Abstract: A medical fluid delivery system includes a source of purified water; a source of concentrate for mixing with water from the water source; a disposable set including a pumping portion, a water line in fluid communication with the source of purified water and the pumping portion, the water line including a filter for filtering the water, a concentrate line in fluid communication with the concentrate source and the pumping portion, and a heater/mixing container in fluid communication with the pumping portion; a medical fluid delivery machine including, a pump actuator operable with the pumping portion of the disposable set, and a heater/mixing pan configured to support the heater/mixing container; and at least one leveling foot positioned and arranged to enable the heater/mixing pan to be oriented in a desired position for mixing the concentrate and purified water. A leveling tray and leveling foot are provided additionally.

Abstract: A dialysis method and system for determining an amount of total chlorine in a partially purified water sample is disclosed. The system includes a water machine that produces at least partially purified water including an at least partially purified water sample and a dialysis machine that provides a dialysis treatment to a patient. The dialysis machine receives the at least partially purified water from the water machine to prepare dialysis fluid for the dialysis treatment. The system also includes a total chlorine detector configured to receive the at least partially purified water sample, at a first time apply a source voltage to the at least partially purified water sample, and at a second time stop applying the source voltage to the at least partially purified water sample and instead monitor a sensed electrical parameter to determine an amount of total chlorine in the at least partially purified water sample.

Abstract: An infusion pump includes a housing with a door pivotally mounted to the housing, a tube channel on the housing configured to hold a tube in the infusion pump, a pumping mechanism including a shuttle, and a slide clamp ejection device.

Abstract: A method and a system comprising an integrated water purifying apparatus with a pre-filter circuit including a particle filter and an activated carbon filter arranged to produce pre-treated water; a fluid circuit arranged to receive pre-treated water from the pre-filter circuit, the fluid circuit including an RO-pump and a Reverse Osmosis (RO) device arranged to produce purified water; a heating device arranged to heat purified water from the RO device to a temperature above 65°0 C.; the water purifying apparatus further arranged to heat disinfect the fluid circuit using the heated purified water. The system further comprises a line set connected to the purified water outlet connector at a water line connector of the line set, wherein the line set includes at least one sterile sterilizing grade filter arranged to further filter the purified water.

Abstract: The invention provides a sensor for measuring both impedance and ECG waveforms that is configured to be worn around a patient's neck. The sensor features 1) an ECG system that includes an analog ECG circuit, in electrical contact with at least two ECG electrodes, that generates an analog ECG waveform; and 2) an impedance system that includes an analog impedance circuit, in electrical contact with at least two (and typically four) impedance electrodes, that generates an analog impedance waveform. Also included in the neck-worn system are a digital processing system featuring a microprocessor, and an analog-to-digital converter. During a measurement, the digital processing system receives and processes the analog ECG and impedance waveforms to measure physiological information from the patient. Finally, a cable that drapes around the patient's neck connects the ECG system, impedance system, and digital processing system.

Abstract: A pharmaceutically acceptable insulin premix formulation contains about 0.1-10.0 Unit/mL of insulin for intravenous administration and preferably further contains a tonicity adjuster. The methods for making and using such formulation are also provided. The pharmaceutically acceptable insulin premix formulation may be aseptically filled into a flexible container assembly to form a pharmaceutical insulin premix product. The insulin premix product can be a sterile and ready-to-use aqueous solution for glycemic control in an individual with metabolic disorders through intravenous infusion. The insulin premix product is unexpectedly stable when freshly prepared and also during its shelf-life of storage at refrigeration temperatures of 2° C. to 5° C. for 24 months followed by additional 30 days at room temperatures of 23° C. to 27° C., even without any added preservative, any added zinc, any added surfactant or any other added stabilizing excipient.

Abstract: A method of cleaning a complex powder transfer system including providing a powder transfer system having a washing fluid source, a spray device valve in fluid communication with the washing fluid source, a backflush valve in fluid communication with the washing fluid source, a receiving device having an upper chamber, a lower chamber, and a membrane filter disposed between the upper and lower chambers. The method includes opening the backflush valve to initiate a backflush cycle, running the backflush cycle to wash the upper chamber with a fluid, and closing the backflush valve after the backflush cycle completes. The method includes opening the spray device valve to initiate a spray device cycle, running the spray device cycle to wash the lower chamber with fluid, and closing the spray device valve after the spray device cycle completes. The method includes opening a pressure valve to provide PCA to the receiving container.

Abstract: There is provided an IV infusion set comprising a patient access configured to connect to a vascular system of a patient, a source of medical fluid, an infusion line having one first end configured to connect to the source of medical fluid and one opposite second end configured to deliver the medical fluid towards the patient access, an infusion apparatus arranged on the infusion line, a sensor configured to emit a pressure signal indicative of a pressure of a medical fluid in the infusion line, and a control unit configured to receive the pressure signal and to determine a patient signal indicative of a vital signal of the patient based on the pressure signal. The IV infusion set further comprises a compliance element configured to attenuate pressure variations of medical fluid the infusion line, and a resistance element configured to reflect pressure waves moving along the infusion line.

