Patents Assigned to Bayer
  • Self-orienting syringe and syringe interface
    Patent number: 10245375
    Abstract: A medical injector including at least one syringe port for engaging at least one syringe and having a locking mechanism. The locking mechanism enables the syringe to self-align with the syringe port for locking engagement upon insertion of the syringe into the syringe port and to axially eject the syringe from the port upon rotational disengagement of the syringe from the port.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: April 2, 2019
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Barry L. Tucker, Kevin P. Cowan, Arthur E. Uber, III, Edward J. Rhinehart, Michael A. Spohn
  • Process for preparing biphenylamines from anilides by ruthenium catalysis
    Patent number: 10246407
    Abstract: The present invention relates to a novel process for preparing substituted biphenylamides of the general formula (V) characterized in that anilides of the formula (II) in a solvent other than tetrahydrofuran, are reacted with an organoboron compound of the formula (III) in the presence of a catalyst system consisting of a ruthenium catalyst, an activator, an oxidizing agent and a metal triflate.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: April 2, 2019
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Thomas Himmler, Lars Rodefeld, Jonathan Hubrich, Lutz Ackermann
  • RADIO-PHARMACEUTICAL COMPLEXES
    Publication number: 20190091354
    Abstract: The invention provides a method for the formation of a tissue-targeting thorium complex, said method comprising; a) forming an octadentate chelator comprising four hydroxypyridinone (HOPO) moieties, substituted in the N-position with a methyl group, and a coupling moiety terminating in a carboxylic acid group; b) coupling said octadentate chelator to at least one tissue-targeting moiety targeting HER2; and c) contacting said tissue-targeting chelator with an aqueous solution comprising an ion of at least one alpha-emitting thorium isotope.
    Type: Application
    Filed: March 20, 2017
    Publication date: March 28, 2019
    Applicants: BAYER PHARMA AKTIENGESELLSCHAFT, Bayer AS
    Inventors: Lars LINDEN, Alan CUTHBERTSON
  • N-CYCLOALKYL-N-[(HETEROCYCLYLPHENYL)METHYLENE]-(THIO)CARBOXAMIDE DERIVATIVES
    Publication number: 20190092765
    Abstract: The present invention relates to fungicidal N-cycloalkyl-N-[(heterocyclylphenyl)methylene] carboxamide derivatives and their thiocarbonyl derivatives, their process of preparation and intermediate compounds for their preparation, their use as fungicides; particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
    Type: Application
    Filed: September 25, 2018
    Publication date: March 28, 2019
    Applicant: Bayer CropScience AG
    Inventors: Christoph BRAUN, Pierre CRISTAU, Peter DAHMEN, Philippe DESBORDES, Mazen ES-SAYED, Hélène LACHAISE, Philippe RINOLFI, Jan-Peter SCHMIDT, Tomoki TSUCHIYA, Jean-Pierre VORS, Ulrike WACHENDORFF-NEUMANN
  • 2-AMINO-N- [7-METHOXY-2, 3-DIHYDROIMIDAZO-[1, 2-C] QUINAZOLIN-5-YL] PYRIMIDINE-5-CARBOXAMIDES
    Publication number: 20190092775
    Abstract: This invention relates to novel 2,3-dihydroimidazo[1,2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: March 1, 2017
    Publication date: March 28, 2019
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Thomas SCHWARZ, Ningshu LIU, Oliver POLITZ, Michael GERISCH, Dieter LANG
  • Method of selecting antioxidants for use in topically applied compositions
    Patent number: 10241121
    Abstract: Antioxidant-containing compositions and methods for confirming antioxidant activity of a composition formulated for topical application to skin. Methods for testing a composition for ability to inhibit both ultraviolet radiation-induced lipid peroxidation on skin and ultraviolet radiation-induced reactive oxygen species formation in the stratum corneum. Compositions and methods for treating and preventing photodamage to skin.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: March 26, 2019
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Thomas A. Meyer, Donathan G. Beasley
  • Nitrogen-containing heterocycles as pesticides
    Patent number: 10239859
    Abstract: The present application relates to novel heterocyclic compounds, to processes and intermediates for the preparation thereof, and their use for controlling animal pests.
