Patents Assigned to bioMérieux
  • Patent number: 12264312
    Abstract: A method for extracting nucleic acids using suitable solid supports, for example silica-based. In particular, the method includes a step of capturing nucleic acids by placing the sample in contact with a suitable solid support, characterized in that, prior to the capture step, said method includes a step of treating the sample with at least one reagent for masking the amine or carboxylic acid functional groups of the proteins and/or polysaccharides of the sample.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: April 1, 2025
    Assignee: BIOMÉRIEUX
    Inventors: Alain Laurent, Arnaud Burr, Ali Laayoun
  • Publication number: 20250102532
    Abstract: A system for extracting components from a biological sample, the system including at least one extraction platform, a magnetic extraction module including a magnetic portion and a securing portion for securing the module to the extraction platform, the magnetic portion including at least one magnet that is fixedly mounted relative to the securing portion, the extraction platform including a pipetting support that is configured to co-operate with a pipetting device, characterised in that the magnetic portion of the magnetic extraction module has at least one position of use in which the magnetic portion is fixed at least relative to the pipetting support.
    Type: Application
    Filed: January 17, 2023
    Publication date: March 27, 2025
    Applicant: BIOMÉRIEUX
    Inventors: Edgard MINASSIAN, Jean-Claude RAYMOND
  • Publication number: 20250092472
    Abstract: A method for in vitro or ex vivo assessment of the risk of complications in a patient admitted to a healthcare facility includes measuring the viral load of at least one torque teno virus (TTV) in a biological sample of the patient, wherein the patient is not undergoing immunosuppressive treatment.
    Type: Application
    Filed: July 19, 2022
    Publication date: March 20, 2025
    Applicants: BIOMERIEUX, BIOASTER, HOSPICES CIVILS DE LYON
    Inventor: François MALLET
  • Publication number: 20250065328
    Abstract: An analysis card for analysing a biological sample by means of an in-vitro diagnostic instrument, the analysis card including a plurality of wells formed in a board, each well containing at least one reagent, the analysis card including a channel for conveying a liquid sample to the wells, characterised in that each well forms, in the board, an internal space defined by a lateral surface, the lateral surface including at least one wall, and in that each well has the at least one reagent deposited only on its lateral surface.
    Type: Application
    Filed: December 28, 2022
    Publication date: February 27, 2025
    Applicant: BIOMERIEUX
    Inventors: Patrick BROYER, Jérôme BLAZE, Frédéric PINSTON, Matthieu GOUJARD
  • Patent number: 12220695
    Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.
    Type: Grant
    Filed: October 31, 2023
    Date of Patent: February 11, 2025
    Assignee: bioMerieux, Inc.
    Inventors: Christopher S. Ronsick, Kirk Ririe, Mark S. Wilson, John D. Walsh, Ryan T. Hill
  • Patent number: 12209959
    Abstract: A method for analysing a biological sample by means of an analysis instrument, the sample including biological agents and being arranged in an analysis receptacle in view of a holographic imaging system, the method including: acquiring a holographic image of the sample, the holographic image associating an intensity value with each pixel, determining, from the image acquired, an image mask which associates an active or inactive state with each pixel in accordance with the intensity values so that an inactive state is associated with pixels which correspond to artefacts caused by elements present in the field of view other than biological agents, determining a value of at least one biomass parameter which represents the quantitative spatial distribution of biological agents in the field of view, using only the pixels of the holographic image having an active state, and supplying the value of the biomass parameter from the analysis results.
    Type: Grant
    Filed: September 23, 2021
    Date of Patent: January 28, 2025
    Assignee: BIOMERIEUX
    Inventors: Dominique Decaux, Emilie Bisceglia, Guillaume Perrin, Philippine Barlas, Emilie Collignon
  • Patent number: 12211681
    Abstract: A method for determining the integrity of at least one complex based on at least one biological sample and at least one matrix, including at least the following steps:—acquiring at least one image,—analyzing the image sent by extracting light intensity values representative of at least one spectral band,—relating the light intensity values to one another to obtain representative spectral data,—determining a state of integrity of the complex by comparing each of the representative spectral data by similarity grouping with a determined similarity threshold,—triggering at least one first alert, by the analysis unit, when the representative data are similar to the first state of integrity or to the second state of integrity.
