Patents Assigned to Bayer Aktiengesellschaft
-
Publication number: 20230234945Abstract: The present disclosure relates to azabicyclyl-substituted heterocyclic compounds of formula (I), wherein A1, A2, m, R3, R4, R5, L, R6, T, the ring Y, p, R7 and Q have the meanings as defined in the specification, to compositions comprising such compounds, to processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.Type: ApplicationFiled: June 8, 2021Publication date: July 27, 2023Applicant: Bayer AktiengesellschaftInventors: Julie GEIST, Anthony MILLET, Cyril MONTAGNE, Lionel NICOLAS, Dominique LOQUE, Vincent THOMAS, Mazen ES-SAYED (DECEASED), Alexander SUDAU
-
Patent number: 11701347Abstract: The present invention relates to the use of 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyridin-2-amine (compound A), more particularly (+)5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyridin-2-amine (compound A?), for treating diffuse large B-cell lymphoma (DLBCL), especially in germinal-centre B-cell type of diffuse large B-cell lymphoma and especially in diffuse large B-cell lymphoma which cells have an amplification or translocation of the MYC gene and/or BCL2 gene and/or an overexpression of MYC and/or BCL2.Type: GrantFiled: February 12, 2019Date of Patent: July 18, 2023Assignees: BAYER AKTIENGESELLSCHAFT, BAYER PHARMA AKTIENGESELLSCHAFTInventor: Arne Scholz
-
Patent number: 11696576Abstract: A pest monitoring system and associated method includes pest monitoring devices for placement at a site and generating a signal upon detection of a pest, and a pesticide dispensing unit including a reservoir housing a diluent and a pesticide module housing a pesticide. A computer device remotely disposed to the pest monitoring devices receives generated signals therefrom, analyzes environmental and historical factor data for the site to determine an amount and placement location of the pest monitoring devices for monitoring the site, and directs deployment of the pest control monitoring devices according to the analysis. The computer device also receives data from the pesticide dispensing unit including an amount or rate of the pesticide substance dispensed from the pesticide module, to form treatment having a concentration of the pesticide substance in the diluent, the treatment being dispensed from the pesticide dispensing unit to treat a detected pest at the site.Type: GrantFiled: April 12, 2018Date of Patent: July 11, 2023Assignee: Bayer AktiengesellschaftInventors: Byron Reid, Volker Gutsmann, Gaelle Fages, Michael Zimmermann, Chris Pienaar, Peter Jardine
-
Patent number: 11691938Abstract: The invention relates to a multi-stage process for preparing 2,6-dialkylphenylacetic acids of the general formula (I) by reacting 2,6-dialkylbromobenzenes with (1) magnesium, (2) a formamide, (3) an acid, (4) hydrogenation of the benzaldehyde obtained, (5) activation of the benzyl alcohol obtained, (6) cyanation of the activated benzyl alcohol and (7) hydrolysis of the nitrile obtained.Type: GrantFiled: April 3, 2019Date of Patent: July 4, 2023Assignee: Bayer AktiengesellschaftInventors: Thomas Himmler, Dirk Brohm, Wahed Ahmed Moradi
-
Patent number: 11691986Abstract: The present invention relates to novel modified macrocyclic compounds with improved tolerability of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).Type: GrantFiled: December 21, 2021Date of Patent: July 4, 2023Assignees: BAYER AKTIENGESELLSCHAFT, BAYER PHARMA AKTIENGESELLSCHAFTInventors: Ulrich Lücking, Daniel Hog, Clara Christ, Ulrike Sack, Franziska Siegel, Philip Lienau, Nicolas Werbeck
-
Patent number: 11690911Abstract: The present invention covers combinations of at least two components, component A and component B, comprising component A being an inhibitor of ATR kinase, particularly an inhibitor of ATR kinase selected from VX-803, VX-970, AZD-6738, a compound of general formula (I) described herein, a compound of general formula (Ib) described herein and Compound A described infra, and component B being a PD-1/PD-L1 inhibitor described herein. Another aspect of the present invention covers the use of such combinations as described herein for the preparation of a medicament for the treatment or prophylaxis of a disease, particularly for the treatment of a hyper-proliferative disease.Type: GrantFiled: July 31, 2018Date of Patent: July 4, 2023Assignees: Bayer Aktiengesellschaft, Bayer Pharma AktiengesellschaftInventor: Antje Margret Wengner
