Patents Assigned to Bayer Aktiengesellschaft
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Publication number: 20240150277Abstract: The present invention includes compounds of formula (I) and methods for its preparation and treatment of disorders with activated peroxisome preoliferator-activated receptor gamma (PPARG), particularly cancer.Type: ApplicationFiled: August 31, 2023Publication date: May 9, 2024Applicants: Bayer Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.Inventors: Stephan SIEGEL, Knut EIS, Timo STELLFELD, Léa Aurelie BOUCHÉ, Elisabeth POOK, Joseph Peter BLUCK, Philip LIENAU, Constantia PANTELIDOU, Isabel Sophie JERCHEL-FURAU, Ulf BRÜEGGEMEIER, Sven CHRISTIAN, Detlev SÜLZLE, Anders Roland FRIBERG, Simon HOLTON, Christian LECHNER, Stefan KAULFUSS, Hanna MEYER, Douglas ORSI, Steven James FERRARA, Jonathan GOLDSTEIN, Matthew MEYERSON, Christopher LEMKE
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Publication number: 20240153163Abstract: The present invention relates to the technical field of producing artificial contrast-enhanced radiological images by way of machine learning methods.Type: ApplicationFiled: November 29, 2021Publication date: May 9, 2024Applicant: Bayer AktiengesellschaftInventors: Matthias LENGA, Marvin PURTORAB
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Patent number: 11975276Abstract: Provided are methods for monitoring a filtration and washing operation on a solid-state bulk material in a filter apparatus for cake filtration. The methods include separating a solid-state bulk material in a suspension medium using a filter element for the cake filtration, leading off the suspension medium in the form of a filtrate stream into a filtrate outlet, measuring at least one parameter value of the filtrate stream over a period of time during the filtration and washing operation, and conducting a change analysis of the at least one parameter value over the period of the filtration and washing operation to achieve the end of the filtration and washing operation and/or the effectiveness of the filtration and washing operation.Type: GrantFiled: April 9, 2019Date of Patent: May 7, 2024Assignee: BAYER AKTIENGESELLSCHAFTInventors: Kathrin Annette Engelhardt, Reinhard Gross
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Patent number: 11976334Abstract: The present invention covers 2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine (in the following called “Compound A”), an inhibitor of ATR kinase, for use in a method of treating a hyper-proliferative disease in a subject.Type: GrantFiled: February 1, 2021Date of Patent: May 7, 2024Assignees: Bayer Aktiengesellschaft, Bayer Pharma AktiengesellschaftInventors: Antje Margret Wengner, Gerhard Siemeister, Bernard Händler, Sven Golfier, Andreas Schlicker, Li Liu
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Publication number: 20240141312Abstract: Described herein are novel systems for targeting, editing or manipulating DNA in a cell or cell free environment, using novel type V B-GEn.1 or B-GEn.2 nucleases and variants thereof, as well as methods and kits for manipulating DNA. Further disclosed are novel and improved single guide RNAs.Type: ApplicationFiled: June 9, 2022Publication date: May 2, 2024Applicant: Bayer AktiengesellschaftInventors: Andre COHNEN, Florian RICHTER, Philipp KNYPHAUSEN, Andreas NEERINCX, Saskia Diana MARKERT, Christien BEDNARSKI, Sören TURAN
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Patent number: 11964953Abstract: The present invention covers aminothiazole compounds of general formula (I), in which R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase zeta (DGK?) regulated disorders, as a sole agent or in combination with other active ingredients.Type: GrantFiled: September 14, 2022Date of Patent: April 23, 2024Assignees: Bayer Aktiengesellschaft, Deutsches KrebsforschungszentrumInventors: Norbert Schmees, Ulrike Roehn, Dennis Kirchhoff, Kirstin Petersen, Mareike Grees, Nicolas Werbeck, Benjamin Bader, Rienk Offringa, Corinna Link
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Publication number: 20240124522Abstract: The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.Type: ApplicationFiled: April 12, 2023Publication date: April 18, 2024Applicants: Bayer Aktiengesellschaft, Bayer Pharma AktiengesellschaftInventors: Donald Bierer, Ingo Flamme, Dmitry Zubov, Thomas Neubauer, Adrian Tersteegen, Cathleen Juhl, Marie Glatz, Jan Dreher, Simon Holton, Carsten Terjung, Lars Baumann, Thorsten Poethko, Jiancheng Xiong, Yibo Qiu
