Patents Assigned to Biosystems Inc.
  • Stimulus-sensitive microparticles and methods of use
    Patent number: 9988686
    Abstract: Provided are stimulus-sensitive microparticles and their use, e.g., in tracking the efficiency of recovery of a rare cell population (e.g., circulating tumor cells) from a mixture of cells; and in supplying control nucleic acids to index a molecular assay independent of the rare cell selection steps.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: June 5, 2018
    Assignee: Cynvenio Biosystems, Inc.
    Inventor: William M. Strauss
  • Systems and methods for assessing data collected from an electrically active cell culture
    Patent number: 9983198
    Abstract: Disclosed herein are systems and methods for assessing electrically active cell cultures. Optionally, the data can be collected using a microelectrode array (MEA). For example, electrically active cells, such as cardiomyocytes, are cultured such that they are in electrical communication with at least a portion of the electrodes of a well of the MEA. The assessments derived from the disclosed methods may be used to reduce the effects of confounding variables in data obtained from an electrically active cell culture. The methods may also be used to determine a quantitative measure of arrhythmia burden. The methods may also be used to decide if a particular culture or set of data is suitable for inclusion in scientific and characterization studies. Also disclosed is a method of finding the global conduction velocity of an electrically active cell culture.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: May 29, 2018
    Assignee: Axion BioSystems, Inc.
    Inventors: Stacie Ann Chvatal, Daniel Christopher Millard, James David Ross
  • DELIVERING AND/OR RECEIVING FLUIDS
    Publication number: 20180132774
    Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.
    Type: Application
    Filed: June 27, 2017
    Publication date: May 17, 2018
    Applicant: Seventh Sense Biosystems, Inc.
    Inventors: Javier Gonzalez-Zugasti, A. David Boccuti, Donald E. Chickering, III, Mark Michelman, Ramin Haghgooie, Shawn Davis, Scott James, Maisam Dadgar, Greg Fisher, Richard L. Miller, Christopher J. Morse, Howard Bernstein, Douglas A. Levinson
  • Magnetic needle separation and optical monitoring
    Patent number: 9964469
    Abstract: Apparatuses and methods for removing magnetic particles from suspensions are described. One embodiment of the apparatus is called a magnetic needle.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: May 8, 2018
    Assignee: Imagion Biosystems, Inc.
    Inventors: Edward R Flynn, Erika Vreeland
  • Method of and System for Printing In-Well Calibration Features
    Publication number: 20180120310
    Abstract: An apparatus and a method are disclosed for printing in-well calibration features onto assay substrates. An apparatus includes a testing substrate; a plurality of capture compound features in a well of the testing substrate; a calibration feature on one of the capture compound features in the well of the testing substrate, where the calibration feature has a known concentration of a compound that is capable of binding to the capture compound; and at least one additional capture compound feature in the same well of the testing substrate, where the at least one additional capture compound feature does not have a calibration feature printed onto the at least one additional capture compound feature. Methods for using the same are disclosed.
    Type: Application
    Filed: December 22, 2017
    Publication date: May 3, 2018
    Applicant: Aushon Biosystems, Inc.
    Inventors: Peter HONKANEN, Christine A. BURNS
  • Methods and composition to generate unique sequence DNA probes, labeling of DNA probes and the use of these probes
    Patent number: 9957571
    Abstract: The invention relates generally to the field of the identification of DNA sequences, genes or chromosomes. Methods and composition to obtain Unique Sequence DNA probes are provided. Compositions comprises of and double stranded DNA containing Unique Sequences from which the repetitive sequences are eliminated according to the method described in this invention. The invention also relates to the preservation of cells that have been identified after immunomagnetic selection and fluorescent labeling in order to further interrogate the cells of interest. Furthermore the invention relates to genetic analysis of cells that have been identified after immunomagnetic selection and fluorescent labeling.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: May 1, 2018
    Assignee: Menarini Silicon Biosystems, Inc.
