Patents Assigned to Bioscience, Inc.
  • Inhibitors of adenosine 5?-nucleotidase
    Patent number: 12168023
    Abstract: Compounds that modulate the conversion of AMP to adenosine by 5?-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5?-nucleotidase, ecto is also provided.
    Type: Grant
    Filed: April 8, 2024
    Date of Patent: December 17, 2024
    Assignee: Arcus Biosciences, Inc.
    Inventors: Laurent Pierre Paul Debien, Jaroslaw Kalisiak, Kenneth V. Lawson, Manmohan Reddy Leleti, Erick Allen Lindsey, Dillon Harding Miles, Eric Newcomb, Jay Patrick Powers, Brandon Reid Rosen, Ehesan Ul Sharif
  • METHOD AND APPARATUS FOR SEARCHING AND ANALYZING CELL IMAGES
    Publication number: 20240412371
    Abstract: A method and apparatus for searching cell images comprising storing cell images in an image database, generating index data for the stored images in the image database, wherein the index data includes image metadata and data extracted from the stored image data by analysis including morphological descriptors, applications of algorithms, machine learning and/or data mining.
    Type: Application
    Filed: October 6, 2022
    Publication date: December 12, 2024
    Applicant: Thrive Bioscience, Inc.
    Inventor: Alan BLANCHARD
  • OX40-Binding Polypeptides and Uses Thereof
    Publication number: 20240409651
    Abstract: Provided herein are VHH-containing polypeptides that bind OX40. In some embodiments, VHH-containing polypeptides that bind and agonize OX40 are provided. Uses of the VHH-containing polypeptides are also provided.
    Type: Application
    Filed: May 8, 2024
    Publication date: December 12, 2024
    Applicant: Inhibrx Biosciences, Inc.
    Inventors: John C. Timmer, William Crago, Kyle Jones, Katelyn Willis, Florian Sulzmaier, Bryan Becklund, Brendan P. Eckelman
  • AUTOMATED INCUBATOR WITH ROBOTIC TRANSPORT
    Publication number: 20240409871
    Abstract: A cell incubator system comprising a housing having an internal chamber having a controlled temperature and gas mixture therein appropriate for the growth of particular cells for incubation of the particular cells in one or more cell culture vessels in the internal chamber and a plurality of cell operation stations in the internal chamber. The stations receive plates having wells for holding cells and wherein the cell operations stations perform operations on cells in the wells. The system has a robotic transport for moving plates from one station to another.
    Type: Application
    Filed: August 22, 2024
    Publication date: December 12, 2024
    Applicant: Thrive Bioscience, Inc.
    Inventor: Alan Blanchard
  • CELL CULTURE INCUBATORS WITH INTEGRATED IMAGING SYSTEMS
    Publication number: 20240409873
    Abstract: Aspects relate to automated cell culture incubators comprising imaging systems, e.g., holographic or phase-contrast imagers, configured for imaging said cells within the incubators.
    Type: Application
    Filed: August 22, 2024
    Publication date: December 12, 2024
    Applicant: Thrive Bioscience, Inc.
    Inventor: Alan Blanchard
  • Methods of decreasing dysbiosis and restoring a microbiome
    Patent number: 12161680
    Abstract: Provided herein are methods for decreasing dysbiosis, restoring the microbiome, and/or increasing recovery of a healthy microbiome (e.g. following a dysbiosis inducing event), by administering pharmaceutical compositions to a subject. Also provided are methods for protecting the microbiome of a subject and/or colonizing the microbiome of a subject by administering pharmaceutical compositions to the subject.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: December 10, 2024
    Assignee: Vedanta Biosciences, Inc.
    Inventors: Jason Norman, Bernat Olle, Bruce Roberts, Rajita Menon
  • Cell sorter with pivotal scuppers
    Patent number: 12162013
    Abstract: A compact sorting flow cytometer system is disclosed. The system includes a flow cell and a deflection unit in communication with the flow cell to receive charged drops and uncharged drops in a stream of a sample biological fluid. The deflection unit includes a case having a deflection cone and chamber, a tub with a drain, and a slot in a base. The deflection unit further includes electrostatic charge plates in the cone forming an electrostatic charge field; and first and second pivotal scuppers, and a center non-pivotal collector arranged along a shaft in the tub of the case. Uncharged drops pass the electrostatic charge field undeflected in a center stream path while charged drops are deflected away from it. The pivotal scuppers pivot between positions to direct charged drops into the tub for aspiration or to pass through the slot in the base for collection.
