Abstract: A method for producing sterile solution product bags includes positioning a manifold assembly onto a filling machine. The manifold assembly includes a plurality of bags, a first filter, and a connection line in fluid communication with the first filter. Each of the plurality of bags includes a bladder and a stem in fluid communication with the bladder and with the connection line. The method includes activating a pump and at least partially filling one or more of the bladders by pumping fluid through the feed line, the first filter, and the connection line. The method includes sealing the stem of each of the filled product bags at a location between the connection line and the bladder, thereby creating one or more at least partially filled and sealed product bags. The method includes separating each of the at least partially filled and sealed product bags from the connection line.

Abstract: A packaged, sealed container system for stable storage of a formulation of an oxygen-sensitive pharmaceutical compound, the packaged, sealed container system comprising a primary container including therein a formulation of an oxygen-sensitive pharmaceutical compound, a secondary outer container comprising a first flexible sheet layer, an opposing second flexible sheet layer, and a seal disposed along a common peripheral edge of the first and second flexible sheet layers, such that the primary container is disposed between and enclosed by the first and second flexible sheet layers of the secondary outer container. An oxygen scavenger is also disposed between and enclosed by the first and second flexible sheet layers of the secondary outer container. The oxygen scavenger is in fluid communication with the contents of the primary container.

Abstract: A method for performing port cleaning of an apparatus having a casing, a fluid circuit enclosed inside the casing, and a port arrangement. The method includes producing a cleaning fluid with the fluid circuit; passing the cleaning fluid through a first port via a first tube of the first port to a first circumferential space, from the first circumferential space via a bypass channel to a second circumferential space, and thereafter to a second tube of a second port; and passing the cleaning fluid from the second tube to a drain.

Abstract: Example systems, methods, and apparatus are disclosed herein for dynamically assigning unique message identifiers for devices in a CAN bus network. The example systems, methods, and apparatus are configured to allow devices, such as infusion pumps, to propose and acquire unique IDs within a CAN bus network. The example systems, methods, and apparatus are configured to use the exchange of information between devices in a CAN bus network to prevent duplicate unique IDs, and to allow for simultaneous unique IDs to be acquired by devices. The disclosed systems, methods, and apparatus prevent human programming errors by minimizing the need for extensive user interaction with devices joining a CAN bus network and need to know and select node IDs during installation. The disclosed systems, methods, and apparatus increase network efficiency and prevent programming errors that might result in patient discomfort or injury in healthcare settings, such as networks including infusion pumps.

Abstract: A medical fluid delivery system comprises: (i) a medical fluid delivery machine including a pneumatic manifold having pump and valve actuation areas and a pumping gasket overlaying the pump and valve actuation areas, sources of positive and negative pneumatic pressure, plural pneumatic valves located between the pneumatic sources and the pump and valve actuation areas, and a control unit in operable communication with the plural pneumatic valves; and (ii) a disposable cassette including a fluid pump chamber that aligns with the pump actuation area when the disposable cassette is mated with the pneumatic manifold, the disposable cassette including sheeting overlaying the fluid pump chamber, wherein the control unit is configured to operate the pneumatic valves to perform a conditioning routine that moves the pumping gasket and the cassette sheeting while mated in an attempt to remove small air pockets from between the pumping gasket and the cassette sheeting.

Abstract: A peritoneal dialysis (“PD”) system includes a housing; a dialysis fluid pump housed by the housing; a dual lumen patient line extending from the housing; a filter set including a final stage filter located along a first line, and which includes a second line in parallel with the first line, the first line in fluid communication with a first lumen of the dual lumen patient line, and the second line in fluid communication with a second lumen of the dual lumen patient line; a pressure sensor located within the housing and positioned so as to sense a static or substantially static PD fluid pressure in the second lumen while fresh PD fluid is pumped through the first lumen and the final stage filter; and a control unit configured to use the sensed static or substantially static pressure in a pressure control routine for the dialysis fluid pump.