    Inventors: John Verrant, Mark Carle Connelly, Brad Foulk, Michael T Kagan, Joost F Swennenhuis, Leon W. M. M. Terstappen, Arjan G. J. Tibbe
  • HOST CELLS WITH ARTIFICIAL ENDOSYMBIONTS
    Publication number: 20180092994
    Abstract: The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell through at least five cell divisions, and methods of introducing such single-celled organisms into eukaryotic cells. The invention also provides methods of using such eukaryotic cells. The invention further provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetotactic bacteria.
    Type: Application
    Filed: November 22, 2017
    Publication date: April 5, 2018
    Applicant: Bell Biosystems, Inc.
    Inventors: Caleb B. Bell, III, Alexey Bazarov
  • Herpes simplex virus vaccine compositions and methods of production and use thereof
    Patent number: 9919045
    Abstract: Vaccine compositions are disclosed for vaccinating a human or animal against herpes simplex virus infections. Also provided are methods of producing vaccines against herpes simplex virus and methods of using such vaccines to prevent or ameliorate herpes simplex virus-associated disease such as genital herpes.
    Type: Grant
    Filed: July 24, 2016
    Date of Patent: March 20, 2018
    Assignee: Sigmovir Biosystems, Inc.
    Inventors: Marina S. Boukhvalova, Jorge C. G. Blanco
  • Compositions and methods for modifying genomes
    Patent number: 9896696
    Abstract: Compositions and methods for modifying genomic DNA sequences are provided. The methods produce double-stranded breaks (DSBs) at pre-determined target sites in a genomic DNA sequence, resulting in mutation, insertion, and/or deletion of DNA sequences at the target site(s) in a genome. Compositions comprise DNA constructs comprising nucleotide sequences that encode a Cpf1 or Csm1 protein operably linked to a promoter that is operable in the cells of interest. The DNA constructs can be used to direct the modification of genomic DNA at pre-determined genomic loci. Methods to use these DNA constructs to modify genomic DNA sequences are described herein. Additionally, compositions and methods for modulating the expression of genes are provided.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: February 20, 2018
    Assignee: Benson Hill Biosystems, Inc.
    Inventors: Matthew Begemann, Benjamin Neil Gray
  • MOLECULAR CHARACTERIZATION OF CIRCULATING TUMOR CELLS
    Publication number: 20180045712
    Abstract: The disclosed invention includes methods and kits for the removal of white blood cells from samples of immunomagnetically enriched rare cells by treating the sample with a leukocyte marker conjugated to a hapten which adheres to the white blood cells and treating the resulting product with a second medium that adheres to the hapten of the white blood cells that are labeled with the leukocyte marker conjugated to hapten and removing the labeled white blood cells.
    Type: Application
    Filed: October 11, 2017
    Publication date: February 15, 2018
    Applicant: Menarini Silicon Biosystems, Inc.
    Inventors: Galla Chandra RAO, Brad FOULK, Denis SMIRNOV, Karl NIELSEN
  • COMPOSITIONS AND METHODS FOR INCREASING PLANT GROWTH AND YIELD USING RICE PROMOTERS
    Publication number: 20180030467
    Abstract: Compositions and methods for improving plant growth are provided herein. Compositions comprise promoter sequences that direct expression of an operably linked nucleotide in a developmentally regulated manner. Polynucleotides, polypeptides, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided.
    Type: Application
    Filed: July 13, 2015
    Publication date: February 1, 2018
    Applicant: Benson Hill Biosystems, Inc.
    Inventors: Thomas P. Brutnell, Douglas W. Bryant, Todd Christopher Mockler, Lin Wang
  • Eukaryotic Cells with Artificial Endosymbionts for Multimodal Detection
    Publication number: 20180008728
    Abstract: The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell, and methods of introducing such single-celled organisms into eukaryotic cells. The invention provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetic bacteria. The invention further provides eukaryotic cells engineered with single-celled organisms to allow for multimodal observation of the eukaryotic cells. Each imaging method (or modality) allows the visualization of different aspects of anatomy and physiology, and combining these allows the imager to learn more about the subject being imaged.
    Type: Application
    Filed: September 20, 2017
    Publication date: January 11, 2018
    Applicant: Bell Biosystems, Inc.