    Type: Grant
    Filed: January 13, 2021
    Date of Patent: January 28, 2025
    Assignee: BIOMERIEUX
    Inventors: Denis Leroux, Jean-Philippe Charrier, Régis Montvernay, Philippe Wandels
  • Patent number: 12191129
    Abstract: A method of identifying a microorganism by mass spectrometry, including acquiring at least one mass spectrum of said microorganism; for each acquired mass spectrum: detecting peaks of the spectrum in a predetermined mass range; generating a list of peaks identifying at most one peak in each interval of a predetermined subdivision of the range of mass-to-charge ratios, the width of the intervals of the subdivision logarithmically increasing along with the mass-to-charge ratio, and analyzing the list(s) of peaks obtained according to a knowledge base of previously-identified microorganisms and/or types of microorganisms.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: January 7, 2025
    Assignee: BIOMERIEUX, INC.
    Inventors: Grégory Strubel, Maud Arsac, Denis Desseree, Pierre-Jean Cotte-Pattat
  • Patent number: 12186754
    Abstract: The invention provides an analysis plate (10) including at least one analysis zone for receiving a sample to be analyzed by mass spectrometry using the MALDI-TOF technique, the plate being of the type having at least one test face (12) with at least one analysis zone defined thereon and of the type in which the plate includes a support (18) that is plane, the plate being characterized in that the support (18) comprises at least one sheet (20) of paper material comprising cellulose fibers, and in that the analysis plate (10) includes at least one ply (24) of metal material.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: January 7, 2025
    Assignee: BIOMÉRIEUX
    Inventors: Patrick Broyer, Nadine Perrot, Jérôme Blaze, Jean-Marie Baumlin
  • Publication number: 20250001411
    Abstract: A method for manufacturing a biological analysis card includes a biological sample pre-treatment chamber configured to receive a biological sample including biological components such as biological cells, said pre-treatment chamber including solid bodies configured to mechanically separate all or some of the components of the biological sample in order to make available all or some of said components of the biological sample for a biological analysis treatment, the method being characterised in that it includes a step of depositing the solid bodies in the pre-treatment chamber in the form of a solid agglomerate, said agglomerate including the solid bodies and a binder which binds the solid bodies together.
    Type: Application
    Filed: October 10, 2022
    Publication date: January 2, 2025
    Applicant: BIOMÉRIEUX
    Inventor: Frédéric FOUCAULT
  • Patent number: 12172169
    Abstract: Systems, methods, and apparatuses are provided for self-contained nucleic acid preparation, amplification, and analysis.
    Type: Grant
    Filed: May 19, 2023
    Date of Patent: December 24, 2024
    Assignees: BioFire Defense, LLC, BioFire Diagnostics, LLC, bioMérieux, S.A.
    Inventors: Kirk M. Ririe, Aaron D. Wernerehl, Christopher P. Pasko, Ali Laayoun, Carole Vachon, Agnès Dupont-Filliard, Laurent Mesta, Andrew C. Hatch, Erik W. Huynh, David E. Jones
  • Publication number: 20240417799
    Abstract: A method for determining in vitro or ex vivo the immune status of an individual, preferably a patient, including a step of detecting and/or quantifying the expression of one or more HERV/MaLR sequences in a biological sample of the individual. Also relates to the tools for implementing the method and to the uses thereof.
    Type: Application
    Filed: July 15, 2024
    Publication date: December 19, 2024
    Applicant: BIOMERIEUX
    Inventors: Marine MOMMERT, Olivier TABONE, Julien TEXTORIS, François MALLET
  • Publication number: 20240412369
    Abstract: The present invention relates to a method for predicting the susceptibility of a microbial strain to an antimicrobial agent, the method being characterized in that it comprises implementation, by data-processing means (4) of a client (2), of steps of: (a) obtaining a hyperspectral image between 390 nm and 900 nm representing at least one colony of said strain in a sample devoid of antimicrobial agent (22); (b) determining a spectrum of the colony based on pixels of said hyperspectral image corresponding to said colony, “test spectrum” below; (c) comparing said test spectrum with microbial classes of a database of predetermined data, “reference microbial class” below, said classes corresponding to a taxonomic level lower than species and being learnt using at least one hyperspectral spectrum of a microbial strain, the database containing, for each reference microbial class, the susceptibility to the microbial agent of the reference microbial class; (d) determining the susceptibility of the microbial strain to
    Type: Application
    Filed: November 24, 2022
    Publication date: December 12, 2024
    Applicant: BIOMERIEUX
    Inventors: Bruno TETART, Nicolas FAURE, Denis LEROUX, Jean-Marc ROCHE, Jordane LALLEMAND
  • Patent number: 12162005
    Abstract: Systems, methods, and apparatus are provided for evacuating and for filling an array at the point of use.
