiologically hydrolyzable and pharmacologically acceptable, is utilized e.g. as a pharmaceutical formulation or nutritional composition, in absence of an oily carrier or diluent which comprises at least one member of the group consisting of C.sub.Type: GrantFiled: July 6, 1989Date of Patent: June 9, 1992Assignee: Bar Ilan UniversityInventor: Shlomo Yehuda
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Patent number: 5093474Abstract: A process for the production of gelatin from fish skins comprises the steps of: (a) cleaning the skins in order to remove therefrom substantially all superfluous material; (b) treating with dilute aqueous alkali; (c) washing with water until the washing water is substantially neutral; (d) treating with dilute aqueous mineral acid; (e) washing with water until the washing water is substantially neutral; (f) treating with dilute aqueous citric acid and/or another suitable organic acid; (g) washing with water until the washing water is substantially neutral; and (h) extracting with water at elevated temperatures not above about 55.degree. c., the washed citric acid-treated skins. In practice, the present process employs much lower temperatures than known heretofore for the treatment steps, which results in a high quality product (e.g. absence of a fishy smell), compared with the prior art.Type: GrantFiled: April 12, 1989Date of Patent: March 3, 1992Assignee: Bar Ilan UniversityInventors: Shlomo Grossman, Margalit Bergman
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Patent number: 5049380Abstract: The present invention describes a novel material which is extractable from plants of the order Malvales and which demonstrates anti-allergic activity.Type: GrantFiled: May 2, 1989Date of Patent: September 17, 1991Assignee: Bar-Ilan UniversityInventors: Shlomo Grossman, Rina Reznik, David Altman
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Patent number: 5024528Abstract: Alignment apparatus including a source of coherent radiation mounted in a reference location and arranged to provide an output beam extending along a reference axis, a laser light reflector mounted at a location sought to be aligned with respect to the reference location and/or the reference axis, a laser light scatterer arranged to receive reflected laser light from the reflector and to produce a speckle pattern and a detector arranged to sense the speckle pattern produced by the laser light scatterer in response to incident reflected laser light, whereby variations in the speckle pattern indicate changes in relative orientation between the reference location and the laser light reflector.Type: GrantFiled: November 13, 1989Date of Patent: June 18, 1991Assignee: Bar Ilan UniversityInventors: Isaac Freund, Michael Rosenbluh