Patents Assigned to Bayer
  • Soft gel capsule preparations
    Patent number: 11793761
    Abstract: The disclosure relates to a pharmaceutical or dietary composition in the form of a soft gel capsule comprising a liquid or semisolid fill and a shell, the fill comprising at least one active ingredient or dietary supplement, dissolved, suspended or solubilized in a solution comprising water and alcohol, and a solubilizer and thickening agent. The disclosure furthermore relates to methods of reducing brittleness and fragility of such soft gel capsules.
    Type: Grant
    Filed: March 17, 2023
    Date of Patent: October 24, 2023
    Assignee: BAYER CONSUMER CARE AG
    Inventors: Aude Barroso, Maria Elena Iglesias, Maria Del Pilar Sanz Saiz, Blanca Alvarez Maluenda, Alberto Prior, Javier Zumeta
  • Fusion proteins, recombinant bacteria, and exosporium fragments for pest control and plant health
    Patent number: 11793196
    Abstract: The present invention relates to a fusion protein having a targeting sequence, exosporium protein, or exosporium protein fragment that targets the fusion protein to the exosporium of a recombinant Bacillus cereus family member and an enzyme having serine protease activity, wherein the enzyme having serine protease activity is from Bacillus firmus or is a variant of such enzyme. The present invention also provides a recombinant Bacillus cereus family member that expresses such fusion protein and exosporium fragments derived from such recombinant Bacillus cereus family member. Methods of using such recombinant Bacillus cereus family members or exosporium fragments derived therefrom for nematode control are also provided.
    Type: Grant
    Filed: March 18, 2020
    Date of Patent: October 24, 2023
    Assignee: Bayer CropScience LP
    Inventors: Damian Curtis, Kevin Bugg
  • 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamides for the treatment of cancer
    Patent number: 11795164
    Abstract: The present invention covers 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide compounds of general formula (1): in which X, R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: August 12, 2022
    Date of Patent: October 24, 2023
    Assignees: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, Deutsches Krebsforschungszentrum
    Inventors: Ilona Gutcher, Norbert Schmees, Lars Röse, Benjamin Bader, Christina Kober, Rafael Carretero, Detlef Stöckigt, Horst Irlbacher, Michael Platten
  • CONTROLLING PLANTS BY MEANS OF ELECTRICAL ENERGY
    Publication number: 20230329221
    Abstract: The present disclosure relates to the control of plants which appear as undesirable matter in a field for crop plants by means of electrical energy.
    Type: Application
    Filed: October 28, 2019
    Publication date: October 19, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventors: Christoph BREITENSTROETER, Sergio JIMENEZ TARODO, James HADLOW
  • Unit operation and use thereof
    Patent number: 11786615
    Abstract: The invention provides a unit operation formed by a device and its use for continuous virus inactivation of a continuous flow of a process fluid. The unit operation formed by a device comprises a single inlet at one end and an outlet at the opposite end and at least one HFI, characterized in that the HFI further comprises at least one installation.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: October 17, 2023
    Assignee: Bayer Aktiengesellschaft
    Inventors: Martin Lobedann, Laura David, Sven-Oliver Borchert, Lisa Marie Waldschmidt
  • System and method for drive member position and fluid injector system mechanical calibration
    Patent number: 11786652
    Abstract: The present disclosure provides improved methods for calibrating the zero position of at least one drive member of an injector system is disclosed. Automated methods of position calibration of the drive member of a fluid injector are disclosed. These methods address sources of error in positional accuracy and fluid delivery inaccuracies, such as disposable syringe tolerance and injector wear over time. According to other embodiments of the present disclosure, methods and fluid injector systems for determining and correcting for the amount of slack in a fluid injection apparatus are described. An understanding of the calibration and the amount of slack in a fluid injection system allows a processor to correct for the slack, thereby ensuring more accurate fluid delivery to the patient and more accurate imaging processes.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: October 17, 2023
