Patents Assigned to Bayer
  • Unit operation and use thereof
    Patent number: 11786615
    Abstract: The invention provides a unit operation formed by a device and its use for continuous virus inactivation of a continuous flow of a process fluid. The unit operation formed by a device comprises a single inlet at one end and an outlet at the opposite end and at least one HFI, characterized in that the HFI further comprises at least one installation.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: October 17, 2023
    Assignee: Bayer Aktiengesellschaft
    Inventors: Martin Lobedann, Laura David, Sven-Oliver Borchert, Lisa Marie Waldschmidt
  • System and method for drive member position and fluid injector system mechanical calibration
    Patent number: 11786652
    Abstract: The present disclosure provides improved methods for calibrating the zero position of at least one drive member of an injector system is disclosed. Automated methods of position calibration of the drive member of a fluid injector are disclosed. These methods address sources of error in positional accuracy and fluid delivery inaccuracies, such as disposable syringe tolerance and injector wear over time. According to other embodiments of the present disclosure, methods and fluid injector systems for determining and correcting for the amount of slack in a fluid injection apparatus are described. An understanding of the calibration and the amount of slack in a fluid injection system allows a processor to correct for the slack, thereby ensuring more accurate fluid delivery to the patient and more accurate imaging processes.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: October 17, 2023
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Michael McDermott, Chelsea Marsh, Michael Spohn, William Barone, Shahab Taheri, Han Min Thu, David Coleman, Jee Hoon Yoo, Vince Delbrugge
  • Method for dynamic pressure control in a fluid injector system
    Patent number: 11779702
    Abstract: A method for dynamic pressure control during a multiphase injection is described wherein the pressures of fluids in the various reservoirs of a fluid delivery system are controlled to provide desired fluid delivery parameters. The methods include advancing the first drive member to expel the first fluid from the first reservoir into a conduit, wherein the fluid is pressurized to a first fluid pressure; measuring the first fluid pressure to provide a target value; while the second reservoir is in fluid isolation from the conduit, advancing or retracting the second drive member to increase or decrease the fluid pressure of the second fluid in the second reservoir to the target value; placing the second reservoir in fluid communication with the conduit; and advancing the second drive member to expel the second fluid from the second reservoir into the conduit.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: October 10, 2023
    Assignee: BAYER HEALTHCARE LLC
    Inventors: William Barone, Michael Spohn, Chelsea Marsh, Michael McDermott, John Volkar
  • Dihydrooxadiazinones
    Patent number: 11773070
    Abstract: The present invention provides dihydrooxydiazinone compounds of general formula (I) in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: July 14, 2022
    Date of Patent: October 3, 2023
    Assignees: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Manuel Ellermann, Stefan Nikolaus Gradl, Charlotte Christine Kopitz, Martin Lange, Adrian Tersteegen, Philip Lienau, Christa Hegele-Hartung, Detlev Sülzle, Timothy A. Lewis, Heidi Greulich, Xiaoyun Wu, Matthew Meyerson, Alex Burgin
  • Sensor based observation of anthropods
    Patent number: 11771074
    Abstract: The present disclosure relates to the sensor based observation of arthropods in a region where plants grow. The subject matter of the present disclosure is a device, system, method and computer program product for the sensor based observation of arthropods, by means of a camera.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: October 3, 2023
    Assignee: Bayer Aktiengesellschaft
    Inventors: Robert Wollenhaupt, Dennis Göke, Stefan Gröger, Ernst-Georg Schmid
  • CYCLIC CHEMERIN-9 DERIVATIVES
    Publication number: 20230303647
    Abstract: The present invention relates to cyclic chemerin-9 derivatives of general formula (I) as described and defined herein, methods of preparing said peptides, and the use of said compounds for the treatment or prophylaxis of diseases, in particular cancer, diabetes, obesity and inflammatory disorders.
