Patents Assigned to Bioscience, Inc.
  • METHOD OF TREATING HEPATITIS C VIRUS IN PATIENTS
    Publication number: 20240390408
    Abstract: The present disclosure describes methods of treating a hepatitis C virus (HCV) infection in a patient in need thereof by orally administering to the patient a therapeutically effective amount of a pharmaceutical composition, which may include one or more of compounds disclosed herein. The methods of treating the HCV infection in the patient may result in clearance of the HCV infection as measured by sustained virologic response.
    Type: Application
    Filed: May 23, 2024
    Publication date: November 28, 2024
    Applicant: Altesa BioSciences, Inc.
    Inventors: Brett Paul GIROIR, Katherine Elizabeth SQUIRES, John Michael CLERICI
  • Skin treatment devices
    Patent number: 12150840
    Abstract: Devices, kits and methods described herein may be for wound healing, including the treatment, amelioration, or prevention of scars and/or keloids by applying and/or maintaining a pre-determined strain in an elastic skin treatment device that is then affixed to the skin surface using skin adhesives to transfer a generally planar force from the bandage to the skin surface. Applicators are used to apply and/or maintain the strains, and some of the applicators are further configured to provide at least some mechanical advantage to the user when exerting loads onto the skin treatment device.
    Type: Grant
    Filed: December 27, 2019
    Date of Patent: November 26, 2024
    Assignee: Neodyne Biosciences, Inc.
    Inventors: John A. Zepeda, Jasper Jackson, William Beasley, Darren Doud, Brett Follmer
  • Gel electrophoresis diagnostic kit and methods of using the same
    Patent number: 12153015
    Abstract: An electrophoretic device for detecting biomarkers in collected bodily fluid and methods of using the same.
    Type: Grant
    Filed: May 22, 2023
    Date of Patent: November 26, 2024
    Assignee: Vital Biosciences Inc.
    Inventors: Mounir A. Koussa, Calvin Domenico, Ronald L. Green, Joshua John Forman, Andrew Ward, Lisa Caldwell
  • Method and system for cell operations using the internet of things
    Patent number: 12152230
    Abstract: A data collection hub and method wherein a controller is configured to receive data from a plurality of sensors sensing conditions related to the performance of operations on cells by at least one instrument. A database stores the data from the plurality of sensors and the controller is configured to compare data from the plurality of sensors for a past operation with the data for a more recent operation.
    Type: Grant
    Filed: June 18, 2023
    Date of Patent: November 26, 2024
    Assignee: Thrive Bioscience, Inc.
    Inventors: Howard Cannon, Thomas Forest Farb
  • NUCLEIC ACIDS ENCODING ENGINEERED MEGANUCLEASES WITH RECOGNITION SEQUENCES FOUND IN THE HUMAN T CELL RECEPTOR ALPHA CONSTANT REGION GENE
    Publication number: 20240382526
    Abstract: Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human T cell receptor alpha constant region gene. The present disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells.
    Type: Application
    Filed: August 2, 2024
    Publication date: November 21, 2024
    Applicant: Precision BioSciences, Inc.
    Inventors: Michael G. Nicholson, James Jefferson Smith, Derek Jantz, Victor Bartsevich, Daniel T. MacLeod, Jeyaraj Antony
  • Systems and methods for cell dissociation
    Patent number: 12146823
    Abstract: A system for dissociating cells from a cell culture vessel. The system comprises an imaging system configured to image a plurality of cells in a cell culture vessel being dissociated from at least one surface of the cell culture vessel by at least one cell dissociation agent; and at least one controller coupled to the imaging system and configured to: control the imaging system to capture a sequence of images of at least some cells in the plurality of cells during dissociation; and identify when to neutralize the at least one cell dissociation agent using the sequence of images.
    Type: Grant
    Filed: March 20, 2023
    Date of Patent: November 19, 2024
    Assignee: Thrive Bioscience, Inc.
    Inventors: Kam Lin Wong, Melanie Scully
  • Process for preparing tetralin compounds
    Patent number: 12145901
    Abstract: The present disclosure describes processes and intermediates useful for preparing a compound of Formula (Xa) or Formula (Xb). The processes and intermediates can be used to prepare the compounds of the disclosure at multigram or kilogram scale.
    Type: Grant
    Filed: September 16, 2022
    Date of Patent: November 19, 2024
    Assignee: Arcus Biosciences, Inc.
