Patents Assigned to Bend Research Inc.
  • Method and device for evaluation of pharmaceutical compositions
    Patent number: 7611630
    Abstract: A membrane-permeation test for evaluating pharmaceutical compositions is described. The method comprises the following steps: (1) providing a microporous membrane having a plurality of pores, the membrane having a feed side and a permeate side, wherein the feed side of the membrane is in fluid communication with the feed solution, and wherein the permeate side of the membrane is in fluid communication with a permeate solution; (2) administering a pharmaceutical composition to an aqueous solution to form a feed solution; and (3) measuring the concentration of drug in the permeate solution; wherein the feed side of the membrane is hydrophilic, and/or wherein the permeate solution comprises an organic fluid.
    Type: Grant
    Filed: March 18, 2005
    Date of Patent: November 3, 2009
    Assignee: Bend Research, Inc.
    Inventors: Walter Christian Babcock, Dwayne Thomas Friesen, Scott Baldwin McCray
  • Controlled release by extrusion of solid amorphous dispersions of drugs
    Patent number: 7550158
    Abstract: Controlled release dosage forms for low solubility drugs are disclosed wherein an amorphous solid dispersion of the drug is coated with a non-dissolving and non-eroding coating that controls the influx of water to the core so as to cause extrusion of a portion of the core, as well as a method of treating a disease or disorder comprising administering such dosage form to a person.
    Type: Grant
    Filed: March 11, 2004
    Date of Patent: June 23, 2009
    Assignee: Bend Research, Inc.
    Inventors: Leah E. Appel, William J. Curatolo, Scott M. Herbig, James A. S. Nightingale, Avinash G. Thombre
  • Pharmaceutical Compositions Of Cholesteryl Ester Transfer Protein Inhibitors And Hmg-Coa Reductase
    Publication number: 20090118328
    Abstract: A solid amorphous dispersion comprises a cholesteryl ester transfer protein (CETP) inhibitor, an inhibitor of 3-hydroxy-3-methylglutaryl-conenzyme A reductase (HMG-CoA reductase inhibitor), and a concentration enhancing polymer. At least a major portion of the CETP inhibitor in the dispersion is amorphous. The solid amorphous dispersion provides concentration-enhancement of the CETP inhibitor when administered to an aqueous use environment.
    Type: Application
    Filed: May 22, 2006
    Publication date: May 7, 2009
    Applicant: BEND RESEARCH, INC.
    Inventors: Dwayne Thomas Friesen, Bruno Caspar Hancock, Rodney James Ketner, David Keith Lyon, James Alan Shriver Nightingale, Ravi Mysore Shanker
  • Solvent-resistant microporous polybenzimidazole membranes and modules
    Patent number: 6986844
    Abstract: Solvent-resistant polybenzimidazole membranes, methods of making them and crosslinking them and composite membranes and hollow fiber membrane modules from them are disclosed.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: January 17, 2006
    Assignee: Bend Research, Inc.
    Inventors: Robert P. Barss, Dwayne T. Friesen, Scott B. McCray, Kendall R. Pearson, Roderick J. Ray, Delores R. Sidwell, James B. West
  • Solvent-resistant microporous polybenzimidazole membranes
    Patent number: 6623639
    Abstract: Solvent-resistant polybenzimidazole membranes, methods of making them and crosslinking them and composite membranes and hollow fiber membrane modules from them are disclosed.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: September 23, 2003
    Assignee: Bend Research, Inc.
    Inventors: Robert P. Barss, Dwayne T. Friesen, Scott B. McCray, Kendall R. Pearson, Roderick J. Ray, Delores R. Sidwell, James B. West
  • Plasma discharge reactors for the preparation of bioactive compounds
    Patent number: 6221319
    Abstract: Plasma discharge reactors of various designs are disclosed; the reactors are capable of synthesizing large numbers of bioactive compounds of great chemical diversity.
    Type: Grant
    Filed: June 23, 1999
    Date of Patent: April 24, 2001
    Assignee: Bend Research, Inc.
    Inventors: Bruce M. Johnson, Walter C. Babcock, James B. West, Dwayne T. Friesen
  • Bacteriorhodopsin preparations having increased information storage times
    Patent number: 6140012
    Abstract: Bacteriorhodopsin materials and matrices are crosslinked with each other to enhance optical data storage lifetimes.
