Abstract: The invention relates to novel binder-drug conjugates (ADCs) having improved properties, to active metabolites of these ADCs and to processes for their preparation. The present invention furthermore relates to the use of these conjugates for the treatment and/or prevention of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases.

Abstract: A system and method for correcting a volume of fluid delivered by a fluid injector during an injection procedure is described. The method included determining and compensating for a volume factor associated with compliance of the fluid injector system and correcting for the volume by one of over-driving the distance that the drive member travels in a fluid reservoir, under-driving the distance that the drive member travels in the fluid reservoir, or lengthening or shortening a fluid delivery time.

Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.

Abstract: The invention relates to a modular system for weed control for a rail vehicle. The modular system has a control unit for producing control signals for controlling valves and mixers in a separate herbicide and mixing module and for producing a second set of control signals for controlling valves of a nozzle rod. The herbicide and mixing module has a container for holding different herbicides and electrical connection elements for connections to the control unit. Furthermore, a nozzle rod is present, which is fitted with a nozzle set, in order to spray herbicides of the herbicide and mixing module. In addition, a camera module is present, which produces a weed signal in response to the detection of a weed, in order to control the spraying of the herbicides. The camera module is at such a distance from the nozzle rod that, despite high speed, there is sufficient time to provide the herbicide at the nozzles.

Abstract: A mobile device is provided that includes biometric sensor(s), and a processor that causes the biometric sensor(s) to acquire a physiological marker of a user, and identify and authenticate the user. The processor sends a message to an authentication server that indicates the user is authenticated, and receives a response from the authentication server that includes a unique authentication code. The processor receives selection of a thereby selected over-the-counter (OTC) drug, and communicates with a point-of-sale (POS) system with contactless payment capability. The processor sends a purchase message to the POS system that includes the unique authentication code, an identifier of the selected OTC drug, and payment information. And the POS system communicates with the authentication server to validate the unique authentication code, and with an authorization server to authorize payment for the selected OTC drug based on the payment information.

Abstract: Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.

Abstract: An animal trap system includes a glue board, an animal trap accelerometer sensor, and a signal unit in close proximity to and in communications with the animal trap accelerometer sensor, wherein the signal unit also contains an accelerometer sensor. The animal trap system is capable of detecting capture events, non-capture events, false positives, and/or the type of animal captured by using differential signal analysis and machine learning techniques. When an acceleration is received by the animal trap accelerometer sensor above a pre-set acceleration threshold value, it sends a capture signal to the signal unit and if the signal unit does not receive such acceleration event, the signal unit transmits a capture signal to an off-site receiver. A method of trapping one or more animals using this system is also provided.

Abstract: A goods carrier for the presentation of product units comprises a goods holder device for holding a plurality of product units, a control unit, a data store, and a position sensor, wherein the position sensor is configured to record measured values relating to a position of the goods carrier, and wherein the control unit is configured to receive the measured values from the position sensor and store them in the data store. A goods carrier may also include an acceleration sensor, a magnetometer, an inventory sensor, or a timer. A method for monitoring a goods carrier may include recording an inventory of product units in the goods carrier, determining a time interval during which there are no product units present in the goods carrier, and displaying the time interval to a person.

Abstract: The invention relates to an automated system and a method for determining the effect of active ingredients on organisms such as insects, Acariformes and nematodes in an assay plate containing wells with the aid of image-acquisition and image-analysis technology. The invention allows the characterization of the population of the organisms at multiple time points.

Abstract: Disclosed are compounds of general formula (I): wherein R1, R2, A, X, Y and Z are as defined herein, methods of preparing the compounds, intermediate compounds useful for preparing the compounds, pharmaceutical compositions and combinations comprising the compounds and the use of the compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.

Abstract: The present disclosure relates to fungicidal active compounds, more specifically to heteroarylphenylaminoquinolines according to formula (I): and analogues thereof, processes and, intermediates for their preparation and use thereof as fungicidal active compound, particularly in the form of fungicide compositions. The present disclosure also relates to methods for the control of phytopathogenic fungi of plants using these compounds or compositions comprising thereof.

Abstract: The present invention relates to spray application device(s) for application of an active ingredient(s) to agricultural crops, to vehicle(s) comprising spray application device(s), to method(s) of spray application by the spray application device(s), to computer program element(s) for controlling the spray application device(s), and for computer program element(s) for controlling vehicle(s) comprising spray application device(s).

Abstract: The present invention comprises a method for the generation of 227Th of pharmaceutically tolerable purity comprising i) preparing a generator mixture comprising 227Ac, 227Th and 223Ra; ii) loading said generator mixture onto a strong base anion exchange resin; iii) eluting a mixture of said 223Ra and 227Ac from said strong base anion exchange resin using a first mineral acid in an aqueous solution; iv) eluting 227Th from said strong base anion exchange resin using a second mineral acid in an aqueous solution whereby to generate a first 227Th solution containing contaminant 223Ra and 227Ac; v) loading the first 227Th solution onto a strong acid cation exchange resin; vi) eluting at least a part of the contaminant 223Ra and 227Ac from said strong acid cation exchange resin using a third mineral acid in aqueous solution; and vii) eluting the 227Th from said strong acid cation exchange resin using a first aqueous buffer solution to provide a second 227Th solution.

Abstract: Compounds of formula (I), formula (I), processes for their production and their R use as pharmaceuticals.

Abstract: The present disclosure relates to immunostimulatory compositions that are effective in eliciting immune responses in avian species. More specifically, these immunostimulatory compositions comprise an immunomodulator composition and an immunostimulatory oligonucleotide that when administered stimulate toll-like receptor 21.

Abstract: The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.