Patents Assigned to Biosystems Inc.
  • Illumination apparatus optimized for synthetic aperture optics imaging using minimum selective excitation patterns
    Patent number: 10429665
    Abstract: A synthetic aperture optics (SAO) imaging method minimizes the number of selective excitation patterns used to illuminate the imaging target, based on the objects' physical characteristics corresponding to spatial frequency content from the illuminated target and/or one or more parameters of the optical imaging system used for SAO. With the minimized number of selective excitation patterns, the time required to perform SAO is reduced dramatically, thereby allowing SAO to be used with DNA sequencing applications that require massive parallelization for cost reduction and high throughput. In addition, an SAO apparatus optimized to perform the SAO method is provided. The SAO apparatus includes a plurality of interference pattern generation modules that can be arranged in a half-ring shape.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: October 1, 2019
    Assignee: Optical Biosystems, Inc.
    Inventors: Chun-Sheu Lee, Jong Buhm Park
  • Magnetic needle separation and optical monitoring
    Patent number: 10429277
    Abstract: Apparatuses and methods for removing magnetic particles from suspensions are described. One embodiment of the apparatus is called a magnetic needle.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: October 1, 2019
    Assignee: Imagion Biosystems, Inc.
    Inventors: Edward R Flynn, Erika Vreeland
  • Isotachophoresis for purification of nucleic acids
    Patent number: 10415030
    Abstract: The present disclosure relates to fluidic systems and devices for processing, extracting, or purifying one or more analytes. These systems and devices can be used for processing samples and extracting nucleic acids, for example by isotachophoresis. In particular, the systems and related methods can allow for extraction of nucleic acids, including non-crosslinked nucleic acids, from samples such as tissue or cells. The systems and devices can also be used for multiplex parallel sample processing.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: September 17, 2019
    Assignee: Purigen Biosystems, Inc.
    Inventors: Lewis A. Marshall, Amy L. Hiddessen, Nathan P. Hoverter, Klint A. Rose, Juan G. Santiago
  • Cell culturing device
    Patent number: 10407707
    Abstract: The invention features devices and kits for capturing and culturing microorganisms (e.g., bacteria, fungi, or protists) and methods of using the devices and kits to detect microorganisms in environmental and other samples. The device includes a nutrient media having a flat growth area on which microorganisms can grow. Samples are collected by contacting the device with any environmental sample, e.g., rolling device on a work surface or exposing device to air, or by filtering a sample through a membrane. Microorganisms deposited on the membrane derive nutrients from the underlying media and grow into colonies that can then be detected using methods known in the art. The detected colonies can be imaged digitally or with film.
    Type: Grant
    Filed: April 16, 2013
    Date of Patent: September 10, 2019
    Assignee: Rapid Micro Biosystems, Inc.
    Inventors: Douglas J. Browne, Sarkis Karakozian, Xiaowei Chen
  • Sequencing and high resolution imaging
    Patent number: 10378053
    Abstract: Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. These have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy of polynucleotide sequencing applications.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: August 13, 2019
    Assignee: Apton Biosystems, Inc.
    Inventors: Bryan P. Staker, Niandong Liu, Manohar R. Furtado, Rixun Fang, Norman Burns, Windsor Owens
  • INCREASING PLANT GROWTH AND YIELD BY USING A PSAN SEQUENCE
    Publication number: 20190233839
    Abstract: Compositions and methods for improving plant growth are provided herein. Polynucleotides encoding photosystem I reaction center subunit N (PSAN) proteins, polypeptides encompassing PSAN proteins, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided.
    Type: Application
    Filed: June 14, 2017
    Publication date: August 1, 2019
    Applicant: Benson Hill Biosystems, Inc.
