Abstract: The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders.

Abstract: The present invention relates to novel substituted acetic acid derivatives, to processes for their preparation and to their use in medicaments, in particular as potent PPAR-delta-activating compounds for the prophylaxis and/or treatment of cardiovascular disorders, in particular dyslipidaemias and coronary heart diseases.

Abstract: The invention relates to novel 1-aza-bicyclic N-biarylamides, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning ability and memory.

Abstract: The present invention relates to pyrazolylarylalkines and to their use, to a process for preparing pyrazolylarylalkines and also to intermediates.

Abstract: A process of using of a particularly substituted phenol as a chain terminator of a polymeric resin is disclosed. The chain terminator is a member selected from among ortho-substituted phenol, metha-substituted phenol, and their corresponding coupled esters. The polymeric resin is selected among polycarbonate, polyester carbonate and polyester. The thus chain terminated resin is suitable for producing molded parts and extrudates. Also disclosed are the process for producing these polymers and processes for producing the molded parts and extrudates.

Abstract: The invention relates to an aqueous pharmaceutical composition containing moxifloxacin and less than 10 ppb iron.

Abstract: The present invention provides a method for the production of polyamide 6 by the hydrolytic polymerization of ?-caprolactam, in which, in the first step, caprolactam ring opening occurs under the action of water and, in the following steps, polycondensation is performed at low temperatures under anhydrous conditions.

Abstract: The present invention relates to natural-colored and pigmented thermoplastic molding compositions and molded parts fabricated therefrom that are laser-absorbing at least in partial spectral regions of the wavelength range from 700 to 1200 nm and that can be welded by laser beam welding and to molded parts that are transparent or translucent to laser light.

Abstract: The present invention relates to a device for controlling insects (1; 7; 10), which is approximately fruit-shaped and which has a three-dimensional structure (2) with open spaces (4) and with a plurality of surfaces (3) within the said structure, which surfaces can be directly contacted by insects from outside the structure (2).

Abstract: The invention relates to the use of riboflavin and of flavin derivatives with chitinase-inhibitory action for controlling arthropods, nematodes and chitin-containing fungi.

Abstract: Reagents which regulate human P2Y1-like G protein-coupled receptor can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, infections such as bacterial, fungal, protozoan, and viral infections, particularly those caused by HIV viruses, pain, cancers, anorexia, bulimia, asthma, CNS diseases such as Parkinson's disease, acute heart failure, hypotension, hypertension, urinary retention, osteoporosis, diabetes, angina pectoris, myocardial infarction, ulcers, asthma, inflammation, allergies, multiple sclerosis, benign prostatic hypertrophy, and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, several mental retardation, and dyskinesias, such as Huntington's disease and Tourett's syndrome.

Abstract: What is described are herbicidal compositions comprising herbicidal compounds of the formula I and a compound which acts as safener. In the formula I, the symbols R1 to R4 denote hydrogen, halogen, alkyl and haloalkyl.

Abstract: A method of preparing a thermoplastic polycarbonate film having an optical retardation value of less than or equal to 20 nm, is described. The method includes: (a) forming a molten extrudate (20) of a thermoplastic polycarbonate polymer in an extruder (11) having a terminal die (17) through which the molten extrudate is passed, the molten extrudate having a temperature of 150° C. to 400° C. upon emerging from terminal die (17); and (b) passing molten extrudate (20), from die (17), between two counter-rotating rolls (23 and 26) each having an elastomeric polymer surface (35 and 38), the counter-rotating rolls having a roll speed ratio and a nip (41), the distance between the terminal die (17) and the nip (41) being a die-nip distance (47). The extrudate temperature, the roll speed ratio and the die-nip distance (47) are each selected such that a thermoplastic polycarbonate film (32) having an optical retardation value of less than or equal to 20 nm is formed.

Abstract: Herbicidal compositions comprising at least one herbicidally active compound of the formula (I) and at least one crop-plant-protecting compound of the formula (II) as safener are described.

Abstract: An agent suitable for imparting antistatic properties to plastics is disclosed. The incorporation of small amounts of perfluoroalkylsulfonic acid salt in plastic resins, notably thermoplastic resins was found to be effective for this purpose.

Abstract: An impact resistant, flame-resistant thermoplastic molding composition suitable for making thin-wall housing parts is disclosed. The composition contains A) 50 to 90 parts by weight of at least one a member selected from the group consisting of polycarbonate and polyester carbonate, B) 5 to 20 parts by weight of rubber-modified vinyl (co)polymer C) 2 to 15 parts by weight of at least one low-volatility, halogen-free flameproofing agent, D) 0.1 to 6 parts by weight of a silicate mineral, and optional E) fluorinated polyolefin, and F) conventional polymer additive wherein the total sum of the parts by weight of the components A) to F) is 100, and wherein the rubber content of the composition referred to the weight of the composition is 2 to 6 wt.-%.

Abstract: A thermoplastic molding composition suitable for producing article having excellent flame proofing and improved stress cracking resistance is disclosed. The composition contains an aromatic polycarbonate and/or polyester carbonate, a toughening agent, an optional thermoplastic (co)polymer and a combination of phosphorus compounds.

Abstract: A process for the separation a substantially adduct-free diaryl carbonate from reaction solution is disclosed. The process entails obtaining a solution that contains diaryl carbonate, catalyst system components and an aromatic solvent, lowering the temperature of the solution, optionally in the presence of a nucleating agent, to produce a crystallization product, and washing the crystallization product with an anhydrous wash solution to remove catalyst residues and impurities.

Abstract: A method of sanitizing chromatographic media is provided. The method includes contacting the media with an acidic chaotropic agent, at low temperature and low pH. The method provides pathogen removal and/or inactivation, including viral inactivation in particular embodiments.