Patents Assigned to Bayer
  • 1,3-thiazol-2-yl substituted benzamides
    Patent number: 10183937
    Abstract: The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: January 22, 2019
    Assignee: Bayer Aktiengesellschaft
    Inventors: Adam James Davenport, Nico Bräuer, Oliver Martin Fischer, Andrea Rotgeri, Antje Rottmann, Ioana Neagoe, Jens Nagel, Anne-Marie Godinho-Coelho, Jürgen Klar
  • ISOTOPE PREPARATION METHOD
    Publication number: 20190015530
    Abstract: The present invention provides a method for the purification of 227Th from a mixture comprising 227Th and 223Ra, said method comprising: i) preparing a first solution comprising a mixture of 227Th and 223Ra ions dissolved in an aqueous solution of first mineral acid; ii) loading said first solution onto a strong base anion exchange resin; iii) eluting 223Ra from said strong base anion exchange resin using a second mineral acid in an aqueous solution; iv) optionally rinsing said strong base anion exchange resin using a first aqueous medium; v) eluting 227Th from said strong base anion exchange resin using a third mineral acid in an aqueous solution whereby to generate a second solution comprising 227Th. The invention further provides a purified 227Th solution, a corresponding pharmaceutical formulation and methods of treatment of neoplastic disease.
    Type: Application
    Filed: December 29, 2016
    Publication date: January 17, 2019
    Applicant: BAYER AS
    Inventors: Dimitrios MANTZILAS, Jan Roger KARLSON, Judit Tjemeland ØSTBY, Janne Olsen FRENVIK
  • Foaming skincare formulations
    Patent number: 10179094
    Abstract: In one aspect, the present invention is directed to formulations comprising at least one pressure generating vehicle along with at least one skincare active agent in a container such that the pressure generating vehicle would eject the formulation as foam, whipped cream or a similar form upon application of external pressure on the container.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: January 15, 2019
    Assignee: Bayer HealthCare LLC
    Inventors: Heidi Naomi Graham, Thomas A. Meyer, Stephen E. Baldwin
  • 2-aryl- and 2-arylalkyl-benzimidazoles as mIDH1 inhibitors
    Patent number: 10179123
    Abstract: The present invention relates to 2-Aryl- and 2-Arylalkyl-benzimidazoles of general formula (I): in which A, R1, R4, R5, R6, R7, R8, R9, R10 and R11 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: July 4, 2016
    Date of Patent: January 15, 2019
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Olaf Panknin, Katja Zimmermann, Roland Neuhaus
  • AMIDES OF ACETIC AND PROPIONIC ACIDS
    Publication number: 20190010150
    Abstract: The invention relates to novel amides of acetic and propionic acids, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning ability and memory.
    Type: Application
    Filed: January 30, 2018
    Publication date: January 10, 2019
    Applicant: Bayer Intellectual Property GmbH
    Inventors: Joachim LUITHLE, Frank-Gerhard BÖß, Christina ERB, Katrin SCHNIZLER, Timo FLESSNER, Marja van KAMPEN, Christoph METHFESSEL
  • Substituted 5-hydroxy-2-phenyl-3-heteroaryl pentanenitrile derivatives, method for the production thereof and use thereof as herbicides and/or plant growth regulators
    Patent number: 10172350
    Abstract: Primarily, the present invention relates to compounds of the formula (I) defined below and to their use as herbicides, in particular for controlling broad-leaved weeds and/or weed grasses in crops of useful plants and/or as plant growth regulators for influencing the growth of crops of useful plants. The present invention also relates to herbicidal or plant growth-regulating compositions comprising one or more compounds of the formula (I). Moreover, the present invention relates to processes for preparing the compounds of the formula (I).
