Patents Assigned to Bayer
  • Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells
    Patent number: 9284591
    Abstract: The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least one chaperone protein.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: March 15, 2016
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Sham-Yuen Chan, Hsinyi Yvette Tang, Yiwen Tao, Yongjian Wu, Ruth Kelly
  • Process for hydrogenating aromatic di- and polyamines to cycloaliphatic di- and polyamines
    Patent number: 9278906
    Abstract: A process for hydrogenating aromatic di- and polyamines is provided comprising the steps of reacting the aromatic amine with hydrogen in the presence of a catalytic system, wherein the catalytic system comprises a heterogeneous catalyst comprising a metal selected from the group consisting of Cr, Mo, W, Mn, Re, Fe, Ru, Os, Co, Rh, Ir, Ni, Pd and/or Pt and a support, and wherein the catalyst system further comprises an organic nitro compound. Hydrogenation of aromatic di- and polyamines having two or more amino groups bound to the aromatic ring produces cycloaliphatic di- and polyamines, which are useful chemical intermediates, e.g., for further reaction with epoxides or isocyanates. The amino groups may also be converted to isocyanates via reaction with phosgene. The resulting cycloaliphatic di- and polyisocyanates may also be used as monomers for making polymers.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: March 8, 2016
    Assignee: Bayer MaterialScience AG
    Inventors: Thomas E. Müller, Christoph Gürtler, Reinhard Halpaap, Ewa Gebauer-Henke, Walter Leitner, Patrick Tomkins, Christoph Thiebes
  • Method for producing light-coloured polyisocyanates
    Patent number: 9279029
    Abstract: The invention relates to a method for producing light-coloured polyisocyanates by phosgenation of mixtures comprising MDA and polycyclic aromatic polyamines that have o-phenylenediamine units incorporated via methylene bridges. The invention further relates to the polyisocyanate mixtures obtainable by this method.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: March 8, 2016
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Thomas Ernst Mueller, Christoph Guertler, Axel Scherer-Werke, Stefan Wershofen, Henning Vogt, Walter Leitner
  • Methods for manufacturing plant cell walls comprising chitin
    Patent number: 9279130
    Abstract: Methods and means are provided for the modification of the reactivity of plant secondary cell walls, particularly in cotton cell walls found in cotton fibers. This can be conveniently achieved by expressing a chimeric gene encoding a Saprolegnia monoica chitin synthase in cotton plants.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: March 8, 2016
    Assignee: BAYER CROPSCIENCE NV
    Inventors: Marc De Block, Frank Meulewaeter, Vincent Bulone, Gea Guerriero
  • Substituted 3-(biphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one
    Patent number: 9278925
    Abstract: The invention relates to substituted 3-(biphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-ones, in particular for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of neoplastic disorders.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: March 8, 2016
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Ningshu Liu, Kai Thede, Ursula Mönning, Arne Scholz, Christoph-Stephan Hilger, Ulf Bömer, Reiner Fischer
  • Medical devices and methods of making and using such devices
    Patent number: 9278022
    Abstract: Devices, such as medical devices for inhibiting conception, and methods of using and/or making these devices. In one aspect of the disclosure, a medical device has a delivery system and a first insert, which is removably coupled to the delivery system and which is designed to be deployed within a portion of a first fallopian tube, and a second insert, which is removably coupled to the delivery system and which is designed to be deployed within a portion of a second fallopian tube. Other aspects of the disclosure include, among other things, inserts made from one or more polymers; inserts which are designed to pierce and remain in place; and inserts which are implanted through a fluid delivery system.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: March 8, 2016
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Quang Tran, Christopher A. Stout, Elisa J. Aldridge, Betsy Swann
  • Pesticidal arylpyrrolidines
    Patent number: 9271499
    Abstract: The invention is directed to arylpyrrolidines compounds which exhibit excellent insecticidal efficacy and which may be used as in the agrochemical field or in the field of veterinary medicine. The compounds are represented by formula (I): wherein the respective substituents are defined in the specification.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: March 1, 2016
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Ulrich Görgens, Jun Mihara, Tetsuya Murata, Daiei Yamazaki, Yasushi Yoneta, Koichi Araki, Norio Sasaki, Kei Domon, Mamoru Hatazawa, Eiichi Shimojo, Teruyuki Ichihara, Masashi Ataka, Katsuhiko Shibuya
  • Process for electrolysis of alkali metal chlorides with oxygen-consuming electrodes
    Patent number: 9273404
    Abstract: Processes for electrolysis of alkali metal chlorides with oxygen-consuming electrodes having startup and shutdown conditions which prevent damage to the constituents of the electrolysis cell.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: March 1, 2016
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Andreas Bulan, Rainer Weber, Jürgen Kintrup
  • Process for the preparation of 1-H-pyrrolidine-2,4-dione derivatives
    Patent number: 9272997
    Abstract: The present invention relates to a novel process for the preparation of 1-H-pyrrolidine-2,4-dione derivatives and to novel intermediates and to a process for their preparation.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: March 1, 2016
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Reiner Fischer, Thomas Himmler
  • BISARYL-BONDED ARYLTRIAZOLONES AND USE THEREOF
    Publication number: 20160051518
    Abstract: The present application relates to novel bisaryl-linked 5-aryl-1,2,4-triazolone derivatives, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.
