Patents Assigned to Bayer HealthCare, LLC
  • Syringe fill adapter
    Patent number: 11007118
    Abstract: A fill adapter for delivery of a medical liquid to a container has a body with a distal end, a proximal end, and a central bore extending between the distal end and the proximal end along a longitudinal axis. The central bore has an angled portion at the proximal end of the body such that a diameter of the central portion increases at the angled portion in a direction from the distal end to the proximal end. The fill adapter further has a flow controller disposed within the central bore at a distal end of the angled portion such that a gap is formed between an outer surface of the flow controller and an inner surface of the central bore. The flow controller is shaped to direct liquid flowing through the central bore to flow through the gap and along the angled portion of the central bore under a Coand? effect.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: May 18, 2021
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Kevin Cowan, James A. Dedig, Michael Spohn, Michael McDermott, Matthew McGee
  • NON-ANTIBODY VEGF ANTAGONISTS FOR THE TREATMENT OF NEOVASCULAR GLAUCOMA
    Publication number: 20210138032
    Abstract: The present invention relates to methods of treating the manifestation of NVG including increased intraocular pressure and anterior segment neovascularization with a non-antibody VEGF antagonist.
    Type: Application
    Filed: June 12, 2018
    Publication date: May 13, 2021
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Sergio Casimiro SILVA LEAL, Oliver ZEITZ, Yuji IWAMOTO, Masato KOBAYASHI
  • Systems and methods for generating simulated computed tomography (CT) images
    Patent number: 11000255
    Abstract: Described is a system for generating simulated CT images. The system can include a CT image simulator, a phantom database, and a scanner database. The phantom database can include one or more virtual phantoms while the scanner database can include information about one or more CT scanners, including a subject CT scanner. The CT image simulator can use information about a subject patient, a virtual phantom, and scanner information about the subject CT scanner to generate a simulated CT image that closely simulates what an actual CT image would look like if performed on the subject patient using the subject CT scanner. The simulated CT image can be displayed on a display screen. Also described is a method of generating a simulated CT image and CT image simulator software that can be used to generate a simulated CT image.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: May 11, 2021
    Assignee: BAYER HEALTHCARE LLC
    Inventor: Mohammad Sedigh Ghamari
  • COMPOSITIONS AND METHODS FOR GENE EDITING BY TARGETING FIBRINOGEN-ALPHA
    Publication number: 20210130824
    Abstract: Provided include compositions, methods, and systems for modulating the expression, function, and/or activity of a target gene, for example a blood-clotting protein such as Factor VIII (FVIII), in a cell by genome editing. Also provided include compositions, methods, and systems for treating a subject having or suspected of having a disorder or health condition, e.g., hemophilia A, employing ex vivo and/or in vivo genome editing.
    Type: Application
    Filed: February 15, 2019
    Publication date: May 6, 2021
    Applicants: CRISPR Therapeutics AG, BAYER Healthcare LLC
    Inventor: Alan Richard Brooks
  • Materials and methods for treatment of autosomal dominant cone-rod dystrophy
    Patent number: 10995328
    Abstract: The present application provides materials and methods for treating a patient with autosomal dominant CORD, both ex vivo and in vivo; materials and methods for editing a GUCY2D gene in a human cell; and materials and methods for editing a R838H, R838C, or R838S mutation in a GUCY2D gene in a human cell. The present application also provides one or more gRNAs or sgRNAs for editing a GUCY2D gene; one or more gRNAs or sgRNAs for editing a R838H, R838C, or R838S mutation in a GUCY2D gene; and a therapeutic comprising at least one or more gRNAs or sgRNAs for editing a R838H, R838C, or R838S mutation in a GUCY2D gene. The present application provides a therapeutic for treating a patient with autosomal dominant CORD. The present application also provides a kit for treating a patient with autosomal dominant CORD. In addition, the present application provides a self-inactivating CRISPR-Cas system.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: May 4, 2021
    Assignees: CRISPR THERAPEUTICS AG, BAYER HEALTHCARE LLC
    Inventors: Ryo Takeuchi, Akiko Noma, Shuying He, Abraham Scaria
  • Identification tag reader system
    Patent number: 10977463
    Abstract: A reader system for reading information on at least one identification tag associated with a syringe connected to a fluid injector has a detector and a background screen spaced apart from the detector such that at least one of the at least one identification tags is positioned in an optical path between the detector and the background screen when the syringe is connected to the fluid injector. The reader system further has an illumination system configured for illuminating at least a portion of the background screen. The detector is configured for detecting and decoding the at least one identification tag.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: April 13, 2021
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Christopher Capone, Jaroslaw Wlodarczyk
  • Syringe with rolling diaphragm
    Patent number: 10933190