    Type: Grant
    Filed: May 11, 1998
    Date of Patent: October 31, 2000
    Assignee: Bend Research, Inc.
    Inventors: Daniel T. Smithey, Brenda M. Simpson
  • Liquid absorbent solutions for separating nitrogen from natural gas
    Patent number: 6136222
    Abstract: Nitrogen-absorbing and -desorbing compositions, novel ligands and transition metal complexes, and methods of using the same, which are useful for the selective separation of nitrogen from other gases, especially natural gas.
    Type: Grant
    Filed: April 11, 1996
    Date of Patent: October 24, 2000
    Assignee: Bend Research, Inc.
    Inventors: Dwayne T. Friesen, Walter C. Babcock, David J. Edlund, David K. Lyon, Warren K. Miller
  • Liquid absorbent solutions for separating nitrogen from natural gas
    Patent number: 6077457
    Abstract: Nitrogen-absorbing and -desorbing compositions, novel ligands and transition metal complexes, and methods of using the same, which are useful for the selective separation of nitrogen from other gases, especially natural gas.
    Type: Grant
    Filed: September 10, 1998
    Date of Patent: June 20, 2000
    Assignee: Bend Research, Inc.
    Inventors: Dwayne T. Friesen, Walter C. Babcock, David J. Edlund, David K. Lyon, Warren K. Miller
  • Ultrapurification of organic solvents
    Patent number: 6059857
    Abstract: A system for the ultrapurification of organic solvents comprising (1) a membrane-based vapor permeation step for selective removal of water vapor from the solvent, wherein a countercurrent sweep stream is used that has a particular partial pressure of water vapor, (2) a filtration step for selective removal of particulates, and (3) an ion exchange step for selective removal of ionic species.
    Type: Grant
    Filed: November 24, 1998
    Date of Patent: May 9, 2000
    Assignee: Bend Research, Inc.
    Inventors: Roderick J. Ray, David D. Newbold, Dwayne T. Friesen, Scott B. McCray, Lori A. Ray
  • Biologically active compounds by catalytic olefin metathesis
    Patent number: 5916983
    Abstract: Biologically active compounds such as pheromones and precursors thereof are produced by catalyzed cross metathesis of dissimilar terminal olefins or of a cyclodiene and a terminal olefin.
    Type: Grant
    Filed: May 27, 1997
    Date of Patent: June 29, 1999
    Assignee: Bend Research, Inc.
    Inventors: Richard L. Pederson, Robert H. Grubbs
  • Asymmetric microporous beads for controlled release
    Patent number: 5888930
    Abstract: A durable and sprayable controlled release bead of active ingredient in the pores of a polymeric micro-porous bead having an anisotropic pore structure of large pores in the interior and small pores at the surface, the gradation of pore sizes between the interior and the surface being continuous.
    Type: Grant
    Filed: March 13, 1997
    Date of Patent: March 30, 1999
    Assignee: Bend Research, Inc.
    Inventors: Kelly L. Smith, Matthew F. Holmes, James W. Brooke
  • Vapor permeation system
    Patent number: 5843209
    Abstract: Membrane-based vapor permeation system for selective removal of a vapor from a fluid feed stream, wherein a countercurrent sweep stream is used that has a particular partial pressure of the vapor to be removed.
    Type: Grant
    Filed: August 13, 1997
    Date of Patent: December 1, 1998
    Assignee: Bend Research, Inc.
    Inventors: Roderick J. Ray, David D. Newbold, Dwayne T. Friesen, Scott B. McCray
  • Preparation of bioactive compounds by plasma synthesis
    Patent number: 5772855
    Abstract: Large numbers of bioactive compounds of great chemical diversity may be rapidly prepared by subjecting organic compound mixtures to a plasma discharge, followed by screening for specific bioactivity.
    Type: Grant
    Filed: April 17, 1997
    Date of Patent: June 30, 1998
    Assignee: Bend Research, Inc.