    Type: Application
    Filed: November 2, 2015
    Publication date: February 25, 2016
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Chantal FÜRSTNER, Jörg KELDENICH, Martina DELBECK, Peter KOLKHOF, Axel KRETSCHMER, Ingo PLUSCHKELL, Elisabeth POOK, Carsten SCHMECK, Hubert TRÜBEL
  • SPIROINDOLINE DERIVATIVES FOR USE AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS
    Publication number: 20160052936
    Abstract: Spiroindoline derivatives, processes for their preparation and pharmaceutical compositions thereof, their use for the treatment of diseases, and their use for the manufacture of medicaments for the treatment of diseases, especially sex-hormone-related diseases in both men and women, in particularly those selected from the group of endometriosis, uterine leiomyoma (fibroids), polycystic ovarian disease, menorrhagia, dysmenorrhea, hirsutism, precocious puberty, gonadal steroid-dependent neoplasia such as cancers of the prostate, breast and ovary, gonadotrope pituitary adenomas, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hypertrophy, contraception, infertility and assisted reproductive therapy such as in vitro fertilization. The present application relates in particular to spiroindoline derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists.
    Type: Application
    Filed: April 8, 2014
    Publication date: February 25, 2016
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Olaf PANKNIN, Sven RING, Stefan BÄURLE, Andrea WAGENFELD, Reinhard NUBBEMEYER, Katrin NOWAK-REPPEL, Gernot LANGER
  • METHODS OF TREATING HEMOPHILIA IN PATIENTS HAVING DEVELOPED INHIBITORY ANTIBODIES
    Publication number: 20160051633
    Abstract: This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.
    Type: Application
    Filed: July 20, 2015
    Publication date: February 25, 2016
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Clark Q. PAN, John E. MURPHY, Baisong MEI, Jonathan S. STRAUSS, Hendri TJANDRA, Jianmin CHEN, Thomas BARNETT, Liang TANG, Deqian WANG
  • Anthranilamides in combination with fungicides
    Patent number: 9265255
    Abstract: The present invention relates to novel active compound combinations which include of the insecticidally active compounds of the formula (I) in combination with fungicidally active compounds (II) and are highly suitable for controlling unwanted animal pests, such as insects, and unwanted phytopathogenic fungi.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: February 23, 2016
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Christian Funke, Heike Hungenberg, Rüdiger Fischer
  • Trifluoromethyl-substituted fused pyrimidines and their use
    Patent number: 9266871
    Abstract: The present application relates to novel trifluoromethyl-substituted fused pyrimidines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: February 23, 2016
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Markus Follmann, Johannes-Peter Stasch, Gorden Redlich, Dieter Lang, Alexandros Vakalopoulos, Frank Wunder, Adrian Tersteegen
  • Pesticidal arylpyrrolidines
    Patent number: 9266830
    Abstract: The invention is directed to arylpyrrolidines compounds which exhibit excellent insecticidal efficacy and which may be used as in the agrochemical field or in the field of veterinary medicine. The compounds are represented by formula (I): wherein the respective substituents are defined in the specification.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: February 23, 2016
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Ulrich Görgens, Jun Mihara, Tetsuya Murata, Daiei Yamazaki, Yasushi Yoneta, Koichi Araki, Norio Sasaki, Kei Domon, Mamoru Hatazawa, Eiichi Shimojo, Teruyuki Ichihara, Masashi Ataka, Katsuhiko Shibuya
  • Active compound combinations comprising specific tetramic acid derivatives
    Patent number: 9265252
    Abstract: The invention provides combinations of insecticides/acaricides and herbicides comprising an effective amount of components (A) and (B), where component (A) is one or more of the tetramic acid derivatives listed in the description, and (B) one or more herbicides from the group of the herbicides likewise listed in the description, where the combinations may optionally additionally comprise crop plant compatibility-increasing substances (safeners). The invention also relates to the use of the combinations for controlling animal pests and unwanted vegetation and to the corresponding methods.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: February 23, 2016
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Michael Deall, Reiner Fischer, Erwin Hacker, Heike Hungenberg, John Bell, Robert Steffens
  • Substituted benzylindazoles for use as Bub1 kinase inhibitors in the treatment of hyperproliferative diseases
    Patent number: 9265763
    Abstract: Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: February 23, 2016
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Marion Hitchcock, Anne Mengel, Vera Pütter, Gerhard Siemeister, Antje Margret Wengner, Hans Briem, Knut Eis, Volker Schulze, Amaury Ernesto Fernandez-Montalvan, Stefan Prechtl, Simon Holton, Jörg Fanghänel, Philip Lienau, Cornelia Preusse, Mark Jean Gnoth
  • Catalyst and method for producing aromatic amines in the gas phase
    Patent number: 9266094
    Abstract: The present invention relates to a catalyst comprising a ceramic support with a BET surface area of less than 40 m2/g and (a) 1.0 to 100 g of at least one metal of groups 8 to 12 of the periodic table of the elements, (b) 1.0 g to 100 g of at least one metal of groups 4 to 6 and 12 of the periodic table of the elements and (c) 1.0 g to 100 g of at least one metal of groups 14 and 15 of the periodic table of the elements per liter of bulk volume of the ceramic support, wherein the catalyst is additionally doped with (d) potassium in a content of from 0.0050% by weight to 0.20% by weight, based on the total weight of the catalyst. The present invention also provides the use of such a catalyst in the catalytic gas phase hydrogenation of nitroaromatics.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: February 23, 2016
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Michael Merkel, Karl-Heinz Wilke, Peter Lehner
  • Substituted imidazopyrazines as Akt kinase inhibitors
    Patent number: 9260435
    Abstract: Compounds of formula (I) which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: February 16, 2016
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Lars Bärfacker, William Scott, Andrea Hägebarth, Stuart Ince, Hartmut Rehwinkel, Oliver Politz, Roland Neuhaus, Ulf Bömer
  • Rechargeable dispenser
    Patent number: D750885
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: March 8, 2016
    Assignee: BAYER CONSUMER CARE AG
    Inventors: Bruno Chazel, Sébastien Lucien Fily