Abstract: Systems and methods for determining a topology for a multi-path connection based on one or more application-level wherein, a method performed by a master topology function includes receiving a request for a topology for a multi-path connection that satisfies an application-level requirement(s) of a particular application and determining a topology for the multi-path connection based on the application-level requirement(s). The topology includes two or more links from a source wireless node to a target wireless communication device and at least one of the two or more links is a multi-hop link from the source wireless node to the target wireless communication device via one or more additional wireless communication devices that operate as relays. The method further includes configuring the source wireless node, the target wireless communication device, and the one or more additional wireless communication devices in accordance with the determined topology.

Abstract: The present invention concerns reagents for the reversible protection of biological molecules. It relates in particular to compounds derived from azaisatoic anhydride and their uses for the protection of biological molecules, particularly enzymes, in order to block their activity. The invention also relates to the biological molecules protected in this manner and to the methods for making use of these reagents.

Abstract: Instruments, systems, and methods for measuring optical density of microbiological samples are provided. In particular, optical density instruments providing improved safety, efficiency, comfort, and convenience are provided. Such optical density instruments include a handheld portion and a base station. The optical density instruments may be used in systems and methods for measuring optical density of biological samples.

Abstract: An in vitro or ex vivo method for determining the risk of complication in a patient, including a step of measuring the expression of C3AR1 in a biological sample from the patient.

Abstract: A method for analysing a biological sample by means of an analysis instrument, the sample including biological agents and being arranged in an analysis receptacle in view of a holographic imaging system, the method including: acquiring a holographic image of the sample, the holographic image associating an intensity value with each pixel, determining, from the image acquired, an image mask which associates an active or inactive state with each pixel in accordance with the intensity values so that an inactive state is associated with pixels which correspond to artefacts caused by elements present in the field of view other than biological agents, determining a value of at least one biomass parameter which represents the quantitative spatial distribution of biological agents in the field of view, using only the pixels of the holographic image having an active state, and supplying the value of the biomass parameter from the analysis results.

Abstract: The invention relates to an in vitro or ex vivo method for determining the risk of incidence of a care-related infection in a patient, including a step of measuring the expression of CIITA in a biological sample from said patient.

Abstract: A method for identifying a pathogen contained in a metagenomic sample and for identifying pathogenic markers in the genome of the pathogen includes: processing the sample to extract DNA from pathogens, sequencing the extracted DNA, thereby producing a set of reads, comparing the reads to a database of genomes of known pathogens to assign reads to the pathogens; producing a pool of reads and assembling them to produce contigs, comparing the contigs to a second database of markers to check whether they contain a marker. The method further includes the step of comparing the reads to the second database to assign reads to the markers, a read being assigned to a marker if it falls entirely into or is astride the marker, and the pool also includes the reads assigned to the markers, the contigs thereby being assembled from reads assigned to a pathogen and reads assigned to markers.

Abstract: A method of measuring an analyte amount in a whole blood sample, including (i) measuring the haematocrit level of the whole blood sample; (ii) measuring an analyte amount directly in the whole blood sample; and (iii) calculating a corrected analyte amount according to relation DP=Pa(DST, DH), where Dp, is the corrected analyte amount, DST is the measured analyte amount, DH is the measured haematocrit level, and Pa is a non-constant polynomial of a degree greater than or equal to 1 having as indeterminate values the measured analyte amount, DST, and the measured haematocrit level, DH, and having its polynomial coefficients depending on the analyte.

Abstract: The present invention is directed to sample test cards having an increased sample well capacity for analyzing biological or other test samples. In one embodiment, the sample test cards of the present invention comprise one or more fluid over-flow reservoirs, wherein the over-flow reservoirs are operatively connected to a distribution channel by a fluid over-flow channel. In another embodiment, the sample test cards may comprise a plurality of flow reservoirs operable to trap air thereby reducing and/or preventing well-to-well contamination. The test card of this invention may comprise from 80 to 140 individual sample wells, for example, in a test card sample test cards of the present invention have a generally rectangular shape sample test card having dimensions of from about 90 to about 95 mm in width, from about 55 to about 60 mm in height and from about 4 to about 5 mm in thickness.

Abstract: An in vitro or ex vivo method for determining the risk of incidence of a care-related infection includes a step of measuring the expression of CD177 in a biological sample from said patient.