    Type: Grant
    Filed: May 31, 2022
    Date of Patent: December 10, 2024
    Assignee: Cytek Biosciences, Inc.
    Inventors: Glen Krueger, David Vrane, Kuncheng Wang, Qiuta Gu
  • Biological fluid filtration system
    Patent number: 12162010
    Abstract: A biological fluid filtration system for scanning a biological fluid so as to filter potentially undesirable constituents from the biological fluid for therapeutic or diagnostic purposes. The biological fluid filtration system generally includes a fluid receiving device adapted to receive a biological fluid. A valve including an inlet, a first outlet, and a second outlet is fluidly connected to the fluid receiving device. The biological fluid within the fluid receiving device is scanned by a scanner to produce scanned data relating to the biological fluid. A control unit in communication with the scanner and the valve receives the scanned data and controls the valve based on the scanned data. The valve is controlled to direct the biological fluid through either the first or second outlet of the valve depending upon the constituents of the biological fluid identified by the control unit.
    Type: Grant
    Filed: March 18, 2021
    Date of Patent: December 10, 2024
    Assignee: Astrin Biosciences, Inc.
    Inventor: Jayant Parthasarathy
  • RECOGNITION SEQUENCES FOR I-CREI-DERIVED MEGANUCLEASES AND USES THEREOF
    Publication number: 20240401110
    Abstract: Methods of cleaving double-stranded DNA that can be recognized and cleaved by a rationally-designed, I-Crel-derived meganuclease are provided. Also provided are recombinant nucleic acids, cells, and organisms containing such recombinant nucleic acids, as well as cells and organisms produced using such meganucleases. Also provided are methods of conducting a custom-designed, I-Crel-derived meganuclease business.
    Type: Application
    Filed: March 14, 2024
    Publication date: December 5, 2024
    Applicant: Precision BioSciences, Inc.
    Inventors: Derek Jantz, James Jefferson Smith
  • Methods for diagnosing and assessing disease using drain fluid
    Patent number: 12157920
    Abstract: The present invention provides methods for using drain fluid obtained from medical procedures to assess diagnostic biomarkers indicative of disease obtained from drain fluid. In some embodiments, the diagnostics biomarkers are cell-free nucleic acids. In some embodiments, the disease is cancer. In some embodiments, a library of cfDNA is prepared and/or sequenced. In some embodiments, the methods comprise extracting nucleic acid from surgical drain fluid; conducting a size selection procedure to isolate cell-free nucleic acid from the surgical drain fluid; and detecting the cell-free nucleic acid.
    Type: Grant
    Filed: April 16, 2024
    Date of Patent: December 3, 2024
    Assignee: Droplet Biosciences, Inc.
    Inventors: Wendy Winckler Adamovich, Seka Lazare, Damion L. Whitfield, Megan Elisabeth Long
  • SPATIALLY ENCODED BIOLOGICAL ASSAYS
    Publication number: 20240392351
    Abstract: The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.
    Type: Application
    Filed: August 2, 2024
    Publication date: November 28, 2024
    Applicant: Prognosys Biosciences, Inc.
    Inventor: Mark S. Chee
  • METHOD OF TREATING HEPATITIS C VIRUS IN PATIENTS
    Publication number: 20240390408
    Abstract: The present disclosure describes methods of treating a hepatitis C virus (HCV) infection in a patient in need thereof by orally administering to the patient a therapeutically effective amount of a pharmaceutical composition, which may include one or more of compounds disclosed herein. The methods of treating the HCV infection in the patient may result in clearance of the HCV infection as measured by sustained virologic response.
    Type: Application
    Filed: May 23, 2024
    Publication date: November 28, 2024
    Applicant: Altesa BioSciences, Inc.
    Inventors: Brett Paul GIROIR, Katherine Elizabeth SQUIRES, John Michael CLERICI
  • Skin treatment devices
    Patent number: 12150840
    Abstract: Devices, kits and methods described herein may be for wound healing, including the treatment, amelioration, or prevention of scars and/or keloids by applying and/or maintaining a pre-determined strain in an elastic skin treatment device that is then affixed to the skin surface using skin adhesives to transfer a generally planar force from the bandage to the skin surface. Applicators are used to apply and/or maintain the strains, and some of the applicators are further configured to provide at least some mechanical advantage to the user when exerting loads onto the skin treatment device.
    Type: Grant
    Filed: December 27, 2019
    Date of Patent: November 26, 2024
    Assignee: Neodyne Biosciences, Inc.
