Patents Assigned to Bayer Intellectual Property GmbH
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Patent number: 9687635Abstract: For selective treatment of diseased tissue sections or organ parts, the surface of medical devices entering into contact with areas thereof under pressure is coated with lipophilic substantially water-insoluble medicaments binding to various tissue components with good adherence thereto, said medicaments having an effect thereupon a short time after entering into contact therewith without exerting a harmful influence upon adjacent healthy tissue.Type: GrantFiled: December 7, 2015Date of Patent: June 27, 2017Assignee: Bayer Intellectual Property GmbHInventors: Ulrich Speck, Bruno Scheller
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Patent number: 9687476Abstract: The present application relates to novel bisaryl-linked 5-aryl-1,2,4-triazolone derivatives, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.Type: GrantFiled: November 2, 2015Date of Patent: June 27, 2017Assignee: Bayer Intellectual Property GmbHInventors: Chantal Fürstner, Jörg Keldenich, Martina Delbeck, Peter Kolkhof, Axel Kretschmer, Ingo Pluschkell, Elisabeth Pook, Carsten Schmeck, Hubert Trübel
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Patent number: 9649374Abstract: The present invention is directed to the neutralizing prolactin receptor antibody 006-H08, as well as maturated forms thereof, and antigen-binding fragments, pharmaceutical compositions containing them and their use in the treatment or prevention of benign disorders and indications mediated by the prolactin receptor such as endometriosis, adenomyosis, non-hormonal female contraception, benign breast disease and mastalgia, lactation inhibition, benign prostate hyperplasia, fibroids, hyper- and normoprolactinemic hair loss, and cotreatment in combined hormone therapy to inhibit mammary epithelial cell proliferation. The antibodies of the invention block prolactin receptor-mediated signaling.Type: GrantFiled: November 18, 2010Date of Patent: May 16, 2017Assignee: Bayer Intellectual Property GMBHInventors: Christiane Otto, Siegmund Wolf, Christoph Freiberg, Axel Harrenga, Simone Greven, Mark Trautwein, Sandra Bruder, Andrea Eicker, Andreas Wilmen
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Patent number: 9649476Abstract: For selective treatment of diseased tissue sections or organ parts, the surface of medical devices entering into contact with areas thereof under pressure is coated with lipophilic substantially water-insoluble medicaments binding to various tissue components with good adherence thereto, said medicaments having an effect thereupon a short time after entering into contact therewith without exerting a harmful influence upon adjacent healthy tissue.Type: GrantFiled: April 19, 2013Date of Patent: May 16, 2017Assignee: Bayer Intellectual Property GmbHInventors: Ulrich Speck, Bruno Scheller
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Patent number: 9642363Abstract: The present invention relates to novel N-arylamide-substituted trifluoroethyl sulfide derivatives of the formula (I) in which X1, X2, X3, X4, R1, R2, R3, n have the meanings given in the description—to their use as acaricides and insecticides for controlling animal pests and to processes and intermediates for their preparation.Type: GrantFiled: December 12, 2012Date of Patent: May 9, 2017Assignees: Bayer Cropscience AG, Bayer Intellectual Property GMBHInventors: Adeline Koehler, Bernd Alig, Angela Becker, Arnd Voerste, Ulrich Goergens, Reiner Fischer, Wahed Ahmed Moradi, Silvia Cerezo-Galvez, Julia Johanna Hahn, Kerstin Ilg, Hans-Georg Schwarz, Takuya Gomibuchi, Masahito Ito, Daiei Yamazaki, Katsuhiko Shibuya, Eiichi Shimojo
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Patent number: 9643974Abstract: The present invention relates to amino-substituted imidazopyndazine compounds of general formula (I): in which A, R1, R2, R3, R4 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.Type: GrantFiled: December 10, 2012Date of Patent: May 9, 2017Assignee: Bayer Intellectual Property GmbHInventors: Knut Eis, Florian Puehler, Ludwig Zorn, Volker Schulze, Detlev Sülzle, Philip Lienau, Andrea Hägebarth, Kirstin Petersen, Ulf Bömer