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Publication number: 20240114882Abstract: The invention relates to a method and a system for pesticide management of an arable field, in particular taking into account health-related data of pollinators. The invention also relates to a computer program product and to a storage medium.Type: ApplicationFiled: October 12, 2020Publication date: April 11, 2024Applicant: Bayer AktiengesellschaftInventors: Simon Franz HOFF, Philipp SENGER
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Patent number: 11951166Abstract: The present invention relates to pharmaceutical compositions and combinations comprising regorafenib or its hydrate, solvate, metabolite or pharmaceutically acceptable salt or a polymorph thereof and a PD-1/PD-L1(2) inhibitor for treating, preventing or managing diseases and conditions including hyperproliferative disorders such as cancer in humans and other mammals.Type: GrantFiled: May 25, 2018Date of Patent: April 9, 2024Assignee: BAYER AKTIENGESELLSCHAFTInventors: Sabine Hoff, Lars Rose, Dieter Zopf, Fabian Kiessling, Wiltrud Lederle, Dennis Doleschel
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Patent number: 11952359Abstract: The present disclosure relates to substituted thiophene carboxamides and analogues thereof of formula (I) that may be used for protecting plants from bacterial diseases, in particular from bacterial diseases caused by bacteria belonging to the genus Xanthomonas.Type: GrantFiled: June 30, 2022Date of Patent: April 9, 2024Assignee: Bayer AktiengesellschaftInventors: David Bernier, Stéphane Brunet, Jérémy Dufour, Thomas Knobloch, Lionel Nicolas, Tomoki Tsuchiya
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Publication number: 20240109850Abstract: The present invention includes compounds of formula (I) and methods for its preparation and treatment of disorders with activated peroxisome preoliferator-activated receptor gamma (PPARG), particularly cancer.Type: ApplicationFiled: August 31, 2023Publication date: April 4, 2024Applicants: Bayer Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.Inventors: Knut EIS, Elisabeth POOK, Ulf BRÜGGEMEIER, Adelaide Clara F. A. DE LEMOS, Sven CHRISTIAN, Isabel Sophie JERCHEL-FURAU, Ulrike RAUH, Nico BRÄUER, Timo STELLFELD, Anders Roland FRIBERG, Christian LECHNER, Stefan KAULFUSS, Hanna MEYER, Charlotte Christine KOPITZ, Steven James FERRARA, Jonathan GOLDSTEIN, Matthew MEYERSON, Christopher LEMKE, Timothy A. LEWIS
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Patent number: 11944690Abstract: The present disclosure relates to a liquid pharmaceutical formulation comprising a DOSA-derived tetra-chelate of formula (I), in which M is an ion of a paramagnetic metal, preferably a Gd3+ ion, and R1, R2, R3, R4 and R5 are as defined in the claims, in a pharmaceutical acceptable solvent. The present disclosure also relates to a method of preparation of said liquid pharmaceutical formulation and to a method of imaging involving said liquid pharmaceutical formulation.Type: GrantFiled: November 21, 2019Date of Patent: April 2, 2024Assignee: BAYER AKTIENGESELLSCHAFTInventors: Stephan Holzschuh, Thomas Frenzel, Gregor Jost, Jessica Lohrke, Wolfgang Ebert, Thomas Brumby, Wolfgang Halfbrodt
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Patent number: 11937594Abstract: The invention relates to a system, a method and the use of the system according to the invention for controlling undesirable plants, in particular on railway tracks, using electrical energy.Type: GrantFiled: July 11, 2019Date of Patent: March 26, 2024Assignee: BAYER AKTIENGESELLSCHAFTInventor: Stephan Voelkening
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Patent number: 11934997Abstract: The invention relates to the monitoring of products by means of active radio tags. According to the invention, packagings of products are provided with an active radio tag that detects at least one environmental condition and/or at least one packaging state, and which emits a signal at time intervals, which provides information about a unique identifier and at least one state in which the respective product is found. The signal is picked up by a receiver that extracts the unique identifier and the state information and transmits same together with location information to an external server.Type: GrantFiled: December 28, 2022Date of Patent: March 19, 2024Assignee: BAYER AKTIENGESELLSCHAFTInventors: Christof Backhaus, Katharina Berger, Uwe Schenkel, Jürgen Schmidt, Walter Speth, Klaus Glismann, Eric Willms, Markus Storz, Arne Wendt, Gregory James Dibble