-
Publication number: 20230201186Abstract: The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: November 30, 2022Publication date: June 29, 2023Applicants: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, Deutsches KrebsforschungszentrumInventors: Norbert SCHMEES, Lars WORTMANN, Dennis KIRCHOFF, Thi Thanh Uyen NGUYEN, Nicolas WERBECK, Ulf BÖMER, Kirstin PETERSEN, Christina KOBER, Detlef STÖCKIGT, Christian LECHNER, Robin Michael MEIER, Simon Anthony HERBERT, Isabel Patrizia KERSCHGENS, Dirk KOSEMUND, Rienk OFFRINGA, Mareike GREES
-
Publication number: 20230192617Abstract: The present invention relates to azabicyclic (thio)amide compounds and the uses thereof for controlling phytopathogenic microorganisms such as phytopathogenic fungi.Type: ApplicationFiled: May 18, 2021Publication date: June 22, 2023Applicants: Bayer CropScience Aktiengesellschaft, Bayer Aktiengesellschaft (Division CropScience)Inventors: Julie GEIST, Anthony MILLET, Cyril MONTAGNE, Lionel NICOLAS, Valerie TOQUIN, Mathieu GOURGUES, Dominique LOQUE, Vincent THOMAS, Philippe RINOLFI, Mazen ES-SAYED (DECEASED), Alexander SUDAU
-
Publication number: 20230196284Abstract: The invention relates to the monitoring of products by means of active radio tags. According to the invention, packagings of products are provided with an active radio tag that detects at least one environmental condition and/or at least one packaging state, and which emits a signal at time intervals, which provides information about a unique identifier and at least one state in which the respective product is found. The signal is picked up by a receiver that extracts the unique identifier and the state information and transmits same together with location information to an external server.Type: ApplicationFiled: December 28, 2022Publication date: June 22, 2023Applicant: Bayer AktiengesellschaftInventors: Christof Backhaus, Katharina Berger, Uwe Schenkel, Jürgen Schmidt, Walter Speth, Klaus Glismann, Eric Willms, Markus Storz, Arne Wendt, Gregory James Dibble
-
Publication number: 20230196285Abstract: The invention relates to the monitoring of products by means of active radio tags. According to the invention, packagings of products are provided with an active radio tag that detects at least one environmental condition and/or at least one packaging state, and which emits a signal at time intervals, which provides information about a unique identifier and at least one state in which the respective product is found. The signal is picked up by a receiver that extracts the unique identifier and the state information and transmits same together with location information to an external server.Type: ApplicationFiled: December 28, 2022Publication date: June 22, 2023Applicant: Bayer AktiengesellschaftInventors: Christof BACKHAUS, Katharina Berger, Uwe Schenkel, Jürgen Schmidt, Walter Speth, Klaus Glismann, Eric Willms, Markus Storz, Arne Wendt, Gregory James Dibble
-
Publication number: 20230192700Abstract: The present invention provides compounds of general formula (I) in which X, R1, R2 and R3 are as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of hyperproliferative disorders such as cancer disorders, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: March 5, 2021Publication date: June 22, 2023Applicants: Bayer Aktiengesellschaft, Deutsches KrebsforschungszentrumInventors: Markus BERGER, Bernd BUCHMANN, Kai THEDE, Philipp BUCHGRABER, Gerhard SIEMEISTER, Patrick STEIGEMANN, Antje Margret WENGNER, Ulf BÖMER, Naomi BARAK, Philip LIENAU
-
Publication number: 20230180756Abstract: The present disclosure relates to triazine and pyrimidine (thio)amide compounds, processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.Type: ApplicationFiled: May 10, 2021Publication date: June 15, 2023Applicant: Bayer AktiengesellschaftInventors: Julie GEIST, Cyril MONTAGNE, Lionel NICOLAS, Valerie TOQUIN, Mathieu GOURGUES, Vincent THOMAS, Mazen ES-SAYED (DECEASED)
-
Publication number: 20230172197Abstract: The present invention relates to agrochemical compositions: their use for foliar application; their use at low spray volumes; their use by unmanned aerial systems (UAS), unmanned guided vehicles (UGV), and tractor mounted boom sprayers fitted with conventional nozzles but also pulse width modulation spray nozzles or rotating disc droplet applicators; and their application for controlling agricultural pests, weeds or diseases, in particular on waxy leaves.Type: ApplicationFiled: May 8, 2020Publication date: June 8, 2023Applicant: Bayer AktiengesellschaftInventors: Malcolm FAERS, Arno RATSCHINSKI, Gorka PERIS URQUIJO, Oliver GAERTZEN, Emilia HILZ, Sybille LAMPRECHT, Silivia CEREZO-GALVEZ