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Patent number: 9636344Abstract: The present invention relates to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II): or a tautomer, solvate or hydrate thereof; and to its use for the treatment of non-Hodgkin's lymphoma.Type: GrantFiled: January 7, 2016Date of Patent: May 2, 2017Assignee: Bayer Intellectual Property GmbHInventors: Jan-Georg Peters, Hans-Christian Militzer, Hartwig Müller
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Patent number: 9610297Abstract: The invention relates to preparations comprising vitamin B12 and a butanol, and to the use of butanol for stabilizing vitamins.Type: GrantFiled: July 24, 2015Date of Patent: April 4, 2017Assignee: Bayer Intellectual Property GmbHInventors: Iris Heep, Hans-Rolf Taterra
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Patent number: 9609863Abstract: Herbicide-safener compositions are described, comprising active herbicidal ingredients from the group of the N-(tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamides and safeners. These herbicide-safener compositions are particularly suitable for use against harmful plants in crops of useful plants.Type: GrantFiled: October 29, 2012Date of Patent: April 4, 2017Assignee: Bayer Intellectual Property GMBHInventors: Ralf Braun, Hartmut Ahrens, Andreas Van Almsick, Simon Dörner-Rieping, Arnim Köhn, Christopher Rosinger, Elmar Gatzweiler, Erwin Hacker
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Patent number: 9603936Abstract: The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.Type: GrantFiled: October 30, 2012Date of Patent: March 28, 2017Assignee: Bayer Intellectual Property GmbHInventors: Ingo Flamme, Johannes Köbberling, Hans-Georg Lerchen, Nils Griebenow, Rudolf Schohe-Loop, Sven Wittrock, Maria Köllnberger, Frank Wunder, Gorden Redlich, Andreas Knorr, Julie Marley, Iain Pritchard
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Patent number: 9596862Abstract: Compositions are provided that improve overall plant vigor and yield by combining agriculturally effective amounts of at least one environmentally friendly biological control agent and at least one insect control agent and or fungicide. A composition of the present invention is particularly effective in the presence of plant parasitic nematode and fungal species. Along with a benefit of reducing insect pressure, the inventive composition enhances the root system of a plant and improves the establishment of the biological control agent within the rhizosphere, thereby enhancing the effectiveness thereof. Use of a composition of the present invention leads to an overall reduction in crop losses caused by either plant parasitic nematodes or fungi and this reduction is much greater than would have bean expected from application of either component alone. Methods for utilizing compositions of the present invention are also provided.Type: GrantFiled: December 19, 2014Date of Patent: March 21, 2017Assignee: Bayer Intellectual Property GmbHInventors: Wolfram Andersch, Paul Hawen Evans, Bernd Springer, Kevin Bugg, Jennifer Riggs, Chi-Yu Roy Chen
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Patent number: 9592245Abstract: The present invention relates to a very low-dosed dosage form for hormone replacement therapy (HRT). More particularly, the present invention concerns a solid oral dosage form comprising about 0.5 mg estradiol and about 0.25 mg drospirenone, and at least one pharmaceutically acceptable excipient. Despite the very low E2 and DRSP doses it has surprisingly been found that a high proportion of the women suffering from moderate to severe hot flushes actually respond to this treatment. Accordingly, the dosage form of the invention may be used as maintenance HRT or may be used already when HRT is initiated.Type: GrantFiled: December 8, 2014Date of Patent: March 14, 2017Assignee: Bayer Intellectual Property GMBHInventors: Stephan Mletzko, Rolf Schürmann, Kerstin Gude
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Patent number: 9560852Abstract: Compositions are provided that improve overall plant vigor and yield by combining agriculturally effective amounts of at least one environmentally friendly biological control agent and at least one insect control agent and or fungicide. A composition of the present invention is particularly effective in the presence of plant parasitic nematode and fungal species. Along with a benefit of reducing insect pressure, the inventive composition enhances the root system of a plant and improves the establishment of the biological control agent within the rhizosphere, thereby enhancing the effectiveness thereof. Use of a composition of the present invention leads to an overall reduction in crop losses caused by either plant parasitic nematodes or fungi and this reduction is much greater than would have been expected from application of either component alone. Methods for utilizing compositions of the present invention are also provided.Type: GrantFiled: April 7, 2009Date of Patent: February 7, 2017Assignee: Bayer Intellectual Property GmbHInventors: Wolfram Andersch, Paul Hawen Evans, Bernd Springer, Kevin Bugg, Jennifer Riggs, Chi-Yu Roy Chen
