Patents Assigned to Biomed
  • Patent number: 11013743
    Abstract: The present invention provides, inter alia, methods, kits, and pharmaceutical compositions for treating or ameliorating the effects of a cancer in a subject in need thereof. The method comprises administering to the subject an effective amount of (i) a first anti-cancer agent, which is BVD-523 or a pharmaceutically acceptable salt thereof and (ii) a second anti-cancer agent, which is a CDK inhibitor or a pharmaceutically acceptable salt thereof, to treat or ameliorate the effects of the cancer. Additional methods for effecting cancer cell death are also provided.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: May 25, 2021
    Assignee: BioMed Valley Discoveries, Inc.
    Inventors: Saurabh Saha, Dean Welsch, Gary DeCrescenzo, Jeffrey James Roix
  • Patent number: 11007362
    Abstract: An exemplary method of inserting a peri-straight electrode array into a cochlea of a recipient includes positioning the peri-straight electrode array and an insertion tool within the recipient such that a distal end of the insertion tool is provided within the recipient at a location that is outside and not touching the cochlea of the recipient, and a straight distal portion of the peri-straight electrode array extends away from the distal end of the insertion tool and into the cochlea. The exemplary method further includes manually interacting with the insertion tool to advance the straight distal portion and at least some of a pre-curved proximal portion into the cochlea without allowing the insertion tool to enter or come in contact with the cochlea, and removing the insertion tool from the recipient such that the peri-straight electrode array remains within the cochlea after the insertion tool is removed from the recipient.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: May 18, 2021
    Assignee: Advanced Biomes AG
    Inventors: Bing Xu, Mark B. Downing, Leonid M. Litvak
  • Publication number: 20210130914
    Abstract: Disclosed are methods for screening biological samples for the presence unknown microbes, such as bacteria and archaea or unknown eukaryotes using rRNA gene sequences or other highly conserved genetic regions, across multiple biological samples using a unique sequence tag (barcode) corresponding to the sample. The screening process tracks the unknown microbe or eukaryote in a diluted sample where the DNA has been prepared using whole genome amplification. The whole genome of the unknown microbe or eukaryote is then sequenced and assembled.
    Type: Application
    Filed: January 11, 2021
    Publication date: May 6, 2021
    Applicant: Shoreline Biome, LLC
    Inventors: Mark Driscoll, Thomas Jarvie
  • Patent number: 10982283
    Abstract: Provided herein are methods for altering a health state of a subject by administering a wellness intervention to subjects found to have quantitative measures of microbial genera in the subject's microbiome that are associated with undesirable health states. Undesirable health states can be inferred by executing models that predict health states based on the quantitative measures, such as relative amounts of selected microbial genera to all microbes. Models are created by statistical methods that analyze datasets that include, for each of a plurality of subjects, verified health states and quantitative measures of each of a plurality of microbes classified at designated taxonomic levels, e.g., genus level.
    Type: Grant
    Filed: April 19, 2020
    Date of Patent: April 20, 2021
    Assignee: Biome Health, Inc.
    Inventors: Alain Mir, Harris Shapiro, Ronald Avignone, Mark Kelleher
  • Publication number: 20210069320
    Abstract: The present invention provides a fusion polypeptide that induces a humoral immune response and a cellular immune response to a virus, containing antigens or fragments thereof of the following (a) and (b), and having an oligomerization activity: (a) an antigen of the virus or a fragment thereof containing a B cell epitope conserved among subtypes of the virus; and (b) an antigen of the virus or a fragment thereof containing a T cell epitope conserved among subtypes of the virus (wherein the antigen(s) or the fragment(s) thereof of (a) and/or (b) have an oligomerization activity, or the fusion polypeptide further contains (c) a polypeptide having an oligomerization activity in addition to the antigens or the fragments thereof (a) and (b)).
    Type: Application
    Filed: December 21, 2018
    Publication date: March 11, 2021
    Applicants: Green BioMed, Inc., KIRIN HOLDINGS KABUSHIKI KAISHA
    Inventor: Kenji SEKIKAWA
  • Publication number: 20210052689
    Abstract: An anti-microbial formulation of native ingredients for human and non-human vertebrate animal feeds, feed supplements/additives, or for direct doses to replace in whole or supplement traditional anti-microbial with side-effects such as allergies, microbial-resistance, and drug-interactions with non-toxic, side-effect free native anti-microbial for all vertebrates. The invention comprises of non-toxic, side-effect free native substances amalgamations having anti-microbial properties for food additives, food supplements, or direct doses. Furthermore, these native formulas can be use with or without other prescription or nonprescription anti-microbial medications. We describe the method of manufacture and also the process of use for this amalgamates.
