Patents Assigned to Bayer
  • Publication number: 20230072421
    Abstract: A compound of general formula (I): wherein: n is 1, 2 or 3; R1, R2, R3 and R4, independently represent OH or Q; and 20 Q represents a tissue-targeting moeity selected from the group consisting of or a stereoisomer, a hydrate, a solvate, or a salt thereof, or a mixture of same, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said 25 compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of soft tissue diseases, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: July 24, 2020
    Publication date: March 9, 2023
    Applicants: Bayer AS, Bayer Aktiengesellschaft
    Inventors: Niels BÖHNKE, Sabine ZITZMANN-KOLBE, Stefanie HAMMER, Sven WITTROCK, Donald BIERER, Thorsten POETHKO, Hans BRIEM, Holger Magnus STEUBER, Martina SCHÄFER, Robin Michael MEIER, Arif CELIK, Cornelia PREUSSE, Antje ROTTMANN, Nicolas WERBECK, Alexander KRISTIAN, Bård INDREVOLL, Alan CUTHBERTSON, Alex PAPPLE
  • Publication number: 20230075876
    Abstract: The present invention relates to an enteric coated pharmaceutical composition comprising a solid dispersion comprising regorafenib and at least one stabilizing agent outside of the solid dispersion, its process of preparation and its use for treating disorders.
    Type: Application
    Filed: February 1, 2021
    Publication date: March 9, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventors: Martin Günter MÜLLER, Werner HOHEISEL
  • Patent number: 11597724
    Abstract: The invention relates to 3-phenylisoxazoline-5-carboxamides of tetrahydro- and dihydrofurancarboxylic acids and esters of the general formula (I) and their agrochemically acceptable salts and to their use in the crop protection sector.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: March 7, 2023
    Assignees: Bayer Aktiengesellschaft, Bayer CropScience Aktiengesellschaft
    Inventors: Olaf Peters, Klaus Bernhard Haaf, Stephen David Lindell, Guido Bojack, Katherine Rose Law, Anu Bheemaiah Machettira, Hansjoerg Dietrich, Elmar Gatzweiler, Christopher Hugh Rosinger
  • Patent number: 11596735
    Abstract: A syringe includes a body and a plunger movably disposed within the body. The syringe may be used with an injector including a drive member. The drive member preferably includes at least one pin adapted to form a retractable abutting connection with an interior of a plunger to enable the drive member to retract the plunger with the body of the syringe.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: March 7, 2023
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Kevin Cowan, John Haury, Jared Neff
  • Patent number: 11598664
    Abstract: A calibration system for calibrating a pressure output of a fluid injector having a housing configured for connecting to the fluid injector; a drive member engagement portion configured for contacting a drive member of the fluid injector; a compressible member, which may have a known modulus of compression, connected at its proximal end to the drive member engagement portion, wherein the compressible member is compressed with movement of the drive member of the fluid injector between a first, uncompressed position and a second, at least partially compressed position of the fluid injector in a distal direction; and a sensor connected to the compressible member is described. The sensor is configured for measuring at least one of a force imparted by the drive member and a displacement of the drive member when the compressible member is in the second, at least partially compressed position.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: March 7, 2023
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Michael McDermott, Chelsea Marsh, Michael Spohn, William Barone, Robert Praniewicz, Edden Rabin, Corey Savannah, Vince Delbrugge
  • Patent number: 11600377
    Abstract: The present disclosure relates to automated systems and methods which assess the quality of radiology examinations and identify actionable changes to improve the quality of future exams. For each of a plurality of imaging studies, a study protocol and set of study metrics can be defined and the defined study protocol can be performed to generate data associated with the imaging study. A metrics assessment can be performed by applying at least a portion of the data associated with the result of the imaging study against the set of study metrics for the imaging study so as to generate a metrics score for the imaging study. The metrics scores can be stored in a score repository and analyzed so as to provide recommendations to improve the examination process.
