Patents Assigned to Biomed
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Patent number: 11013743Abstract: The present invention provides, inter alia, methods, kits, and pharmaceutical compositions for treating or ameliorating the effects of a cancer in a subject in need thereof. The method comprises administering to the subject an effective amount of (i) a first anti-cancer agent, which is BVD-523 or a pharmaceutically acceptable salt thereof and (ii) a second anti-cancer agent, which is a CDK inhibitor or a pharmaceutically acceptable salt thereof, to treat or ameliorate the effects of the cancer. Additional methods for effecting cancer cell death are also provided.Type: GrantFiled: December 19, 2014Date of Patent: May 25, 2021Assignee: BioMed Valley Discoveries, Inc.Inventors: Saurabh Saha, Dean Welsch, Gary DeCrescenzo, Jeffrey James Roix
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Patent number: 11007362Abstract: An exemplary method of inserting a peri-straight electrode array into a cochlea of a recipient includes positioning the peri-straight electrode array and an insertion tool within the recipient such that a distal end of the insertion tool is provided within the recipient at a location that is outside and not touching the cochlea of the recipient, and a straight distal portion of the peri-straight electrode array extends away from the distal end of the insertion tool and into the cochlea. The exemplary method further includes manually interacting with the insertion tool to advance the straight distal portion and at least some of a pre-curved proximal portion into the cochlea without allowing the insertion tool to enter or come in contact with the cochlea, and removing the insertion tool from the recipient such that the peri-straight electrode array remains within the cochlea after the insertion tool is removed from the recipient.Type: GrantFiled: November 16, 2018Date of Patent: May 18, 2021Assignee: Advanced Biomes AGInventors: Bing Xu, Mark B. Downing, Leonid M. Litvak
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Publication number: 20210130914Abstract: Disclosed are methods for screening biological samples for the presence unknown microbes, such as bacteria and archaea or unknown eukaryotes using rRNA gene sequences or other highly conserved genetic regions, across multiple biological samples using a unique sequence tag (barcode) corresponding to the sample. The screening process tracks the unknown microbe or eukaryote in a diluted sample where the DNA has been prepared using whole genome amplification. The whole genome of the unknown microbe or eukaryote is then sequenced and assembled.Type: ApplicationFiled: January 11, 2021Publication date: May 6, 2021Applicant: Shoreline Biome, LLCInventors: Mark Driscoll, Thomas Jarvie
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Patent number: 10982283Abstract: Provided herein are methods for altering a health state of a subject by administering a wellness intervention to subjects found to have quantitative measures of microbial genera in the subject's microbiome that are associated with undesirable health states. Undesirable health states can be inferred by executing models that predict health states based on the quantitative measures, such as relative amounts of selected microbial genera to all microbes. Models are created by statistical methods that analyze datasets that include, for each of a plurality of subjects, verified health states and quantitative measures of each of a plurality of microbes classified at designated taxonomic levels, e.g., genus level.Type: GrantFiled: April 19, 2020Date of Patent: April 20, 2021Assignee: Biome Health, Inc.Inventors: Alain Mir, Harris Shapiro, Ronald Avignone, Mark Kelleher
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Publication number: 20210069320Abstract: The present invention provides a fusion polypeptide that induces a humoral immune response and a cellular immune response to a virus, containing antigens or fragments thereof of the following (a) and (b), and having an oligomerization activity: (a) an antigen of the virus or a fragment thereof containing a B cell epitope conserved among subtypes of the virus; and (b) an antigen of the virus or a fragment thereof containing a T cell epitope conserved among subtypes of the virus (wherein the antigen(s) or the fragment(s) thereof of (a) and/or (b) have an oligomerization activity, or the fusion polypeptide further contains (c) a polypeptide having an oligomerization activity in addition to the antigens or the fragments thereof (a) and (b)).Type: ApplicationFiled: December 21, 2018Publication date: March 11, 2021Applicants: Green BioMed, Inc., KIRIN HOLDINGS KABUSHIKI KAISHAInventor: Kenji SEKIKAWA