    Type: Application
    Filed: August 10, 2021
    Publication date: September 28, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventors: Jan Robert KRÄHLING, Bernd RIEDL, Annette BECK-SICKINGER, Tobias FISCHER, Anne CZERNIAK, Sylvia ELS-HEINDL
  • DOSING SCHEDULE FOR A METHOD OF TREATMENT WITH DHODH INHIBITORS
    Publication number: 20230301969
    Abstract: The present invention provides N-(2-chloro-6-fluorophenyl)-4-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-5-fluoro-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}benzamide for use in a method of cancer treatment using a dose schedule of daily dosing on equal to 4 days up to 5 days followed by a short off period of equal to 2 days up to 3 days, as well as a method of treatment of cancer diseases with a composition comprising said DHODH inhibitor using the new dosing schedule.
    Type: Application
    Filed: August 24, 2021
    Publication date: September 28, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventor: Andreas JANZER
  • HETEROCYCLYL PYRIDINES AS NOVEL FUNGICIDES
    Publication number: 20230295138
    Abstract: The present disclosure relates to heterocyclyl pyridine compounds, processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.
    Type: Application
    Filed: June 1, 2021
    Publication date: September 21, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventors: Julie GEIST, Anthony MILLET, Cyril MONTAGNE, Lionel NICOLAS, Tomoki TSUCHIYA, Dominique LOQUE, Vincent THOMAS
  • Supporting patients in the repeated taking of drugs
    Patent number: 11763924
    Abstract: The invention relates to the technical field of supporting patients in the repeated taking of drugs within the context of a therapeutic treatment. The invention relates to a method, to a system, and to a computer program product that monitor the taking of drugs by a patient and inform the patient or a doctor or another person if a drug portion should not be taken in order to thus optimize the effectiveness of the treatment or reduce risks.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: September 19, 2023
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hubert Trübel, Philip Patrick Böhme, Martin Van Eickels, Wilfried Dinh, Frank Kramer, Carlos Castellon
  • GENE EDITING FOR HEMOPHILIA A WITH IMPROVED FACTOR VIII EXPRESSION
    Publication number: 20230285597
    Abstract: Provided herein, in some embodiments, are materials and methods for treating hemophilia A in a subject ex vivo or in vivo. Also provided herein, in some embodiments, are materials and methods for knocking in a coding sequence encoding a synthetic FVIII having a B domain substitute into a genome.
    Type: Application
    Filed: November 15, 2022
    Publication date: September 14, 2023
    Applicants: CRISPR THERAPEUTICS AG, BAYER HEALTHCARE LLC
    Inventor: Alan Richard BROOKS
  • TOPICAL ANALGESIC GEL COMPOSITIONS
    Publication number: 20230285320
    Abstract: Provided are topical analgesic gel compositions having relatively high payloads of menthol and camphor by micro-emulsion technology and methods of preparing topical analgesic gel compositions having relatively high payloads of menthol and camphor. Topical analgesic gel compositions may include from 12 to 16 wt. % menthol; from 4 to 8 wt. % camphor; from 0.1 to 2 wt. % carbomer; and 60 to 70 wt. % solvent. Topical analgesic gel compositions can have a viscosity from 60,000 to 110,000 centipoise.
    Type: Application
    Filed: March 7, 2023
    Publication date: September 14, 2023
    Applicant: Bayer HealthCare LLC
    Inventors: Debanjan DAS, Emanuel VIZZOTTI, Thomas DANN, Renee NELSON, Courtney C. HAYNES, Soundarya VAITHIANATHAN, Reginald BRADLEY, Reinhard WALTER, Gerard MEISEL
  • HETEROCYCLYL PYRIMIDINES AND TRIAZINES AS NOVEL FUNGICIDES
    Publication number: 20230278994
    Abstract: The present disclosure relates to heterocyclyl pyrimidine and heterocyclyl triazine compounds, processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.
    Type: Application
    Filed: June 1, 2021
    Publication date: September 7, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventors: Julie GEIST, Anthony MILLET, Cyril MONTAGNE, Lionel NICOLAS, Tomoki TSUCHIYA, Vincent THOMAS
  • Nested syringe assembly
    Patent number: 11744948
    Abstract: Provided is an apparatus, system, and method for a nested syringe assembly. The nested syringe assembly includes a first syringe having a cylindrical body defining an inner diameter and a second syringe having a cylindrical body defining an outer diameter. The outer diameter of the second syringe is less than the inner diameter of the first syringe. At least a portion of the cylindrical body of the second syringe is disposed within the cylindrical body of the first syringe.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: September 5, 2023
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Kevin Cowan, Damian Peter Francis Savio, Eric Siu, Richard Sokolov, Peter John Sprada
  • USE OF N-PHENYLACETAMIDES HAVING P2X4 RECEPTOR ANTAGONISTIC ACTIVITY FOR TREATING CERTIAN OCULAR DISORDERS
    Publication number: 20230270729
    Abstract: The use of P2X4 antagonists for the treatment of dry eye syndrome, more in particular substituted N-phenylacetamide compounds of general formula (I), pharmaceutical compositions and combinations comprising said compounds for use in the treatment or prophylaxis of dry eye syndrome and in particular dry eye, ocular neuropathic pain, ocular trauma and post-operative ocular pain.
