Abstract: A system for the automated preparation of a biological sample or of a biological mixture, including at least: a plate support; a plate including a body, from which a plurality of wells extends, the plate being at least partially housed in the plate support; at least one cooling module; wherein the plate is positioned on the cooling module so that each well of the plate is partially inserted into the cooling module, the body of the plate being at a predetermined distance from the cooling module so as to delimit a space between the body of the plate and the cooling module.

Abstract: A method for quantifying at least one microorganism group via at least one mass spectrometry analysis is described. The method includes at least one separation and fragmentation step. The method moreover includes a step that involves measuring the amount of at least one representative peptide or at least one protein representing the microorganism group. The at least one representative peptide or the at least one protein is obtained after the at least one separation and fragmentation step and serves as a quantification marker(s). The amount of the quantification marker(s) is directly correlatable to the amount of the at least one microorganism group.

Abstract: A method for performing fluorescence measurement on a sample, including: illuminating the sample using a light source, acquiring at least one fluorescence image of the illuminated sample, and processing the fluorescence image to determine a fluorescence intensity of the sample; characterized in that processing the fluorescence image to determine a fluorescence intensity of the sample includes: extracting, from the fluorescence image, a region of interest (ROI) free from artefacts, by application of a trained model, and determining the fluorescence intensity of the sample from the extracted region of interest.

Abstract: A method and system for measuring values of one or several characterizing parameters representative of the kinetics of an assay chemical reaction, including: providing a calibration tool having a reaction chamber; for a given set of defining features, performing a series of calibration experiments under different sets of calibration values of at least one operating parameter; providing a digital calibration model representative of the kinetics of the assay chemical reaction in the calibration tool, where the assay digital calibration model includes one or several characterizing parameters, the values of which have a dependency on the given set of defining features used for the calibration experiments; fitting, by computation, the values of the characterizing parameters for the given set of defining features, based on the series of calibration experiment results; and where the reaction chamber is a stirred-tank reactor.

Abstract: A method for detecting an immune cellular response including the steps of: (a) suctioning a defined amount of the sample by an automated suction/discharge device, (b) discharging this amount, using the device, into container R, containing, beforehand, at least one stimulant for secretion of the molecule by the at least one cell, or else not containing such a stimulant, (c) when the container does not contain the stimulant beforehand, introducing into container R the at least one secretion stimulant contained in container E, using the device, and (d) allowing the sample and stimulant to incubate, forming a mixture, by the at least one cell (i) in container R or (ii) in another container S after suctioning and discharge of the mixture using the device, and (e) detecting the immune cellular response, the detection of the immune cellular response indicates the presence of an immune cellular response specific for the stimulant.

Abstract: An obturation element (1) for a well receiving a chemical or biological solution to be analyzed, including for each well, a plug (4) including an insertion sleeve (5) in the form of a cylinder provided with two truncated areas (15) arranged in a symmetrically opposite manner on the outside of the sleeve to form vents, this insertion sleeve (5) being provided with a bottom wall (9) in which a through-cutout (18) is arranged, oriented radially in the direction of the two truncated areas (15).

Abstract: A method for extracting nucleic acids using suitable solid supports, for example silica-based. In particular, the method includes a step of capturing nucleic acids by placing the sample in contact with a suitable solid support, characterized in that, prior to the capture step, said method includes a step of treating the sample with at least one reagent for masking the amine or carboxylic acid functional groups of the proteins and/or polysaccharides of the sample.

Abstract: A system for extracting components from a biological sample, the system including at least one extraction platform, a magnetic extraction module including a magnetic portion and a securing portion for securing the module to the extraction platform, the magnetic portion including at least one magnet that is fixedly mounted relative to the securing portion, the extraction platform including a pipetting support that is configured to co-operate with a pipetting device, characterised in that the magnetic portion of the magnetic extraction module has at least one position of use in which the magnetic portion is fixed at least relative to the pipetting support.

Abstract: The invention provides an analysis plate (10) including at least one analysis zone for receiving a sample to be analyzed by mass spectrometry using the MALDI-TOF technique, the plate being of the type having at least one test face (12) with at least one analysis zone defined thereon and of the type in which the plate includes a support (18) that is plane, the plate being characterized in that the support (18) comprises at least one sheet (20) of paper material comprising cellulose fibers, and in that the analysis plate (10) includes at least one ply (24) of metal material.

Abstract: A method for manufacturing a biological analysis card includes a biological sample pre-treatment chamber configured to receive a biological sample including biological components such as biological cells, said pre-treatment chamber including solid bodies configured to mechanically separate all or some of the components of the biological sample in order to make available all or some of said components of the biological sample for a biological analysis treatment, the method being characterised in that it includes a step of depositing the solid bodies in the pre-treatment chamber in the form of a solid agglomerate, said agglomerate including the solid bodies and a binder which binds the solid bodies together.

Abstract: A method for determining, in vitro or ex vivo, the presence in a patient of an infection by a replicating respiratory virus, including a step i) of determining, in a test sample taken from the mouth or nose of said patient, the level of transcripts of at least one marker gene selected from the interferon-stimulated genes, referred to as ISGs; and associated kits.

Abstract: A method for determining in vitro or ex vivo the immune status of an individual, preferably a patient, including a step of detecting and/or quantifying the expression of one or more HERV/MaLR sequences in a biological sample of the individual. Also relates to the tools for implementing the method and to the uses thereof.

Abstract: An in vitro or ex vivo method for determining the risk of incidence of a healthcare-associated infection in a patient, including a step of measuring the expression of at least one gene encoding a pro-inflammatory cytokine receptor located on chromosome 2 in the region 2q11-2q12, in a biological sample from the patient.

Abstract: An extraction system includes a support bar including a sample well, a reagent well, at least one washing well, and at least one protection and retention housing; a pipetting element removably mounted on the support bar and extending at least partially into the at least one protection and retention housing; and a filtering and transfer device configured to capture and accumulate microorganisms contained in the sample and transfer the captured and accumulated microorganisms, the filtering and transfer device being removably mounted on the support bar and extending at least partially into the at least one protection and retention housing. The filtering and transfer device includes a hollow body having an elongated shape and including a proximal end portion and a distal end portion; and a filtering element fixed to the distal end portion of the hollow body.

Abstract: A method for quantifying at least one microorganism group via at least one mass spectrometry analysis. The method includes at least one separation and fragmentation step. The method moreover includes a step that involves measuring the amount of at least one representative peptide or at least one protein representing the microorganism group. The at least one representative peptide or the at least one protein is obtained after the at least one separation and fragmentation step and serves as a quantification marker(s). The amount of the quantification marker(s) is directly correlatable to the amount of the at least one microorganism group.

Abstract: An analysis plate configured to allow a characterization of microorganisms by mass spectrometry, wherein the analysis plate includes at least one analysis zone configured for a biological sample containing a population of at least one microorganism, wherein all or part of the analysis zone is made of a porous material, the analysis zone including at least one antimicrobial agent.

Abstract: Detection method for sample presence and device associated The invention relates to a detection method of liquid presence inside a well of a transparent or translucent support intended for analysis performed in a device for in vitro detection and/or quantification, the presence of liquid being assessed on the basis of an index of visible pattern likelihood representative of the probability of a pattern to be legible as expected in the field of view of an imager. Said invention allows preventing assay execution without sample and can be applied without wasting sample or sample well support in case of the sample well is not filled by the user. Moreover, this method allows a precise detection of the samples that are transparent or translucent, with low reflectance.