    Inventors: John A. Zepeda, Jasper Jackson, William Beasley, Darren Doud, Brett Follmer
  • Gel electrophoresis diagnostic kit and methods of using the same
    Patent number: 12153015
    Abstract: An electrophoretic device for detecting biomarkers in collected bodily fluid and methods of using the same.
    Type: Grant
    Filed: May 22, 2023
    Date of Patent: November 26, 2024
    Assignee: Vital Biosciences Inc.
    Inventors: Mounir A. Koussa, Calvin Domenico, Ronald L. Green, Joshua John Forman, Andrew Ward, Lisa Caldwell
  • Method and system for cell operations using the internet of things
    Patent number: 12152230
    Abstract: A data collection hub and method wherein a controller is configured to receive data from a plurality of sensors sensing conditions related to the performance of operations on cells by at least one instrument. A database stores the data from the plurality of sensors and the controller is configured to compare data from the plurality of sensors for a past operation with the data for a more recent operation.
    Type: Grant
    Filed: June 18, 2023
    Date of Patent: November 26, 2024
    Assignee: Thrive Bioscience, Inc.
    Inventors: Howard Cannon, Thomas Forest Farb
  • NUCLEIC ACIDS ENCODING ENGINEERED MEGANUCLEASES WITH RECOGNITION SEQUENCES FOUND IN THE HUMAN T CELL RECEPTOR ALPHA CONSTANT REGION GENE
    Publication number: 20240382526
    Abstract: Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human T cell receptor alpha constant region gene. The present disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells.
    Type: Application
    Filed: August 2, 2024
    Publication date: November 21, 2024
    Applicant: Precision BioSciences, Inc.
    Inventors: Michael G. Nicholson, James Jefferson Smith, Derek Jantz, Victor Bartsevich, Daniel T. MacLeod, Jeyaraj Antony
  • Systems and methods for cell dissociation
    Patent number: 12146823
    Abstract: A system for dissociating cells from a cell culture vessel. The system comprises an imaging system configured to image a plurality of cells in a cell culture vessel being dissociated from at least one surface of the cell culture vessel by at least one cell dissociation agent; and at least one controller coupled to the imaging system and configured to: control the imaging system to capture a sequence of images of at least some cells in the plurality of cells during dissociation; and identify when to neutralize the at least one cell dissociation agent using the sequence of images.
    Type: Grant
    Filed: March 20, 2023
    Date of Patent: November 19, 2024
    Assignee: Thrive Bioscience, Inc.
    Inventors: Kam Lin Wong, Melanie Scully
  • Process for preparing tetralin compounds
    Patent number: 12145901
    Abstract: The present disclosure describes processes and intermediates useful for preparing a compound of Formula (Xa) or Formula (Xb). The processes and intermediates can be used to prepare the compounds of the disclosure at multigram or kilogram scale.
    Type: Grant
    Filed: September 16, 2022
    Date of Patent: November 19, 2024
    Assignee: Arcus Biosciences, Inc.
    Inventors: Joel Worley Beatty, Samuel Lawrie Drew, Matthew Epplin, Jeremy Fournier, Balint Gal, Karl T. Haelsig, Clayton Hardman, Jaroslaw Kalisiak, Kenneth Victor Lawson, Manmohan Reddy Leleti, Artur Karenovich Mailyan, Guillaume Mata, Brandon Reid Rosen, Zhang Wang, Kai Yu
  • Inhibitors of cysteine proteases and methods of use thereof
    Patent number: 12145911
    Abstract: The disclosure provides compounds with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.
    Type: Grant
    Filed: May 31, 2022
    Date of Patent: November 19, 2024
    Assignee: Pardes Biosciences, Inc.
    Inventors: Lee D. Arnold, Andy Jennings, Walter Keung
  • Multivalent and Multispecific DR5-Binding Fusion Proteins
    Publication number: 20240376220
    Abstract: The disclosure relates generally to molecules that specifically engage death receptor 5 (DR5), a member of the TNF receptor superfamily (TNFRSF). More specifically the disclosure relates to multivalent and multispecific molecules that bind at least DR5.
    Type: Application
    Filed: April 4, 2024
    Publication date: November 14, 2024
    Applicant: Inhibrx Biosciences, Inc.
    Inventors: John C. Timmer, Kyle S. Jones, Amir S. Razai, Abrahim Hussain, Katelyn M. Willis, Quinn Deveraux, Brendan P. Eckelman