    Abstract: A rolling diaphragm syringe includes a proximal end having an end wall, a distal end having an open-ended discharge neck, a sidewall extending along a longitudinal axis, and a piston engagement portion protruding proximally from a central portion of the end wall and configured for engagement with a piston of a fluid injector. The piston engagement portion has a stem with a first end attached to the end wall, a second end extending proximally from the first end, and at least one protrusion that protrudes radially outward. The sidewall is flexible and rolls upon itself when acted upon by the piston such that an outer surface of the sidewall is folded in a radially inward direction as the piston is advanced from the proximal end to the distal end, and unfolded in a radially outward direction as the piston is retracted from the distal end to the proximal end.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: March 2, 2021
    Assignee: BAYER HEALTHCARE LLC
    Inventors: David Berry, Kevin Cowan, Martin Gibler, Benjamin Krupp, Vince Delbrugge, Michael Spohn
  • System and method for delivering a fluid with a consistent total volumetric flowrate
    Patent number: 10933186
    Abstract: Provided is a method for delivering a medical fluid. The method includes delivering a fluid volume, which includes contrast and/or a flush fluid, at a preselected total volumetric flowrate during a first duration of a fluid delivery procedure. The amount of the contrast agent and the flush fluid in the fluid volume can be controllably varied during the first duration of the fluid delivery procedure so as to substantially maintain a preselected total volumetric flowrate throughout the first duration of the fluid delivery procedure. Also provided is a fluid delivery system capable of performing this method.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: March 2, 2021
    Assignee: BAYER HEALTHCARE LLC
    Inventor: Arthur Uber, III
  • System and method for syringe fluid fill verification and image recognition of power injector system features
    Patent number: 10926043
    Abstract: A fluid injection system and a fluid verification system for confirming that a syringe, containing a fluid for injection, is fully filled with fluid and neither has free space (i.e., air) near the distal end thereof when the syringe is provided in an upright position nor contains air bubbles. Imaging processing techniques and systems are also provided to determine various injection parameters and to verify the type and certain properties of fluid that is present within a syringe.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: February 23, 2021
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Kevin Cowan, Michael Spohn, Michael McDermott
  • System and method for improved fluid delivery in multi-fluid injector systems
    Patent number: 10898638
    Abstract: A method of maintaining an overall flow rate during a sequential delivery of at least two fluids to a patient's blood vessel includes delivering at least a first fluid into the patient's blood vessel at a first flow rate, delivering at least a second fluid into the patient's blood vessel at a second flow rate, and adjusting at least one of a first flow profile of the first flow rate and a second flow profile of the second flow rate to dampen a transient increase in the overall flow rate during a transition between delivering one of the first fluid and the second fluid to delivering the other of the first fluid and the second fluid.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: January 26, 2021
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Michael Spohn, Ralph Schriver, Arthur E. Uber, III, Ronald Heller, Kevin Cowan, Barry Tucker, Edward Rhinehart, Timothy Newing
  • Medical injector system
    Patent number: 10894124
    Abstract: A syringe includes a body and a plunger movably disposed within the body. The syringe may be used with an injector including a drive member. The drive member preferably includes at least one pin adapted to form a retractable abutting connection with an interior of a plunger to enable the drive member to retract the plunger with the body of the syringe.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: January 19, 2021
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Kevin Cowan, John Haury, Jared Neff
  • Magnetic pressure jacket for fluid injector
    Patent number: 10888651
    Abstract: A fluid injector having at least one injector head with a front end configured to releasably receive the at least one syringe is described. The fluid injector further includes at least one pressure jacket releasably associated with the front end of the at least one injector head for securing the at least one syringe during an injection procedure. A connection mechanism releasably connects the at least one pressure jacket to the front end of the at least one injector head. The connection mechanism includes at least one electromagnet.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: January 12, 2021
    Assignee: BAYER HEALTHCARE LLC
    Inventors: James Dedig, Ralph Schriver, Patrick Campbell, Herbert Grubic
  • GENE EDITING FOR HEMOPHILIA A WITH IMPROVED FACTOR VIII EXPRESSION
    Publication number: 20200384125
    Abstract: Provided herein, in some embodiments, are materials and methods for treating hemophilia A in a subject ex vivo or in vivo. Also provided herein, in some embodiments, are materials and methods for knocking in a coding sequence encoding a synthetic FVIII having a B domain substitute into a genome.