-
Patent number: 11667675Abstract: The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.Type: GrantFiled: December 30, 2020Date of Patent: June 6, 2023Assignees: Bayer Aktiengesellschaft, Bayer Pharma AktiengesellschaftInventors: Donald Bierer, Ingo Flamme, Dmitry Zubov, Thomas Neubauer, Adrian Tersteegen, Cathleen Juhl, Marie Glatz, Jan Dreher, Simon Holton, Carsten Terjung, Lars Baumann, Thorsten Poethko, Jiancheng Xiong, Yibo Qiu
-
Publication number: 20230167078Abstract: The present invention covers aminothiazole compounds of general formula (I), in which R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase zeta (DGK?) regulated disorders, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: April 20, 2021Publication date: June 1, 2023Applicants: Bayer Aktiengesellschaft, Deutsches KrebsforschungszentrumInventors: Norbert SCHMEES, Ulrike ROEHN, Dennis KIRCHHOFF, Kirstin PETERSEN, Thi Thanh Uyen NGUYEN, Mareike GREES, Nicolas WERBECK, Ulf BOEMER, Benjamin BADER, Detlef STOECKIGT, Dirk KOSEMUND, Rienk OFFRINGA, Corinna LINK, Katrin NOWAK-REPPEL
-
Publication number: 20230165252Abstract: The present invention relates to active compound combinations, in particular within a fungicide composition, which comprise as compound (A) a compound of formula (I) and as compound (B) a further fungicidally active compound as specified below. Moreover, the invention relates to compositions comprising such compound combination and to the use of the compound combinations and the fungicide compositions as biologically active agent, especially for control of phytopathogenic fungi in crop protection and in the protection of industrial materials and as plant growth regulators.Type: ApplicationFiled: May 26, 2021Publication date: June 1, 2023Applicant: Bayer AktiengesellschaftInventors: Agostinos Michael KLÜKEN, Julie GEIST, Cyril MONTAGNE, Anthony MILLET
-
Publication number: 20230167103Abstract: The present invention covers aminothiazole compounds of general formula (I): in which R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase zeta (DGK?) regulated disorders, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: April 20, 2021Publication date: June 1, 2023Applicants: Bayer Aktiengesellschaft, Deutsches KrebsforschungszentrumInventors: Norbert SCHMEES, Ulrike ROEHN, Dennis KIRCHHOFF, Kirstin PETERSEN, Thi Thanh Uyen NGUYEN, Mareike GREES, Nicolas WERBECK, Ulf BOEMER, Benjamin BADER, Detlef STOECKIGT, Rienk OFFRINGA, Corinna LINK, Giambattista TESTOLIN, Katrin NOWAK-REPPEL
-
Patent number: 11660351Abstract: The invention relates to novel binder-drug conjugates (ADCs) having improved properties, to active metabolites of these ADCs and to processes for their preparation. The present invention furthermore relates to the use of these conjugates for the treatment and/or prevention of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases.Type: GrantFiled: December 14, 2017Date of Patent: May 30, 2023Assignees: BAYER AKTIENGESELLSCHAFT, BAYER PHARMA AKTIENGESELLSCHAFTInventors: Hans-Georg Lerchen, Anne-Sophie Rebstock, Beatrix Stelte-Ludwig, Dennis Kirchhoff, Lisa Dietz, Christoph Mahlert, Simone Greven, Stephan Märsch, Sandra Berndt, Anette Sommer, Stefanie Hammer
-
Patent number: 11659826Abstract: The disclosure relates to the detection of arthropods (beneficial insects and/or pests) in a region in which plants grow via a camera.Type: GrantFiled: September 16, 2019Date of Patent: May 30, 2023Assignee: Bayer AktiengesellschaftInventors: Dennis Göke, Robert Wollenhaupt, Matthias Tempel
-
Publication number: 20230159486Abstract: The present disclosure relates to substituted thiophene carboxamides and analogues thereof of formula (II) that may be used for protecting plants from bacterial diseases, in particular from bacterial diseases caused by bacteria belonging to the genus Xanthomonas.Type: ApplicationFiled: July 3, 2019Publication date: May 25, 2023Applicant: Bayer AktiengesellschaftInventors: David BERNIER, Stéphane BRUNET, Pierre-Yves COQUERON, Jérémy DUFOUR, Thomas KNOBLOCH, Lionel NICOLAS, Tomoki TSUCHIYA