Patents Assigned to Bayer Intellectual Property GmbH
  • Alkoxy-substituted 2,3-dihydroimidazo[1,2-C]quinazolines
    Patent number: 9730943
    Abstract: The present invention relates to alkoxy-substituted 2,3-dihydroimidazo[1,2-c]quinazoline compounds of general formula (I) in which R1, R2 and R3 are as defined in the claims, to methods of preparing said compounds, to intermediates for the preparation of said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: August 15, 2017
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: William Johnston Scott, Manfred Möwes, Ningshu Liu, Ursula Mönning, Ulf Bömer
  • Substituted aminoimidazopyridazines
    Patent number: 9730929
    Abstract: The present invention relates to substituted aminoimidazopyridazine compounds of general formula (I): in which A, R1, R2, R3 and R4 are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: August 15, 2017
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Knut Eis, Florian Pühler, Ludwig Zorn, Arne Scholz, Philip Lienau, Mark Jean Gnoth, Ulf Bömer, Judith Günther, Jörg Fanghänel, Daniel Korr
  • Fungicidal N-bicycloalkyl and N-tricycloalkyl pyrazole-4-(thio)carboxamide derivatives
    Patent number: 9725414
    Abstract: The present invention relates to fungicidal N-bicycloalkyl and N-tricycloalkyl pyrazole-4-(thio)carboxamide derivatives of formula (I), wherein T represents O or S; n represents 0 or 1; and B represents where the bond marked by * is attached to the (CZ2Z3)n-N amide moiety, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: August 8, 2017
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Jurgen Benting, Stephane Brunet, Pierre-Yves Coqueron, Pierre Cristau, Peter Dahmen, Philippe Desbordes, Stephanie Gary, Jorg Greul, Helene Lachaise, Jan-Peter Schmidt, Philippe Rinolfi, Jean-Pierre Vors, Ulrike Wachendorff-Neumann
  • Method of coating a catheter balloon having a fold
    Patent number: 9724497
    Abstract: Various methods for optimizing coating of medical devices, such as balloon catheters are disclosed. One method configures catheter balloon folds based on balloon diameter and volume. Other methods include using a specifically-sized protective sheath, using a vacuum, using pressure, pulling the balloon through a coating solution, using at least one spacer or a wick between at least one fold for metering a therapeutic coating into the folds of the balloon, placing an intermediate layer between the balloon and the therapeutic coating, placing a soluble film having a therapeutic agent around the catheter balloon or inside the folds, and any combination thereof. Balloon catheters and catheter balloons having a specific folding configuration, a specifically-sized protective sheath, an intermediate layer, or a soluble film are also disclosed.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: August 8, 2017
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Benjamin T. Ewing, Gregory G. Brucker, Scott A. Bednar, John R. Periard, Ashok A. Sharma, Steven D. Savage, Arthur E. Uber, Brian P. Dickerson
  • 4-ARYL-N-PHENYL-1,3,5-TRIAZIN-2-AMINES CONTAINING A SULFOXIMINE GROUP
    Publication number: 20170217949
    Abstract: The present invention relates to 4-aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group of general formula (I) or (Ia) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I) or (Ia).
    Type: Application
    Filed: April 14, 2017
    Publication date: August 3, 2017
    Applicant: Bayer Intellectual Property GmbH
    Inventors: Ulrich LÜCKING, Rolf BOHLMANN, Arne SCHOLZ, Gerhard SIEMEISTER, Mark Jean GNOTH, Ulf BÖMER, Dirk KOSEMUND, Philip LIENAU, Gerd RÜHTER, Carsten SCHULTZ-FADEMRECHT
  • Genomics of actinoplanes utahensis
    Patent number: 9719064
    Abstract: The present invention describes the DNA-sequence of the wild type genome as well as all genetic modifications which were introduced into the wild type—and further developed strains, based thereon. Thereby the first genotypic characterization of the developed strains, including the latest production strain, has been accomplished, accounting for the major part of the invention. Furthermore, on the basis of the determined DNA-sequences, potential genes were identified and account, combined with their functional annotation, for another part of the invention. In particular, the gene- and DNA-sequences, as well as protein-sequences derived there out, contribute to the invention which were affected by mutagenic modifications throughout the strain development process, potentially contributing to the increased production yield.