    Inventors: Bruce M. Johnson, Walter C. Babcock, James B. West, Dwayne T. Friesen
  • Solvent resistant hollow fiber vapor permeation membranes and modules
    Patent number: 5753008
    Abstract: A vapor permeation method and apparatus for removing a vapor from a vaporous feed stream, the method and apparatus utilizing highly solvent-resistant composite hollow fiber membranes and a permeate flow countercurrent to the feed flow, wherein the support of the composite membrane is formed by solution casting and has been rendered sufficiently solvent-resistant by a post-casting step to retain at least 20 of its burst pressure when soaked in the solvent used to cast the support.
    Type: Grant
    Filed: July 12, 1995
    Date of Patent: May 19, 1998
    Assignee: Bend Research, Inc.
    Inventors: Dwayne T. Friesen, Scott B. McCray, David D. Newbold, Roderick J. Ray
  • Labile insecticide compositions
    Patent number: 5750126
    Abstract: There is disclosed a pesticidal composition comprising a pH-sensitive non-lignin-based polymer encapsulating both the active agent and a lignin-based UV screening agent.
    Type: Grant
    Filed: January 11, 1996
    Date of Patent: May 12, 1998
    Assignee: Bend Research, Inc.
    Inventors: Kelly L. Smith, Scott H. Herbig
  • Solvent-resistant microporous polymide membranes
    Patent number: 5725769
    Abstract: An asymmetric microporous membrane with exceptional solvent resistance and highly desirable permeability is disclosed. The membrane is made by a solution-casting or solution-spinning process from a copolyamic acid comprising the condensation reaction product in a solvent of at least three reactants selected from certain diamines and dianhydrides and post-treated to imidize and in some cases cross-link the copolyamic acid. The membrane is useful as an uncoated membrane for ultrafiltration, microfiltration, and membrane contactor applications, or may be used as a support for a permselective coating to form a composite membrane useful in gas separations, reverse osmosis, nanofiltration, pervaporation, or vapor permeation.
    Type: Grant
    Filed: July 18, 1995
    Date of Patent: March 10, 1998
    Assignee: Bend Research, Inc.
    Inventors: Warren K. Miller, Scott B. McCray, Dwayne T. Friesen
  • Enantiomeric enrichment of bicyclic alcohols
    Patent number: 5726344
    Abstract: There is disclosed a two-stage enzymatically catalyzed reaction for the selective preparation of the (R)-endo-isomer of norbornenol from a mixture containing all four stereo- and regioisomers of norbornenol, as well as the synthesis of the intermediate product comprising the enantiomerically enriched mono-ester of (R)-endo-norbornenol and a diacid, and of the enantiomerically enriched saturated alcohol (R)-endo-norborneol. There is also disclosed a method for the production of (R)-endo-norborne-2-ol, by chemical reduction of either the enantiomerically enriched monoester and subsequent hydrolysis, or by hydrolysis of the enantiomerically enriched monoester and then chemical reduction.
    Type: Grant
    Filed: August 15, 1995
    Date of Patent: March 10, 1998
    Assignee: Bend Research, Inc.
    Inventors: J. Blair West, Keith DeVries
  • Membrane dehydration of vaporous feeds by countercurrent condensable sweep
    Patent number: 5681433
    Abstract: A process for the dehydration of a vaporous mixture. The basic process involves directing a predominantly condensable water vapor-containing vaporous mixture against the feed side of a membrane while maintaining the feed near saturation without condensing it, directing a condensable vapor sweep stream past the permeate side of the membrane in a countercurrent flow, thereby transporting water vapor in the vaporous mixture from the feed side to the permeate side of the membrane to form a noncondensed combined permeate side mixture of condensable vapor and transported water vapor.
    Type: Grant
    Filed: September 14, 1994
    Date of Patent: October 28, 1997
    Assignee: Bend Research, Inc.
    Inventors: Dwayne T. Friesen, David D. Newbold, Scott B. McCray, Roderick J. Ray
  • Composite hydrogen separation element and module
    Patent number: 5645626
    Abstract: There are disclosed improvements in multicomponent composite metal membranes useful for the separation of hydrogen, the improvements comprising the provision of at least one common-axis hole through all components of the composite membrane and the provision of a gas-tight seal around the periphery of the hole or holes through a coating metal layer of the membrane.
    Type: Grant
    Filed: January 11, 1996
    Date of Patent: July 8, 1997
    Assignee: Bend Research, Inc.
    Inventors: David J. Edlund, David D. Newbold, Chester B. Frost