Abstract: A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.
Type:
Grant
Filed:
July 31, 2012
Date of Patent:
April 22, 2014
Assignee:
Bend Research, Inc.
Inventors:
Walter C. Babcock, William J. Curatolo, Dwayne T. Friesen, Rodney J. Ketner, Julian B. Lo, James A. S. Nightingale, Ravi M. Shanker, James B. West
Abstract: A pharmaceutical composition comprises nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a poorly aqueous soluble non-ionizable polymer.
Type:
Grant
Filed:
April 23, 2008
Date of Patent:
April 22, 2014
Assignee:
Bend Research, Inc.
Inventors:
Corey Jay Bloom, Marshall David Crew, Daniel Tod Smithey, Warren Kenyon Miller, Michael Mark Morgen
Abstract: Pharmaceutical compositions comprise a low-solubility drug adsorbed onto a high surface area substrate to form an adsorbate. The compositions in some embodiments include a concentration-enhancing polymer.
Type:
Grant
Filed:
December 4, 2006
Date of Patent:
April 22, 2014
Assignee:
Bend Research, Inc.
Inventors:
Walter C. Babcock, Dwayne T. Friesen, Ravi M. Shanker, Daniel T. Smithey, Ralph Tadday
Abstract: Pharmaceutical compositions are provided comprising an active agent and a dextran polymer derivative. The compositions include from 0.01 to 99 wt % of an active agent and from 1 to 99.99 wt % of a dextran polymer derivative. The dextran polymer derivative is selected from dextran acetate, dextran propionate, dextran succinate, dextran acetate propionate, dextran acetate succinate, dextran propionate succinate, dextran acetate propionate succinate, and mixtures thereof.
Type:
Grant
Filed:
March 3, 2010
Date of Patent:
April 1, 2014
Assignee:
Bend Research, Inc.
Inventors:
Warren K. Miller, David T. Vodak, Daniel E. Dobry, David K. Lyon, Dwayne T. Friesen, Michael M. Morgen, Corey J. Bloom, Daniel T. Smithey
Abstract: A sample can be collected from an enclosed container by opening a sample collection valve and drawing the sample from the enclosed container. After delivery of the sample out of a fluid flow path, a sanitizing fluid can be directed along the fluid flow path to sanitize the fluid flow path.
Type:
Application
Filed:
May 4, 2012
Publication date:
March 27, 2014
Applicant:
Bend Research, Inc.
Inventors:
David D. Newbold, Douglas L. Millard, Erwin Y. Yu, JR., Paul T. Jeffers, Jeffrey W. Weber
Abstract: Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.
Abstract: Pharmaceutical compositions of a low-solubility drug and lower alkanoate-, phthalate- and trimellitate esters of hydroxypropyl methyl cellulose and lower alkanoate- and succinate esters of cellulose and methyl cellulose are disclosed that provide enhanced concentrations of the drug in a use environment.
Type:
Grant
Filed:
January 23, 2006
Date of Patent:
December 31, 2013
Assignee:
Bend Research, Inc.
Inventors:
Walter Christian Babcock, Dwayne Thomas Friesen, David Kenneth Lyon, Warren Kenyon Miller, Daniel Tod Smithey
Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or bioavailability in a use environment.
Abstract: An exemplary system for dispensing liquid and solid materials can comprise a tank; one or more liquid feeders configured to dispense one or more liquids into the tank; a powder hopper comprising a powder inlet, a powder outlet, and a valve configured to open and close the powder outlet, the powder outlet being coupled to the tank; one or more powder feeders coupled to the powder inlet of the powder hopper; a first scale configured to measure the mass of powder dispensed into the powder hopper; a second scale configured to measure the mass of the liquids dispensed into the tank; and a control system configured to control the dispensing of liquids and powders based at least in part on the mass measurements from the first and second scales.
Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
Type:
Grant
Filed:
June 19, 2012
Date of Patent:
August 6, 2013
Assignee:
Bend Research, Inc.
Inventors:
William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
Abstract: The process comprises delivering a spray solution comprising at least one solute in a solvent to a spray-drying apparatus, using a flash nozzle to atomize the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution is directed to a heat exchanger, thereby increasing the temperature of the spray solution to a temperature T2, wherein T2 is greater than T1. The flash nozzle comprises a central tube through which the spray solution is delivered and an outer tube through which a sweep gas is delivered. The central tube may have a first outer diameter at an inlet and a second outer diameter at an outlet, wherein the first outer diameter is greater than the second outer diameter.