    Type: Application
    Filed: April 15, 2020
    Publication date: December 10, 2020
    Applicants: CRISPR THERAPEUTICS AG, BAYER HEALTHCARE LLC
    Inventor: Alan Richard Brooks
  • System and method for improved fluid delivery in multi-fluid injector systems
    Patent number: 10857286
    Abstract: A method of maintaining an overall flow rate during a sequential delivery of at least two fluids to a patient's blood vessel includes delivering at least a first fluid into the patient's blood vessel at a first flow rate, delivering at least a second fluid into the patient's blood vessel at a second flow rate, and adjusting at least one of a first flow profile of the first flow rate and a second flow profile of the second flow rate to dampen a transient increase in the overall flow rate during a transition between delivering one of the first fluid and the second fluid to delivering the other of the first fluid and the second fluid.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: December 8, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Michael Spohn, Ralph Schriver, Arthur E. Uber, III, Ronald Heller, Kevin Cowan, Barry Tucker, Edward Rhinehart, Timothy Newing
  • Sterility retaining medical connector assembly and method
    Patent number: 10857345
    Abstract: A medical connector assembly for establishing a fluid connection between a first medical device and a second medical device includes a multi-use connector and a plurality of single-use connectors connected in series. The multi-use connector has a proximal end opposite a distal end along a longitudinal length thereof. The plurality of single-use connectors each have a proximal end opposite a distal end along a longitudinal length thereof. The distal end of the multi-use connector is releasably connected to the proximal end of a first of the serially-connected single-use connectors. When a second of the serially-connected single-use connectors is disconnected from the first single-use connector, the first single-use connector remains connected to the multi-use medical connector as a sterility retaining cover.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: December 8, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Arthur E. Uber, III, Kevin Cowan, James A. Dedig, David M. Griffiths, Edward J. Rhinehart, Benjamin Taggart, Mark Trocki
  • Fluid injection system having various systems for controlling an injection procedure
    Patent number: 10850031
    Abstract: A fluid injection system that includes an injector head having a syringe for delivering a fluid to a patient; a mounting structure pivotally connected to the injector head and configured to support the injector head above a surface; and a control system operationally coupled to the injector head for controlling an injection procedure is disclosed. The fluid injection system is provided with various sensors to control various aspects of the fluid injection system, such as the establishment of a reference plane, the determination of a tilt angle of the injector head, and the determination of a temperature of an actuation system of the injector head.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: December 1, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventors: John Shearer, Jr., Christopher Scutt, Walter Grumski, Michael Spohn, Jarrell T. McWilliams, Arlie D. Long, Richard Morton
  • Catheters and related equipment
    Patent number: 10850066
    Abstract: A catheter including at least one distal opening positioned at or near the distal end and at least one proximal opening near the proximal end and proximal to the at least one distal opening is described. The catheter may be configured for delivering at least a first fluid through the at least one distal opening to a central circulation system of a patient and delivering at least a second fluid through the at least one proximal opening to a peripheral circulation system of the patient.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: December 1, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Arthur E. Uber, III, Barry Lynn McDaniel, David M. Griffiths, Michael J. Bonnette, Eric J. Thor
  • Nested syringe assembly
    Patent number: 10835674
    Abstract: Provided is an apparatus, system, and method for a nested syringe assembly. The nested syringe assembly (100) includes a first syringe (104) having a cylindrical body defining an inner diameter and a second syringe (102) having a cylindrical body defining an outer diameter. The outer diameter of the second syringe is less than the inner diameter of the first syringe. At least a portion of the cylindrical body of the second syringe is disposed within the cylindrical body of the first syringe.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: November 17, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Kevin Cowan, Damian Peter Francis Savio, Eric Siu, Richard Sokolov, Peter John Sprada
  • Bladder syringe fluid delivery system
    Patent number: 10835680
    Abstract: A bladder syringe for a fluid delivery system includes a cylindrical body, a cap-bladder assembly, a plunger element disposed in the cylindrical body, and a mounting assembly to secure the cap-bladder assembly to the cylindrical body. The cylindrical body has a distal end and a proximal end and defines a throughbore. The cap-bladder assembly is adapted for connection to the distal end of the cylindrical body, and includes a cap body and a bladder. The cap body defines an interior cavity and a distal discharge conduit and is adapted to engage the distal end of the cylindrical body. A disc-shaped bladder is disposed within the interior cavity and typically includes a central membrane portion. The plunger element is disposed in the throughbore of the cylindrical body and is vented to enable evacuation of the space between the plunger element and the cap-bladder assembly in the cylindrical body.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: November 17, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Kevin P. Cowan, Raymond C. Hoffman, Barry L. Tucker, Jaroslaw Wlodarczyk
  • Injector systems and syringe adapters for use therewith
    Patent number: 10835668
    Abstract: An adapter for releasably attaching a syringe to an injector. The adapter comprises a mounting mechanism positioned at a rear end of the adapter to mount the adapter in a desired position relative to a front wall of the injector; and a syringe carrier section adapted to seat at least a portion of the syringe. The syringe carrier section defines a first opening on a top thereof to allow placement of the syringe therein from the top and a second opening in a rear section thereof to allow the drive member of the injector to communicate forward force to the plunger. A cover portion extends over a rearward end of the first opening and has a first end configured to abut the flange of the syringe when the syringe is positioned within the syringe carrier section.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: November 17, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Erin Novickoff, Molly Bingaman, Collin Grimes, Keith Lipford, Barry Iddon, Richard Seman, Kent Diasabeygunawardena, Isabella Norcini, Emma Diasabeygunawardena, Patrick O'Rourke, Samantha Sutherland, Stephen Schulte, Arthur Uber, III, Mark Trocki, David M. Reilly