Abstract: The present invention relates to novel isoxazoline carboxamide derivatives, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials.
Type:
Grant
Filed:
October 27, 2016
Date of Patent:
October 3, 2017
Assignee:
BAYER CROPSCIENCE AG
Inventors:
Lothar Willms, Monika H. Schmitt, Thomas Frenzel, Klaus Bernhard Haaf, Isolde Haeuser-Hahn, Ines Heinemann, Elmar Gatzweiler, Christopher Hugh Rosinger, Heinz Kehne, Jan Dittgen, Dieter Feucht, Martin Hills, Jan Peter Schmidt, Mazen Es-Sayed, Philipe Rinolfi, Stephane Brunet, Marie-Claire Grosjean-Cournoyer, Helene Lachaise, Jacky Vidal, Pierre-Yves Coqueron, Arounarith Tuch
Abstract: The present invention relates to novel mixtures, to processes for preparing these compounds, to compositions comprising these mixtures, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms or pests in crop protection and in the protection of materials and for enhancing plant health.
Type:
Grant
Filed:
November 28, 2013
Date of Patent:
October 3, 2017
Assignee:
BAYER CROPSCIENCE AG
Inventors:
Haruko Sawada, Stefan Herrmann, Heiko Rieck, Christophe Dubost
Abstract: The present invention relates to amino-substituted imidazopyridazine compounds of general formula (I), in which A, R1, R2, R3, R4, R5 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
Type:
Grant
Filed:
March 27, 2013
Date of Patent:
October 3, 2017
Assignee:
BAYER INTELLECTUAL PROPERTY GMBH
Inventors:
Knut Eis, Florian Puehler, Ludwig Zorn, Volker Schulze, Detlev Sülzle, Philip Lienau, Andrea Hägebarth, Kirstin Petersen, Ulf Bömer
Abstract: Disclosed are compounds of formula (I) which possess pesticidal, especially nematicidal properties wherein in the structural elements have the meaning as indicated in the description.
Type:
Grant
Filed:
October 10, 2014
Date of Patent:
October 3, 2017
Assignee:
BAYER ANIMAL HEALTH GMBH
Inventors:
Hans-Georg Schwarz, Anne Decor, Martin Füβlein, Ulrich Görgens, Kerstin Ilg, Claudia Welz, Peter Lümmen, Adeline Köhler, Kirsten Börngen
Abstract: The present invention relates to novel mixtures, to processes for preparing these compounds, to compositions comprising these mixtures, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms or pests in crop protection and in the protection of materials and as plant growth regulators.
Type:
Grant
Filed:
November 27, 2013
Date of Patent:
October 3, 2017
Assignee:
BAYER CROPSCIENCE AG
Inventors:
Haruko Sawada, Ulrike Wachendorff-Neumann, Elke Hellwege, Heiko Rieck, Stefan Herrmann
Abstract: The present invention is directed to the neutralizing prolactin receptor antibody Mat3, and antigen binding fragments, pharmaceutical compositions containing them and their use in the treatment or prevention of benign disorders and indications mediated by the prolactin receptor such as endometriosis, adenomyosis, non-hormonal female contraception, benign breast disease and mastalgia, lactation inhibition, benign prostate hyperplasia, fibroids, hyper- and normoprolactinemic hair loss, and cotreatment in combined hormone therapy to inhibit mammary epithelial cell proliferation and for the treatment and prevention of antiestrogen-resistant breast cancer. The antibody of the invention blocks prolactin receptor-mediated signalling.
Type:
Grant
Filed:
April 28, 2016
Date of Patent:
October 3, 2017
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Christoph Freiberg, Christiane Otto, Lars Linden, Axel Harrenga, Mark Trautwein, Simone Greven, Andreas Wilmen
Abstract: Compounds of formula (I), which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.
Type:
Application
Filed:
March 10, 2017
Publication date:
September 28, 2017
Applicant:
Bayer Pharma Aktiengesellschaft
Inventors:
Marion HITCHCOCK, Anne MENGEL, Christoph-Stephan HILGER, Lars BÄRFACKER, Hans BRIEM, Gerhard SIEMEISTER, Amaury Ernesto FERNANDEZ-MONTALVAN, Jens SCHRÖDER, Simon HOLTON, Cornelia PREUßE, Ursula MÖNNING
Abstract: Compounds of formula (I) and their use as pharmaceuticals.
Type:
Application
Filed:
September 15, 2015
Publication date:
September 28, 2017
Applicant:
Bayer Pharma Aktiengesellschaft
Inventors:
Lars BÄRFACKER, Thomas MÜLLER, Anne MENGEL, Marion HITCHCOCK, Arwed CLEVE, Hans BRIEM, Gerhard SIEMEISTER, Wilhelm BONE, Amaury Ernesto FERNANDEZ-MONTALVAN, Jens SCHRÖDER, Ursula MÖNNING
Abstract: Compounds of formula (I) as defined herein and their use as pharmaceuticals.
Type:
Application
Filed:
September 17, 2015
Publication date:
September 28, 2017
Applicant:
Bayer Pharma Aktiengesellschaft
Inventors:
Anne MENGEL, Hans-Georg LERCHEN, Manfred MÖWES, Thomas MÜLLER, Lars BÄRFACKER, Marion HITCHCOCK, Arwed CLEVE, Joachim KUHNKE, Hans BRIEM, Gerhard SIEMEISTER, Wilhelm BONE, Amaury Ernesto FERNANDEZ-MONTALVAN, Jens SCHRÖDER, Ursula MÖNNING, Simon HOLTON
Abstract: Compounds of formula (I), processes for their production and their use as Bub1 kinase inhibitors for the treatment of hyperproliferative diseases and/or disorders responsive to induction of cell death.