    Inventors: Caleb B. Bell, III, Alexey Bazarov
  • DEVICES AND METHODS FOR DELIVERING AND/OR RECEIVING FLUID
    Publication number: 20180008183
    Abstract: The present invention generally relates to collecting, determining and/or transmitting information associated with the process of receiving bodily fluid through a device opening and/or delivering substances to a subject. In one aspect, the device includes an information collecting portion and a fluid receiving portion. In another aspect, the two portions are constructed and designed to attach to one another. In one embodiment, actuation of one of the portions causes the other portion to actuate. Methods of time keeping and information transmission are also discussed.
    Type: Application
    Filed: January 28, 2016
    Publication date: January 11, 2018
    Applicant: Seventh Sense Biosystems, Inc.
    Inventors: Donald E. Chickering, III, Li Yang Chu, Sergey Grigoryants, Scott James, Jacob Wachlin
  • Host cells with artificial endosymbionts
    Patent number: 9827333
    Abstract: The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell through at least five cell divisions, and methods of introducing such single-celled organisms into eukaryotic cells. The invention also provides methods of using such eukaryotic cells. The invention further provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetotactic bacteria.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: November 28, 2017
    Assignee: Bell Biosystems, Inc.
    Inventors: Caleb B. Bell, III, Alexey Bazarov
  • Molecular characterization of circulating tumor cells
    Patent number: 9823238
    Abstract: The disclosed invention includes methods and kits for the removal of white blood cells from samples of immunomagnetically enriched rare cells by treating the sample with a leukocyte marker conjugated to a hapten which adheres to the white blood cells and treating the resulting product with a second medium that adheres to the hapten of the white blood cells that are labeled with the leukocyte marker conjugated to hapten and removing the labeled white blood cells.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 21, 2017
    Assignee: Menarini Silicon Biosystems, Inc.
    Inventors: Galla Chandra Rao, Brad Foulk, Denis Smirnov, Karl Nielsen
  • Eukaryotic cells with artificial endosymbionts for multimodal detection
    Patent number: 9814790
    Abstract: The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell, and methods of introducing such single-celled organisms into eukaryotic cells. The invention provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetic bacteria. The invention further provides eukaryotic cells engineered with single-celled organisms to allow for multimodal observation of the eukaryotic cells. Each imaging method (or modality) allows the visualization of different aspects of anatomy and physiology, and combining these allows the imager to learn more about the subject being imaged.
    Type: Grant
    Filed: May 13, 2017
    Date of Patent: November 14, 2017
    Assignee: Bell Biosystems, Inc.
    Inventors: Caleb B. Bell, III, Alexey Bazarov
  • Methods for overcoming resistance to tramadol
    Patent number: 9808432
    Abstract: There is disclosed a method for treating disorders modulated by at least opiate receptor activity or monoamine activity, including acute and chronic pain, comprising administering a pharmaceutical formulation comprising O-desmethyltramadol. Methods are also provided that are effective for overcoming resistance to tramadol in patients.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: November 7, 2017
    Assignee: Syntrix Biosystems Inc.
    Inventor: John A. Zebala
  • Fluid reservoir
    Patent number: 9802197
    Abstract: Provided herein are fluid reservoirs or hoppers for controlled delivery of liquid biological sample to a microfluidic device.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: October 31, 2017
    Assignee: Cynvenio Biosystems, Inc.
    Inventors: Behrad Vahidi, Bernard Strong, Samuel Ferguson
  • NMR methods for monitoring blood clot formation
    Patent number: 9797914
    Abstract: The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: October 24, 2017
    Assignee: T2 Biosystems, Inc.
    Inventors: Thomas Jay Lowery, Jr., Vyacheslav Papkov, Walter W. Massefski, Jr., Rahul K. Dhanda, Edward Chris Thayer
  • Methods and devices for sequencing nucleic acids in smaller batches
    Patent number: 9791409
    Abstract: The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. A plurality of smaller flow cells is employed, each with a relatively small area to be imaged, in order to provide greater flexibility and efficiency.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: October 17, 2017
    Assignee: Intelligent BioSystems, Inc.
    Inventors: Steven Gordon, Thomas Hagerott, Edmund Golaski, Jerzy Olejnik