    Inventors: Joel Worley Beatty, Samuel Lawrie Drew, Matthew Epplin, Jeremy Fournier, Balint Gal, Karl T. Haelsig, Clayton Hardman, Jaroslaw Kalisiak, Kenneth Victor Lawson, Manmohan Reddy Leleti, Artur Karenovich Mailyan, Guillaume Mata, Brandon Reid Rosen, Zhang Wang, Kai Yu
  • Inhibitors of cysteine proteases and methods of use thereof
    Patent number: 12145911
    Abstract: The disclosure provides compounds with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.
    Type: Grant
    Filed: May 31, 2022
    Date of Patent: November 19, 2024
    Assignee: Pardes Biosciences, Inc.
    Inventors: Lee D. Arnold, Andy Jennings, Walter Keung
  • Multivalent and Multispecific DR5-Binding Fusion Proteins
    Publication number: 20240376220
    Abstract: The disclosure relates generally to molecules that specifically engage death receptor 5 (DR5), a member of the TNF receptor superfamily (TNFRSF). More specifically the disclosure relates to multivalent and multispecific molecules that bind at least DR5.
    Type: Application
    Filed: April 4, 2024
    Publication date: November 14, 2024
    Applicant: Inhibrx Biosciences, Inc.
    Inventors: John C. Timmer, Kyle S. Jones, Amir S. Razai, Abrahim Hussain, Katelyn M. Willis, Quinn Deveraux, Brendan P. Eckelman
  • CANNABIS PLANT NAMED 'PTC8506V'
    Publication number: 20240381800
    Abstract: A new and distinct variety of Cannabis sativa designated ‘PTC8506V’ as herein described and illustrated, characterized by elevated levels of THCV and THC.
    Type: Application
    Filed: April 23, 2024
    Publication date: November 14, 2024
    Applicant: Phylos Bioscience, Inc.
    Inventor: Jared Reynbery
  • Linear resistance stepper flow control valve for sheath fluid of flow cytometry systems
    Patent number: 12140524
    Abstract: A system, method, and apparatus are provided for flow cytometry. In one example, the flow cytometry system includes dual laser devices and dual scatter channels to measure velocity of particles in a core stream of sample fluid. The total flow rate of the sample fluid and the sheath fluid around the sample fluid is controlled, and thus held constant, by a feedback control system controlling a vacuum pump based on differential pressure across ends of a flow channel in the flow cell. A stepper flow control valves are disclosed that apply a physical fluid resistance to a flow of sheath fluid in the flow cytometer. The physical fluid resistance regulates a flow rate of the sheath fluid and thereby regulates a flow rate of sample fluid in the flow cytometer.
    Type: Grant
    Filed: December 12, 2020
    Date of Patent: November 12, 2024
    Assignee: Cytek Biosciences, Inc.
    Inventor: David Vrane
  • COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20240366691
    Abstract: Provided herein are methods and compositions for treating cancer, such as gastric cancer, in a subject involving administering a composition comprising a purified bacterial mixture.
    Type: Application
    Filed: April 5, 2022
    Publication date: November 7, 2024
    Applicant: Vedanta Biosciences, Inc.
    Inventor: Rajita Menon
  • Tattoo removal
    Patent number: 12133674
    Abstract: Described herein are methods and apparatuses for the application of electric energy treatment(s) to skin tissue to alter pigmentation, and in particular to remove a tattoo. These methods and apparatuses may deliver pulsed electrical energy having a pulse duration in submicrosecond pulse range to provide high-field strength pulses that may effectively release tattoo ink and allow removal of tattoo ink regardless of ink color or composition.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: November 5, 2024
    Assignee: Pulse Biosciences, Inc.
    Inventors: Edward A. Ebbers, Darrin R. Uecker, Richard L. Nuccitelli
  • Hydrogel particles as feeder cells and as synthetic antigen presenting cells
    Patent number: 12134779
    Abstract: The present disclosure provides feeder hydrogel particles that can function to support the growth, proliferation, and/or activation of a target cell in culture. The present disclosure also provides methods of culturing target cells with feeder hydrogel particles.
    Type: Grant
    Filed: November 1, 2023
    Date of Patent: November 5, 2024
    Assignee: Slingshot Biosciences, Inc.
    Inventors: Anh Tuan Nguyen, Jeffrey Kim, Keunho Ahn, Daixuan Zhang
  • Dosage forms, packaging, and vaporization device for vaporizable formulations
    Patent number: 12128172
    Abstract: A single dose vaporizable formulation including room temperature solid extracts and other botanical extracts and methods of processing and packaging single dose portions of vaporizable formulations. Also, methods of dispensing single dose portions, including segmented dose formulations and applicator-tab devices for vaporizers. A vaporizer having a heating chamber element with an indentation or cavity sized to receive a similarly-shaped, single dose vaporizable formulation.
