Abstract: A product bag includes a bladder and an elongated filtration device. The bladder includes opposing first and second film layers defining a product chamber. The first and second film layers are sealed together along a perimeter seal extending along at least a portion of a perimeter of the bladder. The elongated filtration device includes a housing, a filtration membrane disposed in the housing, an inlet adapted for receiving a fluid to be filtered, and an outlet in fluid communication with the product chamber. A majority of the elongated filtration device is embedded between the first and second film layers of the perimeter seal of the bladder to provide for a compact form factor.

Abstract: A medical fluid treatment system includes a source of purified water; at least one concentrate for mixing with the water from the source to form a treatment fluid; a disposable set including a pumping portion, a concentrate line in fluid communication with the concentrate source and the pumping portion, and a patient line in fluid communication with the pumping portion, the patient line including a filter having a membrane configured to filter the treatment fluid, the filter configured such that (i) fresh treatment fluid flowing from the pumping portion towards a patient flows through the membrane and (ii) used treatment fluid flowing through the filter from the patient to the pumping portion bypasses the membrane; and a medical fluid delivery machine including a pump actuator operable with the pumping portion of the disposable set.

Abstract: Methods, systems, and apparatuses for integrating medical device data are disclosed. In an example embodiment, a processor receives infusion therapy progress data, receives renal failure therapy progress data, and displays derivative data types. Each of the derivative data types includes at least one infusion parameter, at least renal failure therapy parameter, and at least one of the mathematical operation. The example data processor receives a selection of one of the derivative data types, and calculates derivative data by applying the at least one mathematical operation, as specified by the derivative data type, to infusion therapy progress data that relates to the at least one infusion parameter, as specified by the derivative data type, and renal failure therapy progress data that relates to the at least one renal failure therapy parameter, as specified by the derivative data type. The processor also displays the derivative data.

Abstract: Peritoneal dialysis, such as automated peritoneal dialysis (“APD”) is provided with any one or more or all of the following sensing or feedback features: impedance sensing to detect peritonitis, temperature sensing to detect peritonitis, bio-MEMS sensing to detect peritonitis, and glucose control for diabetes patients, wherein each sensing or feedback feature analyzes patient effluent fluid or fluid dwelling within a patient's peritoneal cavity.

Abstract: A graph database for outbreak tracking and management is disclosed. In an example embodiment, an outbreak management system includes a memory device storing instructions that define a graph database for disease outbreak tracking. The instructions specify for a given host that a host node is created and an episode node is connected to the host node via a ‘case’ link. The episode node is associated with episode parameters that are related to a disease classification of the host. In addition, the instructions specify that an outbreak node is connected to the episode node via a ‘part of’ link to indicate that the host has become part of an outbreak of the disease. The outbreak node is connected to a definition node via a ‘defined as’ link. The definition node specifies disease parameters of the disease that is related to the outbreak node.

Abstract: A pneumatic system for a medical fluid machine operating a medical fluid cassette, the pneumatic system including an interface for supplying positive pneumatic pressure and negative pneumatic pressure to the medical fluid cassette; a source of positive pneumatic pressure; a source of negative pneumatic pressure; and a pneumatic pump including a first head and a second head, wherein the first head is dedicated to supplying positive pneumatic pressure to the positive pneumatic pressure source and the second head is dedicated to supplying negative pneumatic pressure to the negative pneumatic pressure source.

Abstract: A reconstitution device includes a body, a first piercing member located at a first end of the body, and a receptacle located at the second end of the body. The receptacle includes a collar configured to engage a vial, and a cap extending from the collar and holding a second piercing member. The second piercing member is disposed within the collar. The reconstitution device includes a first fluid pathway formed within and extending from the first piercing member to the second piercing member. The reconstitution device includes a second fluid pathway formed within and extending from the second piercing member to a portion of the body between the first piercing member and the second piercing member.

Abstract: The present invention provides a hemostatic porous composite sponge comprising: i) a matrix of a biomaterial; and ii) one hydrophilic polymeric component comprising reactive groups wherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that said polymeric component is coated onto a surface of said matrix of a biomaterial, or said matrix is impregnated with said polymeric material, or both.

Abstract: Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. The subject phase invertible compositions are prepared by combining a crosslinker and a proteinaceous substrate. The proteinaceous substrate includes one or more proteins and a polyamine, where the polyamine and a proteinaceous substrate are present in synergistic viscosity enhancing amounts, and may also include one or more of: a carbohydrate, a tackifying agent, a plasticizer, or other modification agent. In certain embodiments, the crosslinker is a heat-treated dialdehyde, e.g., heat-treated glutaraldehyde. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications.

Abstract: The present disclosure relates to a water purification apparatus that comprises a reverse osmosis device, RO-device, producing a purified water flow and to a corresponding method. The proposed method comprises detecting at least one fluid property of purified water in the purified water path and regulating a flow rate of water in the recirculation path to fulfill one or more predetermined criteria of the purified water in the purified water path, based on the at least one detected fluid property. The present disclosure also relates to a computer program and a computer program product implementing the method.

