Patents Assigned to Bayer Aktiengesellschaft
  • Patent number: 12269179
    Abstract: System for automatically manipulating primary packaging in secondary packaging, comprising a robot having at least one robot arm with a clamping gripper installed at a tool centre point, wherein each tool centre point has a force-torque sensor, an image recording module for recording images of at least the upper segment of the primary packaging, comprising at least two stereo cameras for recording 3-D images, and one or more processors for providing a three-dimensional point cloud, controlling the image recording module and controlling the robot on the basis of the analysis of the three-dimensional point cloud and the measurements from the force-torque sensors.
    Type: Grant
    Filed: June 24, 2022
    Date of Patent: April 8, 2025
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Carl-Helmut Coulon, Carsten Thomas, Armin Schweiger, Daniel Felipe Ordoñez Apraez
  • Patent number: 12258323
    Abstract: The present invention provides dihydrooxydiazinone compounds of general formula (I): in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: July 11, 2022
    Date of Patent: March 25, 2025
    Assignees: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Manuel Ellermann, Stefan Nikolaus Gradl, Charlotte Christine Kopitz, Martin Lange, Adrian Tersteegen, Philip Lienau, Christa Hegele-Hartung, Detlev Sülzle, Timothy A. Lewis, Heidi Greulich, Xiaoyun Wu, Matthew Meyerson, Alex Burgin
  • Patent number: 12258343
    Abstract: The present invention covers a method for preparing 2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine (“the compound of formula (I)” in the following) as well as intermediate compounds useful in the preparation of the compound of formula (I). The present invention also covers polymorphic form B of the compound of formula (I) with very high purity.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: March 25, 2025
    Assignees: BAYER AKTIENGESELLSCHAFT, BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Johannes Platzek, Philipp Rubenbauer, Hendricus Nicolaas Sebastiaan Van Der Haas, Sonja Elisabeth Hoogeveen, Matthijs Cornelis Maria Van Oers, Reinerus Gerardus Gieling, Jeroen Alexander Dekker
  • Patent number: 12252278
    Abstract: The present invention relates to an unmanned aerial vehicle (UAV) for agricultural weed management. The UAV comprises a control and processing unit (20), and a camera (30). The control and processing unit is configured to control the UAV to fly to a location inside the canopy of a crop and below the vertical height of the crop and/or between a row of a plurality of crops and below the vertical height of the plurality of crops. The control and processing unit is configured to control the camera to acquire at least one image relating to the ground at the location inside the canopy of a crop and below the vertical height of the crop and/or between a row of a plurality of crops and below the vertical height of the plurality of crops. The control and processing unit is configured to analyse the at least one image to determine the presence of at least one weed and its location on the ground.
    Type: Grant
    Filed: February 25, 2021
    Date of Patent: March 18, 2025
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Malcolm Faers, Andrew Charles Chapple
  • Publication number: 20250084391
    Abstract: Described herein are novel systems for targeting, editing or manipulating DNA in a cell or cell free environment, using novel type V B-GEn.7 (SEQ ID NO: 1) and variants thereof, as well as methods and kits for manipulating DNA.
    Type: Application
    Filed: December 20, 2022
    Publication date: March 13, 2025
    Applicant: Bayer Aktiengesellschaft
    Inventors: Andre COHNEN, Florian RICHTER, Philipp KNYPHAUSEN, Andreas NEERINCX, Saskia Diana MARKERT, Christien BEDNARSKI, Sören TURAN, Theresa VOGT, Jaishree CHITTOOR
  • Patent number: 12227501
    Abstract: The present invention relates to compounds of formula (I) processes for their production and their use as pharmaceuticals. The compounds are inhibitors of Casein kinase 1 alpha and/or delta (CSNK1? and/or ?) useful for the treatment of proliferative disorders.
    Type: Grant
    Filed: February 6, 2020
    Date of Patent: February 18, 2025
    Assignees: Bayer Aktiengesellschaft, Dana-Farber Cancer Institute, Inc., The Broad Institute, Inc.
    Inventors: Volker Schulze, Anne Mengel, Jens Schröder, Adelaide Clara Faria Alvares De Lemos, Wilhelm Bone, Ulf Bömer, Detlev Sülzle, Clara Christ, Roman Hillig, Christian Lechner, Steven Corsello, Katarzyna Handing, Alisha Caliman, Ulrike Rauh, Stefan Kaulfuss, Jérémie Xavier G. Mortier
  • Publication number: 20250051802
    Abstract: Described herein are novel systems for targeting, editing or manipulating DNA in a cell, using novel M-SmallCas9 nucleases and variants thereof. The M-SmallCas9 nucleases are derived from wildtype or parental small type II CRISPR Cas9 endonucleases, and display improved fidelity compared to parental type II CRISPR Cas9 enzymes in combination with a simple PAM sequences and are small endonuclease size.