Abstract: A packaged, sealed container system for stable storage of a formulation of an oxygen-sensitive pharmaceutical compound, the packaged, sealed container system comprising a primary container including therein a formulation of an oxygen-sensitive pharmaceutical compound, a secondary outer container comprising a first flexible sheet layer, an opposing second flexible sheet layer, and a seal disposed along a common peripheral edge of the first and second flexible sheet layers, such that the primary container is disposed between and enclosed by the first and second flexible sheet layers of the secondary outer container. An oxygen scavenger is also disposed between and enclosed by the first and second flexible sheet layers of the secondary outer container. The oxygen scavenger is in fluid communication with the contents of the primary container.

Abstract: The invention provides a neck-worn sensor (referred to herein as the ‘necklace’) that is a single, body-worn system that measures the following parameters from an ambulatory patient: heart rate, pulse rate, pulse oximetry, respiratory rate, temperature, thoracic fluid levels, stroke volume, cardiac output, and a parameter sensitive to blood pressure called pulse transit time. From stroke volume, a first algorithm employing a linear model can estimate the patient's pulse pressure. And from pulse pressure and pulse transit time, a second algorithm, also employing a linear algorithm, can estimate systolic blood pressure and diastolic blood pressure. Thus, the necklace can measure all five vital signs along with hemodynamic parameters. It also includes a motion-detecting accelerometer, from which it can determine motion-related parameters such as posture, degree of motion, activity level, respiratory-induced heaving of the chest, and falls.

Abstract: Example dispensing devices for applying a hemostatic agent or other sealant to a biological tissue.

Abstract: Dialysis is enhanced by using nanoclay sorbents to better absorb body wastes in a flow-through system. The nanoclay sorbents, using montmorillonite, bentonite, and other clays, absorb significantly more ammonium, phosphate, and creatinine, and the like, than conventional sorbents. The montmorillonite, the bentonite, and the other clays may be used in wearable systems, in which a dialysis fluid is circulated through a filter with the nanoclay sorbents. Waste products are absorbed by the montmorillonite, the bentonite, and the other clays and the dialysis fluid is recycled to a patient's peritoneum. Using an ion-exchange capability of the montmorillonite, the bentonite, and the other clays, waste ions in the dialysis fluid are replaced with desirable ions, such as calcium, magnesium, and bicarbonate. The nanoclay sorbents are also useful for refreshing a dialysis fluid used in hemodialysis and thus reducing a quantity of the dialysis fluid needed for the hemodialysis.

Abstract: A dialysis system is disclosed. An example dialysis system includes a water treatment device configured to provide purified water and a dialysis machine including a dialysate holding tank, and a dialysate mixing pump connected to a source of concentrate. The dialysis machine is configured to prepare dialysate using the purified water by receiving an indication that a batch of dialysate is needed, transmitting a first message to the water treatment device to begin providing the purified water, and causing the dialysate mixing pump to pump a concentrate from the source of concentrate for mixing with the purified water to form the dialysate for storage in the dialysate holding tank. After the batch of the dialysate has been stored to the dialysate holding tank, the dialysis machine transmits a second message to the water treatment device to stop providing the purified water.

Abstract: Infusion pump alignment features for vertically-oriented IV tubes are disclosed. In an example, an infusion pump housing includes a tube channel having a radial curvature for bending an IV tube from a horizontal orientation to a vertical orientation when the infusion pump is positioned for operation. The housing also includes a hood having a first side and a second side that are divided by the tube channel. The infusion pump has a door that is connected to the housing for enclosing the tube channel and the hood. The door includes a cavity having dimensions to receive the hood when the door is in a closed position. The hood is configured to engage the cavity to prevent the door from closing if the IV tube is not positioned along the tube channel.

Abstract: A urea separation apparatus is described herein. In an embodiment, the urea separation apparatus includes a blood compartment that is a part of an extracorporeal circuit fluidly connected to a patient and configured to receive blood of the patient. The apparatus also includes a waste membrane enclosing the blood compartment that is configured to filter waste from the blood. The apparatus further includes a dialysis fluid compartment located on an opposite side of the waste membrane from the blood compartment. The dialysis fluid compartment includes dialysis fluid that absorbs the waste from the waste membrane. The apparatus moreover includes a charged membrane enclosing the dialysis fluid compartment. The charged membrane is configured to filter at least a portion of the waste from the dialysis fluid. Additionally, the apparatus includes a urea compartment that circulates secondary fluid for absorbing the portion of the waste from the charged membrane.