    Inventors: Benjamin Neil Gray, Henry D. Priest
  • Molecular characterization of circulating tumor cells
    Patent number: 10365266
    Abstract: The disclosed invention includes methods and kits for the removal of white blood cells from samples of immunomagnetically enriched rare cells by treating the sample with a leukocyte marker conjugated to a hapten which adheres to the white blood cells and treating the resulting product with a second medium that adheres to the hapten of the white blood cells that are labeled with the leukocyte marker conjugated to hapten and removing the labeled white blood cells.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: July 30, 2019
    Assignee: Menarini Silicon Biosystems, Inc.
    Inventors: Galla Chandra Rao, Brad Foulk, Denis Smirnov, Karl Nielsen
  • Perfusion filtration systems
    Patent number: 10358626
    Abstract: Provided herein are tubular membrane filter elements, tangential flow filtration systems comprising such filter elements and methods of using such filter elements and filtration systems.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: July 23, 2019
    Assignee: Artemis Biosystems, Inc.
    Inventors: Maurizio V. Cattaneo, Remco A. Spanjaard
  • Methods and apparatuses for sorting target particles
    Patent number: 10350595
    Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: July 16, 2019
    Assignee: Orca Biosystems, Inc.
    Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
  • TWO-STAGE THERMAL CONVECTION APPARATUS AND USES THEREOF
    Publication number: 20190210028
    Abstract: Disclosed is a multi-stage thermal convection apparatus such as a two-stage thermal convection apparatus and uses thereof. In one embodiment, the two-stage thermal convection apparatus includes a temperature shaping element that assists a thermal convection mediated Polymerase Chain Reaction (PCR). The invention has a wide variety of applications including amplifying nucleic acid without cumbersome and expensive hardware associated with many prior devices. In a typical embodiment, the apparatus can fit in the palm of a user's hand for use as a portable, simple to operate, and low cost PCR amplification device.
    Type: Application
    Filed: August 22, 2018
    Publication date: July 11, 2019
    Applicant: Ahram Biosystems, Inc.
    Inventor: Hyun Jin Hwang
  • CLINICAL AND/OR CONSUMER TECHNIQUES AND DEVICES
    Publication number: 20190209820
    Abstract: The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from other tissues of the body. In some cases, the device may contain a substance transfer component such as needles or microneedles, which can be inserted into the skin or another organ to deliver and/or receiving fluid or other substances from the subject. In some embodiments, the device may include an activator constructed and arranged to insert one or more substance transfer components into the skin or other organ. In certain cases, the device may also include a storage chamber for receiving a fluid received from the subject.
    Type: Application
    Filed: July 30, 2018
    Publication date: July 11, 2019
    Applicant: Seventh Sense Biosystems, Inc.
    Inventors: Donald E. Chickering, III, Douglas A. Levinson, Shawn Davis, Ramin Haghgooie, Howard Bernstein, David R. Walt
  • OMEGA AMPLIFICATION
    Publication number: 20190203271
    Abstract: The present disclosure provides compositions, methods and kits for Omega amplification technologies. In addition, the present disclosure provides compositions, methods and kits for universal FQ probe and for G-quadruplex detection methods for use in isothermal amplification technologies.
    Type: Application
    Filed: May 24, 2017
    Publication date: July 4, 2019
    Applicant: Atila Biosystems, Inc.
    Inventors: Youxiang WANG, Xin CHEN, Rong WANG, Zhijie YANG, Yu ZHAO
  • Devices for control of condensation and methods of use thereof
    Patent number: 10330343
    Abstract: The present invention relates to devices including a heating element with an opening, which can control condensation of liquid samples during thermal incubation. The opening of the heating element can provide direct access to the samples in a process that may be automated. The invention also provides methods for heating containers.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: June 25, 2019
    Assignee: T2 Biosystems, Inc.
    Inventor: Adam Suchocki
  • Methods and materials for detecting genetic or epigenetic elements
    Patent number: 10329619
    Abstract: This document provides methods and materials for detecting genetic and/or epigenetic elements. For example, methods and materials for detecting the presence or absence of target nucleic acid containing a genetic or epigenetic element, methods and materials for detecting the amount of target nucleic acid containing a genetic or epigenetic element within a sample, kits for detecting the presence or absence of target nucleic acid containing a genetic or epigenetic element, kits for detecting the amount of target nucleic acid containing a genetic or epigenetic element present within a sample, and methods for making such kits are provided.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: June 25, 2019
    Assignee: Cascade Biosystems, Inc.
