Abstract: The present invention provides specific small molecule compounds that modulate degradation and stability of Wiskott-Aldrich Syndrome protein (WASp), methods and uses thereof in innate and acquired immune-related disorders or conditions, specifically, in primary and secondary immune-deficiencies.

Abstract: There is provided a computer implemented method of determining a state of a medical condition of a subject, comprising: computing a tree that includes representations computed from genetic sequences of a plurality of microbes within a microbiome sample of a subject, wherein the tree includes the representations of the plurality of microbes arranged according to a taxonomy hierarchy, mapping the tree to a data structure that defines the taxonomy hierarchy and defines positions between neighboring representations of the plurality of microbes, feeding the data structure into a machine learning model that processes neighboring representations according to position, and obtaining the state of the medical condition of the subject as an outcome of the machine learning model.

Abstract: Described herein are synthetic cyclic peptide mimetics comprising alternating D-amino acids and L-amino acids and amino acid derivatives, such as aza-amino acids and azasulfuryl-amino acids. Optionally, the cyclic peptide mimetics may be conjugated to another agent via a linker to form cyclic peptide mimetic conjugates. The cyclic peptide mimetics described herein may be used as diagnostic or therapeutic agents for diagnosis or treatment of amyloidogenic diseases.

Abstract: Disclosed herein are thin films and methods of forming thin films. An example thin film may comprise Ba—Ti—O configured to exhibit a structure where a distance of one or more neighboring Ti—Ti atoms is less than 3 ?.

Abstract: A system and method of speech modification may include: receiving a recorded speech, comprising one or more phonemes uttered by a speaker; segmenting the recorded speech to one or more phoneme segments (PS), each representing an uttered phoneme; selecting a phoneme segment (PSk) of the one or more phoneme segments (PS); extracting a portion of the recorded speech, said portion corresponding to a first timeframe ({tilde over (T)}) that comprises the selected phoneme segment; receiving a representation () of a phoneme of interest P*; and applying a machine learning (ML) model on (a) the extracted portion of the recorded speech and (b) on the representation () of the phoneme of interest P*, to generate a modified version of the extracted portion of recorded speech, wherein the phoneme of interest (P*) substitutes the selected phoneme segment (PSk).

Abstract: A masking assembly is presented for use in inspecting a region of interest by creating structured high photon energy radiation to interact with the region of interest. The masking assembly comprises at least one mask structure, the mask structure having a predetermined effective thickness t, and comprising a mask pattern formed by an arrangement of spaced-apart features of absorption properties with respect to said high photon energy radiation different from spaces between said features. The arrangement of said features along a lateral dimension of the pattern defines a predetermined effective pattern size P. The features have a characteristic lateral size/providing a substantially high aspect ratio t/l.

Abstract: An artificial neuron unit and neural network for processing of input light are described. The artificial neuron unit comprises a modal mixing unit, such as multimode optical fiber, configured for receiving input light and applying selected mixing to light components of two or more modes within the input light and for providing exit light, and a filtering unit configured for applying preselected filter onto said exit light for selecting one or more modes of the exit light thereby providing output light of the artificial neuron unit.

Abstract: The present disclosure relates to layered 2D MoS2 nanostructures wherein light-matter interactions are enhanced by intercalation with transition metal atoms and/or post-transition metal atoms, specifically Cu and/or Sn. Photodetectors comprising Cu and/or Sn intercalated 2D MoS2 nanostructures amplify the response in the near-infrared for devices based on 2D MoS2.

Abstract: An assay method for target molecules in a sample using optical emission from magnetic beads, comprising: a) preparing the magnetic beads so, if excited, they produce optical emission as a consequence of contact between the beads, reporter molecules and target molecules in the sample; b) providing the prepared magnetic beads in a solution in a container, with one or more magnets producing a magnetic field inside the container that causes the beads to aggregate into a clump inside the container in less than 30 seconds; c) exciting the optical emission from the magnetic beads in the clump; and d) measuring the optical emission from the magnetic beads in the clump.

Abstract: It has been found that the prodrug 1-(butyryloxy)ethyl-5-amino-4-oxopentanoate (AN-233), an oral active conjugate of BA (histone deacetylase inhibitor) and ALA (heme precursor), is useful for the treatment of hemoglobinopathies including but not limited to sickle cell disease and thalassemias. In one embodiment, AN-233 activates ?-globin transcription, induces HbF expression, produces an anti-sickling effect, or combinations thereof when administered to a subject in need thereof.

