Patents Assigned to Bayer
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Patent number: 11577022Abstract: A syringe includes a barrel having a distal end, a proximal end, and a sidewall extending therebetween along a longitudinal axis. At least one engagement member protrudes from a terminal portion of the sidewall in a proximal direction along the longitudinal axis. The at least one engagement member tapers axially in a direction from the distal end toward the proximal end. The at least one engagement member is configured for engagement with a locking mechanism of a fluid injector to releasably lock the syringe with the fluid injector. A taper of the at least one engagement member is configured to rotationally guide the syringe into alignment with the locking mechanism and axially eject the syringe upon rotation of the syringe. The locking mechanism operatively engages the at least one engagement member regardless of an orientation of the syringe about the longitudinal axis relative to the injector.Type: GrantFiled: December 13, 2019Date of Patent: February 14, 2023Assignee: BAYER HEALTHCARE LLCInventors: Kevin Cowan, Barry Tucker, Arthur Uber, III, Edward Rhinehart, James Neill, Glen Williams, Michael Spohn
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Patent number: 11576985Abstract: A diagnostic contrast composition includes a carrier fluid and a non-decaying gas-evolving fluid incorporated in the carrier fluid. The gas-evolving fluid has a vapor pressure sufficient to evolve the gas from a circulatory system within a lung of a patient. The gas-evolving fluid is a composition containing a sufficient quantity of atoms with an atomic number higher than 8 to provide an increased absorption sufficient to increase a Hounsfield Unit measurement in an image in a CT imaging system. The gas-evolving fluid is selected from the group consisting of xenon gas, krypton gas, sulfur hexafluoride, a perfluorocarbon, a brominated perfluorocarbon, and combinations thereof. The carrier fluid is selected from the group consisting of water, saline, saline comprising one or more blood proteins, and saline comprising dissolved lipids.Type: GrantFiled: July 28, 2020Date of Patent: February 14, 2023Assignee: BAYER HEALTHCARE LLCInventor: Arthur Uber, III
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Patent number: 11578323Abstract: Aspects of this invention inter alia relate to novel systems for targeting, editing or manipulating DNA in a cell, comprising one or more heterologous vector(s) encoding a SluCas9 nuclease from Staphylococcus lugdunensis or variants thereof, and one or more guide RNAs (gRNAs), or a SluCas9 nuclease or variant thereof and one or more gRNAs.Type: GrantFiled: December 14, 2018Date of Patent: February 14, 2023Assignees: BAYER HEALTHCARE LLC, CRISPR THERAPEUTICS AGInventors: Andre Cohnen, Moritz Schmidt, Wayne Coco, Ashish Gupta, Jan Tebbe, Cindy Schulenburg, Christian Pitzler, Michael Biag Gamalinda, Sabine Jach, Florian Richter, Anup Arumughan, Corinna Saalwächter
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Publication number: 20230042677Abstract: Disclosed is an intrauterine system (100, 300, 400, 500, 600) comprising a frame (102, 302, 402, 502, 602), a removal thread (218, 326, 436, 626) and at least one pharmaceutically active agent. The frame has a first end (104, 304, 404, 504, 604), a second end (106, 306, 406, 506, 606) and a length L. The first end of the frame comprises a first locking part (108, 308, 408, 508, 608) and the second end of the frame comprises a second locking part (110, 310, 410, 510, 610), the first locking part and the second locking part being arranged to form a lock (202, 312, 432). The removal thread is attached to the first end of the frame. The removal thread is configured to guide the first locking part to the second locking part. Further, disclosed is a kit comprising the aforementioned intrauterine system and an inserter.Type: ApplicationFiled: January 20, 2021Publication date: February 9, 2023Applicant: Bayer OyInventors: Mikael STOLT, Taina TJÄDER, Christine TALLING, Risto HAKALA, Heikki SALO, Mira KAUTTO, Marina ALLEN, Jari RISKI, Petri PERÄLÄ