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Publication number: 20210052689Abstract: An anti-microbial formulation of native ingredients for human and non-human vertebrate animal feeds, feed supplements/additives, or for direct doses to replace in whole or supplement traditional anti-microbial with side-effects such as allergies, microbial-resistance, and drug-interactions with non-toxic, side-effect free native anti-microbial for all vertebrates. The invention comprises of non-toxic, side-effect free native substances amalgamations having anti-microbial properties for food additives, food supplements, or direct doses. Furthermore, these native formulas can be use with or without other prescription or nonprescription anti-microbial medications. We describe the method of manufacture and also the process of use for this amalgamates.Type: ApplicationFiled: August 24, 2020Publication date: February 25, 2021Applicant: Beneficial Biome Solutions, IncInventors: Douglas Steven Pernikoff, Grant Lee Weber
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Patent number: 10925500Abstract: The present invention relates to novel lip/cheek probes for detection of pulse-based differences in light absorbence across the vascularized tissue of a lip or cheek of a patient. These probes are fabricated to provide signals to estimate arterial oxygen saturation, and/or to obtain other photoplethysmographic data. The present invention also relates to a combined probe/cannula. The present invention also relates to other devices that combine a pulse oximeter probe with a device supplying oxygen or other oxygen-containing gas to a person in need thereof, and to sampling means for exhaled carbon dioxide in combination with the novel lip/cheek probes. In certain embodiments, an additional limitation of a control means to adjust the flow rate of such gas is provided, where such control is directed by the blood oxygen saturation data obtained from the pulse oximeter probe.Type: GrantFiled: June 30, 2017Date of Patent: February 23, 2021Assignees: University Of Florida Research Foundation, Inc., Beta Biomed Services, Inc.Inventors: Richard J. Melker, George Worley, Joachim S. Gravenstein
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Patent number: 10920222Abstract: The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.Type: GrantFiled: December 2, 2019Date of Patent: February 16, 2021Assignee: SNIPR Biome ApSInventors: Morten Sommer, Virginia Martinez, Eric Van Der Helm, Jakob Krause Haaber, Ana De Santiago Torio, Christian Grøndahl, Jasper Clube
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Publication number: 20210032618Abstract: Disclosed are methods for lysis of cells, such as bacteria present in microbiomes, that combine three lysis steps—(1) heat, (2) detergent and (3) base—into a single step and that can be completed in a short period of time, e.g., a few minutes. The methods combine a normally incompatible detergent and base lysis, allows for simplified removal of detergent after lysis, and importantly, yields improved quantities of genomic DNA (gDNA) from difficult to lyse bacteria.Type: ApplicationFiled: August 19, 2020Publication date: February 4, 2021Applicant: Shoreline Biome, LLCInventors: Mark Driscoll, Thomas Jarvie
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Patent number: 10906043Abstract: A portable microfluidic system capable of rapid diagnosis is described, which is able to analyze genetic, protein and cell composition of a sample in parallel for specific diseases from a relatively small sample. The method uses a single microfluidic chip integrated into a unique portable microfluidic platform and provides improved diagnostic accuracy, allows for frequent monitoring and is suitable for easy use in clinical settings.Type: GrantFiled: January 13, 2014Date of Patent: February 2, 2021Assignee: Biomed Canada CorporationInventors: Gong Zhang, Francis Lin, Edward Stewart Richmond, Marshall Ring
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Patent number: 10894990Abstract: Disclosed are methods for screening biological samples for the presence unknown microbes, such as bacteria and archaea or unknown eukaryotes using rRNA gene sequences or other highly conserved genetic regions, across multiple biological samples using a unique sequence tag (barcode) corresponding to the sample. The screening process tracks the unknown microbe or eukaryote in a diluted sample where the DNA has been prepared using whole genome amplification. The whole genome of the unknown microbe or eukaryote is then sequenced and assembled.Type: GrantFiled: May 16, 2017Date of Patent: January 19, 2021Assignee: Shoreline Biome, LLCInventors: Mark Driscoll, Thomas Jarvie
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Publication number: 20210009996Abstract: The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.Type: ApplicationFiled: September 23, 2020Publication date: January 14, 2021Applicant: SNIPR Biome ApSInventors: Morten SOMMER, Virginia MARTINEZ, Eric VAN DER HELM, Jakob Krause HAABER, Ana DE SANTIAGO TORIO, Christian GRØNDAHL, Jasper CLUBE
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Patent number: 10857090Abstract: Compositions for use in oral hygiene contain a Lactobacillus helveticus strain. Compositions further containing a Lactobacillus plantarum strain, especially Lactobacillus plantarum SD5870, are particularly effective. The combination of Lactobacillus helveticus LAFTI L10 and Lactobacillus plantarum SD5870 synergistically improves oral hygiene. The compositions are particularly useful against dental caries.Type: GrantFiled: July 4, 2014Date of Patent: December 8, 2020Assignee: Stellar Biome Inc.Inventors: Natalia Yudina, Maxim Daniel Seferovic