Abstract: A medical fluid delivery system including remote machine updating and control is disclosed. An example medical fluid delivery system includes a medical fluid delivery device for a patient. The medical fluid delivery system also includes a server in communication with the medical fluid delivery device and a software application for a mobile device. The software application causes an icon to be displayed representing the medical fluid delivery device. The medical fluid delivery system further includes a first communication link between the medical fluid delivery device and the server, and a second communication link between the server and the software application. The software application receives status updates from the medical fluid delivery device via the server and the first and second links.

Abstract: A dialysis system includes a dialysis machine including at least one pump positioned and arranged to pump a dialysis fluid; and a dialysis fluid source located separate from and in fluid communication with the dialysis fluid machine, the dialysis fluid source including a purified water line for carrying purified water, a source of a first concentrate, a source of a second concentrate, a first concentrate pump positioned and arranged to pump first concentrate from the first concentrate source, and a second concentrate pump positioned and arranged to pump second concentrate from the second concentrate source, wherein dialysis fluid is prepared for delivery from the dialysis fluid source to the dialysis machine by mixing the purified water with the first concentrate pumped by the first concentrate pump and the second concentrate pumped by the second concentrate pump.

Abstract: Infusion pump alignment features for vertically-oriented IV tubes are disclosed. In an example, an infusion pump housing includes a tube channel having a radial curvature for bending an IV tube from a horizontal orientation to a vertical orientation when the infusion pump is positioned for operation. The housing also includes a hood having a first side and a second side that are divided by the tube channel. The infusion pump has a door that is connected to the housing for enclosing the tube channel and the hood. The door includes a cavity having dimensions to receive the hood when the door is in a closed position. The hood is configured to engage the cavity to prevent the door from closing if the IV tube is not positioned along the tube channel.

Abstract: A renal therapy apparatus includes a blood filter, a blood pump, a treatment fluid pump, and a control unit configured to control at least one of the blood pump or the treatment fluid pump during a filter cleaning sequence. The blood filter includes a plurality of hollow fiber membranes. During the filter cleaning sequence, a fluid mixture is formed by mixing air with a blood-compatible and physiologically safe fluid. Also during the filter cleaning sequence, the fluid mixture is transferred across insides and/or outsides of the plurality of hollow fiber membranes at least one time. The use of the fluid mixture enables the filter cleaning sequence to be performed during the blood treatment.

Abstract: A dialysis system is disclosed. The example dialysis system includes a housing, a pump actuator housed by the housing, a fluid pumping cassette coupled operably to the housing and including a flexible membrane covering a pump chamber, and a mechanically actuated piston head provided by the pump actuator and positioned to extend towards and away from the fluid pumping cassette. The fluid pumping cassette is positioned such that the flexible membrane of the fluid pumping cassette faces the piston head so that the piston head can push the flexible membrane into the pump chamber of the fluid pumping cassette to expel a fluid from the pump chamber. The example dialysis system also includes a controller programmed to perform a leak test by monitoring a sensed position of the mechanically actuated piston head while the mechanically actuated piston head applies a force to the flexible membrane of the fluid pumping cassette.

Abstract: A device or system includes a mixer comprising a three-dimensional lattice defining a plurality of tortuous, interconnecting passages therethrough. The mixer is in communication with sources or streams of at least two separate components which, when mixed, form a combined fluid stream. The sources or streams may be, at least initially, on opposite sides of the mixer, or the sources or streams may be on the upstream side of the mixer with an outlet disposed downstream of the mixer. A related method may include providing a mixer comprising a three-dimensional lattice defining a plurality of tortuous, interconnecting passages therethrough, and selecting a material for the mixer based on physical characteristics of said material, said characteristics including a selected one or more of mean flow pore size, thickness and porosity volume.

Abstract: A peritoneal dialysis system is disclosed. An example peritoneal dialysis system includes a water treatment device including a water treatment processor and a first memory and a peritoneal dialysis (“PD”) machine including a PD processor and a second memory. The PD machine is configured to mix water treated by the water treatment device with at least one concentrate to produce a peritoneal dialysis fluid for treatment. The example peritoneal dialysis system also includes a data link between the water treatment processor and the PD processor. The water treatment device is configured to prepare an amount of treated water and, upon communication between the water treatment processor and PD processor over the data link, deliver the amount of the treated water to the PD machine for use in mixing the peritoneal dialysis fluid for the treatment. The treated water has a purity corresponding to an injectable quality or a sterile quality.

Abstract: A system for monitoring water quality for dialysis, dialysis fluids, and body fluids treated by dialysis fluids, is disclosed. The system uses microelectromechanical systems (MEMS) sensors for detecting impurities in input water or dialysis fluid, and in the prepared dialysate. These sensors may also be used to monitor and check the blood of the patient being treated. These sensors include ion-selective sensors, for ions such as ammonium or calcium, and also include amperometric array sensors, suitable for ions from chlorine or chloramines, e.g., chloride. These sensors assist in the monitoring of water supplies from a city water main or well. The sensors may be used in conjunction with systems for preparing dialysate solutions from water for use at home or elsewhere.