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Michael McDermott, Chelsea Marsh, Michael Spohn, William Barone, Shahab Taheri, Han Min Thu, David Coleman, Jee Hoon Yoo, Vince Delbrugge
  • 4,5-annulated 1,2,4-triazolones
    Patent number: 11787797
    Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: October 17, 2023
    Assignees: BAYER AKTIENGESELLSCHAFT, BAYER PHARMA AKTIENGESELLSCHAFT, THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE GENERAL HOSPITAL CORPORATION
    Inventors: Stefan Nikolaus Gradl, Duy Nguyen, Knut Eis, Judith Günther, Timo Stellfeld, Andreas Janzer, Sven Christian, Thomas Mueller, Sherif El Sheikh, Han Jie Zhou, Changjia Zhao, David B. Sykes, Steven James Ferrara, Kery Liu, Simon Anthony Herbert, Claudia Merz, Michael Niehues, Carl Friedrich Nising, Martina Schäfer, Katja Zimmermann, Jörg Knäblein, Kai Thede, Thomas Faupel
  • Method for dynamic pressure control in a fluid injector system
    Patent number: 11779702
    Abstract: A method for dynamic pressure control during a multiphase injection is described wherein the pressures of fluids in the various reservoirs of a fluid delivery system are controlled to provide desired fluid delivery parameters. The methods include advancing the first drive member to expel the first fluid from the first reservoir into a conduit, wherein the fluid is pressurized to a first fluid pressure; measuring the first fluid pressure to provide a target value; while the second reservoir is in fluid isolation from the conduit, advancing or retracting the second drive member to increase or decrease the fluid pressure of the second fluid in the second reservoir to the target value; placing the second reservoir in fluid communication with the conduit; and advancing the second drive member to expel the second fluid from the second reservoir into the conduit.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: October 10, 2023
    Assignee: BAYER HEALTHCARE LLC
    Inventors: William Barone, Michael Spohn, Chelsea Marsh, Michael McDermott, John Volkar
  • Sensor based observation of anthropods
    Patent number: 11771074
    Abstract: The present disclosure relates to the sensor based observation of arthropods in a region where plants grow. The subject matter of the present disclosure is a device, system, method and computer program product for the sensor based observation of arthropods, by means of a camera.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: October 3, 2023
    Assignee: Bayer Aktiengesellschaft
    Inventors: Robert Wollenhaupt, Dennis Göke, Stefan Gröger, Ernst-Georg Schmid
  • Dihydrooxadiazinones
    Patent number: 11773070
    Abstract: The present invention provides dihydrooxydiazinone compounds of general formula (I) in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: July 14, 2022
    Date of Patent: October 3, 2023
    Assignees: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Manuel Ellermann, Stefan Nikolaus Gradl, Charlotte Christine Kopitz, Martin Lange, Adrian Tersteegen, Philip Lienau, Christa Hegele-Hartung, Detlev Sülzle, Timothy A. Lewis, Heidi Greulich, Xiaoyun Wu, Matthew Meyerson, Alex Burgin
  • DOSING SCHEDULE FOR A METHOD OF TREATMENT WITH DHODH INHIBITORS
    Publication number: 20230301969
    Abstract: The present invention provides N-(2-chloro-6-fluorophenyl)-4-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-5-fluoro-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}benzamide for use in a method of cancer treatment using a dose schedule of daily dosing on equal to 4 days up to 5 days followed by a short off period of equal to 2 days up to 3 days, as well as a method of treatment of cancer diseases with a composition comprising said DHODH inhibitor using the new dosing schedule.
    Type: Application
    Filed: August 24, 2021
    Publication date: September 28, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventor: Andreas JANZER
  • CYCLIC CHEMERIN-9 DERIVATIVES
    Publication number: 20230303647
    Abstract: The present invention relates to cyclic chemerin-9 derivatives of general formula (I) as described and defined herein, methods of preparing said peptides, and the use of said compounds for the treatment or prophylaxis of diseases, in particular cancer, diabetes, obesity and inflammatory disorders.