Type:
Application
Filed:
September 22, 2011
Publication date:
August 1, 2013
Applicant:
Bend Research, Inc.
Inventors:
Dwayne T. Friesen, David D. Newbold, John M. Baumann, Devon B. DuBose, Douglas L. Millard
Abstract: A composition comprises a solid dispersion comprising a low-solubility drug and at least one polymer. At least a major portion of the drug in the dispersion is amorphous. The polymer has a glass transition temperature of at least 100° C. measured at a relative humidity of fifty percent. Another aspect of the invention comprises the same composition except that the dispersion has a glass transition temperature of at least 50° C. at a relative humidity of fifty percent. In another aspect of the invention, a composition comprises a solid dispersion comprising a low-solubility drug and a stabilizing polymer. At least a major portion of the drug in the dispersion is amorphous. The composition also includes a concentration-enhancing polymer that increases the concentration of the drug in a use environment. The stabilizing polymer has a glass transition temperature that is greater than the glass transition temperature of the concentration-enhancing polymer at a relative humidity of 50%.
Type:
Grant
Filed:
June 10, 2003
Date of Patent:
July 9, 2013
Assignee:
Bend Research, Inc.
Inventors:
Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Ravi M. Shanker
Abstract: A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A heating device can be provided to heat the liquid prior to introduction into the drying chamber.
Type:
Application
Filed:
September 1, 2011
Publication date:
June 27, 2013
Applicant:
BEND RESEARCH, INC.
Inventors:
Daniel E. Dobry, James M. Mullin, Douglas L. Millard, Dwayne T. Friesen, David D. Newbold, John M. Baumann, Devon B. Dubose
Abstract: A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A ratio of the length between the first end and second end to a maximum width between opposing internal surfaces of the interior of the drying chamber can be at least 5 to 1.
Type:
Application
Filed:
September 1, 2011
Publication date:
June 20, 2013
Applicant:
BEND RESEARCH, INC.
Inventors:
Daniel E. Dobry, James M. Mullin, Douglas L. Millard
Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or bioavailability in a use environment.
Type:
Grant
Filed:
September 7, 2012
Date of Patent:
April 30, 2013
Assignee:
Bend Research, Inc.
Inventors:
William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
Abstract: Pharmaceutical compositions comprise a low-solubility drug adsorbed onto a high surface area substrate to form an adsorbate. The compositions in some embodiments include a concentration-enhancing polymer.
Type:
Grant
Filed:
July 28, 2008
Date of Patent:
March 5, 2013
Assignee:
Bend Research, Inc.
Inventors:
Walter C. Babcock, Dwayne T. Friesen, Ravi M. Shanker, Daniel T. Smithey, Ralph Tadday
Abstract: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
Type:
Grant
Filed:
June 12, 2012
Date of Patent:
March 5, 2013
Assignee:
Bend Research, Inc.
Inventors:
Marshall D. Crew, William J. Curatolo, Dwayne T. Friesen, Michael Jon Gumkowski, Douglas A. Lorenz, James A. S. Nightingale, Roger B. Ruggeri, Ravi M. Shanker
Abstract: Pharmaceutical compositions comprising a poorly water soluble ionizable drug, a cationic species and a dispersion polymer are disclosed, together with a process for forming the compositions. The neutral form of the drug has (i) a solubility of less than 1 mg/ml, in aqueous solution at a pH between 6 and 7, (ii) a solubility of less than 20 mg/mL in a volatile organic solvent, and (iii) an acidic pKa value of greater than 5. At least 90 wt % of the drug in the solid dispersion being in a non-crystalline form. The drug, the cationic species, and the dispersion polymer constitute at least 80 wt % of the solid dispersion.
Type:
Grant
Filed:
October 8, 2007
Date of Patent:
February 12, 2013
Assignee:
Bend Research, Inc.
Inventors:
Rodney James Ketner, Douglas Alan Lorenz, David Keith Lyon
Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.
Type:
Grant
Filed:
July 27, 2012
Date of Patent:
February 5, 2013
Assignee:
Bend Research, Inc.
Inventors:
William J. Curatolo, Scott M. Herbig, James A. S. Nightingale