Abstract: Novel chemical conjugates of psychotropic drugs and organic acids, uses thereof in the treatment of psychotic and/or proliferative disorders and diseases and as chemosensitizing agents, and their syntheses are disclosed. The organic acids are selected to reduce side effects induced by the psychotropic drugs and/or to exert an anti-proliferative activity.
Type:
Grant
Filed:
March 25, 2004
Date of Patent:
June 9, 2009
Assignees:
Ramot At Tel Aviv University Ltd., Bar-Ilan University
Inventors:
Abraham Nudelman, Ada Rephaeli, Irit Gil-Ad, Abraham Weizman
Abstract: A pharmaceutical composition and method for inducing or accelerating a healing process of a skin wound are described. The pharmaceutical composition contains, as an active ingredient, a therapeutically effective amount of an agent for either enhancing PKC production and/or enhancing PKC activation; and a pharmaceutically acceptable carrier. The method is effected by administering the composition to a wound.
Abstract: Provided are novel polymerizable monomers allowing preparation of exceptionally useful surface coatings by polymerization. Embodiments include highly reticulated chiral nanoparticles useful, for example, for covalently grating biological ligands, epitaxial growth of conductive polymers onto surface modified indium tin oxide (ITO) electrodes and arrays of gold nanodots and electroconductive polymers.
Abstract: Novel chemical conjugates of psychotropic drugs and organic acids, uses thereof in the treatment of psychotic and/or proliferative disorders and diseases and as chemosensitizing agents, and their syntheses are disclosed. The organic acids are selected to reduce side effects induced by the psychotropic drugs and/or to exert an anti-proliferative activity.
Type:
Application
Filed:
December 27, 2007
Publication date:
May 8, 2008
Applicants:
Ramot At Tel Aviv University Ltd., Bar-Ilan University
Inventors:
Abraham Nudelman, Ada Rephaeli, Irit Gil-Ad, Abraham Weizman
Abstract: The present invention provides dinucleoside boranophosphate derivatives of the general formula I: wherein X and X? each independently is an unsubstituted or substituted purine or pyrimidine residue; Y and Y? each independently is H or OH; Z1 to Z5 each independently is O? or BH3?, but excluding the compounds wherein Z1 to Z5 are each O?; W1 to W4 each independently is O, CH2, NH or C(Halogen)2; n and n? each independently is 0 or 1; m is 3, 4 or 5; and M+ represents a pharmaceutically acceptable cation, and to pharmaceutical compositions thereof. These dinucleoside boranophosphates are useful for prevention or treatment of diseases or disorders modulated by P2Y receptors such as type 2 diabetes, cystic fibrosis and cancer.
Abstract: The invention provides novel inorganic boranophosphate salts that can be used as fertilizers, in detergent formulations, as additive in melts for the glass industry, in boron neutron-capture therapy of cancer, and as synthetic building blocks in the synthesis of boranonucleotides of various lengths.
Abstract: 2-Substituted-5?-O-(1-boranotriphosphate)adenosine derivatives having at position 2 a radical R1 selected from the group consisting of H; halogen; O-hydrocarbyl; S-hydrocarbyl; NR3R4; and hydrocarbyl optionally substituted by halogen, CN, SCN, NO2, OR3, SR3 or NR3R4; wherein R3 and R4 are each independently H or hydrocarbyl or R3 and R4 together with the nitrogen atom to which they are attached form a saturated or unsaturated heterocyclic ring optionally containing 1-2 further heteroatoms selected from oxygen, nitrogen and sulfur, and pharmaceutically acceptable salts or diastereoisomers thereof or a mixture of diastereoisomers, are useful for treatment of type 2 diabetes.
Type:
Grant
Filed:
October 23, 2002
Date of Patent:
January 15, 2008
Assignees:
Bar-Ilan University, University of Montpellier
Inventors:
Bilha Fischer, Victoria Kleiman-Nahum, Pierre Petit
Abstract: Novel chemical conjugates of psychotropic drugs and organic acids, uses thereof in the treatment of psychotic and/or proliferative disorders and diseases and as chemosensitizing agents, and their syntheses are disclosed. The organic acids are selected to reduce side effects induced by the psychotropic drugs and/or to exert an anti-proliferative activity.
Type:
Application
Filed:
December 11, 2006
Publication date:
August 23, 2007
Applicants:
Ramot At Tel Aviv University Ltd., Bar-Ilan University
Inventors:
Abraham Nudelman, Ada Rephaeli, Irit Gil-Ad, Abraham Weizman
Abstract: An Interactive Transparent Individual Cells Biochip Processor (ITICBP) device is described, which is useful for assessing a single, individual living cell at identifiable location or assessing group of cells each at identifiable location.
Abstract: Novel chemical conjugates of psychotropic drugs and organic acids, uses thereof in the treatment of psychotic and/or proliferative disorders and diseases and as chemosensitizing agents, and their syntheses are disclosed. The organic acids are selected to reduce side effects induced by the psychotropic drugs and/or to exert an anti-proliferative activity.
Type:
Application
Filed:
December 11, 2006
Publication date:
May 3, 2007
Applicants:
Ramot At Tel Aviv University Ltd., Bar-Ilan University
Inventors:
Abraham Nudelman, Ada Rephaeli, Irit Gil-Ad, Abraham Weizman
Abstract: The invention relates to fluorescent N2,N3-etheno-purine (2?-deoxy) riboside derivatives and fluorescent oligonucleotide probes comprising one or more moieties thereof, their preparation and uses thereof for staining DNA/RNA and for detection and quantitation of genetic material.