    Type: Application
    Filed: June 28, 2021
    Publication date: August 31, 2023
    Applicants: Bayer Aktiengesellschaft, The Johns Hopkins University
    Inventors: Stefan BÄURLE, William SCHUBERT, Jens NAGEL, Carsten TERJUNG, David FINIS, Samuel YIU, Hui LIN, Minjie CHEN, Stefanie SEO
  • Multi-use disposable system and syringe therefor
    Patent number: 11738152
    Abstract: A syringe including a syringe body extending from a proximal end to a distal end, and a stabilizing element provided on the distal end of the syringe body, a portion of the stabilizing element extending substantially perpendicular to a longitudinal axis of the syringe body. A multi-use disposable set (MUDS) includes a plurality of syringes, each syringe having a syringe body, a proximal end, a distal end spaced apart from the proximal end along a longitudinal axis of the syringe body, a stabilizing element provided on the distal end, a portion of the stabilizing element extending substantially perpendicular to the longitudinal axis of the syringe body, and a manifold in fluid communication with the distal end of each of the plurality of syringes.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: August 29, 2023
    Assignee: BAYER HEALTHCARE, LLC
    Inventors: John Haury, Alison R. Von Moger, Mark Silvio Profaca
  • SUBSTITUTED N-PHENYLACETAMIDES HAVING P2X4 RECEPTOR ANTAGONISTIC ACTIVITY
    Publication number: 20230257351
    Abstract: Substituted N-phenylacetamide compounds of general formula (I), methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases.
    Type: Application
    Filed: June 28, 2021
    Publication date: August 17, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventors: Stefan BÄURLE, Sven RING, Jens NAGEL, Alexis LAUX-BIEHLMANN, Reinhard NUBBEMEYER, Elisabeth POOK, Sven WITTROCK, Daryl Simon WALTER, Robert John SCOTT
  • Forecast of MRI images by means of a forecast model trained by supervised learning
    Patent number: 11727571
    Abstract: The present disclosure deals with the quickening of MRI examinations. Subjects of the present disclosure are a method, a system, a computer program product, a use, a contrast agent for use and a kit.
    Type: Grant
    Filed: September 14, 2020
    Date of Patent: August 15, 2023
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Martin Rohrer, Arthur Uber, III
  • System and method for delivering a fluid with a consistent total volumetric flowrate
    Patent number: 11717605
    Abstract: Provided is a method for delivering a medical fluid. The method includes delivering a fluid volume, which includes contrast and/or a flush fluid, at a preselected total volumetric flowrate during a first duration of a fluid delivery procedure. The amount of the contrast agent and the flush fluid in the fluid volume can be controllably varied during the first duration of the fluid delivery procedure so as to substantially maintain a preselected total volumetric flowrate throughout the first duration of the fluid delivery procedure. Also provided is a fluid delivery system capable of performing this method.
    Type: Grant
    Filed: February 17, 2021
    Date of Patent: August 8, 2023
    Assignee: BAYER HEALTHCARE LLC
    Inventor: Arthur Uber, III
  • Pump head with tamper element
    Patent number: D999633
    Type: Grant
    Filed: June 5, 2021
    Date of Patent: September 26, 2023
    Assignee: Bayer Consumer Care AG
    Inventors: Pil Ho Chung, Mark Prommel
  • Pump head
    Patent number: D999634
    Type: Grant
    Filed: June 5, 2021
    Date of Patent: September 26, 2023
    Assignee: Bayer Consumer Care AG
    Inventors: Pil Ho Chung, Mark Prommel