Abstract: The present invention relates to pyrrolo[2.1-a]dihydroisoquinolines which are inhibitors of phosphodiesterase 10a and can be used for combating cancer.
Type:
Grant
Filed:
December 4, 2001
Date of Patent:
August 16, 2005
Assignee:
Bayer Pharmaceuticals Corporation
Inventors:
Maria Theresia Niewöhner, Marcus Bauser, Jens-Kerim Ergüden, Dietmar Flubacher, Paul Naab, Thorsten-Oliver Repp, Jürgen Stoltefuss, Nils Burkhardt, Andrea Sewing, Michael Schauer, Karl-Heinz Schlemmer, Olaf Weber, Stephen J. Boyer, Mark Miglarese, Ulrich Niewöhner
Abstract: A composition of matter (e.g., a molded article) is described. More particularly, the composition of matter includes: (a) a resinous component selected from at least one member of the group consisting of (co)polyester, (co)polycarbonates, acrylontrile-butadiene-styrene, polyamide, polyurethane, polyalkyl(meth)acrylate and styrene copolymers; (b) at least one dye; (c) a carrier represented by the following formula, R1[—O—(CH2)n]mOR2 wherein R2 is butyl, R1 is H, n is 2 or 3, and m is 2-35; and (d) optionally emulsifier. Also described is a dye bath that includes: (a) water; (b) at least one dye; (c) a carrier represented by the above formula; and (d) optionally an emulsifier.
Abstract: A process for producing phosgene having low content of carbon tetrachloride is disclosed. The process entails reacting carbon monoxide with chlorine in the presence of elemental carbon, in a reactor. Critically the temperature of the gas stream emerging from the reactor is restricted to 30 to 80° C. and its pressure, measured directly downstream from said reactor is restricted to 120 to 400 kPaabs. The phosgene thus produced has a content of carbon tetrachloride that is less than 150 ppm.
Type:
Grant
Filed:
October 12, 1999
Date of Patent:
August 16, 2005
Assignee:
Bayer Aktiengesellschaft
Inventors:
Jürgen Heuser, Hermann Kauth, Christian Kords
Abstract: The invention relates to a process for the preparation of isocyanates in the gas phase, in which the possibilities for back-mixing and byproduct formation are reduced by improving the mixing of the starting materials in a tubular reactor.
Abstract: Process for the continuous preparation of thermoplastically processable polyurethane elastomers with improved softening properties is disclosed. The process is carried out in a tubular reactor at a ratio of the circumferential speed of the stirrer (in m/sec) in the tubular reactor and the throughput (in g/sec) of >0.03 m/g.
Type:
Grant
Filed:
May 17, 2000
Date of Patent:
August 16, 2005
Assignee:
Bayer Aktiengesellschaft
Inventors:
Wolfgang Bräuer, Wolfgang Kaufhold, Friedemann Müller, Jürgen Winkler, Herbert Heidingsfeld, Wolfgang Röhrig, Hans-Georg Hoppe
Abstract: The present invention relates to novel trifluorobutenyl imidazole thioether derivatives of the following formula (I) wherein R1 represents hydrogen or halogen, R2 represents hydrogen, halogen or alkoxycarbonyl, R3 represents hydrogen, alkyl, alkenyl, cycloalkyl or aralkyl, and n represents 0,1 or 2, with the proviso that R1, R2 and R3 do not all represent hydrogen at the same time, to a process for their preparation and to their use as nematicides.
Abstract: Reagents which regulate human transient receptor potential channel and reagents which bind to human transient receptor potential channel gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, urinary incontinence, overactive bladder, benign prostatic hyperplasia, lower urinary tract syndromes, and CNS disorders.
Type:
Application
Filed:
April 10, 2003
Publication date:
August 11, 2005
Applicant:
Bayer HealthCare AG
Inventors:
Masahiro Shiroo, Noriyuki Yamamoto, Fumihiko Hayashi, Johannes Floeckner, Peter Reinemer, Jeffrey Encinas, Shinichi Watanabe, Masaomi Tajimi, Toshio Kokubo
Abstract: The invention relates to a write-once optical data carrier in which organic and/or inorganic light-absorbing compounds are used as the information layer, especially for high-density optical data carriers which function with a blue laser in the wavelength range of 360-460 nm. The invention also relates to the application of the above-mentioned light-absorbing compound to a suitable substrate (especially polycarbonate), e.g., by spin coating.
Type:
Grant
Filed:
March 23, 2001
Date of Patent:
August 9, 2005
Assignee:
Bayer Aktiengesellschaft
Inventors:
Horst Berneth, Friedrich-Karl Bruder, Karin Hassenrück
Abstract: Glycosylated interleukin-2 muteins are described. A method of producing the muteins using mammalian cells is included. The muteins may be incorporated into pharmaceutical preparations useful for, e.g., cancer therapy.
Abstract: The invention relates to a process for reducing the monomeric aziridine content in a polyaziridine forming reaction mixture by adding to the polyaziridine forming reaction mixture an excess of an organic carbonate scavenger wherein the excess is based on the equivalent ratio of scavenger to monomeric aziridine, and to a product obtained by this process and to a coating composition containing the product obtained by the process.
