Patents Assigned to Biomed
  • Patent number: 11578119
    Abstract: The present disclosure is directed to leukotoxin-binding antibodies and antigen-binding fragments thereof. The antibodies and fragments can be used, for example, to detect leukotoxin and/or in methods of treating and preventing Staphylococcus aureus infections.
    Type: Grant
    Filed: June 7, 2021
    Date of Patent: February 14, 2023
    Assignees: MedImmune LLC, Humabs BioMed SA
    Inventors: Christine Tkaczyk, Bret Sellman, Qun Du, Melissa Damschroder, Davide Corti, Andrea Minola
  • Patent number: 11576962
    Abstract: The present invention provides a fusion polypeptide that induces a humoral immune response and a cellular immune response to a virus, containing antigens or fragments thereof of the following (a) and (b), and having an oligomerization activity: (a) an antigen of the virus or a fragment thereof containing a B cell epitope conserved among subtypes of the virus; and (b) an antigen of the virus or a fragment thereof containing a T cell epitope conserved among subtypes of the virus (wherein the antigen(s) or the fragment(s) thereof of (a) and/or (b) have an oligomerization activity, or the fusion polypeptide further contains (c) a polypeptide having an oligomerization activity in addition to the antigens or the fragments thereof (a) and (b)).
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: February 14, 2023
    Assignee: Green BioMed, Inc.
    Inventor: Kenji Sekikawa
  • Patent number: 11578333
    Abstract: The invention relates to the production and use of Cas-encoding sequences and vectors comprising these. Aspects of the invention provide products, vectors, delivery vehicles, uses and methods for producing Cas-encoding sequences in bacterial or archaeal cells.
    Type: Grant
    Filed: March 8, 2021
    Date of Patent: February 14, 2023
    Assignee: SNIPR Biome ApS
    Inventors: Virginia Martinez, Ruben Vazquez-Uribe, Adam Takos, Eric Van Der Helm, Jasper Clube
  • Publication number: 20220411513
    Abstract: Provided is an anti-PD-L1 antigen binding protein, capable of binding to primate-derived PD-L1 with a KD value of 1×10?8 M or less. The antigen binding protein can block the binding of PD-1 and CD80 to PD-L1, stimulate the secretion of cytokines in immune cells, and can inhibit tumor growth and/or tumor cell proliferation. Also provided is a fusion protein, comprising human TGFBRII or a fragment thereof and the antigen binding protein. Also provided is an application of the antigen binding protein and/or the fusion protein in the prevention and treatment of tumors or cancers.
    Type: Application
    Filed: September 29, 2020
    Publication date: December 29, 2022
    Applicant: Harbour BioMed (Shanghai) Co., Ltd
    Inventors: Yun HE, Shuwen REN, Bin LIU, Xin GAN, Donghai LI, Fei CHEN, Ling WANG, Jin LI, Yiping RONG
  • Patent number: 11534191
    Abstract: A loading device for loading a medical device into a catheter is provided. The loading device comprises a body having a lumen to receive an expandable portion of a medical device. The lumen has a length as the expandable portion when the latter is in a collapsed configuration and has a diameter that is greater than the collapsed configuration. The body comprises a first portion and a second portion that are reversibly separable to expose the lumen in an open configuration and enclose the lumen in a closed configuration. The first and second portions each comprise an inner face having a groove defining a first portion of the lumen and a second portion of the lumen, respectively. The body also has a distal tip portion to reversibly couple with a hemostatic valve of a delivery catheter. A method of loading a medical device into a catheter is also provided.
    Type: Grant
    Filed: December 24, 2019
    Date of Patent: December 27, 2022
    Assignee: Anaconda Biomed, S.L.