    Type: Application
    Filed: August 31, 2022
    Publication date: February 13, 2025
    Applicant: Bayer Aktiengesellschaft
    Inventors: Andre COHNEN, Florian RICHTER, Andreas NEERINCX
  • Patent number: 12221479
    Abstract: The present disclosure relates to combinations of at least two components, component A and component B, component A being anti-CEACAM6 antibody TPP-3310 and component B being an anti-TIM-3 antibody, preferentially cobolimab, MBG-453, BMS-986258, Sym-023, LY-3321367 or INCAGN-2390.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: February 11, 2025
    Assignees: Bayer Aktiengesellschaft, Deutsches Krebsforschungszentrum
    Inventors: Jörg Willuda, Mark Trautwein, Rienk Offringa, Hans-Henning Böhm, Philipp Beckhove
  • Patent number: 12215168
    Abstract: The present invention relates to an isolated antibody or antigen-binding fragment thereof that binds to human A2AP. The isolated antibody or antigen-binding fragment according to the present invention i) cross-reacts with rabbit and/or cynomolgus A2AP, ii) does not inhibit human plasmin activity, and iii) increases plasmin mediated clot lysis in the presence of A2AP.
    Type: Grant
    Filed: November 30, 2023
    Date of Patent: February 4, 2025
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Stefan Heitmeier, Julia Glunz, Melanie Fischer, Cindy Schulenburg, Hannah Jörißen, Christoph Thiel, Andreas Wilmen, Ernst Weber
  • Patent number: 12213484
    Abstract: The present invention relates to solvent-free aqueous suspension concentrates having high active ingredient concentration, good biological efficacy and good rheological stability, and to processes for production thereof. The formulations of the invention are suitable for the field of plant protection.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: February 4, 2025
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Gorka Peris, Pierre Philippe Haas, Stefan Herrmann
  • Patent number: 12202805
    Abstract: The present invention relates to a novel and improved process for preparing (5S)-{[2-(4-carboxyphenyl)ethyl][2-(2-{[3-chloro-4?-(trifluo-romethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]amino}-5,6,7,8-tetrahydroquinoline-2-carboxylic acid of the formula (I) and to novel crystalline forms of it, which is i.a. the pseudopolymorphic form monohydrate I (I-M-I) or the pseudopolymorphic form monohydrate II (I-M-II), furthermore the present invention relates to a novel and selective crystallization process for preparation of the pseudopolymorphic form monohydrate I (I-M-I) or the pseudopolymorphic form monohydrate II (I-M-II), preferably monohydrate I of formula (I-M-I) and to pharmaceutical compositions comprising monohydrate I of formula (I-M-I) and to its use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of pulmonary and cardiopulmonary and cardiovascular diseases.
    Type: Grant
    Filed: November 10, 2023
    Date of Patent: January 21, 2025
    Assignees: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft
    Inventors: Britta Olenik, Birgit Keil, Bernd Rösler, Peter Fey, Heiko Schirmer, Guido Becker, Julian Egger, Clemens Bothe, Helene Faber
  • Patent number: 12195448
    Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).
    Type: Grant
    Filed: April 13, 2023
    Date of Patent: January 14, 2025
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Alexandros Vakalopoulos, Marie-Pierre Collin-Kröpelin, Nuria Ortega Hernandez, Andre Dieskau, Melissa Boultadakis-Arapinis, Lisa Candish, Timo Stellfeld, Ilka Mathar, Lucas Hudson Hofmeister, Peter Sandner, Frank Wunder, Lisa Dietz, Robert Alan Webster, Carsten Schmeck, Thomas Mondritzki
  • Patent number: 12185723
    Abstract: Compounds having herbicidal activity effective against economically important harmful plants are disclosed. The disclosed compounds exhibit herbicidal activity even at relatively low application rates, while at the same time may exhibit compatibility with crop plants. The disclosed compounds may further be effective and efficient against a large number of weeds and against a broad spectrum of weed grasses. As disclosed herein, 3-phenylisoxazoline-5-carboxamides of S-containing cyclopentenylcarboxylic esters of formula (I) and their salts exhibit herbicidal activity against a broad spectrum of economically important mono- and dicotyledonous annual harmful plants.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: January 7, 2025
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Andreas Van Almsick, Klaus Bernhard Haaf, Guido Bojack, Elisabeth Asmus, Elmar Gatzweiler, Christopher Hugh Rosinger
  • Patent number: 12187705
    Abstract: The present invention relates to novel heteroaryl-triazole and heteroaryl-tetrazole compounds of the general formula (I), in which the structural elements Y, Q1, Q2, R1, R2, R3a, R3b, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: January 7, 2025
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Alexander Arlt, Werner Hallenbach, Hans-Georg Schwarz, Martin Fuesslein, Heinz-Juergen Wroblowsky, Marc Linka, Sascha Eilmus, Kerstin Ilg, Ulrich Goergens, Arunas Jonas Damijonaitis, Yolanda Cancho Grande, Ulrich Ebbinghaus-Kintscher, Peter Jeschke, Weijie Ha, Iring Heisler, Andreas Turberg
  • Patent number: 12180187
    Abstract: What are described are compounds of the general formula (I) and agrochemically acceptable salts thereof and their preparation and their use in the crop protection sector.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: December 31, 2024
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Michael Gerhard Hoffmann, Estella Buscato Arsequell, Harald Jakobi, Thomas Mueller, Erin Nicole Smith, Elisabeth Asmus, Anu Bheemaiah Machettira, Elmar Gatzweiler, Christopher Hugh Rosinger, Dirk Schmutzler
  • Patent number: 12180227
    Abstract: The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, such as compounds of the general formula (I): to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.
