Abstract: A holding stand for a multicoupling for filling and/or emptying a chemical plant container is provided, having a mounting device for the essentially stationary fastening of the holding stand and at least one compensating device, couplable indirectly or directly to the multicoupling, for varying a position of the multicoupling in relation to the mounting device in the vertical direction and/or in the horizontal direction and/or for varying an angular position of the multicoupling in relation to the mounting device about a vertical and/or horizontal axis of rotation. It thereby becomes possible for a multicoupling to be coupled simply.

Abstract: The present application relates to novel substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazol-3-ones, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of lung inflammation disorders.

Abstract: The invention relates to a neutralization plant (100) comprising at least one reaction chamber (102) having a first feed (114) for an acid-containing product and at least one further feed (116) for a base-containing product, wherein at least one of the feeds (114, 116) comprises at least one valve means (118, 120) for controlling the inflow amount into the reaction chamber (102), wherein the ion controller apparatus (104, 204, 205) comprises at least one evaluation device (106, 206) set up for determining at least one actual ion concentration based on an actual pH of the mixture (122) present in the reaction chamber (102) and wherein the ion controller apparatus (104, 204) comprises at least one ion controller device (108, 208) comprising at least one ion controller (110, 210.1, 210.2, 211) set up for controlling the valve means (118, 120) according to the actual ion concentration and a target ion concentration.

Abstract: The application relates to a computer-implemented method for creating a model of a bioreaction—fermentation process or whole-cell catalysis process—with an organism on the basis of measured data.

Abstract: The invention relates to a combination of two or more pharmaceutically active substances, of which at least one is a metabolic product (“metabolite”) of the other (“parent substance”), wherein in particular the dosages thereof are selected such that genotypically or phenotypically related variability in the conversion of the parent substance to the metabolite in particular individuals is compensated for.

Abstract: A method and a computer-implemented system for automatically monitors and determines the status of entire process sections in a process unit in a computer-implemented manner.

Abstract: Methods operate a plant set up for performing at least one chemical reaction, wherein said method comprises providing process reactors of optimal technical and economic suitability for forming the production plant and wherein this providing operation comprises selecting in at least partially automated fashion the process reactors of optimal technical and economic suitability for forming the production plant from a multiplicity of process reactors taking account of reactor-specific technical parameters assigned to the process reactors of the multiplicity of process reactors and recorded in a database and of predefined process-specific technical criteria by performing at least one selection step for each process reactor of the multiplicity of process reactors which comprises verifying whether at least one reactor-specific technical parameter assigned to this process reactor and/or at least one process-specific and reactor-specific technical target value derived from at least one reactor-specific technical param

Abstract: The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.

Abstract: Provided are systems, methods, and computer programs for predicting the menstrual bleeding pattern of a woman using an intrauterine active-ingredient-releasing system. Some embodiments comprise acquiring data on the bleeding pattern of a woman during a period of time beginning with insertion of an intrauterine active-ingredient-releasing system and acquiring one or a plurality of predictor values. Some embodiments include determining a future bleeding pattern of the woman based a classification model configured to classify the woman in one of several bleeding pattern categories. Additionally, some embodiments may comprise displaying the determined future bleeding pattern to one or more of the woman or a physician.

Abstract: A reaction chamber for a chemical reactor comprises a casing (100) of the reaction chamber, a floor (200) of the reaction chamber having an opening (300) located in the floor, an agitator shaft (400) located in the chamber and having at least one agitator element (500), connected thereto, wherein the agitator shaft (400), seen in the longitudinal direction, has a beginning (600) and an end (700). In the opening (300) of the floor (200) a removable sleeve (800) is provided, which projects out of the reaction chamber. The sleeve (800) is arranged in alignment with the axis of rotation of the agitator shaft (400). The internal diameter of the sleeve (800) is greater than the diameter of the agitator shaft (400) and the agitator shaft (400), at the beginning (600) thereof and/or at the end (700) thereof, is adapted to absorb reversibly a torque provided by means of a further shaft and/or to transmit a torque to a further shaft.

Abstract: The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.

Abstract: A method of reacting phosgene with a second compound containing one or more of hydroxyl, thil, amino and/or formamide groups, wherein phosgene has a GHS hazard identification of GHS06 and is obtainable from the reaction of carbon monoxide and chlorine and wherein the second compound is capable of a chemical reaction with phosgene is provided.