    Type: Grant
    Filed: July 30, 2021
    Date of Patent: March 7, 2023
    Assignee: BAYER HEALTHCARE LLC
    Inventors: John Volkar, Corey A. Kemper
  • Patent number: 11597901
    Abstract: Disclosed herein is a sterilizable adapter for a cell culture vessel comprising a body, an upper connection and/or a lid, at least one port, a ventilation passage, a lower internal connection suitable for connection to a cell culture vessel and a cell retention device and/or a cell separation device as well as a device comprising said sterilizable adapter and a method for cell cultivation using said sterilizable adapter.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: March 7, 2023
    Assignees: Bayer Aktiengesellschaft, BAYER HEALTHCARE LLC
    Inventors: Annette Eidt, Wolf Kloeckner, Helmut Brod, Martin Poggel, Bernd Tscheschke
  • Patent number: 11599850
    Abstract: The invention relates to the monitoring of products by means of active radio tags. According to the invention, packagings of products are provided with an active radio tag that detects at least one environmental condition and/or at least one packaging state, and which emits a signal at time intervals, which provides information about a unique identifier and at least one state in which the respective product is found. The signal is picked up by a receiver that extracts the unique identifier and the state information and transmits same together with location information to an external server.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: March 7, 2023
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Christof Backhaus, Katharina Berger, Uwe Schenkel, Jürgen Schmidt, Walter Speth, Klaus Glismann, Eric Willms, Markus Storz, Arne Wendt, Gregory James Dibble
  • Publication number: 20230064809
    Abstract: The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, m, n, o and p are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: November 24, 2020
    Publication date: March 2, 2023
    Applicants: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, Deutsches Krebsforschungszentrum
    Inventors: Norbert SCHMEES, Lars WORTMANN, Dennis KIRCHHOFF, Thi Thanh Uyen NGUYEN, Nicolas WERBECK, Ulf BÖMER, Kirstin PETERSEN, Christina KOBER, Detlef STÖCKIGT, Christian LECHNER, Rienk OFFRINGA
  • Publication number: 20230065629
    Abstract: The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: November 4, 2021
    Publication date: March 2, 2023
    Applicants: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft
    Inventors: Anja GIESE, Jürgen KLAR, Alexander Helmut Michael EHRMANN, Jens WILLWACHER, David ENGEL, Andre Philippe DIESKAU, Antje KAHNERT, Alexey GROMOV, Carsten SCHMECK, Niels LINDNER, Thomas MÜLLER, Anna Lena ANDREEVSKI, Jan DREHER, Karl COLLINS
  • Publication number: 20230064983
    Abstract: Compounds of formula (I) processes for their production and their use as pharmaceuticals.
    Type: Application
    Filed: September 22, 2022
    Publication date: March 2, 2023
    Applicants: Bayer Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Stephan SIEGEL, Franziska SIEGEL, Volker SCHULZE, Markus BERGER, Jeremie Xavier G. MORTIER, Detlev SÜLZLE, Ulf BÖMER, Daniel KORR, Jens SCHRÖDER, Ursula MÖNNING, Michael NIEHUES, Matthew MEYERSON, Heidi GREULICH, Bethany KAPLAN
  • Publication number: 20230064576
    Abstract: The present disclosure relates to heterocyclyl pyridazine compounds, processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.