Abstract: Handheld gas spray systems for mixing and dispensing multi-component compositions.

Abstract: A medical fluid delivery system and apparatus for remote machine updating and control are disclosed. An example medical fluid delivery apparatus includes a processor and a dialysis fluid circuit including at least one dialysis fluid pump. The processor is configured to receive a disinfection input to begin a disinfection procedure and cause the at least one dialysis fluid pump to perform a disinfection procedure on the dialysis fluid circuit using a disinfection fluid. The processor is also configured to, after the disinfection procedure is complete, start a disinfection timer. When a dialysis input is received before the disinfection timer reaches zero, the processor enables a dialysis treatment to be performed. When the disinfection timer reaches zero before the dialysis input is received, the processor prevents the dialysis treatment from being performed until the disinfection procedure is performed again.

Abstract: The present disclosure relates to establishing secure communication between a dialysis machine and a fluid preparation device. In an example, a dialysis machine includes a control unit configured to establish a short-range wireless connection with an external fluid preparation device. The control unit establishes the short-range wireless connection by causing a user interface to display a prompt to enter a passkey associated with a fluid preparation device, using the received passkey to pair with the fluid preparation device, and creating a new bonding table or write to an empty bonding table using the passkey. The control unit is also configured to generate a shared key using the passkey and at least one predetermined criterion and use the shared key to authenticate with the fluid preparation device. When authentication with the fluid preparation device is successful, the control unit enables data communication using the short-range connection with the fluid preparation device.

Abstract: Polymeric compositions, methods, and delivery devices for inhibiting bleeding are disclosed. The method includes applying a dried material topically to a wound site, where the material may include a cross-linked biologically compatible polymer which forms a hydrogel when exposed to blood and where the material may not include an active agent such as thrombin. A spring-loaded delivery device as described herein may be used to apply the dried material.

Abstract: A dialysis method to enable a patient to undergo both peritoneal dialysis and extracorporeal blood treatments is disclosed. The method includes determining, via a base unit controller, whether a peritoneal dialysis treatment or an extracorporeal blood treatment is to be performed. If the peritoneal dialysis treatment is to be performed, the method includes operating first software instructions that cause a base unit to use a first fluid stored in a fluid container. If the extracorporeal blood treatment is to be performed, the method includes operating second software instructions that cause the base unit to use a second, different fluid from an online source and selectively move the second, different fluid to a blood treatment unit for use in the extracorporeal blood treatment. The blood treatment unit is operable with the base unit to perform the extracorporeal blood treatment on a patient.

Abstract: A medical fluid management assembly includes a pneumatic manifold, a pump and valve engine, and a fluid manifold. The pneumatic manifold includes a plurality of pneumatic passageways and a plurality of pneumatic connectors. The pump and valve engine includes a plurality of valve chambers, at least one pump chamber, and a plurality of pneumatic connectors mated sealingly and releasably with the pneumatic connectors of the pneumatic manifold. The pump and valve engine also includes a plurality of fluid connectors. The fluid manifold includes a plurality of fluid pathways and a plurality of fluid connectors mated sealingly and releasably with the fluid connectors of the pump and valve engine.

Abstract: A hemodialysis system includes a dialyzer; a dialysis fluid circuit including a fresh dialysis fluid pump, and a used dialysis fluid pump; a blood circuit including a blood pump operable with an arterial line upstream of the dialyzer, a medical fluid source in fluid communication with the arterial line between a patient end of the arterial line and the blood pump, a drip chamber located along a venous line; a blood rinseback sequence wherein blood is transferred to the patient by the medical fluid, wherein the medical fluid is introduced from its source into the arterial line between an arterial line patient end and the blood pump, and flowed through the dialyzer, through the venous drip chamber along the venous line; and a blood circuit priming sequence initiated in the blood circuit via the arterial line.

Abstract: A capacitive priming sensor for a medical fluid delivery system is disclosed. In an example embodiment, a priming sensor includes a housing including a recessed section configured to accept a portion of a tube. The recessed section of the housing includes a first side including a first conductive plate and a member including a second conductive plate. The member is moveably connected to a second side of the recessed section for detecting insertion of the portion of the tube into the housing of the priming sensor. The recessed section also includes a third side opposing the first side. The third side includes a third conductive plate disposed across from a top portion of the first conductive plate, and a fourth conductive plate disposed across from a bottom portion of the first conductive plate. The priming sensor also includes capacitive sensors or detectors for measuring capacitances between the conductive plates.

Abstract: The present disclosure relates to parenteral nutrition formulations, including ready-to-use parenteral nutrition formulations which are reconstituted from multi-chamber containers and amino acid formulations. More particularly, the present disclosure is directed to formulations comprising butyrate derivatives, specifically arginine butyrate, for use with adult or pediatric patients. The disclosure further provides for methods of reducing or preventing systemic and local inflammation of patients receiving parenteral nutrition, and methods of maintaining or ameliorating their systemic immunity and local immunity, as well as the patients' gut barrier functions.