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Publication number: 20230039977Abstract: Disclosed is an inserter (1100, 1300, 1400, 1500) for an intrauterine system (1102, 1336, 1402, 1502), comprising a handle body (1104, 1306, 1416, 1504), a measurement tube (1110, 1328, 1406, 1510), a plunger (1132, 1202, 1362, 1450, 1532), a flange (1122, 1404, 1522), a finger holder (1124, 1314, 1446, 1524), and a means (1126, 1526) for reversibly locking removal thread (1128, 1358, 1414) of the intrauterine system. A proximal end (1106, 1440, 1506) of the measurement tube is movably attached to a distal end (1108, 1330, 1454, 1508) of the handle body, and the measurement tube is arranged to remain outside a cervix channel during insertion. The plunger is movably arranged inside the handle body and the measurement tube. The present disclosure also provides a kit comprising the inserter and the intrauterine system.Type: ApplicationFiled: January 20, 2021Publication date: February 9, 2023Applicant: Bayer OyInventors: Taina TJÄDER, Mikael STOLT, Heikki SALO, Mira KAUTTO, Marina ALLEN, Kimmo LAAKSONEN, Jari RISKI, Petri PERÄLÄ
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Patent number: 11572357Abstract: The present invention covers new quinoline compounds of general formula (I), in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: May 7, 2019Date of Patent: February 7, 2023Assignee: Bayer Animal Health GmbHInventors: Walter Hübsch, Nils Griebenow, Hans-Georg Schwarz, Daniel Kulke, Claudia Böhm, Kirsten Börngen, Bernd Alig, Wei Zhuang, Iring Heisler, Thomas Ilg, Johannes Köbberling, Adeline Köhler, Niels Lindner, Ulrich Görgens, Claudia Welz, Maike Hink
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Patent number: 11573281Abstract: Systems, methods, and computer program products for determining different states of a contrast agent in different types of tissue can involve generating a magnetic resonance waveform for the contrast agent in an examination region that includes multiple tissue types. The contrast agent may have different relaxation-shortening effects in each different tissue type. The generated waveform may be compared to database waveforms to determine the concentration of the contrast agent in each tissue type in the examination region.Type: GrantFiled: October 18, 2019Date of Patent: February 7, 2023Assignee: Bayer AktiengesellschaftInventors: Gunnar Schütz, Gregor Jost
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Publication number: 20230034584Abstract: The present invention is related to an inhibitor or antagonist of SHP2 for the treatment and/or prevention of a neoplastic disease.Type: ApplicationFiled: December 3, 2020Publication date: February 2, 2023Applicant: Bayer AktiengesellschaftInventors: Tibor SCHOMBER, Ulf BRÜGGEMEIER, Michael BECKER, Sona PIRKULIYEVA
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Patent number: 11565035Abstract: Described is an injector system for implementing a split bolus injection procedure. The injector system includes a processor and a non-transitory storage medium having programming instructions stored therein that, when executed by the processor, enable the injector system to operate as a parameter generation system for use in determining parameters associated with a split bolus injection protocol via which injection of the contrast agent by the injector system is controlled. The split bolus injection protocol includes at least a loading injection and a diagnostic injection, wherein the loading injection is performed before the diagnostic injection, and wherein a pause separates the loading injection from the diagnostic injection. Also described is a method for patient imaging using a split bolus injection technique and a system having an imaging device and the injector system described above.Type: GrantFiled: June 14, 2018Date of Patent: January 31, 2023Assignee: BAYER HEALTHCARE LLCInventors: John Volkar, Corey Kemper
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Patent number: 11564392Abstract: This disclosure relates to methods for use in inactivating viruses. The methods of inactivating viruses with N-methylglucamides is applicable to the purification process of biologically-active drugs such as protein subunits, proteins (enzymes, factors, etc.), recombinant proteins, antibodies, vaccine or gene therapeutic products. The detergents used in this method are based on multiple N-methylglucamide homologs, consisting of a hydrophilic glucose moiety and hydrophobic fatty acid tail, linked by an amide bond. Additionally, these sugar-based detergents are nonionic by nature, which do not disrupt the drug protein, plasma biologies, non-enveloped viral vaccine or adeno associated viral particles.Type: GrantFiled: September 12, 2018Date of Patent: January 31, 2023Assignee: Bayer Healthcare LLCInventors: Shengjiang Liu, Allison Titong, Wensheng Wang, Nicholas Spadoni