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: January 8, 2019
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Marc Mosrin, Harald Jakobi, Hansjoerg Dietrich, Elmar Gatzweiler, Christopher Hugh Rosinger, Dirk Schmutzler
  • Substituted pyrazolo[1,5-A]pyridines and their use
    Patent number: 10174021
    Abstract: The present application relates to novel substituted pyrazolo[1,5-a]pyridines of the formula (I-A) to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: January 8, 2019
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Alexandros Vakalopoulos, Damian Brockschnieder, Frank Wunder, Johannes-Peter Stasch, Tobias Marquardt, Lisa Dietz, Volkhart Min-Jian Li
  • Substituted pyridyl-cycloalkyl-carboxylic acids, compositions containing them and medical uses thereof
    Patent number: 10172814
    Abstract: The present invention relates to substituted Pyridyl-cycloalkyl-carboxylic acids of general formula (I), to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular in mammals, such as diseases associated with pains, or for the treatment or prophylaxis of pain syndromes (acute and chronic), inflammatory-induced pain, pelvic pain, cancer-associated pain, endometriosis-associated pain as well as endometriosis and adenomyosis as such, cancer as such, and proliferative diseases as such like endometriosis.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: January 8, 2019
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Nico Bräuer, Jens Nagel, Horst Irlbacher, Andrea Rotgeri, Wolfgang Schwede, Henrik Dahllöf, Marcus Koppitz, Michaele Peters, Anne-Marie Godinho-Coelho
  • SPRAY DEVICE WITH FLOW MEASUREMENT
    Publication number: 20190000065
    Abstract: The invention relates to the application of liquid active substances with the aid of a portable spray device. The subject matter of the present invention is a portable device for applying active substances, and a method for applying active substances with the aid of a portable spray device.
    Type: Application
    Filed: August 21, 2018
    Publication date: January 3, 2019
    Applicant: Bayer CropScience Aktiengesellschaft
    Inventor: Volker GUTSMANN
  • INTELLIGENT SPRAY SYSTEM
    Publication number: 20190000066
    Abstract: The present invention relates to the application of liquid active substances. The subject matter of the present invention is a system, a method and a computer program product for the application of an active substance concentrate from a replaceable cartridge in a diluted form onto a target object with the aid of a portable spray device, wherein important parameters of the spray process are exchanged between the cartridge and/or the spray device and/or an external computer system.
    Type: Application
    Filed: August 21, 2018
    Publication date: January 3, 2019
    Applicant: Bayer CropScience Aktiengesellschaft
    Inventors: Volker GUTSMANN, Byron REID, Chris PIENAAR, Peter JARDINE, Gaelle FAGES, Michael ZIMMERMANN
  • Substituted oxopyridine derivatives
    Patent number: 10167280
    Abstract: The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: January 1, 2019
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Susanne Röhrig, Eloisa Jimenez Nunez, Karl-Heinz Schlemmer, Adrian Tersteegen, Henrik Teller, Alexander Hillisch, Stefan Heitmeier, Martina Victoria Schmidt, Jens Ackerstaff, Jan Stampfuß
  • Devices, systems and methods for determining parameters of one or more phases of an injection procedure
    Patent number: 10166326
    Abstract: A system for enabling delivery of fluid in an injection procedure to be performed on a patient in connection with a diagnostic imaging procedure is disclosed. The system includes a controller operably associated with at least one pressurizing mechanism though which at least one of a first and a second fluid contained within at least one fluid container is injectable into the patient. The first fluid includes a contrast enhancing agent while the second fluid does not. The controller includes a programming system for programming an injection protocol having a plurality of phases to effect enhancement of at least one region of interest of the patient over a scan duration of the diagnostic imaging procedure. The programming system includes an algorithm that enables computation of a ratio of the first and second fluids based on at least a peak enhancement that occurs in at least one region of interest.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: January 1, 2019
    Assignee: BAYER HEALTHCARE LLC
    Inventors: John F. Kalafut, David A. Mishler
  • [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones
    Patent number: 10167293
    Abstract: The present invention covers [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of disorders, in particular of gynecological disorders, hyperproliferative disorders, metabolic disorders, or inflammatory disorders as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: January 1, 2019
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Marcus Koppitz, Holger Siebeneicher, Holger Steuber, Antonius Ter Laak, Reinhard Nubbemeyer, Antje Rottmann, Horst Irlbacher, Benjamin Bader, Michaele Peters, Andrea Wagenfeld, Ildiko Terebesi
  • Seed treatment apparatus
    Patent number: 10165723
    Abstract: A seed treatment apparatus provides for minimal waste of products for treating seeds, in that it is precisely controllable and automatically adjustable. A volume of seeds to be treated and a flow rate of treatment product for treating the seeds can both be sensed. At least one of the flow rate of the treatment product and the volume of seeds can automatically be adjusted if it is determined that a ratio of the flow rate of treatment product to the volume of seeds is not the same as a predetermined flow rate to volume ratio.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: January 1, 2019
    Assignee: Bayer CropScience LP
    Inventors: Greg A. Reineccius, Steven Schulz
  • SUBSTITUTED PERHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AND THE USE OF SAME
    Publication number: 20180370965
    Abstract: The present application relates to novel (2-phenylimidazo[1,2-a]pyridin-3-yl)methyl-substituted perhydropyrrolo[3,4-c]pyrrole derivatives, to methods for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apneas and central sleep apneas and snoring.