    Type: Grant
    Filed: December 9, 2020
    Date of Patent: October 29, 2024
    Assignee: Resurgent Biosciences. Inc
    Inventor: Eric Greenbaum
  • Methods of treatment using treatment applicator with protected electrodes
    Patent number: 12128231
    Abstract: Described herein are methods of treating a tissue using a treatment tip apparatus (e.g., devices, systems, etc.) including one, or more preferably a plurality, of electrodes that are protected by an electrode partition, such as an electrode housing (which may be retractable) until pressed against the tissue for deployment of the electrodes and delivery of a therapeutic treatment. In particular, these methods may include the use of a plurality of treatment electrodes (e.g., needle electrodes) and in some examples may include for the delivery of nanosecond pulsed electric fields.
    Type: Grant
    Filed: August 10, 2021
    Date of Patent: October 29, 2024
    Assignee: Pulse Biosciences, Inc.
    Inventors: Kevin L. Moss, Christopher J. Foster, Cameron D. Hinman, David J. Danitz, Darrin R. Uecker
  • Synthetic methods for preparation of 4-(2-chloro-4-methoxy-5-methylphenyl)-n-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-n-prop-2-ynyl-1,3-thiazol-2-amine
    Patent number: 12128033
    Abstract: The present disclosure relates to the fields of chemistry and medicine, more particularly to processes for making 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thi-azol-2-amine (Compound 1), pharmaceutically acceptable salts, and crystalline forms thereof, for the treatment of congenital adrenal hyperplasia (CAH).
    Type: Grant
    Filed: March 14, 2024
    Date of Patent: October 29, 2024
    Assignees: Neurocrine Biosciences, Inc., Sanofi
    Inventors: Andrew Becker, Joel Radisson
  • Apparatuses for contactless loading and imaging of microfluidic chips and related methods
    Patent number: 12128415
    Abstract: An apparatus for loading and imaging a microfluidic chip can comprise a housing having walls that define a vacuum chamber and a first receptacle disposed within the vacuum chamber, the first receptacle defining a space for receiving one or more microfluidic chips. The apparatus can also include a negative pressure source, a light source, and an optical sensor coupled to the housing. The negative pressure source can be configured to reduce pressure within the vacuum chamber, the light source can be positioned to illuminate at least a portion of the space for receiving the chip(s), and the optical sensor can be positioned to capture an image of at least a portion of the space for receiving the chip(s).
    Type: Grant
    Filed: March 8, 2021
    Date of Patent: October 29, 2024
    Assignee: Pattern Bioscience, Inc.
    Inventors: Ross Johnson, Jonathan Isom, David Bussian, Nicolas Arab
  • Apoptotic cell mimic
    Patent number: 12130285
    Abstract: Provided herein are hydrogel beads that mimic live, dead, and apoptotic cells. The present disclosure also provides kits and compositions of hydrogel beads. The present disclosure further comprises methods of using the kits, compositions, and hydrogel beads to determine if a target cell sample includes one or more live, dead, or apoptotic cells.
    Type: Grant
    Filed: March 18, 2024
    Date of Patent: October 29, 2024
    Assignee: Slingshot Biosciences, Inc.
    Inventors: Keunho Ahn, Zhenyu Deng, Martina De Geus, Anh Tuan Nguyen
  • Biological fluid filtration system
    Patent number: 12128406
    Abstract: A biological fluid filtration system for scanning a biological fluid so as to filter potentially undesirable constituents from the biological fluid for therapeutic or diagnostic purposes. The biological fluid filtration system generally includes a fluid receiving device adapted to receive a biological fluid. A valve including an inlet, a first outlet, and a second outlet is fluidly connected to the fluid receiving device. The biological fluid within the fluid receiving device is scanned by a scanner to produce scanned data relating to the biological fluid. A control unit in communication with the scanner and the valve receives the scanned data and controls the valve based on the scanned data. The valve is controlled to direct the biological fluid through either the first or second outlet of the valve depending upon the constituents of the biological fluid identified by the control unit.
    Type: Grant
    Filed: March 18, 2021
    Date of Patent: October 29, 2024
    Assignee: Astrin Biosciences, Inc.
    Inventor: Jayant Parthasarathy