Abstract: The present invention provides a system for imaging an object comprising: an optical imaging unit for imaging an object on a detection array, the optical imaging unit defining an optical axis and comprising a multicore fiber configured to collect light from the object at an input edge of the multicore fiber and transfer collected light to an output edge of the multicore fiber; a displacing unit configured to shift the input edge of the multicore fiber relatively to the object in a plane substantially perpendicular to the optical axis to obtain a set of shifted images of the object; and an operating unit configured to operate the displacing unit by setting a shifting amplitude to either a first amplitude inferior or equal to the diameter of a core of the multicore fiber or a second amplitude superior or equal to the diameter of the multicore fiber.

Abstract: Processes for laminating a graphene-coated printed circuit board (PCB) are disclosed. An example laminated PCB may include a lamination stack that may include an inner core, an adhesive layer, and at least one graphene-metal structure. Pressure and heat—which may be applied under vacuum or controlled gas atmosphere—may be applied to the lamination stack, after all materials have been placed. The graphene of the graphene-metal structure is designed to promote high frequency performance and heat management within the PCB.

Abstract: A system and corresponding method are described. The system comprises an RF transmission unit comprising an arrangement of one or more transmission antenna elements configured for transmitting radiation in one or more elected frequency ranges toward an inspection region; RF collection unit comprising one or more collection antenna elements configured for receiving radiation in said one or more frequency ranges from at least a portion of said inspection region; and a control system. The control system is configured for receiving and processing data on collected RF signals from the RF collection unit for determining one or more parameters on a at least one object located in said inspection region.

Abstract: Processes for laminating a conductive-lubricant coated Printed Circuit Board (PCB) are disclosed. An example laminated PCB may include a lamination stack that may further include a core, an adhesive layer, and at least one graphene-metal structure or at least one hexagonal Boron Nitride metal (h-BN-metal) structure. The materials of the PCB may change in accordance with the invention described herein, including the materials of the core, the materials of the conductive-lubricant coatings, or the metal layers of the conductive-lubricant-metal structures. Doping processes for each change in materials used are also described herein. The conductive-lubricant of the conductive-lubricant-metal structure will promote high frequency performance and heat management within the PCB. Furthermore, a removal process of those materials post-lamination is described herein to promote protection of materials and subsequent removal of protective layers without breakage or tearing.

Abstract: A method for estimating an information unit represented by DNA strands, the method includes (a) sequencing the DNA strands to provide noisy copies of an encoded version of the information unit; wherein the information unit comprises information unit elements; (b) neural network (NN) processing the multiple noisy copies by one or more NNs to provide a soft estimate of the encoded information unit; wherein the soft estimate comprises estimated encoded information unit elements and an encoded information unit elements estimated confidence parameter; and (c) decoding the soft estimate of the encoded information unit to provide a prediction of the information unit.

Abstract: Provided herein are compositions and methods comprising phosphonates, N-halamines or combination thereof for dental care. Specifically, for removing tartar (calculus), including mature tartar.

Abstract: Peptides, peptidomimetics and small molecules, collectively referred to as “decoy peptides”, are provided, which interfere with binding to a TIR domain of a toll-like receptor 4 (TLR4), and inhibit a TLR4-induced signaling pathway. These decoy peptides may be useful for treating diseases associated with induction of TLR4 signaling pathway such as a disease or disorder secondary to a cardiovascular disease, sepsis or an inflammatory disease.

Abstract: A method for measuring voltage droop and temperature in a circuit include using capacitive coupling to couple a bias voltage of a current controlled oscillator (CCO) to a noisy digital Vcc (VCCD) supply, so that a frequency of the CCO is independent of a DC Vcc level of the noisy VCCD supply and the CCO measures an AC voltage droop of the noisy VCCD supply and a temperature which is dependent upon the AC voltage droop.

Abstract: Systems and methods of predicting glottal insufficiency by at least one hardware processor including receiving a voice recording comprising a phonation by a subject, analysis of the voice recording to calculate a fundamental frequency contour curve of the phonation, and measurement of at least one of (i) a time period from a start of the phonation until the contour curve reaches a settled level, (ii) a slope of the contour curve during the time period, and (iii) an area under the contour curve during that time period. In certain embodiments, the processor subsequently, determines a glottal closure insufficiency in the subject based on these measurements.

Abstract: A system for use in imaging through diffusive media is presented. The system comprising: an imaging unit comprising light source unit comprising light source(s) providing coherent illumination with selected wavelength range, and a spatial light modulator configured for selectively varying spatial pattern of wavefront of light generated by the light source(s); a collection unit comprising detector array(s) and located next to said light source unit for collecting light reflected from a sample illuminated by said light source unit. And a control system comprising processing unit(s) and connected to said light source unit and said collection unit, said control system is configured for selectively varying spatial pattern of wavefront of light generated by the light source(s) in accordance with spatial pattern of light collected by said detector array(s) of the collection unit to satisfy a reflectance condition indicative of relation between wavefront spatial pattern and collected light spatial pattern.