Type:
Grant
Filed:
October 31, 2002
Date of Patent:
August 9, 2005
Assignee:
Bayer MaterialScience LLC
Inventors:
Lanny D. Venham, Douglas A. Wicks, Karsten Danielmeier, Joseph P. Mandara
Abstract: The invention relates to solvent-borne polyurethane resins with a high carbonate group content which are dilutable in water, to aqueous coating compositions prepared thereof, to a process for preparing them and to their use.
Type:
Grant
Filed:
November 5, 2003
Date of Patent:
August 9, 2005
Assignee:
Bayer Aktiengesellschaft
Inventors:
Martin Melchiors, Thomas Münzmay, Torsten Pohl, Uwe Klippert
Abstract: The present invention encompasses a process for preparing arylolefins by reacting one or more arylamines with one or more organic nitrites, in the presence of one or more olefins which bear at least one hydrogen atom on the double bond and in the presence of acid and in the presence of palladium or one or more palladium compounds.
Type:
Grant
Filed:
August 12, 2002
Date of Patent:
August 9, 2005
Assignee:
Bayer Aktiengesellschaft
Inventors:
Markus Eckert, Albert Schnatterer, Walter Lange
Abstract: The present invention relates to novel heterocyclic fluoroalkenyl thioethers of the formula (I) in which X represents hydrogen, halogen or alkyl, m represents integers from 2 to 10, n represents 0, 1 or 2. y represents unsubstituted or substituted methylene and p represents 1, 2 or 3, and to processes for their preparation and to their use as pesticides.
Type:
Grant
Filed:
June 29, 2001
Date of Patent:
August 9, 2005
Assignee:
Bayer Cropscience AG
Inventors:
Udo Kraatz, Bernd Gallenkamp, Heiko Rieck, Albrecht Marhold, Peter Wolfrum, Wolfram Andersch, Christoph Erdelen, Peter Lösel, Andreas Turberg, Olaf Hansen, Achim Harder
Abstract: Reagents which regulate human neuropeptide Y-like G protein-coupled receptor (NPY-like GPCR) protein and reagents which bind to human NPY-like GPCR gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, obesity, diabetes, anxiety, hypertension, cocaine withdrawal, congestive heart failure, memory enhancement, cardiac and cerebral vasospasm, pheochromocytoma, ganglioneuroblastoma, Huntington's disease, Alzheimer's disease, and Parkinson's disease.
Abstract: The present invention relates to aqueous silica sol-modified PU dispersions and their use as coating materials, in particular [lacuna] textiles and leather.
Type:
Grant
Filed:
May 9, 2001
Date of Patent:
August 9, 2005
Assignee:
Bayer Aktiengesellschaft
Inventors:
Thorsten Rische, Detlef-Ingo Schütze, Jürgen Meixner, Tillmann Hassel, Roland Komorek, Lutz Schmalstieg
Abstract: Reagents which regulate human inositol polyphosphate 5-phosphatase and reagents which bind to human inositol polyphosphate 5-phosphatase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, COPD, asthma, diabetes, and cancer.
Abstract: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
Type:
Grant
Filed:
January 23, 2003
Date of Patent:
August 2, 2005
Assignee:
Bayer Pharmaceuticals Corporation
Inventors:
Dhanapalan Nagarathnam, Jacques Dumas, Holia Hatoum-Mokdad, Stephen Boyer, Chunguang Wang, Hans Pluempe, Achim Feurer, Samir Bennabi
Abstract: The present invention relates to a method for increasing the growth rate of cells in static liquid media by using gelatinising agents and to a method for increasing the expression of genes in these cells, and also to the use of gelatinising agents, such as xanthan, in these methods.
Type:
Grant
Filed:
September 23, 2002
Date of Patent:
August 2, 2005
Assignee:
Bayer Aktiengesellschaft
Inventors:
Christian Aichinger, Peter Schreier, Dana Schöneberg
Abstract: A device for regulating the air volume flow for a laboratory exhaust, has a rectangular housing (6) which can be arranged on the laboratory exhaust. The device is equipped with inflow devices that can be connected to the interior of the laboratory exhaust and with outflow devices (8, 12, 13) that can be connected to an exhaust air system. The interior of housing (6) is divided by a partition (17) into two parts, namely a calming part on the exhaust side and a measurement and regulating part on the outflow side, and these two parts are connected by an air deflection area (18). A rectangular measurement orifice (20, 25) has pressure measurement devices (22, 23, 24, 28, 29) and a rectangular regulating flap (21) arranged one after the other at a distance in the direction of flow between a housing wall and the partition (17).
Type:
Grant
Filed:
February 5, 2001
Date of Patent:
August 2, 2005
Assignees:
Waldner Laboreinrichtungen GmbH & Co. KG, Bayer AG
Inventors:
Konrad Kreuzer, Frank Barth, Horst Esch