Abstract: The present invention covers combinations comprising one or more inhibitors of DGKalpha and one or more inhibitors of DGKzeta Another aspect of the present invention covers the use of such combinations as described herein for the preparation of a medicament for the treatment or prophylaxis of a disease, particularly of a condition with dysregulated immune responses, particularly cancer, or a viral infection or another disorder associated with aberrant DGKalpha and/or DGKzeta signaling.

Abstract: The invention relates to a spray unit comprising an axle (20), a disc (30), a disc shape modifying assembly (40) and a liquid applicator (50). The disc is configured to spin about the axle centred on the centre of the disc. The liquid applicator is configured to apply liquid to a surface of the disc. The disc shape modifying assembly is configured to modify the trajectory of the liquid droplets that leave the spray unit by way of varying the diameter of the disc.

Abstract: The present invention relates to a novel method for preparing alkyl 4-oxotetrahydrofuran-2-carboxylate (I)

Abstract: The present invention is concerned with the application of biological and/or chemical substances or mixtures of substances, more particularly of crop protection products, and/or nutrients outdoors. Subjects of the present invention are a method, a computer system, an apparatus and a computer program product for dynamically adapting application parameters to variable air movements.

Abstract: The present invention relates to crop protection compounds and to compositions which comprise specific compounds as safeners for reducing phytotoxic effects of agrochemicals, especially herbicides. The invention relates more particularly to certain [5-(phenyl)-5-(heteroaryl)-1H-pyrazol-3-yl)oxy] acetic acid derivatives of the general formula (I) and their salts, to processes for preparing them and to their use as plant protection compounds (safeners).

Abstract: Compounds of formula (I), process for their production and their use as pharmaceuticals.

Abstract: The invention relates to a process for preparing optically active 4-substituted 1,2,3,4-tetrahydroquinolines comprising enantioselective hydrogenation of the corresponding 4-substituted 1,2-dihydroquinolines in presence of a chiral iridium (P,N)-ligand catalyst and an additive.

Abstract: Compounds of formula (I), formula (I), processes for their production and their use as pharmaceuticals.

Abstract: A device for agricultural management includes a processing unit to determine at least one geographical location of an agricultural land area, the determination comprising utilization of a GPS unit. Agricultural data is provided from an input unit to the processing unit. The processing unit determines agricultural management data, the determination comprising utilization of the at least one geographical location and the agricultural data. An output unit outputs agricultural management information to a user of the device on the basis of the agricultural management data.

Abstract: The present disclosure relates to azabicyclyl-substituted heterocyclic compounds of formula (I), wherein A1, A2, m, R3, R4, R5, L, R6, T, the ring Y, p, R7 and Q have the meanings as defined in the specification, to compositions comprising such compounds, to processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.

Abstract: The present invention relates to the technical field of producing artificial contrast-enhanced radiological images by way of machine learning methods.

Abstract: The present invention deals with the selection of antibodies and/or antibody fragments in a selection method. Subjects of the present invention are a method, a system and a computer program product for generating score values for pairs of genes which encode the variable domains of light and heavy chains of antibodies and/or antibody fragments. Antibodies and/or antibody fragments can be selected on the basis of the score values.

Abstract: The present invention relates to crop protection compounds and to compositions which comprise specific compounds as safeners for reducing phytotoxic effects of agrochemicals, especially herbicides. The invention relates more particularly to certain [(1-phenyl-5-(heteroaryl)-1H-1,2,4-triazol-3-yl)oxy]acetic acid derivatives of the general formula (I) and their salts, to processes for preparing them and to their use as crop protection compounds (safeners).

Abstract: The present invention relates to novel heteroaryl-triazole compounds of the general formula (I), in which the structural elements X, Y, R1, R2, R3a, R3b, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.

Abstract: The present invention relates to active compound combinations, in particular within a fungicide composition, which comprise as compound (A) a compound of formula (I) and as compound (B) a further fungicidally active compound as specified below. Moreover, the invention relates to compositions comprising such compound combination and to the use of the compound combinations and the fungicide compositions as biologically active agent, especially for control of phytopathogenic fungi in crop protection and in the protection of industrial materials and as plant growth regulators.

Abstract: Isophthalamides of the general formula (I) are described as herbicides. In this formula (I), X, Y and Z represent radicals such as hydrogen, alkyl and halogen. Q represents a heterocyclic ring such as tetrazolyl.

Abstract: The present invention relates to aqueous dispersions comprising an ALS inhibitor, typically a sulfonylurea herbicide, specifically from the class of triazolinones herbicides, a HPPD inhibitor, specifically a triketone as from the class of 2-benzoyl-1,3-cyclohexanedione herbicides, optionally a safener from the class of the sulfonamides, a water-soluble herbicide present as a salt, specifically glyphosate and to dispersions resulting from dispersing the concentrate suspension in water, to a method of making the aqueous suspension and to a method of controlling unwanted plants using these dispersions.

Abstract: The invention relates to a process for preparing optically active 4-substituted 1,2,3,4-tetrahydroquinolines comprising enantioselective hydrogenation of the corresponding 4-substituted 1,2-dihydroquinolines in presence of a chiral iridium (P,N)-ligand catalyst.

Abstract: A method of training a prediction tool to generate at least one synthetic full-contrast image from zero-contrast and low-contrast images of a subject may involve receiving a training set a set of images of a set of subjects, the images of each subject comprising a full-contrast image, a low-contrast image, a first zero-contrast image acquired prior to the acquisition of the full-contrast image, and a second zero-contrast image acquired prior to the acquisition of the low-contrast image. An artificial neural network may be trained with the training set by applying the first and second zero-contrast images from the set of images and the low-contrast images from the set of images as input to the artificial neural network and using a cost function to compare the output of the artificial neural network with the full-contrast images from the set of images to train parameters of the artificial neural network using backpropagation.

Abstract: The present disclosure relates to substituted thiophene carboxamides derivatives of formula (I) and (II), their use for controlling phytopathogenic microorganisms and compositions comprising thereof.