    Type: Application
    Filed: December 19, 2019
    Publication date: March 2, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventors: Victor CHEN, Pierre SRISTAU, Mazen ES-SAYED, Julie GEIST, Mathieu GOURGUES, Dominique LOQUE, Anthony MILLET, Anne-Sophie REBSTOCK, Alexander SUDAU, Vincent Pierre Andre THOMAS, Valére TOQUIN, Tomoki TSUCHIYA
  • Publication number: 20230062100
    Abstract: The present invention covers aminoquinolone compounds of general formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8, X and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: November 24, 2020
    Publication date: March 2, 2023
    Applicants: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, DEUTSCHES KREBSFORSCHUNGSZENTRUM
    Inventors: Norbert SCHMEES, Lars WORTMANN, DENNIS KIRCHOFF, Thi Thanh Uyen NGUYEN, Nicolas WERBECK, Ulf BÖMER, Kirstin PETERSEN, Christina KOBER, Detlef STÖCKIGT, Christian LECHNER, Robin Michael MEIER, Simon Anthony HERBERT, Isabel Patrizia KERSCHGENS, DIRK KOSEMUND, Julien LEFRANC, Rienk OFFRINGA
  • Patent number: 11591311
    Abstract: The present invention covers 3-oxo-6-heteroaryl-2-phenyl-2,3-dihydropyri-dazine-4-carboxamide compounds of general formula (I): in which R1, R2, R4, R5, R6, X, Y and Z are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: February 28, 2023
    Assignees: BAYER AKTIENGESELLSCHAFT, BAYER PHARMA AKTIENGESELLSCHAFT, DEUTSCHES KREBSFORSCHUNGSZENTRUM
    Inventors: Ilona Gutcher, Ulrike Röhn, Ludwig Zorn, Lars Röse, Benjamin Bader, Christina Kober, Rafael Carretero, Detlef Stöckigt, Michael Platten
  • Publication number: 20230053411
    Abstract: The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: September 9, 2021
    Publication date: February 23, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventors: Adam James DAVENPORT, Nico BRÄUER, Oliver Martin FISCHER, Andrea ROTGERI, Antje ROTTMANN, Ioana NEAGOE, Jens NAGEL, Anne-Marie GODINHO-COELHO, Jürgen KLAR
  • Publication number: 20230055705
    Abstract: The present disclosure relates to substituted thiophene carboxamides derivatives, their use for controlling phytopathogenic microorganisms and compositions comprising thereof.
    Type: Application
    Filed: December 17, 2020
    Publication date: February 23, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventors: Jeremy DUFOUR, Lionel NICOLAS, Thomas KNOBLOCH, Stephane BRUNET, Sybille LAMPRECHT
  • Publication number: 20230054449
    Abstract: The present disclosure relates to pyridazine (thio)amide compounds, processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.
    Type: Application
    Filed: November 27, 2019
    Publication date: February 23, 2023
    Applicants: Bayer Aktiengesellschaft, Bayer CropScience AG
    Inventors: Victor CHEN, Pierre CRISTAU, Jérémy DUFOUR, Mazen ES-SAYED, Julie GEIST, Mathieu GOURGUES, Dominique LOQUE, Anthony MILLET, Daniel RACKL, Anne-Sophie REBSTOCK, Philippe RINOLFI, Yoshitaka SATO, Alexander SUDAU, Vincent THOMAS, Valérie TOQUIN
  • Patent number: 11583435
    Abstract: The present invention relates to an arrangement comprising an intrauterine system, an inserter for the intrauterine system and a package for the inserter.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: February 21, 2023
    Assignee: Bayer HealthCare LLC
    Inventors: Joonas Mikkonen, Tero Jalkanen, Mikko Virtanen, Taina Tjaeder, Karym El Sayed
  • Patent number: 11583877
    Abstract: The invention relates to a device and method for applying a spraying means using a portable spraying device.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: February 21, 2023
    Assignee: Bayer CropScience Aktiengesellschaft
    Inventors: Walter Mayer, Christof Backhaus, Jule Vorholzer, Burak Yardim, Juan Carlos Lagonera
  • Publication number: 20230046892
    Abstract: The present disclosure relates to substituted thiophene carboxamides derivatives of formula (I) and (II), their use for controlling phytopathogenic microorganisms and compositions comprising thereof.
    Type: Application
    Filed: December 17, 2020
    Publication date: February 16, 2023
    Applicant: Bayer Aktiengesellschaft
    Inventors: Jeremy DUFOUR, Lionel NICOLAS, Tomoki TSUCHIYA, Thomas KNOBLOCH, Stephane BRUNET, Sybille LAMPRECHT