    Type: Application
    Filed: August 24, 2020
    Publication date: February 25, 2021
    Applicant: Beneficial Biome Solutions, Inc
    Inventors: Douglas Steven Pernikoff, Grant Lee Weber
  • Patent number: 10925500
    Abstract: The present invention relates to novel lip/cheek probes for detection of pulse-based differences in light absorbence across the vascularized tissue of a lip or cheek of a patient. These probes are fabricated to provide signals to estimate arterial oxygen saturation, and/or to obtain other photoplethysmographic data. The present invention also relates to a combined probe/cannula. The present invention also relates to other devices that combine a pulse oximeter probe with a device supplying oxygen or other oxygen-containing gas to a person in need thereof, and to sampling means for exhaled carbon dioxide in combination with the novel lip/cheek probes. In certain embodiments, an additional limitation of a control means to adjust the flow rate of such gas is provided, where such control is directed by the blood oxygen saturation data obtained from the pulse oximeter probe.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: February 23, 2021
    Assignees: University Of Florida Research Foundation, Inc., Beta Biomed Services, Inc.
    Inventors: Richard J. Melker, George Worley, Joachim S. Gravenstein
  • Patent number: 10920222
    Abstract: The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: February 16, 2021
    Assignee: SNIPR Biome ApS
    Inventors: Morten Sommer, Virginia Martinez, Eric Van Der Helm, Jakob Krause Haaber, Ana De Santiago Torio, Christian Grøndahl, Jasper Clube
  • Publication number: 20210032618
    Abstract: Disclosed are methods for lysis of cells, such as bacteria present in microbiomes, that combine three lysis steps—(1) heat, (2) detergent and (3) base—into a single step and that can be completed in a short period of time, e.g., a few minutes. The methods combine a normally incompatible detergent and base lysis, allows for simplified removal of detergent after lysis, and importantly, yields improved quantities of genomic DNA (gDNA) from difficult to lyse bacteria.
    Type: Application
    Filed: August 19, 2020
    Publication date: February 4, 2021
    Applicant: Shoreline Biome, LLC
    Inventors: Mark Driscoll, Thomas Jarvie
  • Patent number: 10906043
    Abstract: A portable microfluidic system capable of rapid diagnosis is described, which is able to analyze genetic, protein and cell composition of a sample in parallel for specific diseases from a relatively small sample. The method uses a single microfluidic chip integrated into a unique portable microfluidic platform and provides improved diagnostic accuracy, allows for frequent monitoring and is suitable for easy use in clinical settings.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: February 2, 2021
    Assignee: Biomed Canada Corporation
    Inventors: Gong Zhang, Francis Lin, Edward Stewart Richmond, Marshall Ring
  • Patent number: 10894990
    Abstract: Disclosed are methods for screening biological samples for the presence unknown microbes, such as bacteria and archaea or unknown eukaryotes using rRNA gene sequences or other highly conserved genetic regions, across multiple biological samples using a unique sequence tag (barcode) corresponding to the sample. The screening process tracks the unknown microbe or eukaryote in a diluted sample where the DNA has been prepared using whole genome amplification. The whole genome of the unknown microbe or eukaryote is then sequenced and assembled.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: January 19, 2021
    Assignee: Shoreline Biome, LLC
    Inventors: Mark Driscoll, Thomas Jarvie
  • Publication number: 20210009996
    Abstract: The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.
    Type: Application
    Filed: September 23, 2020
    Publication date: January 14, 2021
    Applicant: SNIPR Biome ApS
    Inventors: Morten SOMMER, Virginia MARTINEZ, Eric VAN DER HELM, Jakob Krause HAABER, Ana DE SANTIAGO TORIO, Christian GRØNDAHL, Jasper CLUBE
  • Patent number: 10857090
    Abstract: Compositions for use in oral hygiene contain a Lactobacillus helveticus strain. Compositions further containing a Lactobacillus plantarum strain, especially Lactobacillus plantarum SD5870, are particularly effective. The combination of Lactobacillus helveticus LAFTI L10 and Lactobacillus plantarum SD5870 synergistically improves oral hygiene. The compositions are particularly useful against dental caries.
    Type: Grant
    Filed: July 4, 2014
    Date of Patent: December 8, 2020
    Assignee: Stellar Biome Inc.
    Inventors: Natalia Yudina, Maxim Daniel Seferovic
  • Publication number: 20200352544
    Abstract: The present disclosure provides a positioning method for head and neck assessment comprising positioning a probe to the head and neck structures of a subject according to reference planes defined by light beams.