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Patent number: 9555022Abstract: The present invention relates to substituted triazolopyridine compounds of general formula (I): in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease of uncontrolled cell growth, proliferation and/or survival as well as to the use of intermediate compounds for the preparation of said compounds.Type: GrantFiled: June 14, 2011Date of Patent: January 31, 2017Assignee: Bayer Intellectual Property GmbHInventors: Volker Schulze, Dirk Kosemund, Hartmut Schirok, Benjamin Bader, Philip Lienau, Antje Margret Wengner, Hans Briem, Simon Holton, Gerhard Siemeister, Stefan Prechtl, Marcus Koppitz, Detlef Stöckigt, Olaf Prien
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Publication number: 20170007612Abstract: The present invention relates to a process for the preparation of a solid, orally administrable pharmaceutical composition, comprising 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide in hydrophilized form, and its use for the prophylaxis and/or treatment of diseases.Type: ApplicationFiled: February 10, 2016Publication date: January 12, 2017Applicant: Bayer Intellectual Property GmbHInventor: Klaus BENKE
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Patent number: 9539331Abstract: The invention relates to preparations comprising amorphous emodepside in a polyvinylpyrrolidone matrix, pharmaceuticals comprising such preparations, and their use against endoparasites in animals or humans.Type: GrantFiled: December 18, 2012Date of Patent: January 10, 2017Assignee: Bayer Intellectual Property GmbHInventors: Venkata-Rangarao Kanikanti, Petra Lange, Hans-Jürgen Hamann, Peter Kleinebudde
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Patent number: 9533972Abstract: The present application relates to sodium 1-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-olate, to processes for its preparation, to its use for the treatment and/or prophylaxis of diseases and to its use for the preparation of medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and haematological diseases and kidney diseases, and for promoting wound healing.Type: GrantFiled: November 15, 2011Date of Patent: January 3, 2017Assignee: Bayer Intellectual Property GmbHInventors: Hans-Christian Militzer, Jörg Gries, Stefan Koep
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Patent number: 9522904Abstract: Process for the preparation of triazinyl-substituted oxindoles of formula (3) and salts thereof by reacting an oxindole (1) with a triazine (2) in the presence of a carbonate, a hydroxide, a phosphate or a mixture of two or more of the aforementioned compounds, and also the compounds of formula (3) and salts thereof (3?) and the use of both for producing crop protection agents.Type: GrantFiled: January 14, 2015Date of Patent: December 20, 2016Assignee: Bayer Intellectual Property GmbHInventors: Gunter Karig, Mark James Ford, Konrad Siegel
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Patent number: 9512126Abstract: The present invention relates to substituted imidazopyridazine compounds of general formula I in which R3, R5 and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.Type: GrantFiled: March 11, 2013Date of Patent: December 6, 2016Assignee: Bayer Intellectual Property GmbHInventors: Marcus Koppitz, Ulrich Klar, Antje Margret Wengner, Roland Neuhaus, Gerhard Siemeister
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Patent number: 9504254Abstract: The present invention relates to compositions for controlling plant pests, which contain the compound of the formula (I) in a mixture with fungicidally active compounds, except for cyclopropylcarboxamide derivatives and azolylmethylcycloalkanes.Type: GrantFiled: December 13, 2013Date of Patent: November 29, 2016Assignee: Bayer Intellectual Property GmbHInventors: Christoph Erdelen, Wolfram Andersch, Klaus Stenzel, Astrid Mauler-Machnik, Wolfgang Krämer