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Publication number: 20230027346Abstract: The application relates to substituted hydantoinamides of formula (I) as ADAMTS7 antagonists, to processes for their preparation, their use alone or in combination for the treatment or prophylaxis of diseases, in particular of cardiovascular diseases, including atherosclerosis, coronary artery disease (CAD), peripheral vascular disease (PAD), arterial occlusive disease or restenosis after angioplasty. R1 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, heteroaryl or phenyl; R2 is hydrogen, cyano, halogen, alkylsulfonyl, alkyl, cycloalkyl or alkoxy; R3, R4, R5, R6, R7 and R8 are independently hydrogen, halogen, alkyl or alkoxy; most groups being optionally substituted; with the proviso that at least one of R2, R3, R4 is H; X1, X2, X3, X4, X5 and X6 are independently N or C; with the proviso that in each ring maximal one X is N.Type: ApplicationFiled: November 12, 2020Publication date: January 26, 2023Applicants: BAYER AKTIENGESELLSCHAFT, THE BROAD INSTITUTE, INC.Inventors: Daniel MEIBOM, Yolanda CANCHO GRANDE, Pierre WASNAIRE, Sarah Anna Liesa JOHANNES, Kristin BEYER, Till FREUDENBERGER, Damian BROCKSCHNIEDER, Dmitry ZUBOV, Dzianis MENSHYKAU, Tanja KRAINZ, Bryan MACDONALD, Yi XING, Nadine ELOWE, Guzman SANCHEZ
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Publication number: 20230027985Abstract: The application relates to substituted hydantoinamides of formula (I) as ADAMTS7 antagonists, to processes for their preparation, their use alone or in combination for the treatment or prophylaxis of diseases, in particular of cardiovascular diseases, including atherosclerosis, coronary artery disease (CAD), peripheral vascular disease (PAD), arterial occlusive disease or restenosis after angioplasty. R1 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, 5- to 6-membered heteroaryl or phenyl; R2 is hydrogen or alkyl; A is 5-membered heteroaryl; Z is 6- to 10-membered aryl or 5- to 10-membered heteroaryl; all groups being optionally substituted.Type: ApplicationFiled: November 12, 2020Publication date: January 26, 2023Applicants: Bayer Aktiengesellschaft, The Broad Institute, Inc.Inventors: Daniel MEIBOM, Yolanda CANCHO GRANDE, Pierre WASNAIRE, Sarah Anna Liesa JOHANNES, Niels LINDNER, Kristin BEYER, Till FREUDENBERGER, Damian BROCKSCHNIEDER, Ilka MATHAR, Jürgen KLAR, Dmitry ZUBOV, Dzianis MENSHYKAU, Tanja KRAINZ, Eric STEFAN, Bryan MACDONALD, Yi XING, Nadine ELOWE, Guzman SANCHEZ
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Publication number: 20230026494Abstract: The present disclosure relates to substituted thiophene carboxam-ides and analogues thereof of formula (I) that may be used for protecting plants from bacterial diseases, in particular from bacterial diseases caused by bacteria belonging to the genus Xanthomanoas.Type: ApplicationFiled: June 30, 2022Publication date: January 26, 2023Applicant: Bayer AktiengesellschaftInventors: David BERNIER, Stéphane Brunet, Jérémy Dufour, Thomas Knobloch, Lionel Nicolas, Tomoki Tsuchiya
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Patent number: 11560680Abstract: An apparatus for weed control includes a processing unit that receives at least one image of an environment. The processing unit analyses the at least one image to determine at least one vegetation control technology from a plurality of vegetation control technologies to be used for weed control for at least a first part of the environment. An output unit outputs information that is useable to activate the at least one vegetation control technology.Type: GrantFiled: July 2, 2018Date of Patent: January 24, 2023Assignee: Bayer AktiengesellschaftInventors: Hinnerk Baßfeld, Thomas Arians, Pascal Day, Virginie Giraud, James Hadlow
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Publication number: 20230013419Abstract: The present invention covers P2X3 inhibitor compounds of general formula (I) in which R1 and R2 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of neurogenic disorders, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: June 25, 2020Publication date: January 19, 2023Applicants: Bayer Aktiengesellschaft, Bayer Pharma AktiengesellschaftInventors: Antje ROTTMANN, Oliver Martin FISCHER, Kai THEDE, Simon Anthony HERBERT, Ursula GANZER, Andrea ROTGERI, Elisabeth POOK
