Patents Assigned to Bend Research Inc.
  • PHARMACEUTICAL SOLID DISPERSIONS
    Publication number: 20130029965
    Abstract: A composition comprises a solid dispersion comprising a low-solubility drug and at least one polymer. In another aspect of the invention, a composition comprises a solid dispersion comprising a low-solubility drug and a stabilizing polymer. At least a major portion of the drug in the dispersion is amorphous. The composition also includes a concentration-enhancing polymer that increases the concentration of the drug in a use environment. The stabilizing polymer has a glass transition temperature that is greater than the glass transition temperature of the concentration-enhancing polymer at a relative humidity of 50%.
    Type: Application
    Filed: September 11, 2012
    Publication date: January 31, 2013
    Applicant: BEND RESEARCH, INC.
    Inventors: Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Ravi M. Shanker
  • Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus
    Patent number: 8343550
    Abstract: Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: January 1, 2013
    Assignee: Bend Research, Inc.
    Inventors: Ronald A. Beyerinck, Heather L. M. Deibele, Dan E. Dobry, Roderick J. Ray, Dana M. Settell, Ken R. Spence
  • Solid pharmaceutical dispersions with enhanced bioavailability
    Patent number: 8337899
    Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: December 25, 2012
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
  • PHARMACEUTICAL COMPOSITIONS OF SEMI-ORDERED DRUGS AND POLYMERS
    Publication number: 20120322805
    Abstract: A solid composition of a low-solubility drug and a concentration-enhancing polymer has a portion of the drug in a semi-ordered state.
    Type: Application
    Filed: August 23, 2012
    Publication date: December 20, 2012
    Applicant: BEND RESEARCH, INC.
    Inventors: Walter C. Babcock, William B. Caldwell, Marshall D. Crew, Dwayne T. Friesen, Ravi M. Shanker, Daniel T. Smithey
  • Nanoparticles comprising a drug, ethylcellulose, and a bile salt
    Patent number: 8309129
    Abstract: A pharmaceutical composition comprises nanoparticles comprising a poorly water-soluble drug, ethylcellulose, and a bile salt.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: November 13, 2012
    Assignee: Bend Research, Inc.
    Inventors: Warren Kenyon Miller, Michael Mark Morgen, Daniel Tod Smithey
  • Solid pharmaceutical dispersions with enhanced bioavailability
    Patent number: 8263128
    Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: September 11, 2012
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
  • Solid pharmaceutical dispersions with enhanced bioavailability
    Patent number: 8257741
    Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.
    Type: Grant
    Filed: June 9, 2003
    Date of Patent: September 4, 2012
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
  • Pharmaceutical compositions of semi-ordered drugs and polymers
    Patent number: 8257739
    Abstract: A solid composition of a low-solubility drug and a concentration-enhancing polymer has a portion of the drug in a semi-ordered state.
    Type: Grant
    Filed: August 5, 2003
    Date of Patent: September 4, 2012
    Assignee: Bend Research, Inc.
    Inventors: Walter C. Babcock, William B. Caldwell, Marshall D. Crew, Dwayne T. Friesen, Ravi M. Shanker, Daniel T. Smithey
  • Taste-masked drugs in rupturing multiparticulates
    Patent number: 8236349
    Abstract: A pharmaceutical composition comprises multiparticulates comprising a drug, a matrix material, and swelling agent. In one aspect, the multiparticulates comprise a core comprising a drug, and a coating surrounding the core. The coating is selected from the group consisting of (i) a water-permeable, substantially drug-impermeable coating, and (ii) an anti-enteric coating.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: August 7, 2012
    Assignee: Bend Research Inc.
    Inventors: Leah Elizabeth Appel, Dwayne Thomas Friesen, Edward Dennis LaChapelle, Sanjay Konagurthu, Richard Frank Falk, Joseph P. Reo
  • Pharmaceutical compositions of dispersions of amorphous drugs mixed with polymers
    Patent number: 8236328
    Abstract: A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.
    Type: Grant
    Filed: July 8, 2008
    Date of Patent: August 7, 2012
    Assignee: Bend Research, Inc.
    Inventors: Walter C. Babcock, William J. Curatolo, Dwayne T. Friesen, Rodney J. Ketner, Julian B. Lo, James A. S. Nightingale, Ravi M. Shanker, James B. West
  • Pharmaceutical compositions with enhanced performance
    Patent number: 8207232
    Abstract: Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) and hydroxypropyl methyl cellulose acetate (HPMCA) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low-solubility drug and such polymers, the polymers provide enhanced aqueous concentrations and/or improved physical stability.
