Abstract: The invention relates to substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones of the formula (Ia) for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of tumor disorders. The invention also relates to novel compounds of the formula (I) in which W, X, Y, Z, A, B, D and G have the meanings given above, to a plurality of processes and intermediates for their preparation, and to their use as pesticides and/or herbicides and/or fungicides. The invention also relates to selectively herbicidal compositions comprising, firstly, the halogen-substituted spirocyclic ketoenols and, secondly, a crop plant compatibility-improving compound.
Type:
Grant
Filed:
February 14, 2012
Date of Patent:
April 7, 2015
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Ningshu Liu, Kai Thede, Ursula Mönning, Arne Scholz, Christoph-Stephan Hilger, Ulf Bömer, Reiner Fischer
Abstract: Semi-rigid polyurethane foams having a density of 90 to 180 kg/m3 and a compressive strength of 20 to 95 kPa are produced by reacting a polyisocyanate with an isocyanate-reactive component that includes an o-toluenediamine initiated polyether polyol. These foams are particularly useful as composites for automotive interior components.
Type:
Grant
Filed:
February 14, 2013
Date of Patent:
April 7, 2015
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Rolf Albach, Monika Haselbach, Harald Fietz
Abstract: The invention relates to novel amides of acetic and propionic acids, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning ability and memory.
Type:
Grant
Filed:
August 16, 2013
Date of Patent:
April 7, 2015
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Joachim Luithle, Frank-Gerhard Bob, Christina Erb, Katrin Schnizler, Timo Flessner, Marja V. Kampen, Christoph Methfessel
Abstract: The invention relates to novel insecticidal active compound combinations comprising, firstly, compounds which act as insecticides on nicotinergic acetylcholine receptors as agonists and antagonists, and at least one active compound from the group of the anthranilamides, which combinations are suitable for protecting plants against attack by pests.
Type:
Grant
Filed:
December 12, 2011
Date of Patent:
March 31, 2015
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Christian Funke, Reiner Fischer, Rüdiger Fischer, Heike Hungenberg, Wolfram Andersch, Wolfgang Thielert, Anton Kraus
Abstract: The present invention relates to a process for preparing tetrazole-substituted anthranilic acid diamide derivatives of the formula (I) in which R1, R2, R3, R4, Q and Z have the meanings given in the description, by reacting benzoxazinones with amines.
Type:
Grant
Filed:
August 24, 2012
Date of Patent:
March 31, 2015
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Sergii Pazenok, Werner Lindner, Hartmut Scheffel
Abstract: The present invention relates to substituted sulphonamido phenoxybenzamide compounds of general formula (I): in which A, R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined in the claims, to pharmaceutical compositions and combinations containing said compounds, to methods of preparing said compounds, and to the use of said compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
Type:
Grant
Filed:
October 28, 2009
Date of Patent:
March 31, 2015
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Ingo Hartung, Marion Hitchcock, Florian Puhler, Gerhard Siemeister, Roland Neuhaus
Abstract: The present invention relates to novel heterocyclic alkanol derivatives, to processes for preparing these compounds, to compositions comprising these compounds and to their use as biologically active compounds, in particular for controlling harmful microorganisms in crop protection and in the protection of materials and as plant growth regulators.
Type:
Grant
Filed:
March 13, 2013
Date of Patent:
March 31, 2015
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Carl Friedrich Nising, Pierre Cristau, Hendrik Helmke, Gorka Peris, Tomoki Tsuchiya, Pierre Wasnaire, Jürgen Benting
Abstract: The invention relates to bimetallic complexes in which the ligand contains a salophen unit which complexes copper, manganese or cobalt and a phenanthroline unit which complexes palladium and the two systems are linked by a continuous conjugated system. The invention further relates to the use of these bimetallic complexes as catalysts for the oxidative carbonylation of aromatic hydroxy compounds to form diaryl carbonates, a process for preparing diaryl carbonates using the bimetallic complex as catalyst and also diaryl carbonates prepared by oxidative carbonylation of aromatic hydroxy compounds using the bimetallic complexes of the invention as catalysts.
Type:
Grant
Filed:
December 9, 2010
Date of Patent:
March 24, 2015
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Christoph Gürtler, Thomas Ernst Müller, Pieter Ooms, Johann Rechner, Friedhelm Risse, Angelina Prokofieva, Franco Doro, Burkhard Köhler, Walter Leitner, Aurel Wolf
Abstract: The invention relates to novel substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders and tumor disorders.
