Patents Assigned to Bayer
  • Detection of arthropods
    Patent number: 11659826
    Abstract: The disclosure relates to the detection of arthropods (beneficial insects and/or pests) in a region in which plants grow via a camera.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: May 30, 2023
    Assignee: Bayer Aktiengesellschaft
    Inventors: Dennis Göke, Robert Wollenhaupt, Matthias Tempel
  • Combination of ATR kinase inhibitors with PARP inhibitors
    Patent number: 11660301
    Abstract: The present invention covers combinations of at least two components, component A and component B, comprising component A being an ATR kinase inhibitor, particularly Compound A, and component B being a PARP inhibitor, such as olaparib. Another aspect of the present invention covers the use of such combinations as described herein for the preparation of a medicament for the treatment or prophylaxis of a disease, particurlarly for the treatment of a hyper-proliferative disease.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: May 30, 2023
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Antje Margret Wengner, Gerhard Siemeister
  • Antibody drug conjugates (ADCs) having enzymatically cleavable groups
    Patent number: 11660351
    Abstract: The invention relates to novel binder-drug conjugates (ADCs) having improved properties, to active metabolites of these ADCs and to processes for their preparation. The present invention furthermore relates to the use of these conjugates for the treatment and/or prevention of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: May 30, 2023
    Assignees: BAYER AKTIENGESELLSCHAFT, BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Hans-Georg Lerchen, Anne-Sophie Rebstock, Beatrix Stelte-Ludwig, Dennis Kirchhoff, Lisa Dietz, Christoph Mahlert, Simone Greven, Stephan Märsch, Sandra Berndt, Anette Sommer, Stefanie Hammer
  • SUBSTITUTED THIOPHENECARBOXAMIDES AND ANALOGUES AS ANTIBACTERIALS AGENTS
    Publication number: 20230159486
    Abstract: The present disclosure relates to substituted thiophene carboxamides and analogues thereof of formula (II) that may be used for protecting plants from bacterial diseases, in particular from bacterial diseases caused by bacteria belonging to the genus Xanthomonas.
    Type: Application
    Filed: July 3, 2019
    Publication date: May 25, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventors: David BERNIER, Stéphane BRUNET, Pierre-Yves COQUERON, Jérémy DUFOUR, Thomas KNOBLOCH, Lionel NICOLAS, Tomoki TSUCHIYA
  • SUBSTITUTED THIOPHENECARBOXAMIDES AND ANALOGUES AS ANTIBACTERIALS AGENTS
    Publication number: 20230159506
    Abstract: The present disclosure relates to thienyloxazolones and analogues thereof of formula (III) that may be used for protecting plants from bacterial diseases, in particular from bacterial diseases caused by bacteria belonging to the genus Xanthomonas.
    Type: Application
    Filed: July 3, 2019
    Publication date: May 25, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventors: David BERNIER, Stéphane BRUNET, Jérémy DUFOUR, Thomas KNOBLOCH, Lionel NICOLAS, Tomoki TSUCHIYA
  • Heterocycle derivatives as pesticides
    Patent number: 11655258
    Abstract: The present invention relates to novel fused bicyclic heterocycle derivatives of formula (I) in which Aa, Ab, Ac, Ad and Q have the meanings mentioned above, agrochemical formulations containing the compounds of formula (I) and their use as acaricides and/or insecticides for controlling animal pests, particularly arthropods and especially insects and arachnids.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: May 23, 2023
    Assignee: Bayer Aktiengesellschaft
    Inventors: Dominik Hager, Ruediger Fischer, Laura Hoffmeister, Nina Kausch-Busies, Marc Mosrin, David Wilcke, Matthieu Willot, Kerstin Ilg, Ulrich Goergens, Andreas Turberg
  • ILDR2 antagonists and combinations thereof
    Patent number: 11655297
    Abstract: The present invention relates to a novel pharmaceutical combination comprising an ILDR2 antagonist according to any of the aforementioned claims, plus one or more other therapeutically active compounds, and to novel specific ILDR2 antagonists.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: May 23, 2023
    Assignees: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, Compugen LTD.
    Inventors: Lars Röse, Uwe Gritzan, Julia Hütter, Spencer Liang, Andrew Pow, John Hunter, Ofer Levy, Ilan Vaknin
  • SUBSTITUTED THIOPHENE CARBOXAMIDES AND DERIVATIVES THEREOF AS MICROBICIDES
    Publication number: 20230150968
    Abstract: The present disclosure relates to substituted thiophene carboxamides derivatives, their use for controlling phytopathogenic microorganisms and compositions comprising thereof.