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Patent number: 11934998Abstract: The invention relates to the monitoring of products by means of active radio tags. According to the invention, packagings of products are provided with an active radio tag that detects at least one environmental condition and/or at least one packaging state, and which emits a signal at time intervals, which provides information about a unique identifier and at least one state in which the respective product is found. The signal is picked up by a receiver that extracts the unique identifier and the state information and transmits same together with location information to an external server.Type: GrantFiled: December 28, 2022Date of Patent: March 19, 2024Assignee: BAYER AKTIENGESELLSCHAFTInventors: Christof Backhaus, Katharina Berger, Uwe Schenkel, Jürgen Schmidt, Walter Speth, Klaus Glismann, Eric Willms, Markus Storz, Arne Wendt, Gregory James Dibble
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Patent number: 11934999Abstract: The invention relates to the monitoring of products by means of active radio tags. According to the invention, packagings of products are provided with an active radio tag that detects at least one environmental condition and/or at least one packaging state, and which emits a signal at time intervals, which provides information about a unique identifier and at least one state in which the respective product is found. The signal is picked up by a receiver that extracts the unique identifier and the state information and transmits same together with location information to an external server.Type: GrantFiled: December 28, 2022Date of Patent: March 19, 2024Assignee: BAYER AKTIENGESELLSCHAFTInventors: Christof Backhaus, Katharina Berger, Uwe Schenkel, Jürgen Schmidt, Walter Speth, Klaus Glismann, Eric Willms, Markus Storz, Arne Wendt, Gregory James Dibble
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Patent number: 11934996Abstract: The invention relates to the monitoring of products by means of active radio tags. According to the invention, packagings of products are provided with an active radio tag that detects at least one environmental condition and/or at least one packaging state, and which emits a signal at time intervals, which provides information about a unique identifier and at least one state in which the respective product is found. The signal is picked up by a receiver that extracts the unique identifier and the state information and transmits same together with location information to an external server.Type: GrantFiled: December 28, 2022Date of Patent: March 19, 2024Assignee: BAYER AKTIENGESELLSCHAFTInventors: Christof Backhaus, Katharina Berger, Uwe Schenkel, Jürgen Schmidt, Walter Speth, Klaus Glismann, Eric Willms, Markus Storz, Arne Wendt, Gregory James Dibble
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Patent number: 11926623Abstract: The invention relates to novel compounds of the formula (I) in which X, R1, R2, R3, V and n have the meanings given above, to the use thereof as acaricides and/or insecticides for controlling animal pests and to methods and intermediates for the preparation thereof.Type: GrantFiled: June 19, 2019Date of Patent: March 12, 2024Assignee: Bayer AktiengesellschaftInventors: Matthieu Willot, Rüdiger Fischer, Dominik Hager, Laura Hoffmeister, David Wilcke, Kerstin Ilg, Ulrich Goergens
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Patent number: 11922269Abstract: The present disclosure is concerned with the technical field of marking objects with optically readable codes and reading out (decoding) the codes. Subjects of the present disclosure are a method, a system and a computer program product for decoding optically readable codes introduced in surfaces of objects.Type: GrantFiled: December 15, 2022Date of Patent: March 5, 2024Assignee: BAYER AKTIENGESELLSCHAFTInventors: Benjamin Hoetter, Gregor Fischer, Klaus Ruelberg, Dirk Schäfer
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Publication number: 20240070440Abstract: Systems, methods, and computer programs disclosed herein relate to training a machine learning model to generate multimodal representations of objects, and to the use of said representations for predictive purposes.Type: ApplicationFiled: February 23, 2022Publication date: February 29, 2024Applicant: Bayer AktiengesellschaftInventors: Johannes HOEHNE, Steffen VOGLER, Matthias LENGA