    Type: Grant
    Filed: March 14, 2022
    Date of Patent: December 10, 2024
    Assignees: BIOMERIEUX, INC., BIOFIRE DEFENSE, LLC
    Inventors: Aaron Wernerehl, David E. Jones, Taylor Zimmerman, Kirk M. Ririe
  • Publication number: 20240337671
    Abstract: A method for quantifying endotoxins in a biological sample with an analysis medium added to the field of view of an imager, the analysis medium including at least one analysis chamber and a plurality of reference chambers, including the steps of, for each of a plurality of measuring times of a measuring period: a) acquiring an image and determining light intensity valves in the reference and analysis chambers; b) determining a calibration relationship connecting the light intensity value and the concentration at this measuring time; c) determination of at least one endotoxin concentration in a biological sample from said calibration relationship and the intensity value in the analysis chamber at said measurement time; the method subsequently including the step of d) determining a temporal evolution of an endotoxin concentration in the biological sample over the course of the measuring period from the endotoxin concentration for a plurality of measurement times.
    Type: Application
    Filed: July 19, 2022
    Publication date: October 10, 2024
    Applicant: BIOMERIEUX
    Inventors: Matthieu GOUJARD, Patrick BROYER, Frédéric PINSTON
  • Patent number: 12110556
    Abstract: A kit for in vitro measurement of a at least one IL7R gene transcript in a blood sample, including specific reagents for measuring the transcript, and a control sample calibrated to contain the IL7R gene transcript corresponding to the mean quantity measured in a pool of reference blood samples from human patients in a state of septic shock when reference blood samples are taken, or who were in a state of septic shock within 72 h after taking the reference blood samples, and who were known to have survived, and/or a calibrated to contain the quantity of an IL7R gene transcript corresponding to the mean quantity measured in reference blood samples from patients in a state of septic shock when the reference blood samples are taken, or who were in a state of septic shock within 72 h after taking the reference blood samples, and not to have survived.
    Type: Grant
    Filed: April 26, 2022
    Date of Patent: October 8, 2024
    Assignees: BIOMERIEUX, HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD
    Inventors: Elisabeth Cerrato, Benjamin Delwarde, Guillaume Monneret, Estelle Peronnet, Julien Textoris, Fabienne Venet
  • Publication number: 20240318268
    Abstract: A method for determining, in vitro or ex vivo, the presence in a patient of an infection by a replicating respiratory virus, including a step i) of determining, in a test sample taken from the mouth or nose of said patient, the level of transcripts of at least one marker gene selected from the interferon-stimulated genes, referred to as ISGs; and associated kits.
    Type: Application
    Filed: July 7, 2022
    Publication date: September 26, 2024
    Applicants: BIOMÉRIEUX, HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD LYON I
    Inventors: Sophie ASSANT, Karen BRENGEL-PESCE, Marine MOMMERT
  • Patent number: 12099054
    Abstract: The invention relates to unmasking endotoxins in compositions so that previously present, but undetectable endotoxins are rendered detectable.
    Type: Grant
    Filed: September 29, 2020
    Date of Patent: September 24, 2024
    Assignee: BIOMÉRIEUX DEUTSCHLAND GMBH
    Inventors: Johannes Reich, Holger Grallert
  • Patent number: D1057197
    Type: Grant
    Filed: August 25, 2021
    Date of Patent: January 7, 2025
    Assignee: bioMérieux
    Inventors: Cyril Mézière, Philippe Marbaix, Enrico Balatri
  • Patent number: D1057199
    Type: Grant
    Filed: August 10, 2022
    Date of Patent: January 7, 2025
    Assignee: BIOMÉRIEUX, INC.
    Inventors: Michael Z. Blair, Jared Bullock, Greg Krisher