    Type: Application
    Filed: December 17, 2020
    Publication date: May 18, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventors: Jeremy DUFOUR, Lionel NICOLAS, Thomas KNOBLOCH, Stephane BRUNET, Sybille LAMPRECHT
  • LIQUID PHARMACEUTICAL FORMULATIONS POLYETHYLENE GLYCOL-BASED PRODRUGS OF ADRENOMEDULLIN AND USE
    Publication number: 20230149553
    Abstract: The present invention relates to novel liquid pharmaceutical formulations, preferably for inhalation, comprising polyethylene glycol (PEG)-based prodrugs of Adrenomedullin (PEG-ADM) and the use thereof for the treatment and/or prevention of acute lung injury/acute respiratory distress syndrome (ALI/ARDS).
    Type: Application
    Filed: March 31, 2021
    Publication date: May 18, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventors: Florian UNGER, Stefan Christian SCHNEID, Hans-Walter MOTZKUS, Carina HAASBACH
  • RAPID DETECTION OF VIRAL INFECTION USING RT-PCR
    Publication number: 20230151442
    Abstract: A lysis buffer comprising one non-ionic surfactant is provided which can be used as a one-step reagent of the preparation, storage, amplification, and/or detection of nucleic acids. Various embodiments of the lysis buffer of the invention comprise other substances that are compatible or useful in lysing cells, storing nucleic acids, amplifying nucleic acids, purifying nucleic acids, detecting nucleic acids, and/or other procedures for analysis of nucleic acids. Methods and kits based on the lysis buffer are also provided, including those for rapid lysis of cells and direct use of the resulting cell lysates in RT-PCR.
    Type: Application
    Filed: April 1, 2021
    Publication date: May 18, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventors: Stefan GOLZ, Holger SUMMER, Silke AIGNER, Heidrun ELLINGER-ZIEGELBAUER, Kirsten LEINEWEBER, Thomas MÜLLER
  • Active compound combinations having insecticidal/acaricidal properties
    Patent number: 11647750
    Abstract: The present invention relates to novel active compound combinations comprising at least one known compound of the formula (I) and at least one further active compound, which combinations are highly suitable for controlling animal and microbial pests such as unwanted insects and/or unwanted acarida and/or unwanted nematodes.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: May 16, 2023
    Assignee: Bayer Aktiengesellschaft
    Inventors: Silvia Cerezo-Galvez, Christian Marienhagen, Holger Weckwert, Wolfgang Thielert, Marita John
  • Medical fluid injector
    Patent number: 11648346
    Abstract: Systems and methods for intelligently delivering fluid to a targeted tissue are described. The systems and methods may include directing a pump to distribute fluid to a targeted tissue and receiving one or more signals from an intracorporeal sensing system, where the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue. The systems and methods may also include determining whether the one or more sensed feedback parameters are within an acceptable range. If the one or more sensed feedback parameters are not within the acceptable range, the systems and methods may include determining an adjusted velocity for the plunger necessary to adjust the pressure of the fluid in the pump so that the one or more sensed feedback parameters move within the acceptable range and directing the pump to distribute the fluid at the adjusted velocity.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: May 16, 2023
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Arthur Uber, III, Michael Yanniello, Barry Tucker, David Mishler, Edward Rhinehart, Mark Trocki, Martin Uram, John Brosovich
  • SUBSTITUTED AMINOQUINOLONES AS DGKALPHA INHIBITORS FOR IMMUNE ACTIVATION
    Publication number: 20230148194
    Abstract: The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: November 24, 2020
    Publication date: May 11, 2023
    Applicants: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, Deutsches Krebsforschungszentrum
    Inventors: Norbert SCHMEES, Lars WORTMANN, DENNIS KIRCHHOFF, Thi Thanh Uyen NGUYEN, Nicolas WERBECK, Ulf BÖMER, Kirstin PETERSEN, Christina KOBER, Detlef STÖCKIGT, Christian LECHNER, Robin Michael MEIER, Simon Anthony HERBERT, Isabel Patrizia KERSCHGENS, DIRK KOSEMUND, Rienk OFFRINGA, Mareike GREES
  • Syringe tip with fluid wicking drip flanges
    Patent number: 11642464
    Abstract: Provided is a fluid wicking tip. The fluid wicking tip includes a plurality of drip flanges arranged to wick fluid between narrow spaces defined between any two drip flanges. The narrow spaces are dimensioned to facilitate wicking by capillary action. Also provided is a syringe that includes the fluid wicking tip. Also provided is a modular syringe system that includes a syringe and a sleeve configured to be slidably disposed over the syringe.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: May 9, 2023
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Michael McDermott, Kevin Cowan, Michael Spohn
  • Specific antibody-drug-conjugates (ADCs) with KSP inhibitors and anti-CD123-antibodies
    Patent number: 11643469
    Abstract: The invention relates to specific Antibody-Drug-Conjugates (ADCs) with KSP inhibitors and anti-CD123-antibodies, to the use of these conjugates for the treatment and/or prophylaxis of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.
