Patents Assigned to Bayer Aktiengesellschaft
  • Publication number: 20190351066
    Abstract: The invention relates to novel prodrugs or conjugates of the general formula (Ia) in which La, n, R and D have the definitions given in the description and which have a structural motif reduced to an asparagine derivative as cleavage site for tumour-associated proteases such as legumain, in which cytotoxic drugs, for example kinesin spindle protein inhibitors, are released by legumain cleavage, and to the use of these prodrugs or conjugates for treatment and/or prevention of diseases, and to the use of these prodrugs or conjugates for production of medicaments for treatment and/or prevention of diseases, especially of hyperproliferative and/or angiogenic disorders, for example cancers. Reduction of the legumain-cleavable substrate peptide sequence to an asparagine derivative as structural motif, as a result of slowed legumain cleavage, achieves an increase in stability in the lysosomes of healthy organs while simultaneously maintaining the high anti-tumour effect.
    Type: Application
    Filed: December 18, 2017
    Publication date: November 21, 2019
    Applicants: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft
    Inventors: Hans-Georg LERCHEN, Anne-Sophie REBSTOCK, Leo MARX, Sarah Anna Liesa JOHANNES, Beatrix STELTE-LUDWIG, Lisa DIETZ, Hannah JOERISSEN, Christoph MAHLERT, Simone GREVEN, Anette SOMMER
  • Patent number: 10472354
    Abstract: The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: November 12, 2019
    Assignee: Bayer Aktiengesellschaft
    Inventors: Adam James Davenport, Nico Bräuer, Oliver Martin Fischer, Andrea Rotgeri, Antje Rottmann, Ioana Neagoe, Jens Nagel, Anne-Marie Godinho-Coelho, Jürgen Klar
  • Publication number: 20190328897
    Abstract: The invention relates to novel binder-drug conjugates (ADCs) having improved properties, to active metabolites of these ADCs and to processes for their preparation. The present invention furthermore relates to the use of these conjugates for the treatment and/or prevention of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases.
    Type: Application
    Filed: December 14, 2017
    Publication date: October 31, 2019
    Applicants: Bayer Pharma Aktiengesellschaft, Bayer Aktiengesellschaft
    Inventors: Hans-Georg LERCHEN, Anne-Sophie REBSTOCK, Beatrix STELTE-LUDWIG, Dennis KIRCHHOFF, Lisa DIETZ, Christoph MAHLERT, Simone GREVEN, Stephan MÄRSCH, Sandra BERNDT, Anette SOMMER, Stefanie HAMMER
  • Publication number: 20190313643
    Abstract: The invention relates to novel compounds of the formula (I) in which Aa, Ab, Ac, Ad, R1, Q and n have the definitions given above, to their use as acaricides and/or insecticides for controlling animal pests and to processes and intermediates for their preparation.
    Type: Application
    Filed: August 9, 2017
    Publication date: October 17, 2019
    Applicants: Bayer CropScience Aktiengesellschaft, Bayer Aktiengesellschaft
    Inventors: Laura HOFFMEISTER, Rüdiger FISCHER, Dominik HAGER, Nina KAUSCH-BUSIES, Marc MOSRIN, David WILCKE, Matthieu WILLOT, Kerstin ILG, Ulrich GOERGENS, Simon Anthony HERBERT, Anton LISHCHYNSKYI, Andreas TURBERG, Anthony MILLET
  • Publication number: 20190308933
    Abstract: The present invention relates to compounds of the formula (I), in particular to phenylamidines of the formula (I), to a process for their preparation, to the use of phenylamidines of the formula (I) according to the invention for controlling unwanted microorganisms, in particular phytopathogenic fungi and also to a composition for this purpose, comprising the phenylamidines of the formula (I) according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms, in particular phytopathogenic fungi, characterized in that the compounds of the formula (I) are applied to the microorganisms, in particular to the phytopathogenic fungi and/or in their habitat.
    Type: Application
    Filed: December 13, 2017
    Publication date: October 10, 2019
    Applicants: Bayer CropScience Aktiengesellschaft, Bayer Aktiengesellschaft
    Inventors: Cyril MONTAGNE, Mazen ES-SAYED, Andreas GÖRTZ, Ulrike WACHENDORFF-NEUMANN
  • Patent number: 10434201
    Abstract: The invention provides a method for continuous virus inactivation. The product stream is segmented by introducing a separating medium which is immiscible with the product stream and the segmented product stream is transported into a reactor 1 as detention segment under virus-inactivating conditions for the required detention time.