Abstract: Method for configuring a production plant designed for performing at least one chemical reaction, wherein the production plant has at least one plant module, and a plant module for configuring the production plant, which plant module is chosen from a module database running on a first server system and/or is combined from a component database running on a second server system.

Abstract: A production installation having at least two process modules (P1, . . . , Pn) that can be connected to one another for production engineering purposes and a communication network (2), wherein each process module (P1, . . . , Pn) has an electronic device by means of which the respective process module (P1, . . . , Pn) can be connected to the communication network (2) for communications engineering purposes and is set up to control and/or regulate the respective process module (P1, . . . , Pn) to independently carry out a particular process section of the production.

Abstract: The invention relates to a method particularly for reacting phosgene with compounds that contain hydroxyl, thiol, amino and/or formamide groups, comprising the steps of: (I) providing a reactor which has a first reaction chamber (300, 310, 320, 330, 340, 350) and a second reaction chamber (200, 210, 220, 230, 240, 250, 260), the first and the second reaction chambers being separated from one another by means of a porous carbon membrane (100, 110, 120, 130, 140, 150); (II) providing carbon monoxide and chlorine in the first reaction chamber; and simultaneously (III) providing a compound containing hydroxyl, thiol, amino and/or formamide groups in the second reaction chamber. The porous carbon membrane is configured to catalyze the reaction of carbon monoxide and chlorine to obtain phosgene, and to allow this formed phosgene to pass into the second reaction chamber. The invention also relates to a reactor that is suitable for carrying out the claimed method.

Abstract: A production arrangement for performing a chemical reaction with a standard transport container in accordance with DIN ISO 668 for accommodating a plurality of processing units disposed inside the standard transport container for assisting and/or performing a processing basic operation, and a supply network, disposed inside the standard transport container, for supplying the processing units with material and/or power and/or information. Owing to the supply network disposed inside the standard transport container, the availability of material and/or power and/or information can be ensured over a large area of the standard transport container, such that the same standard transport container with the same supply network can be re-used for different configurations of processing units and, in the event of a modification for performing a different chemical reaction, the processing units can simply be interchanged such that different chemical reactions can be performed with little outlay.

Abstract: The invention provides an apparatus and a process for continuous virus inactivation. The apparatus for continuous virus inactivation in a product stream comprises a tube or hose 1 having an inlet 4 and an outlet 5 in each case connected to a product flow line 8 for conveying the product stream, where the tube or the hose 1 is curved and/or helically coiled with a number n of windings around a coil axis h and has one or more changes in direction and/or bends 2 in the coil axis h having an angle ? of from 45° to 180° to alter the direction of action of the normals of the centrifugal force and the apparatus is characterized by a Dean number>0 and a torsion parameter>0.

Abstract: Processing unit for assisting and/or performing a processing basic operation for a chemical reaction, with an operating unit for preparing a contribution for the processing basic operation and a frame for accommodating the operating units, the frame having an extension dL in the longitudinal direction which corresponds substantially to an integral multiple ZL of an integral portion NL of an extension LL, in the longitudinal direction of an interior of a standard transport container, in accordance with DIN ISO 668, and/or the frame having an extension dQ in the transverse direction with corresponds substantially to an integral multiple ZQ of an integral portion NQ of an extension LQ in the transverse direction of an interior of a standard transport container, in particular in accordance with DIN ISO 668, wherein different processing units can be stored in a pool for different processing basic operations and be assembled in modular and flexible manner in the standard transport container for the synthesis of a g

Abstract: The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.

Abstract: The invention concerns a computerized method for producing a two-dimensional plant model of a modular production plant for producing a chemical product, the production plant comprising at least two processing modules, which can be connected to one another for production purposes, and at least one processing container in which the processing modules can be accommodated at least partially, as required, wherein, for each processing container, a common two-dimensional container model (2) of its the base area (3) and of the base area (3) of a container environment at least partially surrounding the processing container and of predefinable size being generated, wherein, for each processing module, a two-dimensional module model (5) of its base area is generated, wherein the container model (2) and the module model (5) are divided into fields (1, 4) which are of equal size and preferably square, there being assigned to each field (4) of a module model (5) a module property concerning the occupancy of the particular