    Inventors: Robert Ros Fàbrega, Iñaki Galve Murillo, Ofir Arad Hadar, Ane Lizarazu Gonzalez
  • Patent number: 11534487
    Abstract: The present invention provides a fusion polypeptide that induces a humoral immune response and a cellular immune response to a virus, containing antigens or fragments thereof of the following (a) and (b), and having an oligomerization activity: (a) an antigen of the virus or a fragment thereof containing a B cell epitope conserved among subtypes of the virus; and (b) an antigen of the virus or a fragment thereof containing a T cell epitope conserved among subtypes of the virus (wherein the antigen(s) or the fragment(s) thereof of (a) and/or (b) have an oligomerization activity, or the fusion polypeptide further contains (c) a polypeptide having an oligomerization activity in addition to the antigens or the fragments thereof (a) and (b)).
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: December 27, 2022
    Assignee: Green BioMed, Inc.
    Inventor: Kenji Sekikawa
  • Patent number: 11512138
    Abstract: Polypeptides and proteins that specifically bind to and immunologically recognize CD276 are disclosed. Chimeric antigen receptors (CARs), anti-CD276 binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the polypeptides and proteins are also disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.
    Type: Grant
    Filed: March 18, 2020
    Date of Patent: November 29, 2022
    Assignees: The United States of America, as Presented by the Secretary, Department of Health and Human Services, Biomed Valley Discoveries, Inc.
    Inventors: Rimas J. Orentas, Zhongyu Zhu, Crystal L. Mackall, Dimiter S. Dimitrov, Bradley St. Croix, Saurabh Saha
  • Publication number: 20220363781
    Abstract: Related are an anti-TSLP antibody or an antigen-binding fragment thereof, nucleic acid molecules coding the same, and a method for preparing the same. The anti-TSLP antibody or the antigen-binding fragment thereof have high affinity to TSLP, capable of effectively binding with TSLP and blocking the proliferative effect of TSLP with respect to Ba/F3-hTSLPR-hIL7R? cells, and blocking the capability of TSLP in activating and secreting cytokines with respect to PBMC. At the same time, further related are a medicinal composition comprising the antibody or the antigen-binding fragment thereof, and uses of the composition in preparing a medicament for preventing and/or treating asthma, allergic inflammation, an allergic reaction or autoimmune disease.
    Type: Application
    Filed: December 8, 2020
    Publication date: November 17, 2022
    Applicants: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD., Harbour Biomed (Suzhou) Co., Ltd.
    Inventors: Liang XIAO, Jinqiu HE, Tongtong XUE, Hongshui LIU, Jingyi WANG, Hongzhuan GU, Shuntao LUO, Yiping RONG, Dengnian LIU, Yun HE
  • Publication number: 20220348652
    Abstract: Disclosed herein are recombinant antibodies exhibiting binding affinity to CD47 polypeptide. According to some embodiments of the present disclosure, the recombinant antibodies are capable of blocking the interaction of CD47 and signal receptor protein-alpha (SIRP?). Accordingly, also disclosed herein are pharmaceutical compositions comprising the recombinant antibodies, and uses thereof in the treatment CD47-related diseases.
    Type: Application
    Filed: April 22, 2022
    Publication date: November 3, 2022
    Applicant: AnTaimmu BioMed Co., Ltd.
    Inventors: San-Tai SHEN, Yueh-Liang TSOU, Jen-Chieh LIN, Chia-Chi LIU
  • Patent number: 11484611
    Abstract: A method for sterilizing biological materials is disclosed. A dehydrated biological material is put into a closed container. The closed container is then decompressed under a vacuum. Subsequently, 0.01 g/m3 to 1000 g/m3 of a sterilizing gas, i.e., pure ozone, is introduced into the container for a period of time until the biological material is sterilized.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: November 1, 2022
    Assignee: FM&G Biomed Co., Ltd.
    Inventor: Lynn L. H. Huang
  • Patent number: 11485973
    Abstract: The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.
    Type: Grant
    Filed: September 23, 2020
    Date of Patent: November 1, 2022
    Assignee: SNIPR Biome ApS
    Inventors: Morten Sommer, Virginia Martinez, Eric Van der Helm, Jakob Krause Haaber, Ana De Santiago Torio, Christian Grøndahl, Jasper Clube
  • Publication number: 20220290133
    Abstract: The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.