    Type: Grant
    Filed: July 4, 2016
    Date of Patent: March 26, 2019
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Peter Jeschke, Oliver Gutbrod, Reiner Fischer, Elke Hellwege, Peter Loesel, Olga Malsam, Sascha Eilmus, Kerstin Ilg, Daniela Portz, Ulrich Goergens, Anton Lishchynskyi
  • Thermoplastic polyurethanes, use of these material for the preparation of T-frames for intrauterine systems and T-frames made out of this material
    Patent number: 10238531
    Abstract: The present invention relates to a novel thermoplastic polyurethane (TPU) elastomer, T-frames made thereof as well as the use of the new TPU in manufacturing of T-frames for intrauterine systems for contraception and therapy.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: March 26, 2019
    Assignee: Bayer Oy
    Inventors: Taina Tjäder, Nina Stenroos, Christian Wamprecht, Wolfgang Kaufhold
  • Method for producing bis(3-aminophenyl)disulfides and 3-aminothiols
    Patent number: 10239831
    Abstract: The present invention relates to a novel method for preparing bis(3-aminophenyl) disulphides of the general formula (I) and 3-aminothiols of the general formula (II), where X,Y have the meanings stated in the description, which serve as intermediates for the preparation of phenyl sulphoxides having insecticidal, acaricidal and nematicidal activity.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: March 26, 2019
    Assignee: BAYER CROPSCIENCE AG
    Inventors: Thomas Himmler, Julia Johanna Hahn
  • Cotton variety ST 5115GLT
    Patent number: 10238064
    Abstract: The cotton variety ST 5115GLT is disclosed. The invention relates to seeds, plants, plant cells, plant tissue, harvested products and cotton lint as well as to hybrid cotton plants and seeds obtained by repeatedly crossing plants of variety ST 5115GLT with other plants. The invention also relates to plants and varieties produced by the method of essential derivation from plants of ST 5115GLT and to plants of ST 5115GLT reproduced by vegetative methods, including but not limited to tissue culture of regenerable cells or tissue from ST 5115GLT.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: March 26, 2019
    Assignees: BAYER CROPSCIENCE LP, COTTON SEED INTERNATIONAL PROPRIETARY LIMITED
    Inventors: Michael Swindle, Michael Robinson
  • Methods and compositions for controlling weed infestation and improving grass quality
    Patent number: 10231456
    Abstract: Methods for controlling unwanted vegetation, such as weeds, to turfgrass by applying an active compound combination including a triazolinone herbicide, for example, sulfonylamino-carbonyl-triazolinone, and at least one sulfonylurea herbicides, to turfgrass is described herein. The disclosure also provides for active compound combinations and methods of improving turfgrass quality.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: March 19, 2019
    Assignee: BAYER CROPSCIENCE LP
    Inventors: Bruce Spesard, Don Myers, Laurence Mudge, Matt Bradley
  • Pharmaceuticals containing fluoroquinolones
    Patent number: 10231925
    Abstract: The invention relates to the use of quaternary ammonium compounds for preventing precipitations of fluoroquinolones from their solutions and to stable, tolerated pharmaceuticals which are particularly suitable for parenteral use and which contain, in dissolved form, a fluoroquinolone and a quaternary ammonium compound.
    Type: Grant
    Filed: February 23, 2007
    Date of Patent: March 19, 2019
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Iris Heep, Kristine Fraatz, Hans-Jürgen Hamann, Markus Edingloh
  • 5-substituted imidazole derivatives
    Patent number: 10231453
    Abstract: The present invention relates to novel 5-substituted imidazolylmethyl derivatives, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials and as plant growth regulators.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: March 19, 2019
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Sebastian Hoffmann, Hendrik Helmke, Peter Dahmen, Ulrike Wachendorff-Neumann, David Bernier, Ricarda Miller, Pierre-Yves Coqueron, Pierre Genix, Sven Wittrock, Jean-Pierre Vors, Philippe Kennel, Stephane Brunet, Sebastien Naud, Ruth Meissner
  • Retail point seed treatment systems and methods
    Patent number: 10235644
    Abstract: An automated seed treatment system is adapted for on-site operation at a retail seed distributor. A sealed seed-treater vessel is configured to apply a plurality of chemical treatments to a batch of seed based on a seed treatment recipe. A programmable system controller is electrically coupled to a pump controller of each of a plurality of pump-stations. The programmable system controller is configured to receive a material transfer indication from each of the plurality of pump-stations and issue commands to the pump controller of each pump-station in response to the seed treatment recipe.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: March 19, 2019
    Assignee: BAYER CROPSCIENCE LP
    Inventors: Greg A. Reineccius, Jaco Ernest Van Der Westhuizen, Alan W. Geiss, Bradley W. May, Tharacad S. Ramanarayanan, Marc Jean-Marie Andrieux
  • PRODRUGS OF CYTOTOXIC ACTIVE AGENTS HAVING ENZYMATICALLY CLEAVABLE GROUPS
    Publication number: 20190077752
    Abstract: The invention relates to novel prodrugs or conjugates of the general formula (Ia) in which cytotoxic drugs, for example kinesin spindle protein inhibitors, are masked with legumain-cleavable groups and hence release the drug, and to the use of these prodrugs or conjugates for treatment and/or prevention of diseases, and to the use of these prodrugs or conjugates for production of medicaments for treatment and/or prevention of diseases, especially of hyperproliferative and/or angiogenic disorders, for example cancers.