Abstract: Described is a process for making a dry and stable hemostatic composition, said process comprising a) providing a first component comprising a dry preparation of a coagulation inducing agent, b) providing a second component comprising a dry preparation of a biocompatible polymer suitable for use in hemostasis, c) providing said first component and said second component in a combined form in a final container, c1) either by filling said first component and said second component into said final container so as to obtain a dry mixture in said final container, c2) or by providing said first component or said second component in said final container and adding said second component or said first component so as to obtain a combination of said first component with said second component in said final container, d) finishing the final container to a storable pharmaceutical device containing said first component and said second component in a combined form as a dry and stable hemostatic composition.

Abstract: A flexible multi-chamber bag for storing and reconstituting parenteral nutrition solutions is disclosed. The flexible multi-chamber bag comprises a first peelably sealing wall and a second peelably sealing wall between the two polymer films extending from the top edge to the bottom edge and separating the first bag into a first chamber between the first peelably sealing wall and the second peelably sealing wall, a first space between the left edge and the first peelably sealing wall, a second space between the second peelably sealing wall and the right edge; a third peelably sealing wall extending from the left edge to the first peelably sealing wall to separate the first space to form a third chamber and a fourth chamber; and a fourth peelably sealing wall extending from the right edge to the second peelably sealing wall to separate the second space to form a second chamber and a fifth chamber.

Abstract: A medical fluid delivery machine includes a medical fluid pump, at least one of a positive air pressure source or a negative air pressure source for supplying positive or negative pressure air, a pneumatic manifold including an air passageway, a pneumatic valve, and a bracket. The pneumatic valve defines a valve aperture sized and arranged such that when the pneumatic valve is abutted against the pneumatic manifold, the valve aperture engages the manifold aperture, the pneumatic valve including a gasket that extends around the valve aperture.

Abstract: A water purification apparatus (1) comprising a Reverse Osmosis, RO, device (26). The RO device (26) comprises a RO membrane (26a) and a feed pump (23). The apparatus (1) also comprises a recirculation mechanism (33) arranged to recirculate a portion of the reject water to the feed water, a temperature sensor device arranged to measure a temperature indicative of the temperature of the RO membrane (26a), and a flow rate sensor device arranged to measure a flow rate indicative of the permeate flow rate of the permeate water. The apparatus (1) further comprises a control arrangement (50) configured to control recirculation to achieve a predetermined recovery ratio.

Abstract: A renal therapy system is disclosed. In an example, the renal therapy system includes a home renal therapy machine that stores, to a log file, dates of when renal therapies were performed and a type of each renal therapy that was performed. The system also includes a server that receives the log file from the home renal therapy machine. The server compares the dates and types of performed renal therapies stored in the log file to a device program that specifies dates for performing renal therapies and the types of renal therapies to be performed. The server displays a flag in a user interface of a clinician computer when there is a deviation from the comparison.

Abstract: The present disclosure relates to parenteral nutritional formulations, including ready-to-use parenteral nutrition formulations. More particularly, the present disclosure is directed to lipid formulations or emulsions and multi-chamber containers comprising same, wherein the lipid emulsion contains glycerophosphorylcholine as a choline source. The present disclosure further relates to methods of providing choline to a patient in need of parenteral nutrition and methods of avoiding and/or treating choline deficiency and liver damage.

Abstract: An airtrap for a medical or physiological fluid in one embodiment includes a conical housing having a radius that increases from its top to its bottom when the housing is positioned for operation; a medical or physiological fluid inlet located at an upper portion of the conical housing; a medical or physiological fluid outlet located at a lower portion of the conical housing, the inlet and the outlet positioned and arranged so that medical or physiological fluid spirals in an increasing arc around an inside of the conical housing downwardly from the inlet to the outlet; and a gas collection area located at an upper portion of the conical housing. In another embodiment, the airtrap is shaped like a seahorse having a head section and a tail section. Any of the airtraps herein may be used for example in blood sets, peritoneal dialysis cassette tubing, and drug delivery sets.