    Type: Grant
    Filed: April 25, 2016
    Date of Patent: October 8, 2019
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Peter Schwan, Andrea Vester, Martin Lobedann
  • Patent number: 10421042
    Abstract: The invention relates to an ultrafiltration unit for continuous buffer or medium exchange, a method for continuous buffer or medium exchange in the ultrafiltration unit, and a plant in particular for (semi)continuous production of biopharmaceutical and biological macromolecular products in particular, such as proteins, e.g. monoclonal antibodies and vaccines, comprising the ultrafiltration unit according to the invention.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: September 24, 2019
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Schwan, Lutz-Peter Lenz, Kerstin Baumarth, Martin Lobedann
  • Publication number: 20190269134
    Abstract: The present invention relates to the use of a compound of the general formula (I) in which M and D have the meanings given in the description for controlling animal pests, in particular nematodes.
    Type: Application
    Filed: November 6, 2017
    Publication date: September 5, 2019
    Applicants: Bayer Aktiengesellschaft, Bayer CropScience Aktiengesellschaft
    Inventors: Martin FÜßLEIN, Heinz-Jürgen WROBLOWSKY, Susanne KÜBBELER, Dominik HAGER, Nina KAUSCH-BUSIES, Roland ANDREE, Johannes-Rudolf JANSEN, Hans-Georg SCHWARZ, Daniela PORTZ, Kerstin ILG, Olga MALSAM, Sascha EILMUS, Peter LÖSEL, Stefan HERRMANN, Angela BECKER, Arnd VOERSTE, Ulrich GÖRGENS, Anton LISHCHYNSKYI, Andreas TURBERG
  • Publication number: 20190263805
    Abstract: The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
    Type: Application
    Filed: September 6, 2017
    Publication date: August 29, 2019
    Applicants: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft
    Inventors: Henrik TELLER, Alexandros VAKALOPOULOS, Melissa BOULTADAKIS ARAPINIS, Alexander STRAUB, Hanna TINEL, Markus BRECHMANN, Matthias Beat WITTWER, Maximilian Andreas KULLMANN, Till FREUDENBERGER, Thomas MONDRITZKI, Tobias MARQUARDT
  • Publication number: 20190248811
    Abstract: The invention relates to novel compounds of the formula (I) in which Q, Aa, Ab, Ac, Ad, R1 and n have the definitions given above, to their use as acaricides and/or insecticides for controlling animal pests and to processes and intermediates for their preparation.
    Type: Application
    Filed: September 15, 2017
    Publication date: August 15, 2019
    Applicants: Bayer CropScience Aktiengesellschaft, Bayer Aktiengesellschaft
    Inventors: Ruediger FISCHER, Dominik HAGER, Laura HOFFMEISTER, Nina KAUSCH-BUSIES, Marc MOSRIN, David WILCKE, Matthieu WILLOT, Kerstin ILG, Ulrich GOERGENS, Andreas TURBERG
  • Publication number: 20190241562
    Abstract: The present application relates to novel 7-substituted 1-pyridylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
    Type: Application
    Filed: July 4, 2017
    Publication date: August 8, 2019
    Applicants: Bayer Pharma Aktiengesellschaft, Bayer Aktiengesellschaft
    Inventors: Henrik TELLER, Melissa BOULTADAKIS ARAPINIS, Alexandros VAKALOPOULOS, Anne-Sophie REBSTOCK, Alexander STRAUB, Hanna TINEL, Markus BRECHMANN, Matthias Beat WITTWER, Maximillian Andreas KULLMANN, Klaus MÜNTER, Thomas MONDRITZKI, Tobias MARQUARDT
  • Patent number: 10369542
    Abstract: The present invention relates to a multistage stirred reactor, comprising a multiplicity of mutually adjacent reaction chambers and stirring elements for mixing the contents of at least one of the reaction chambers, wherein, between adjacent reaction chambers, there is in each case provided at least one opening that can be closed by means of closure means, such that in the open state there is a fluidic connection between the adjacent reaction chambers and in the closed state the adjacent reaction chambers are separated from one another. At least one of the closure means (300, 310, 320) is connected to an actuation rod (500, 510, 520) that is guided out of the stirred reactor.