    Type: Grant
    Filed: July 16, 2021
    Date of Patent: December 31, 2024
    Assignees: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft
    Inventors: Martina Delbeck, Michael Hahn, Thomas Müller, Klemens Lustig, Karl Collins, Niels Lindner, Janine Nicolai, Moritz Beck-Broichsitter, Udo Albus, Doris Gehring, Björn Rosenstein
  • Patent number: 12171229
    Abstract: The present invention relates to novel heteroaryl-triazole and heteroaryl-tetrazole compounds of the general formula (I), in which the structural elements Y, Q1, Q2, R1, R2, R3, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.
    Type: Grant
    Filed: August 11, 2023
    Date of Patent: December 24, 2024
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Alexander Arlt, Werner Hallenbach, Hans-Georg Schwarz, Martin Fuesslein, Heinz-Juergen Wroblowsky, Estella Buscato Arsequell, Marc Linka, Kerstin Ilg, Arunas Jonas Damijonaitis, Ulrich Ebbinghaus-Kintscher, Ulrich Goergens, Yolanda Cancho Grande, Peter Jeschke, Joachim Telser, Iring Heisler, Andreas Turberg
  • Patent number: 12173068
    Abstract: The present disclosure relates to an isolated antibody or antigen-binding fragment thereof that binds to human Sema3A. The isolated antibody or antigen-binding fragment according to the present disclosure i) binds to human Sema3A of the sequence of SEQ ID NO: 600 with a dissociation constant (KD)?50 nM, ?20 nM, ?10 nM, ?1 nM, or ?0.1 nM; ii) cross-reacts with mouse, cynomolgus, rat, pig and/or dog Sema3A, particularly wherein said isolated antibody or antigen-binding fragment thereof binds to mouse, cynomolgus, rat, pig and/or dog Sema3A with a dissociation constant (KD)?50 nM, ?20 nM, ?10 nM, ?1 nM, or ?0.1 nM; iii) binds to human Sema3A of the sequence of SEQ ID NO: 600 with a binding activity as measured by surface plasmon resonance (SPR) of ?60%, ?70%, ?80%, or ?90%; iv) inhibits the activity of human Sema3A of the sequence of SEQ ID NO: 600 in an in vitro mesangial cell migration assay with an EC50 of ?10 nM, ?5 nM, ?2.
    Type: Grant
    Filed: December 29, 2023
    Date of Patent: December 24, 2024
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Dorian Schönfeld, Karoline Dröbner, Ernst Weber, Katharina Filarsky, Philipp Ellinger, Fionnuala Mary McAleese Eser, Ingo Flamme, Winfried Wunderlich, Antje Schmidt, Yalda Sedaghat, Kenneth Young
  • Patent number: 12171230
    Abstract: The present invention provides compositions comprising herbicidally active compounds (A) and (B), where (A) represents one or more compounds of the general formula (I) or their agrochemically acceptable salts [component (A)], and (B) represents one or more herbicides [component (B)]. The application furthermore relates to a method and to the use of the herbicidal composition according to the invention for controlling harmful plants or for regulating growth.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: December 24, 2024
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Klaus Trabold, Lothar Lorentz, Hubert Menne, Elmar Gatzweiler, Christopher Hugh Rosinger, Klaus Bernhard Haaf
  • Publication number: 20240417407
    Abstract: The present invention covers furoindazole compounds of general formula (I): in which R1, R2, R3, R4, R5, R6a and R6b are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of autoimmune diseases such as multiple sclerosis, psoriasis, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, primary and secondary autoimmune uveitis, inflammatory disorders like endometriosis, inflammatory eye diseases, inflammatory kidney diseases, inflammatory liver diseases like non-alcoholic, alcoholic- and toxic fatty liver diseases, lung diseases like asthma, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease and metabolic and metabolic-endocrine disorders like metabolic syndrome, insulin resistance, diabetes mellitu
    Type: Application
    Filed: February 18, 2022
    Publication date: December 19, 2024
    Applicant: Bayer Aktiengesellschaft
    Inventors: Olaf PANKNIN, Frank SACHER, Nicole SCHMIDT, Gernot Langer, Katrin Nowak-Reppel, Antje Rottmann, Hideki Miyatake Ondozabal, Holger Siebeneicher, Hana Cernecka, Simon Anthony Herbert