Type:
Grant
Filed:
March 12, 2010
Date of Patent:
March 24, 2015
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Mario Jeske, Dirk Heimbach, Susanne Röhrig, Yolanda Cancho Grande, Dirk Schneider, Ulrich Rester, Eckhard Bender, Mark Meininghaus, Katja Zimmermann, Dmitry Zubov, Anja Buchmüller, Georges Von Degenfeld, Christoph Gerdes, Michael Gerisch, Mark Jean Gnoth, Kersten Matthias Gericke
Abstract: The present application relates to novel carboxylic acid derivatives having an oxo-substituted azaheterocyclic partial structure, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
Type:
Grant
Filed:
April 6, 2009
Date of Patent:
March 24, 2015
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Michael Hahn, Eva-Maria Becker, Andreas Knorr, Dirk Schneider, Johannes-Peter Stasch, Karl-Heinz Schlemmer, Frank Wunder, Friederike Stoll, Stefan Heitmeier, Klaus Münter, Nils Griebenow, Thomas Lampe, Sherif El Sheikh, Volkhart Min-Jian Li
Abstract: Compounds of Formula (I), which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals. The compounds of formula (I) a: useful for the treatment of cancer.
Type:
Grant
Filed:
December 13, 2011
Date of Patent:
March 24, 2015
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Hartmut Rehwinkel, Andrea Hägebarth, Oliver Politz, Roland Neuhaus, Ulf Bömer
Abstract: The invention relates to imidazo[1,2-b]pyridazines of general formula (I) a process for their manufacture and their use for the treatment of benign and malignant neoplasia.
Type:
Grant
Filed:
July 27, 2011
Date of Patent:
March 24, 2015
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Hartmut Rehwinkel, Andrea Hägebarth, Oliver Politz, Roland Neuhaus, Ulf Bömer
Abstract: The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
Type:
Grant
Filed:
February 18, 2013
Date of Patent:
March 24, 2015
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Kai Thede, Ingo Flamme, Felix Oehme, Jens-Kerim Ergüden, Friederike Stoll, Joachim Schuhmacher, Hanno Wild, Peter Kolkhof, Hartmut Beck, Jörg Keldenich, Metin Akbaba, Mario Jeske
Abstract: The invention relates to sun protection compositions for application on the skin, containing special polyurethanes and special sun filter combinations, and to the use of said polyurethanes and sun filter combinations for producing sun protection products.
Type:
Grant
Filed:
March 1, 2011
Date of Patent:
March 24, 2015
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Sophie Viala, Sebastian Dorr, Steffen Hofacker
Abstract: The present invention relates to control of plant pathogens, particularly fungi or oomycetes, by inhibiting one or more biological functions, particularly by inhibiting saccharopine dehydrogenase gene(s) using RNA interference. The invention provides methods and compositions using RNA interference of plant pathogens target genes for such control. The invention is also directed to methods for making transgenic plants tolerant to said plant pathogens, and to transgenic plants and seeds generated thereof.
Type:
Application
Filed:
October 3, 2012
Publication date:
March 19, 2015
Applicant:
Bayer Intellectual Property GmbH
Inventors:
Thomas Delebarre, Cécile Dorme, Bernd Essigmann, Frédéric Schmitt, François Villalba, Eric Paget
Abstract: The present invention relates to screw elements for multiscrew extruders with pairs of co-rotating and fully wiping screws, to the use of these screw elements in multiscrew extruders and to a method of generating screw elements according to the invention.
Type:
Grant
Filed:
June 9, 2009
Date of Patent:
March 17, 2015
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Michael Bierdel, Thomas König, Ulrich Liesenfelder
Abstract: The invention relates to alkoxysilane groups comprising prepolymers and the use thereof as binding agents for sealants. More specifically the invention relates to alkoxysilyl polyurethanes prepared from a polyol having a number-average molecular weight of from greater than 20,000 to 30,000 and an isocyanate alkoxysilane.
Abstract: The invention relates to an aqueous adhesive composition containing at least one acrylate polymer with a glass transition temperature Tg>50° C. and at least one amorphous polyurethane or polyurethane-polyurea polymer with a glass transition temperature Tg<+10° C., the use of the adhesive compositions for the manufacture of heat-activated adhesive layers, and planar formations containing adhesive layers based on the adhesive composition.
Type:
Grant
Filed:
June 3, 2011
Date of Patent:
March 17, 2015
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Jörg Büchner, Harald Kraus, Pantea Nazaran, Dirk Dijkstra
Abstract: The invention relates to a method for producing nitrobenzene, in which crude nitrobenzene is first produced by nitrating benzene and said crude nitrobenzene is then washed in succession in at least one acid wash, in at least one alkaline wash and in at least one neutral wash, at least one additional wash with an aqueous solution of a potassium salt being interposed between the last alkaline wash and the first neutral wash.
Abstract: Compounds of formula (I) which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
Type:
Grant
Filed:
July 7, 2011
Date of Patent:
March 10, 2015
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Stuart Ince, Andrea Hägebarth, Oliver Politz, Roland Neuhaus, Ulf Bömer, William Scott