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Publication number: 20230017200Abstract: The present invention provides dihydrooxydiazinone compounds of general formula (I): in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: July 11, 2022Publication date: January 19, 2023Applicants: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.Inventors: Manuel ELLERMANN, Stefan Nikolaus GRADL, Charlotte Christine KOPITZ, Martin LANGE, Adrian TERSTEEGEN, Philip LIENAU, Christa HEGELE-HARTUNG, Detlev SÜLZLE, Timothy A. LEWIS, Heidi GREULICH, Xiaoyun WU, Matthew MEYERSON, Alex BURGIN
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Patent number: 11553888Abstract: An apparatus for radiopharmaceutical quantification of a body part includes a processor configured to receive at least one gamma image of a body part acquired by at least one gamma camera configured to detect gamma and/or X-rays. The at least one gamma image comprises spectral energy data that includes data resulting from decay of at least one radiopharmaceutical. The processor is configured to determine an activity of the at least one radiopharmaceutical at a plurality of spatial positions in the body part and determines a spatial distribution of the at least one radiopharmaceutical in the body part. The determination for a spatial position of the plurality of spatial positions comprises correlating a generated synthetic spectrum to an experimental spectrum generated from the spectral energy data for at least one position in the at least one gamma image that corresponds to that spatial position.Type: GrantFiled: July 23, 2018Date of Patent: January 17, 2023Assignee: Bayer AktiengesellschaftInventors: Cecilia Hindorf, Erik Larsson, Gustav Brolin, Tomas Ohlsson
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Patent number: 11555052Abstract: This disclosure relates to methods for the prevention of the reduction of disulfide bonds in a polypeptide expressed in a recombinant host cell, comprising, following fermentation, adding selenite and/or its salts or derivatives to a harvest solution of the recombinant host cell, wherein the disulfide bond in the polypeptide remains non-reduced.Type: GrantFiled: September 26, 2018Date of Patent: January 17, 2023Assignee: Bayer HealthCare LLCInventor: Kathryn Kwant
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Patent number: 11547794Abstract: A plunger for use with a syringe has a plunger body with a proximal end, a distal end, and a circumferential sidewall extending between the proximal end and the distal end along a plunger longitudinal axis. The plunger further has at least one resiliently deflectable retaining member having a first segment attached to the plunger body and a second segment protruding toward the distal end of the plunger body and deflectable relative to the first segment. The plunger further has at least one actuation member associated with the at least one resiliently deflectable retaining member. The at least one actuation member interacts with a piston to deflect the at least one resiliently deflectable retaining member upon rotation of the plunger relative to the piston. The plunger is engageable with the piston regardless of a rotational orientation of the piston relative to the plunger.Type: GrantFiled: December 16, 2019Date of Patent: January 10, 2023Assignee: Bayer Healthcare LLCInventors: Michael Swantner, Richard Seman, Barry Tucker, Arthur Uber, III, Kevin Cowan, James Dedig, Christopher Capone, Jaroslaw Wlodarczyk
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Patent number: 11548854Abstract: The present application relates to the use of heterocyclic compounds for controlling animal pests including arthropods, insects and nematodes, to novel heterocyclic compounds, to processes for their preparation and to intermediates for preparing the heterocyclic compounds.Type: GrantFiled: November 9, 2020Date of Patent: January 10, 2023Assignee: BAYER CROPSCIENCE AGInventors: Eike Kevin Heilmann, Joerg Greul, Axel Trautwein, Hans-Georg Schwarz, Isabelle Adelt, Roland Andree, Peter Luemmen, Maike Hink, Martin Adamczewski, Mark Drewes, Angela Becker, Arnd Voerste, Ulrich Goergens, Kerstin Ilg, Johannes-Rudolf Jansen, Daniela Portz