    Type: Application
    Filed: August 10, 2021
    Publication date: September 28, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventors: Jan Robert KRÄHLING, Bernd RIEDL, Annette BECK-SICKINGER, Tobias FISCHER, Anne CZERNIAK, Sylvia ELS-HEINDL
  • HETEROCYCLYL PYRIDINES AS NOVEL FUNGICIDES
    Publication number: 20230295138
    Abstract: The present disclosure relates to heterocyclyl pyridine compounds, processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.
    Type: Application
    Filed: June 1, 2021
    Publication date: September 21, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventors: Julie GEIST, Anthony MILLET, Cyril MONTAGNE, Lionel NICOLAS, Tomoki TSUCHIYA, Dominique LOQUE, Vincent THOMAS
  • Supporting patients in the repeated taking of drugs
    Patent number: 11763924
    Abstract: The invention relates to the technical field of supporting patients in the repeated taking of drugs within the context of a therapeutic treatment. The invention relates to a method, to a system, and to a computer program product that monitor the taking of drugs by a patient and inform the patient or a doctor or another person if a drug portion should not be taken in order to thus optimize the effectiveness of the treatment or reduce risks.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: September 19, 2023
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hubert Trübel, Philip Patrick Böhme, Martin Van Eickels, Wilfried Dinh, Frank Kramer, Carlos Castellon
  • GENE EDITING FOR HEMOPHILIA A WITH IMPROVED FACTOR VIII EXPRESSION
    Publication number: 20230285597
    Abstract: Provided herein, in some embodiments, are materials and methods for treating hemophilia A in a subject ex vivo or in vivo. Also provided herein, in some embodiments, are materials and methods for knocking in a coding sequence encoding a synthetic FVIII having a B domain substitute into a genome.
    Type: Application
    Filed: November 15, 2022
    Publication date: September 14, 2023
    Applicants: CRISPR THERAPEUTICS AG, BAYER HEALTHCARE LLC
    Inventor: Alan Richard BROOKS
  • TOPICAL ANALGESIC GEL COMPOSITIONS
    Publication number: 20230285320
    Abstract: Provided are topical analgesic gel compositions having relatively high payloads of menthol and camphor by micro-emulsion technology and methods of preparing topical analgesic gel compositions having relatively high payloads of menthol and camphor. Topical analgesic gel compositions may include from 12 to 16 wt. % menthol; from 4 to 8 wt. % camphor; from 0.1 to 2 wt. % carbomer; and 60 to 70 wt. % solvent. Topical analgesic gel compositions can have a viscosity from 60,000 to 110,000 centipoise.
    Type: Application
    Filed: March 7, 2023
    Publication date: September 14, 2023
    Applicant: Bayer HealthCare LLC
    Inventors: Debanjan DAS, Emanuel VIZZOTTI, Thomas DANN, Renee NELSON, Courtney C. HAYNES, Soundarya VAITHIANATHAN, Reginald BRADLEY, Reinhard WALTER, Gerard MEISEL
  • HETEROCYCLYL PYRIMIDINES AND TRIAZINES AS NOVEL FUNGICIDES
    Publication number: 20230278994
    Abstract: The present disclosure relates to heterocyclyl pyrimidine and heterocyclyl triazine compounds, processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.
    Type: Application
    Filed: June 1, 2021
    Publication date: September 7, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventors: Julie GEIST, Anthony MILLET, Cyril MONTAGNE, Lionel NICOLAS, Tomoki TSUCHIYA, Vincent THOMAS
  • Pump head with tamper element
    Patent number: D999633
    Type: Grant
    Filed: June 5, 2021
    Date of Patent: September 26, 2023
    Assignee: Bayer Consumer Care AG
    Inventors: Pil Ho Chung, Mark Prommel
  • Pump head
    Patent number: D999634
    Type: Grant
    Filed: June 5, 2021
    Date of Patent: September 26, 2023
    Assignee: Bayer Consumer Care AG
    Inventors: Pil Ho Chung, Mark Prommel
  • Syringe plunger
    Patent number: D1002840
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: October 24, 2023
    Assignee: Bayer Healthcare LLC
    Inventors: Kevin Cowan, John Haury