Abstract: A superconducting short circuit current limiter (40a) for an alternating current system includes AC reactors having superconducting direct current bias windings (4a, 4b) that at normal conditions maintain the reactor's cores in saturated state. There are at least two AC coils (3a, 3b) for each phase operating at opposite half periods or at both half periods. The reactor may also have an additional feedback coil (42a, 42b) that at least partly compensates for the bias field of the superconducting coil at fault conditions enhancing a limiting capacity of the reactor. The reactor's core can be configured for decreasing its dimensions and mass as compared with known devices and for decreasing core losses. High voltage/high current devices include several standard modules connected in series or/and in parallel. A positional relationship of the modules is defined for decreasing necessary numbers of Amp?re-turns of superconducting and non-superconducting coils.
Abstract: Thrombin-conjugated nanoparticles, wherein said nanoparticles comprise one or more organic and/or inorganic compounds and process for preparing the same are provided. The thrombin-conjugated nanoparticles are suitable for use in the preparation of fibrin-based biological sealant.
Abstract: A superconducting coil having form of pancake or double pancake wound of non-insulated superconducting wire (tape) with insulating layer between adjacent turns composed of epoxy resin filled with ceramic powder of high thermal conductivity. A superconducting coil composed of several pancakes and/or double pancakes and includes layers of said epoxy with or without additional spacers between adjacent pancakes. Pancakes or double pancakes as well as coils, consisting of several pancakes and/or double pancakes that have a solenoid form or racetrack or saddle forms.
Type:
Application
Filed:
September 30, 2005
Publication date:
April 6, 2006
Applicants:
Bar Ilan University, RICOR Cryogenic & Vacuum Systems
Inventors:
Alexander Friedman, Shuki Wolfus, Yosef Yeshurun, Zvi Bar-Haim
Abstract: The present invention discloses a process for making rare earth (RE) doped optical fiber by using RE oxide coated silica nanoparticles as the precursor material, more particularly the method of the present invention involves preparation of stable dispersions (sol) of RE oxide coated silica nanoparticles at ambient temperature and applying a thin coating on the inner surface of silica glass tube following dip coating technique or any other conventional methods, of the said silica sol containing suitable dopants selected from Ge, Al, P, etc.
Type:
Grant
Filed:
October 22, 2001
Date of Patent:
May 10, 2005
Assignees:
Council of Scientific & Industrial Research, Bar-Ilan University
Inventors:
Ranjan Sen, Minati Chatterjee, Milan Kanti Naskar, Mrinmay Pal, Mukul Chandra Paul, Shyamal Kumar Bhadra, Kamal Dasgupta, Dibyendu Ganguli, Tarun Bandyopadhyay, Aharon Gedanken
Abstract: A method and system for determining a shape of a three-dimensional object from a planar top view thereof images the object on a planar substrate using a Differential Interference Contrast light microscope so that the object reflects from different points of a surface of the object colors that are indicative of a slope of the surface at each respective point. Successive digital color images are generated having a plurality of pixels each having a hue that correlates to a unique slope of the surface corresponding to the pixel. The slope of the surface at each point is inferred using a pre-calibrated color-depth characteristic derived using a sample formed of an identical material to the object to calculate local slope for each pixel. In a practical system, a user specifies a type of material being imaged and a corresponding color-depth characteristic is read that may be stored in a pre-compiled database.
Abstract: A method for reducing the rate of deterioration of perishable horticultural produce by causing the horticultural produce to be treated post harvest with nitric oxide in an amount and for a period of time sufficient to reduce the rate of deterioration of the horticultural produce.
Type:
Grant
Filed:
June 5, 2000
Date of Patent:
April 13, 2004
Assignees:
Bar-Ilan University, The University of Newcastle Research Associates
Limited
Abstract: A solid, gel type non-aqueous electrolyte for use in an electrochemical cell, the electrolyte including: (a) at least one polymer compound; (b) at least one organic solvent, and (c) at least one electrolytically active salt represented by the formula:
M′(ZRnXq-n)m
in which: M′ is selected from the group consisting of magnesium, calcium, and aluminum; Z is selected from the group consisting of aluminum, boron, phosphorus, antimony and arsenic; R represents radicals selected from the following groups: alkyl, alkenyl, aryl, phenyl, benzyl, and amido; X is a halogen (I, Br, Cl, F); m=2-3; n=0-5 and q=6 for Z=phosphorus, antimony, and arsenic, and n=0-3 and q=4 for Z=aluminum and boron, wherein the polymer compound, organic solvent, and electrolytically active salt interact to form a non-aqueous electrolyte having a solid, gel type structure.
Abstract: A pharmaceutical composition and method for inducing or accelerating a healing process of a skin wound are described. The pharmaceutical composition contains, as an active ingredient, a therapeutically effective amount of at least one agent for modulating PKC production and/or activation, and a pharmaceutically acceptable carrier. The method is effected by administering the composition to a wound.
Abstract: C8-substituted purine nucleotide analogs, such as ATP analogs, and their use is described, including their use as inhibitors of NTPDases and thereby as tools to modulate the conversion of nucleotides into nucleoside derivatives, and thus modulate the levels of these compounds. Such modulation further provides for the modulation of the activity and function of many processes which are affected by these compounds.
Type:
Grant
Filed:
June 9, 2000
Date of Patent:
September 9, 2003
Assignees:
Bar-Ilan University, Universite de Sherbrooke
Inventors:
Adrien R. Beaudoin, Fernand-Pierre Gendron, Efrat Halbfinger, Bilha Fischer