Abstract: A focus adjustment method for acquiring an image of a surface of interest of a sample by a holographic imager includes the steps of: placing the sample including at least one reference object having a known shape and described by characterising parameters having at least position parameters acquiring an image and determining the position of the reference object with respect to the acquisition plane, by applying a light diffraction model involving the spatial parameters of the reference object estimated by approximating the appearance of the reference object in the holographic image acquired, and determining the position of the surface of interest with respect to the acquisition plane from a position of the reference object and focus adjustment of the image acquisition.

Abstract: The present invention concerns reagents for the reversible protection of biological molecules. It relates in particular to compounds derived from azaisatoic anhydride and their uses for the protection of biological molecules, particularly enzymes, in order to block their activity. The invention also relates to the biological molecules protected in this manner and to the methods for making use of these reagents.

Abstract: An in vitro or ex vivo method for determining the risk of incidence of a healthcare-associated infection includes a step of measuring the expression of TAP2 in a biological sample from said patient.

Abstract: The subject of the invention relates to a tool for manipulating a plurality of plugs, taking the form of a comb (1) comprising: a body (7) provided with a row of teeth (4) having pointed distal portions (4p) spaced apart in a linear direction in order to engage with the cavities of the plugs; a system for separating the plugs from the teeth (4) that comprises a slide returned elastically and guided to slide with respect to the body (7) in a direction parallel to the direction of extension of the teeth, the slide being provided with the fingers of the comb, which are movable by sliding between the teeth (4), and a control (11a) accessible from a first portion (1a) of the comb and which, when pressed to move translationally, causes the fingers of the comb to slide in the direction of the pointed distal portions (4p) in order to eject the plugs from the teeth (4).

Abstract: The invention relates to a device comprising: a support tray (7) for tubes receiving samples to be analyzed, this tray (7) having holes (8) adapted to each receive a tube bearing on the upper surface and with its bottom protruding from the tray; a lid (10) provided with chimneys (11) arranged according to a distribution similar to the distribution of the holes of the tray, this lid (10) being designed to occupy at least one position of superposition above the tray (7), so that the lid can be removably assembled to the tray to form a unitary assembly for holding the tubes and to position the chimneys (11) above the tubes in order to guide the pipette tips penetrating inside the tubes.

Abstract: An in vitro or ex vivo method, based on the measurement of the expression of cytokine(s), from a patient's blood sample, incubated with a stimulus, for determining the risk of occurrence of a healthcare-associated infection in the patient, within seven days following the day on which the collection of the biological sample has been performed from the patient.

Abstract: A method, computer program product, and apparatus are provided for controlling components of a detection device. The device may detect turbidity of liquid with sensors such as a density sensor and/or nephelometric sensor. A light modulation pattern may reduce or eliminate interference in sensor readings. Readings may be performed during off cycles of an illumination light to reduce interference but to provide improved visibility of a tube. Dark and light sensor readings may be performed with an emitter respectively off or on to account for ambient light in subsequent readings. Readings from the density sensor and/or nephelometric sensor may be used to calculate McFarland values. The device may be zeroed based on an emitter level that results in a sensor reading satisfying a predetermined criterion.

Abstract: A method for quantifying the sensibility of a test microorganism to a concentration of an antimicrobial agent includes: preparing two liquid samples including the microorganism, one having the antimicrobial agent and one without; for each sample acquiring, by a flow cytometer, a digital set values including a fluorescence, forward, or side scatter distribution, and computing: a first coordinate value corresponding to the acquired distribution main mode and an acquired distribution first area for values greater than the first coordinate value, and a second coordinate value, greater than the first, for which an acquired distribution second area between the values equals a first area predefined percentage over 50%; computing a ratio according to: Q = QT ? ( ATB ) - Mode ? ( ATB ) QT ? ( no ? ? ATB ) - Mode ? ( no ? ? ATB ) where Mode(ATB) and QT(ATB) are the first and second coordinate values with the antimicrobial agent concentration, and Mode(no ATB) and QT(no ATB) are r

Abstract: A process of determining a phenotypic trait of a bacterial strain comprises sequencing part or all of the genome of the strain, and applying to the sequenced genome a predetermined model for predicting the trait, the model having groups of genome sequences as variables. According to the invention, the groups are chosen so that a co-occurrence rate in the genome of the bacterial species of the constituent genome sequences of the groups is above a predetermined threshold, and the groups are clusterings of the genome sequences according to their co-occurrence rates in the genome of the bacterial species.