Type:
Application
Filed:
March 8, 2017
Publication date:
September 28, 2017
Applicant:
Bayer Pharma Aktiengesellschaft
Inventors:
Marion HITCHCOCK, Christoph-Stephan HILGER, Anne MENGEL, Hans BRIEM, Simon HOLTON, Vera PÜTTER, Gerhard SIEMEISTER, Stefan PRECHTL, Amaury Ernesto FERNANDEZ-MONTALVAN, Christian STEGMANN, Cornelia PREUßE, Mark Jean GNOTH
Abstract: Compounds of formula (I) and their use as pharmaceuticals.
Type:
Application
Filed:
September 17, 2015
Publication date:
September 28, 2017
Applicant:
Bayer Pharma Aktiengesellschaft
Inventors:
Anne MENGEL, Thomas MÜLLER, Lars BÄRFACKER, Marion HITCHCOCK, Arwed CLEVE, Hans BRIEM, Gerhard SIEMEISTER, Wilhelm BONE, Amaury Ernesto FERNANDEZ-MONTALVAN, Jens SCHRÖDER, Ursula MÖNNING
Abstract: The present invention relates to a composition comprising at least one biological control agent and at least one insecticide. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.
Type:
Grant
Filed:
September 29, 2016
Date of Patent:
September 26, 2017
Assignee:
Bayer CropScience AG
Inventors:
Elke Hellwege, Wolfram Andersch, Klaus Stenzel, Bernd Springer
Abstract: The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.
Type:
Grant
Filed:
March 18, 2015
Date of Patent:
September 26, 2017
Assignee:
BAYER PHARMA AKTIENGESELLSCHAFT
Inventors:
Alexandros Vakalopoulos, Philipp Buchgraber, Niels Lindner, Markus Follmann, Frank Wunder, Johannes-Peter Stasch, Tobias Marquardt, Gorden Redlich, Lisa Dietz, Volkhart Min-Jian Li
Abstract: The present invention relates to novel 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular and renal diseases.
Type:
Grant
Filed:
November 2, 2015
Date of Patent:
September 26, 2017
Assignee:
BAYER PHARMA AKTIENGESELLSCHAFT
Inventors:
Carsten Schmeck, Michael Gerisch, Nils Griebenow, Peter Kolkhof, Florian Kölling, Anna Engelen, Axel Kretschmer, Dieter Lang, Klemens Lustig, Thomas Mondritzki, Elisabeth Pook, Hartmut Beck, Frank Süβmeier, Sonja Vollmer, Pierre Wasnaire
Abstract: The present invention relates to 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
Type:
Grant
Filed:
July 3, 2014
Date of Patent:
September 26, 2017
Assignee:
Bayer Pharma Aktiengesellschaft
Inventors:
Dirk Kosemund, Ulrich Lücking, Arne Scholz, Gerhard Siemeister, Philip Alexander Lienau
Abstract: Heteroarylpiperidine and -piperazine derivatives of the formula (I) in which the symbols A, X, Y, L1, L2, G, Q, p, R1, R2 and R10 are each as defined in the description, and salts, metal complexes and N-oxides of the compounds of the formula (I), and the use thereof for controlling phytopathogenic harmful fungi and processes for preparing compounds of the formula (I).
Type:
Grant
Filed:
August 10, 2015
Date of Patent:
September 26, 2017
Assignee:
BAYER CROPSCIENCE AG
Inventors:
Tomoki Tsuchiya, Pierre Wasnaire, Sebastian Hoffmann, Pierre Cristau, Thomas Seitz, Joachim Kluth, Stefan Hillebrand, Juergen Benting, Daniela Portz, Ulrike Wachendorff-Neumann
Abstract: The present invention relates to novel fungicidal active compound combinations or compositions comprising a phenylamidine compound of formula (I) and further active compounds (II) and (III) selected from the groups (A), (B) and/or (C), to a process for preparing these active compound combinations or compositions and to the use thereof as biologically active compound combinations or compositions, especially for the control of phytopathogenic fungi in plants and/or in the protection of materials and/or as plant growth regulators.
Type:
Grant
Filed:
February 10, 2015
Date of Patent:
September 26, 2017
Assignee:
BAYER CROPSCIENCE AKTIENGESELLSCHAFT
Inventors:
Andreas Goertz, Thomas Seitz, Peter Dahmen, Ulrike Wachendorff-Neumann
Abstract: The present invention relates to fungicidal N-cycloalkyl-N-[(bicyclylphenyl)methylene]carboxamide derivatives and their thiocarbonyl derivatives, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
Type:
Grant
Filed:
June 24, 2014
Date of Patent:
September 26, 2017
Assignee:
BAYER CROPSCIENCE AG
Inventors:
Jurgen Benting, Pierre Cristau, Peter Dahmen, Philippe Desbordes, Stephanie Gary, Philippe Rinolfi, Tomoki Tsuchiya, Ulrike Wachendorff-Neumann
Abstract: The present invention relates to new macrolide derivatives, in particular new tylosin derivatives of the formula (IIa), a pharmaceutical or veterinary composition comprising the derivatives; a method for preparation thereof; a method for treating and/or preventing bacterial infections in an animal, wherein the method comprises administering the derivatives or the composition; and a use of the derivatives for the manufacture of medicaments for treating and/or preventing bacterial infections in an animal.
Type:
Grant
Filed:
May 23, 2014
Date of Patent:
September 26, 2017
Assignees:
THE KITASAKO INSTITUTE, BAYER ANIMAL HEALTH GMBH
Inventors:
Michael Scott Carpenter, William A. Bachman, John Bischoff, Theresa C. DeSantis, Anna Erixon, Gregg Herman, Kimberly McCormack, Mark G. Neuhalfen, Sean Hang Cho, Craig A. Braun, Jeffrey Rodriguez