    Type: Grant
    Filed: August 1, 2011
    Date of Patent: August 1, 2017
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Klaus Selber, Bernhard Weingaertner, Hermann Wehlmann, Winfried Rosen, Alfred Pühler, Patrick Schwientek, Jörn Kalinowski, Udo Wehmeier
  • 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives, method of production thereof and use thereof for the treatment of diseases
    Patent number: 9717739
    Abstract: The invention relates to 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives of Formula I with progesterone antagonizing action and method of production thereof, use thereof for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular of fibroids of the uterus (myomas, uterine leiomyoma), endometriosis, heavy menstrual bleeds, meningiomas, hormone-dependent breast cancers and complaints associated with the menopause or for fertility control and emergency contraception.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: August 1, 2017
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Wolfgang Schwede, Ulrich Klar, Carsten Moller, Andrea Rotgeri, Wilhelm Bone
  • Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists
    Patent number: 9714242
    Abstract: The invention relates to novel benzothiophene-, benzofuran-, and indole ureas and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning, and/or memory.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: July 25, 2017
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Timo Fleβner, Frank-Gerhard Böβ, Christina Erb, Frank-Thorsten Hafner, Katrin Schnizler, Dieter Lang, Joachim Luithle, Marja Van Kampen, Franz-Josef Van Der Staay
  • Dust particles separator for seeding machine
    Patent number: 9699956
    Abstract: A seeding machine (1) and method of use, for introducing seed material into a soil (11), with a first ploughing device for drawing at least one furrow into the soil and a filling device for closing the first furrow. A dust separator (5) separates air during the seeding process into an air component (13) and a dust component (7). A line from the dust separator delivers the dust component separated from the air component into the soil.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: July 11, 2017
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Adrian Christopher Arnold, Lubos Vrbka, Charles Andrew Chapple
  • Anthranilamides in combination with fungicides
    Patent number: 9700049
    Abstract: The present invention relates to novel active compound combinations which include of the insecticidally active compounds of the formula (I) in combination with fungicidally active compounds (II) and are highly suitable for controlling unwanted animal pests, such as insects, and unwanted phytopathogenic fungi.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: July 11, 2017
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Christian Funke, Heike Hungenberg, Ruediger Fischer
  • Method for generating a contrast medium-assisted X-ray image and X-ray system
    Patent number: 9693742
    Abstract: A method is disclosed for generating at least one x-ray image of a patient having incorporated contrast medium, using x-rays having an energy spectrum and an x-ray detector. The energy spectrum is modified by at least one first filter arranged in the beam path in front of the patient, the patient absorbing a dose in order to generate detector data for the x-ray image and the x-ray image having a CNR value which represents the ratio of the maximum contrast in the image to the noise. The energy spectrum and contrast medium are matched to each other, taking into account the thickness of the patient to be x-rayed, in such a way that an optimization criterion which is taken from an x-ray image that is generated or simulated by way of trials is maximized. Furthermore, an x-ray system is also disclosed.
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: July 4, 2017
    Assignees: SIEMENS AKTIENGESELLSCHAFT, BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Michael Grasruck, Gregor Jost
  • Fungicide pyrazole carboxamides derivatives
    Patent number: 9695126
    Abstract: The present invention relates to pyrazole carboxamides derivatives of formula (1) wherein Y represents CR5 or N, T represents S or O, X1 and X2 represent a chlorine or a fluorine atom, and Z1 represents a substituted or non-substituted cyclopropyl; Their process of preparation, their use as fungicide, and/or anti-mycotoxin active agents, and/or insecticide, and/or nematicide, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: July 4, 2017
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Guenter Bartels, Angela Becker, Juergen Benting, Christoph-Andreas Braun, Peter Dahmen, Philippe Desbordes, Christophe Dubost, Stephanie Gary, Ulrich Gorgens, Hiroyuki Hadano, Benoit Hartmann, Thomas Knobloch, Marc Kosten, Norbert Lui, Ruth Meissner, Sergiy Pazenok, Rachel Rama, Arnd Voerste, Ulrike Wachendorff-Neumann
  • PREPARATIONS CONTAINING AMORPHOUS EMODEPSIDE
    Publication number: 20170182118
    Abstract: The invention relates to preparations comprising amorphous emodepside in a polyvinylpyrrolidone matrix, pharmaceuticals comprising such preparations, and their use against endoparasites in animals or humans.