    Type: Grant
    Filed: May 18, 2005
    Date of Patent: June 26, 2012
    Assignee: Bend Research, Inc.
    Inventors: Walter C. Babcock, Dwayne T. Friesen, David Keith Lyon, Warren Kenyon Miller, Daniel Tod Smithey
  • Pharmaceutical compositions providing enhanced drug concentrations
    Patent number: 8202912
    Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: June 19, 2012
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
  • Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
    Patent number: 8197848
    Abstract: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: June 12, 2012
    Assignee: Bend Research, Inc.
    Inventors: Marshall D. Crew, William J. Curatolo, Dwayne T. Friesen, Michael J. Gumkowski, Douglas A. Lorenz, James A. S. Nightingale, Roger B. Ruggeri, Ravi M. Shanker
  • Pharmaceutical compositions of drugs and neutralized acidic polymers
    Patent number: 8173142
    Abstract: Pharmaceutical compositions comprised of low-solubility and/or acid-sensitive drugs and neutralized acidic polymers are disclosed.
    Type: Grant
    Filed: June 5, 2006
    Date of Patent: May 8, 2012
    Assignee: Bend Research, Inc.
    Inventors: Marshall Crew, Dwayne T. Friesen, Rodney J. Ketner, Ravi M. Shanker, James B. West
  • Pharmaceutical compositions of cholesteryl ester transfer protein inhibitor
    Patent number: 8048452
    Abstract: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
    Type: Grant
    Filed: June 2, 2006
    Date of Patent: November 1, 2011
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Dwayne T. Friesen, Michael J. Gumkowski, Douglas A. Lorenz, James A. S. Nightingale, Roger B. Ruggeri, Ravi M. Shanker
  • Pharmaceutical compositions providing enhanced drug concentrations
    Patent number: 8026286
    Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
    Type: Grant
    Filed: December 20, 2000
    Date of Patent: September 27, 2011
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
  • Dosage forms comprising a CETP inhibitors and an HMG-CoA reductase inhibitor
    Patent number: 7897175
    Abstract: A dosage form comprises (1) a solid amorphous dispersion comprising a cholesterol ester transfer protein inhibitor and an acidic concentration-enhancing polymer and (2) an HMG-CoA reductase inhibitor. The solid amorphous dispersion and the HMG-CoA reductase inhibitor are combined in the dosage form so that the solid amorphous dispersion and the HMG-CoA reductase inhibitor are substantially separate from one another in the dosage form.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: March 1, 2011
    Assignee: Bend Research, Inc.
    Inventors: Dwayne T. Friesen, David K. Lyon, Douglas A. Lorenz, Bruno C. Hancock, Timothy J. McDermott, Ravi M. Shanker
  • Pharmaceutical compositions comprising drug and concentration-enhancing polymers
    Patent number: 7887840
    Abstract: A solubility-improved drug form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same drug form without the concentration-enhancing polymer.
    Type: Grant
    Filed: June 20, 2002
    Date of Patent: February 15, 2011
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Dwayne T. Friesen
  • NANOPARTICLES COMPRISING A NON-IONIZABLE POLYMER AND AN AMINE-FUNCTIONALIZED METHACRYLATE COPOLYMER
    Publication number: 20100297237
    Abstract: A pharmaceutical composition comprises nanoparticles comprising a poorly water soluble drug, a poorly aqueous soluble non-ionizable polymer, and an amine-functionalized methacrylate copolymer.
    Type: Application
    Filed: December 5, 2008
    Publication date: November 25, 2010
    Applicant: Bend Research, Inc.
    Inventors: Corey J. Bloom, Marshall David Crew, Warren Kenyon Miller
  • Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles
    Patent number: 7780988
    Abstract: Homogeneous solid amorphous dispersions of drugs in concentration-enhancing polymers are formed in desirable larger particle sizes with minimal fines by using an atomizer and process conditions capable of producing droplets having an average diameter of at least 50 microns and a D10 of at least 10 microns.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: August 24, 2010
    Assignee: Bend Research, Inc.
    Inventors: Ronald A. Beyerinck, Roderick J. Ray, Dan E. Dobry, Dana M. Settell