    Type: Grant
    Filed: April 29, 2022
    Date of Patent: May 9, 2023
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Hans-Georg Lerchen, Anne-Sophie Rebstock, Yolanda Cancho Grande, Sven Wittrock, Beatrix Stelte-Ludwig, Dennis Kirchhoff, Christoph Mahlert, Simone Greven, Stephan Märsch
  • SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION
    Publication number: 20230139936
    Abstract: The present invention covers aminothiazole compounds of general formula (I), in which R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase zeta (DGK?) regulated disorders, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: September 14, 2022
    Publication date: May 4, 2023
    Applicants: Bayer Aktiengesellschaft, Deutsches Krebsforschungszentrum
    Inventors: Norbert SCHMEES, Ulrike ROEHN, Dennis KIRCHHOFF, Kirstin PETERSEN, Mareike GREES, Nicolas WERBECK, Benjamin BADER, Rienk OFFRINGA, Corinna LINK
  • Authenticating, establishing and tracking eligibility of a patient to purchase an over-the-counter drug
    Patent number: 11636935
    Abstract: A method is provided for authenticating, and establishing and tracking eligibility of a patient to purchase an over-the-counter (OTC) drug from a retailer, the patient using a client device or terminal and the retailer having a server. The server is 5 configured to redirect the client device or terminal to a backend platform to authenticate the patient, access a storage to search for any information that indicates the patient is ineligible to purchase the OTC drug; and without any information that indicates the patient is ineligible, administer a questionnaire to the patient to assess the eligibility for the OTC drug. And the backend platform redirects the client device 10 or terminal back to the server to complete the online sale of the OTC drug to the patient when the patient is eligible, or cancel the online sale of the OTC drug to the patient when the patient is ineligible.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: April 25, 2023
    Assignee: Bayer Healthcare LLC
    Inventors: Rama Penta, Jeffrey Brittain, William Hanisak, Audrey Belkin, Steven Rusche
  • Use of fungicides for controlling mosaic scab in apples
    Patent number: 11632958
    Abstract: Described is the use of compositions comprising a fungicide selected from the group of succinate dehydrogenase inhibitors, in particular fluopyram and a fungicide selected from the group of phosphonates, in particular fosetyl-aluminium for controlling Mosaic scab and reducing Venturia inequalis inoculum in apples, to a method for treating apple plants or apple plant parts for controlling Mosaic scab scab and reducing Venturia inequalis inoculum in apples and to a method for controlling Mosaic scab scab and reducing Venturia inequalis inoculum in plants and plant parts, in particular leaves by treating them with compositions comprising a fungicide selected from the group of succinate dehydrogenase inhibitors, in particular fluopyram and a fungicide selected from the group of phosphonates, in particular fosetyl-aluminium.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: April 25, 2023
    Assignee: Bayer Aktiengesellschaft
    Inventors: Sybille Lamprecht, Luk De Maeyer, Gilbert Labourdette
  • 2-HETEROARYL-3-OXO-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES FOR THE TREATMENT OF CANCER
    Publication number: 20230121195
    Abstract: The present invention covers 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide compounds of general formula (1): in which X, R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: August 12, 2022
    Publication date: April 20, 2023
    Applicants: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, Deutsches Krebsforschungszentrum
    Inventors: Ilona GUTCHER, Ulrike RÖHN, Norbert SCHMEES, Ludwig ZORN, Lars RÖSE, Benjamin BADER, Christina KOBER, Rafael CARRETERO, Detlef STÖCKIGT, Horst IRLBACHER, Michael PLATTEN
  • PYRAZOLOTRIAZINES
    Publication number: 20230117034
    Abstract: The present invention provides compounds of general formula (I), in which X, R1, R2 and R3 are as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of hyperproliferative disorders such as cancer disorders, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: December 9, 2020
    Publication date: April 20, 2023
    Applicants: Bayer Aktiengesellschaft, Deutsches Krebsforschungszentrum
    Inventors: Kai THEDE, Philipp BUCHGRABER, Gerhard SIEMEISTER, Patrick STEIGEMANN, Antje Margret WENGNER, Ulf BOEMER, Naomi BARAK, Philip LIENAU