    Type: Application
    Filed: December 2, 2016
    Publication date: December 27, 2018
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Martina DELBECK, Michael HAHN, Thomas MÜLLER, Heinrich MEIER, Klemens LUSTIG, Johanna MOSIG, Luisella TOSCHI, Udo ALBUS, Doris GEHRING, Björn ROSENSTEIN
  • Use of 2-chloro-3-(methylsulfanyl)-N-(1-methyl-1H-tetrazol-5-yl)-4-(trifluoromethyl)benzamide or its salts for controlling unwanted plants in areas of transgenic crop plants being tolerant to HPPD inhibitor herbicides
    Patent number: 10159249
    Abstract: The use of 2-chloro-3-(methylsulfanyl)-N-(1-methyl-1H-tetrazol-5-yl)-4-(trifluoromethyl)benzamide or its salts for controlling unwanted plants in areas of transgenic crop plants being tolerant to HPPD inhibitor herbicides by containing one or more chimeric gene(s) comprising (I) a DNA sequence encoding hydroxyphenylpyruvate dioxygenase (HPPD) derived from a member of a group of organisms consisting of (a) Avena, (b) Pseudomonas, (c) Synechococcoideae, (d) Blepharismidae, (e) Rhodococcus, (f) Picrophilaceae, (g) Kordia, or (II) one or more mutated DNA sequences of HPPD encoding genes of the before defined organisms, preferably from Pseudomonas, or (III) one or more DNA sequences encoding mutated maize (Zea mays) or soybean (Glycine max) HPPD each being mutated as described in WO 2012/021785.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: December 25, 2018
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Fabien Poree, Christian Waldraff, Bernd Laber, Arnim Koehn, Elmar Gatzweiler, Klaus Trabold
  • Attachment device for medical fluid container
    Patent number: 10159788
    Abstract: An attachment device for connecting a fluid path set to a medical container includes a body having a pointed distal end configured for puncturing a membrane of the medical container and a proximal end configured for connecting to the fluid path set. The attachment device further includes a fluid channel extending along a longitudinal axis of the body between the distal end and the proximal end. The fluid channel is configured for delivering a medical fluid between the medical container and the fluid path set. At least one deflectable retaining element projects from the body of the attachment device between the distal end and the proximal end. The at least one retaining element is configured from non-removably retaining the attachment device with the medical container after the attachment device is connected to the medical container.
    Type: Grant
    Filed: May 1, 2014
    Date of Patent: December 25, 2018
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Ralph H. Schriver, James A. Dedig
  • Methods of inhibiting, preventing, killing and/or repelling insects using simulated blends of chenopodium
    Patent number: 10159248
    Abstract: The present invention provides natural and/or simulated, synthetic, synergistic pesticidal compositions comprising terpenes, such as extracts from Chenopodium ambrosioides near ambrosioides, or compositions based on those found in Chenopodium ambrosioides near ambrosioides. The present invention also provides methods of using said compositions to kill, inhibit, prevent and/or repel plant pests from contacting and/or damaging plants.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: December 25, 2018
    Assignee: Bayer CropScience LP
    Inventors: Desmond Jimenez, Giselle Janssen, Dennis Long, Brett Highland, Tara Lu, Gerardo Bueno, Nicholas Wright
  • strain, antifungal compounds, and methods for their use
    Patent number: 10159257
    Abstract: The present invention relates to a composition comprising a biologically pure culture of a fungicidal Paenibacillus sp. strain comprising a variant fusaricidin synthetase lacking a functional adenylation domain in the third module. The present invention also provides a composition comprising a biologically pure culture of a fungicidal Paenibacillus sp. strain or a cell-free extract thereof comprising at least one Paeniserine and at least one Paeniprolixin. Also provided are isolated compounds and methods of treating a plant to control a plant disease with the disclosed compositions and compounds.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: December 25, 2018
    Assignee: Bayer CropScience LP
    Inventors: Jeremy Beau, Daniel M. Joo, Patrick Schwientek, Colleen S. Taylor, Bjorn A. Traag
  • Process for preparing 3-chloro-2-vinylphenol
    Patent number: 10160707
    Abstract: The present invention describes a novel process for preparing 3-chloro-2-vinylphenol which, owing to the chemoselectivity achieved, also allows direct conversion into (3-chloro-2-vinylphenyl)methane-sulphonate.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: December 25, 2018
    Assignee: Bayer CropScience Aktiengesellschaft
    Inventors: Florian Erver, Mark James Ford