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: August 6, 2019
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Sebastian Falß, Leslaw Mleczko, Karl-Robert Boos, Sigurd Buchholz
  • Patent number: 10369541
    Abstract: A method operates a production plant, the method having process modules, wherein, for each process module, the amount of material that is respectively present in this process module and is to be processed by this process module is continuously or discretely detected and compared with a prescribed limit value for the amount, wherein a mass inflow into the respective process module is increased or decreased if the amount of material that is respectively present in this process module and is to be processed by this process module is less than or greater than the limit value for the amount, or a mass outflow from the respective process module is increased or decreased if the amount of material that is respectively present in this process module and is to be processed by this process module is greater than or less than the limit value for the amount.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: August 6, 2019
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Achim Küpper, Stefan Ochs
  • Publication number: 20190185466
    Abstract: The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: November 15, 2018
    Publication date: June 20, 2019
    Applicant: Bayer Aktiengesellschaft
    Inventors: Adam James DAVENPORT, Nico BRÄUER, Oliver Martin FISCHER, Andrea ROTGERI, Antje ROTTMANN, Ioana NEAGOE, Jens NAGEL, Anne-Marie GODINHO-COELHO, Jürgen KLAR
  • Patent number: 10308499
    Abstract: A holding stand for a multicoupling for filling and/or emptying a chemical plant container is provided, having a mounting device for the essentially stationary fastening of the holding stand and at least one compensating device, couplable indirectly or directly to the multicoupling, for varying a position of the multicoupling in relation to the mounting device in the vertical direction and/or in the horizontal direction and/or for varying an angular position of the multicoupling in relation to the mounting device about a vertical and/or horizontal axis of rotation. It thereby becomes possible for a multicoupling to be coupled simply.
    Type: Grant
    Filed: September 19, 2012
    Date of Patent: June 4, 2019
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Florian Lipski, Gerhard Monscheuer, Lars Frye, Oliver Reinold, Yasar Guendogan, Reinhard Engelstaedter
  • Publication number: 20190160048
    Abstract: The present application relates to novel substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazol-3-ones, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of lung inflammation disorders.
    Type: Application
    Filed: May 8, 2017
    Publication date: May 30, 2019
    Applicants: BAYER AKTIENGESELLSCHAFT, BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Nicole BIBER, Damian BROCKSCHNIEDER, Kersten Matthias GERICKE, Florian KÖLLING, Klemens LUSTIG, Jörg MEDING, Heinrich MEIER, Thomas NEUBAUER, Martina SCHÄFER, Andreas TIMMERMANN, Dmitry ZUBOV, Carsten TERJUNG, Niels LINDNER, Volker BADOCK, Dieter MOOSMAYER, Hideki MIYATAKE ONDOZABAL, Steven MOORE, Alexander SCHULZ
  • Patent number: 10300449
    Abstract: The invention relates to a neutralization plant (100) comprising at least one reaction chamber (102) having a first feed (114) for an acid-containing product and at least one further feed (116) for a base-containing product, wherein at least one of the feeds (114, 116) comprises at least one valve means (118, 120) for controlling the inflow amount into the reaction chamber (102), wherein the ion controller apparatus (104, 204, 205) comprises at least one evaluation device (106, 206) set up for determining at least one actual ion concentration based on an actual pH of the mixture (122) present in the reaction chamber (102) and wherein the ion controller apparatus (104, 204) comprises at least one ion controller device (108, 208) comprising at least one ion controller (110, 210.1, 210.2, 211) set up for controlling the valve means (118, 120) according to the actual ion concentration and a target ion concentration.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: May 28, 2019
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventor: Achim Küpper
  • Patent number: 10296708
    Abstract: The application relates to a computer-implemented method for creating a model of a bioreaction—fermentation process or whole-cell catalysis process—with an organism on the basis of measured data.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: May 21, 2019
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Tobias Neymann, Lukas Hebing, Sebastian Engell
  • Patent number: 10285958
    Abstract: The invention relates to a combination of two or more pharmaceutically active substances, of which at least one is a metabolic product (“metabolite”) of the other (“parent substance”), wherein in particular the dosages thereof are selected such that genotypically or phenotypically related variability in the conversion of the parent substance to the metabolite in particular individuals is compensated for.
    Type: Grant
    Filed: May 27, 2013
    Date of Patent: May 14, 2019
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Stefan Willmann, Thomas Eiβing, Kristin Dickschen
  • Patent number: 10261480
    Abstract: A method and a computer-implemented system for automatically monitors and determines the status of entire process sections in a process unit in a computer-implemented manner.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: April 16, 2019
    Assignee: Bayer Aktiengesellschaft
    Inventor: Thomas Ross