    Type: Application
    Filed: July 23, 2020
    Publication date: November 12, 2020
    Applicant: AmCad Biomed Corporation
    Inventors: Argon CHEN, Hao-Chien WANG, Chiung-Nien CHEN, Pei-Lin LEE, Chin-Chung SHU, Edward Chia-Hao LIU, Shu-Ning YU
  • Patent number: 10815303
    Abstract: A fusion protein for restoring functions of failing immune cells and application thereof. The fusion protein has a functional area for recognizing the failing immune cell and a functional area for conducting activation and amplification on the failing immune cell. The two functional areas are connected through a non-functional amino acid fragment with a certain length. The functional area for recognition uses the immune checkpoint specific antibody to recognize a phenotypic receptor of failing immune cells. The functional area for conducting activation and amplification adopts the cytokine or functionally-similar mutants, a ligand of the phenotypic receptor or functionally-similar mutants or an activating antibody to activate failing immune cells.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: October 27, 2020
    Assignee: Shanghai Biomed-Union Biotechnology Co., Ltd.
    Inventors: Xilian Yue, Gentao Liu, Guoxiang Wu
  • Patent number: 10792338
    Abstract: A method of promoting wound healing or connective tissue reconstruction and a method of treating ischemia in a subject in need thereof are disclosed. The methods comprising topically administering to the subject about 10-30 mg per cm2 wound tissue of Erythropoietin and about 100-300 mg per cm2 wound tissue of Fibronectin, thereby promoting wound healing or connective tissue reconstruction or treating ischemia in the subject. Unit dosage forms, pharmaceutical compositions, cosmetic compositions and formulations comprising Erythropoietin and/or Fibronectin are also disclosed.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: October 6, 2020
    Assignee: Remedor Biomed Ltd.
    Inventor: Saher Hamed
  • Patent number: 10780256
    Abstract: A system for integrating an antibacterial-element receptacle into an autoinjector cap facilitates the pre-injection treatment, the post-injection treatment, and prevents the accidental delivery of the injection. The system includes a cap assembly, an autoinjector body, and an antiseptic-soaked dressing. The cap assembly encloses the needle of the autoinjector and prevents the accidental trigger of the injection mechanism. The autoinjector body refers to the body of any conventional autoinjector. The antiseptic-soaked dressing is applied to the patient's skin prior to the delivery of the injection to disinfect and sterilize the injection area. The antiseptic-soaked dressing is housed in the cap assembly, between a receptacle and a removable cover. The removable cover is releasably mounted to the receptacle to allow access to the antiseptic-soaked dressing.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: September 22, 2020
    Assignee: Silcor Biomed, LLC.
    Inventors: Silvestre Cordoba, Frank A. Scarfone
  • Patent number: 10774322
    Abstract: Disclosed are methods for lysis of cells, such as bacteria present in microbiomes, that combine three lysis steps—(1) heat, (2) detergent and (3) base—into a single step and that can be completed in a short period of time, e.g., a few minutes. The methods combine a normally incompatible detergent and base lysis, allows for simplified removal of detergent after lysis, and importantly, yields improved quantities of genomic DNA (gDNA) from difficult to lyse bacteria.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: September 15, 2020
    Assignee: Shoreline Biome, LLC
    Inventors: Mark Driscoll, Thomas Jarvie
  • Patent number: 10760075
    Abstract: The invention provides methods for treating or preventing microbial (eg, bacterial) infections and means for performing these methods. In particular, treatment of infections requiring rapid and durable therapy is made possible, such as for treating acute conditions such as septicemia, sepsis, SIRS or septic shock. The invention is particularly useful, for example, for treatment of microbes such as for environmental, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system. The invention also useful for the treatment of pathogenic bacterial infections in subjects receiving a treatment for a disease or condition, such as a transplant or a treatment for cancer, a viral infection or an autoimmune disease.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: September 1, 2020
    Assignee: SNIPR Biome ApS
    Inventors: Morten Sommer, Virginia Martinez, Eric Van Der Helm, Jakob Krause Haaber, Ana De Santiago Torio, Christian Grøndahl, Jasper Clube
  • Patent number: 10758526
    Abstract: The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a molecularly targeted agent; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof, wherein the monoclonal antibody contains: (i) a heavy chain variable region (VH), which includes an amino acid sequence selected from SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, and SEQ ID NO:7; and (ii) a light chain variable region (VL), which includes an amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: September 1, 2020
    Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH, Biomed Valley Discoveries, Inc.
    Inventors: Saurabh Saha, Xiaoyan M. Zhang, Dimiter Dimitrov, Zhongyu Zhu, Brad St. Croix, Enrique Zudaire