    Type: Application
    Filed: May 19, 2022
    Publication date: September 15, 2022
    Applicant: SNIPR Biome ApS
    Inventors: Morten SOMMER, Virginia MARTINEZ, Eric VAN DER HELM, Jakob Krause HAABER, Ana DE SANTIAGO TORIO, Christian GRØNDAHL, Jasper CLUBE
  • Publication number: 20220282245
    Abstract: The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.
    Type: Application
    Filed: May 20, 2022
    Publication date: September 8, 2022
    Applicant: SNIPR Biome ApS
    Inventors: Morten SOMMER, Virginia MARTINEZ, Eric VAN DER HELM, Jakob Krause HAABER, Ana DE SANTIAGO TORIO, Christian GRØNDAHL, Jasper CLUBE
  • Publication number: 20220275380
    Abstract: The invention relates to means for carrying out conjugation between bacteria, and in particular the invention relates to carrier (ie, donor) bacteria comprising antimicrobial agents and methods of use. A carrier bacterium is capable of conjugative transfer of DNA encoding the agent to a target cell (ie, recipient cell). The invention provides novel plasmids that are devoid a functional hypC2 nucleotide sequence for these purposes.
    Type: Application
    Filed: August 21, 2020
    Publication date: September 1, 2022
    Applicant: SNIPR Biome ApS
    Inventor: Andreas PORSE
  • Patent number: 11421227
    Abstract: The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: August 23, 2022
    Assignee: SNIPR Biome ApS
    Inventors: Morten Sommer, Virginia Martinez, Eric Van Der Helm, Jakob Krause Haaber, Ana De Santiago Torio, Christian Grøndahl, Jasper Clube
  • Publication number: 20220259588
    Abstract: The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.
    Type: Application
    Filed: April 25, 2022
    Publication date: August 18, 2022
    Applicant: SNIPR Biome ApS
    Inventors: Morten SOMMER, Virginia MARTINEZ, Eric VAN DER HELM, Jakob Krause HAABER, Ana DE SANTIAGO TORIO, Christian GRØNDAHL, Jasper CLUBE
  • Publication number: 20220257838
    Abstract: This disclosure relates to scaffolds made of a braid of bioabsorbable polymeric fibers for implantation within a lumen of a mammalian body and, in particular, to such scaffolds that are configured to divert blood flow from a pathology associated with a blood vessel.
    Type: Application
    Filed: May 6, 2022
    Publication date: August 18, 2022
    Applicant: Fluid Biomed Inc.
    Inventors: Alim P. Mitha, John H. Wong
  • Publication number: 20220227843
    Abstract: The present invention provides binding molecules, including monoclonal antibodies, multi-specific antibodies, and antibody fragments, that specifically bind to the coronavirus, such as SARS-CoV-2, and methods of use thereof. In some aspects of the invention, the binding molecules are human antibodies, fragments, or derivatives thereof that specifically bind to SARS-CoV-2 spike protein. In some aspects of the invention, the binding molecules function to neutralize SARS-CoV-2. The present invention also relates to methods of using the binding molecules and compositions for diagnosis and treatment.
    Type: Application
    Filed: January 12, 2022
    Publication date: July 21, 2022
    Applicant: Antaimmu BioMed Co., Ltd.
    Inventors: San-Tai Shen, Ing-Chien Chen, Kuang-Kai Liu, Frederick Y. Luh
  • Patent number: 11390600
    Abstract: The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.
    Type: Grant
    Filed: July 7, 2020
    Date of Patent: July 19, 2022
    Assignees: Biomed Valley Discoveries, Inc., Vertex Pharmaceuticals Incorporated
    Inventors: Gary DeCrescenzo, Dean Welsch, Petinka I. Vlahova, Stephan X. M. Boerrigter, Alexander Aronov, Ali Keshavarz-Shokri, Alexander N. Scangas, Kathy Stavropoulos, Benjamin Littler, Irina Nikolaevna Kadiyala, Rossitza Gueorguieva Alargova
  • Patent number: D974922
    Type: Grant
    Filed: May 11, 2021
    Date of Patent: January 10, 2023
    Assignee: Biom Innovations Inc.
    Inventors: Will Gahagan, Hank Schellenger