    Type: Application
    Filed: March 21, 2017
    Publication date: March 14, 2019
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Hans-Georg LERCHEN, Anne-Sophie REBSTOCK, Leo MARX, Sarah Anna Liesa JOHANNES, Beatrix STELTE-LUDWIG, Lisa DIETZ, Carsten TERJUNG, Christoph MAHLERT, Simone GREVEN, Anette SOMMER, Sandra BERNDT
  • Use of substituted 2,3-dihydroimidazo[1,2-C]quinazolines for treating lymphomas
    Patent number: 10226469
    Abstract: Described herein are pharmaceutical combinations and compositions comprising a) a 2,3-dihydroimidazo[1,2-c]quinazoline compound, or a salt thereof, and b) one more additional active agents. The pharmaceutical combinations described herein may be useful for treating non-Hodgkin's lymphoma (NHL), particularly 1st line, 2nd line, relapsed, refractory, indolent or aggressive non-Hodgkin's lymphoma (NHL); follicular lymphoma (FL); chronic lymphocytic leukemia (CLL); marginal zone lymphoma (MZL); diffuse large B-cell lymphoma (DLBCL); mantle cell lymphoma (MCL); transformed lymphoma (TL); or peripheral T-cell lymphoma (PTCL).
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: March 12, 2019
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Ningshu Liu, Katja Haike, Juliane Paul, Antje Margret Wengner
  • Synergistic pre-emergent and post-emergent weed control compositions and methods of use thereof
    Patent number: 10226042
    Abstract: Methods and compositions for synergistic pre-emergent and post-emergent weed control are disclosed. In particular, the present disclosure relates to an herbicidal composition comprising at least one pre-emergent herbicide and at least one post-emergent herbicide, wherein the pre-emergent herbicide and the post-emergent herbicide synergistically inhibit pre-emergent and post-emergent development of a weed. The disclosure further relates to herbicidal compositions comprising isoxaben, 2,4-D, mecoprop-P, and dicamba.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: March 12, 2019
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Bruce Spesard, Brian R. James, Guillaume Huchet, Raymond L. Cheek
  • Compounded media powder formulation and method of preparation of liquid medium for cell culture
    Patent number: 10227559
    Abstract: The present invention provides a compounded cell culture medium powder formulation comprising: a basal medium powder and a cell culture media supplement, wherein the cell culture media supplement comprises and one or more salts; one or more growth factors; one or more inorganic ions; an amino acid supplement comprising one or more of asparagine, glutamine, histidine, and serine; one or more buffers; and one or more anti-foaming agents. The invention further provides methods of making a compounded cell culture medium powder formulation methods of making a cell culture medium for growing mammalian cells and methods of producing a protein of interest by culturing cells in the cell culture medium and isolating the protein of interest.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: March 12, 2019
    Assignee: Bayer HealthCare LLC
    Inventors: Yuval Shimoni, Volker Möhrle
  • 3-amino-1,5,6,7-tetrahydro-4H-indol-4-ones
    Patent number: 10227299
    Abstract: Compounds of formula (I) as described herein processes for their production and their use as anti-cancer agents.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: March 12, 2019
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Keith Graham, Ulrich Klar, Hans Briem, Gerhard Siemeister, Ursula Mönning, Jozsef Balint
  • NEW 2-SUBSTITUTED INDAZOLES, METHODS FOR PRODUCING SAME, PHARMACEUTICAL PREPARATIONS THAT CONTAIN SAME, AND USE OF SAME TO PRODUCE DRUGS
    Publication number: 20190071432
    Abstract: The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.
    Type: Application
    Filed: February 28, 2017
    Publication date: March 7, 2019
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Ulrich BOTHE, Holger SIEBENEICHER, Nicole SCHMIDT, Judith GÜNTHER, Holger STEUBER, Ulf BÖMER, Martin LANGE, Reinhard NUBBEMEYER, Nicholas Charles RAY, Pascal SAVY