    Type: Application
    Filed: January 4, 2017
    Publication date: June 29, 2017
    Applicant: Bayer Intellectual Property GmbH
    Inventors: Kanikanti VENKATA-RANGARAO, Petra LANGE, Hans-Jürgen HAMANN, Peter KLEINEBUDDE
  • Medical device for dispersing medicaments
    Patent number: 9687635
    Abstract: For selective treatment of diseased tissue sections or organ parts, the surface of medical devices entering into contact with areas thereof under pressure is coated with lipophilic substantially water-insoluble medicaments binding to various tissue components with good adherence thereto, said medicaments having an effect thereupon a short time after entering into contact therewith without exerting a harmful influence upon adjacent healthy tissue.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: June 27, 2017
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Ulrich Speck, Bruno Scheller
  • Bisaryl-bonded aryltriazolones and use thereof
    Patent number: 9687476
    Abstract: The present application relates to novel bisaryl-linked 5-aryl-1,2,4-triazolone derivatives, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: June 27, 2017
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Chantal Fürstner, Jörg Keldenich, Martina Delbeck, Peter Kolkhof, Axel Kretschmer, Ingo Pluschkell, Elisabeth Pook, Carsten Schmeck, Hubert Trübel
  • Fungicide N-cycloalkyl-N-bicyclicmethylene-carboxamide derivatives
    Patent number: 9686985
    Abstract: The present invention relates to N-cycloalkyl-N-bicyclicmethylene-carboxamide or thiocarboxamide derivatives, their process of preparation, preparation of intermediate compounds, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: June 27, 2017
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Jurgen Benting, Peter Dahmen, Philippe Desbordes, Stephanie Gary, Helene Lachaise, Philippe Rinolfi, Ulrike Wachendorff-Neumann
  • Arylaminoalcohol-substituted 2,3-dihydroimidazo[1,2-C]quinolines
    Patent number: 9675616
    Abstract: The present invention relates to substituted phenoxypyridine compounds of general formula (I); in which R1, R2 and R3 are as defined in the claims, to methods of preparing said compounds, to intermediates for the preparation of said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: June 13, 2017
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: William Johnston Scott, Orlin Petrov, Manfred Möwes, Ningshu Liu, Ulf Bömer
  • Triazolopyridines
    Patent number: 9676766
    Abstract: The present invention relates to triazolopyridine compounds of general formula (I) which are Monopolar Spindle 1 kinase (Mps-1 or TTK) inhibitors: Formula (I), in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis proliferative of diseases, as well as to intermediate compounds useful in the preparation of said compounds.
    Type: Grant
    Filed: November 17, 2010
    Date of Patent: June 13, 2017
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Volker Schulze, Marcus Koppitz, Dirk Kosemund, Hartmut Schirok, Benjamin Bader, Philip Lienau, Antje Margret Wengner, Hans Briem, Simon Holton, Gerhard Siemeister, Stefan Prechtl, Ulf Bömer
  • ANTI-C4.4A ANTIBODIES AND USES THEREOF
    Publication number: 20170158775
    Abstract: The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 29 kDa C4.4a polypeptide, which is over expressed in several tumors, e.g. lung, colorectal, pancreas, prostate, renal and breast cancer. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of C4.4a in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
    Type: Application
    Filed: February 6, 2017
    Publication date: June 8, 2017
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Lars LINDEN, Yong-Jiang CAO, Gabriele LEDER, Beatrix STELTE-LUDWIG, Axel HARRENGA, Ricarda FINNERN, Frank DITTMER, Anke MAYER-BARTSCHMID, Juergen FRANZ, Simone GREVEN, Jörg WILLUDA, Jan TEBBE
  • 4-aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group
    Patent number: 9669034
    Abstract: The present invention relates to 4-aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group of general formula (I) or (Ia) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I) or (Ia).
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: June 6, 2017
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Ulrich Lücking, Rolf Bohlmann, Arne Scholz, Gerhard Siemeister, Mark Jean Gnoth, Ulf Bömer, Dirk Kosemund, Philip Lienau, Gerd Rühter, Carsten Schultz-Fademrecht