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Publication number: 20200352544Abstract: The present disclosure provides a positioning method for head and neck assessment comprising positioning a probe to the head and neck structures of a subject according to reference planes defined by light beams.Type: ApplicationFiled: July 23, 2020Publication date: November 12, 2020Applicant: AmCad Biomed CorporationInventors: Argon CHEN, Hao-Chien WANG, Chiung-Nien CHEN, Pei-Lin LEE, Chin-Chung SHU, Edward Chia-Hao LIU, Shu-Ning YU
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Patent number: 10815303Abstract: A fusion protein for restoring functions of failing immune cells and application thereof. The fusion protein has a functional area for recognizing the failing immune cell and a functional area for conducting activation and amplification on the failing immune cell. The two functional areas are connected through a non-functional amino acid fragment with a certain length. The functional area for recognition uses the immune checkpoint specific antibody to recognize a phenotypic receptor of failing immune cells. The functional area for conducting activation and amplification adopts the cytokine or functionally-similar mutants, a ligand of the phenotypic receptor or functionally-similar mutants or an activating antibody to activate failing immune cells.Type: GrantFiled: April 7, 2017Date of Patent: October 27, 2020Assignee: Shanghai Biomed-Union Biotechnology Co., Ltd.Inventors: Xilian Yue, Gentao Liu, Guoxiang Wu
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Patent number: 10792338Abstract: A method of promoting wound healing or connective tissue reconstruction and a method of treating ischemia in a subject in need thereof are disclosed. The methods comprising topically administering to the subject about 10-30 mg per cm2 wound tissue of Erythropoietin and about 100-300 mg per cm2 wound tissue of Fibronectin, thereby promoting wound healing or connective tissue reconstruction or treating ischemia in the subject. Unit dosage forms, pharmaceutical compositions, cosmetic compositions and formulations comprising Erythropoietin and/or Fibronectin are also disclosed.Type: GrantFiled: October 14, 2015Date of Patent: October 6, 2020Assignee: Remedor Biomed Ltd.Inventor: Saher Hamed
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Patent number: 10780256Abstract: A system for integrating an antibacterial-element receptacle into an autoinjector cap facilitates the pre-injection treatment, the post-injection treatment, and prevents the accidental delivery of the injection. The system includes a cap assembly, an autoinjector body, and an antiseptic-soaked dressing. The cap assembly encloses the needle of the autoinjector and prevents the accidental trigger of the injection mechanism. The autoinjector body refers to the body of any conventional autoinjector. The antiseptic-soaked dressing is applied to the patient's skin prior to the delivery of the injection to disinfect and sterilize the injection area. The antiseptic-soaked dressing is housed in the cap assembly, between a receptacle and a removable cover. The removable cover is releasably mounted to the receptacle to allow access to the antiseptic-soaked dressing.Type: GrantFiled: March 19, 2018Date of Patent: September 22, 2020Assignee: Silcor Biomed, LLC.Inventors: Silvestre Cordoba, Frank A. Scarfone
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Patent number: 10774322Abstract: Disclosed are methods for lysis of cells, such as bacteria present in microbiomes, that combine three lysis steps—(1) heat, (2) detergent and (3) base—into a single step and that can be completed in a short period of time, e.g., a few minutes. The methods combine a normally incompatible detergent and base lysis, allows for simplified removal of detergent after lysis, and importantly, yields improved quantities of genomic DNA (gDNA) from difficult to lyse bacteria.Type: GrantFiled: December 26, 2017Date of Patent: September 15, 2020Assignee: Shoreline Biome, LLCInventors: Mark Driscoll, Thomas Jarvie
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Patent number: 10760075Abstract: The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.Type: GrantFiled: April 30, 2018Date of Patent: September 1, 2020Assignee: SNIPR Biome ApSInventors: Morten Sommer, Virginia Martinez, Eric Van Der Helm, Jakob Krause Haaber, Ana De Santiago Torio, Christian Grøndahl, Jasper Clube
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Patent number: 10758526Abstract: The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a molecularly targeted agent; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof, wherein the monoclonal antibody contains: (i) a heavy chain variable region (VH), which includes an amino acid sequence selected from SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, and SEQ ID NO:7; and (ii) a light chain variable region (VL), which includes an amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein.Type: GrantFiled: June 9, 2015Date of Patent: September 1, 2020Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH, Biomed Valley Discoveries, Inc.Inventors: Saurabh Saha, Xiaoyan M. Zhang, Dimiter Dimitrov, Zhongyu Zhu, Brad St. Croix, Enrique Zudaire