    Inventors: Kenneth D. Smith, Nina Yazvenko, Mariya Smit
  • Compositions and methods for modifying genomes
    Patent number: 10316324
    Abstract: Compositions and methods for modifying genomic DNA sequences are provided. The methods produce double-stranded breaks (DSBs) at pre-determined target sites in a genomic DNA sequence, resulting in mutation, insertion, and/or deletion of DNA sequences at the target site(s) in a genome. Compositions comprise DNA constructs comprising nucleotide sequences that encode a Cms1 protein operably linked to a promoter that is operable in the cells of interest. The DNA constructs can be used to direct the modification of genomic DNA at pre-determined genomic loci. Methods to use these DNA constructs to modify genomic DNA sequences are described herein. Additionally, compositions and methods for modulating the expression of genes are provided.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: June 11, 2019
    Assignee: Benson Hill Biosystems, Inc.
    Inventors: Matthew Begemann, Benjamin Neil Gray
  • Multiwell microelectrode array with optical stimulation
    Patent number: 10317391
    Abstract: An electro-optical stimulation and recording system is disclosed, including a substrate and a plurality of wells coupled to the substrate. The system also includes at least one electrode set disposed proximate a respective one of the plurality of wells, wherein the electrode set comprises at least one electrode configured to collect an electric signal associated with at least a portion of the respective well. The system also includes a light-emitting element set corresponding to a respective one of the wells and configured to deliver optical stimulation to at least a portion of the respective well.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: June 11, 2019
    Assignee: Axion BioSystems, Inc.
    Inventors: Isaac Perry Clements, Amanda Jervis Preyer, Swaminathan Rajaraman, Daniel Christopher Millard, James David Ross
  • THREE-STAGE THERMAL CONVECTION APPARATUS AND USES THEREOF
    Publication number: 20190168215
    Abstract: Disclosed is a multi-stage thermal convection apparatus and uses thereof. In one embodiment, the invention features a three-stage thermal convection apparatus that includes a temperature shaping element for assisting a thermal convection mediated Polymerase Chain Reaction (PCR). The invention has a wide variety of applications including amplifying nucleic acid without cumbersome and expensive hardware associated with many prior devices. In a typical embodiment, the apparatus can fit in the palm of a user's hand for use as a portable, simple to operate, and low cost PCR amplification device.
    Type: Application
    Filed: August 22, 2018
    Publication date: June 6, 2019
    Applicant: Ahram Biosystems, Inc.
    Inventor: Hyun Jin Hwang
  • DELIVERING AND/OR RECEIVING FLUIDS
    Publication number: 20190159709
    Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a rotatable element that actuates the deployment actuator.
    Type: Application
    Filed: July 25, 2017
    Publication date: May 30, 2019
    Applicant: Seventh Sense Biosystems, Inc.
    Inventors: Vincent James Barone, Jerry Brightbill, Bernard Bunner, Li Yang Chu, Ping Gong, Scott James, Inderpal Singh
  • Pyrimidinecarboxamides as CXCR2 modulators
    Patent number: RE47415
    Abstract: There is disclosed pyridine- and pyrimidinecarboxamide compounds useful as pharmaceutical agents, synthesis processes, and pharmaceutical compositions which include pyridine- and pyrimidinecarboxamides compounds. More specifically, there is disclosed a genus of CXCR2 inhibitor compounds that are useful for treating a variety of inflammatory and neoplastic disorders.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: June 4, 2019
    Assignee: Syntrix Biosystems, Inc.
    Inventors: Dean Y. Maeda, John A. Zebala
  • Modular cartridge assembly
    Patent number: D852977
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: July 2, 2019
    Assignee: T2 Biosystems, Inc.
    Inventors: Adam Suchocki, Steven Anthony Scampini, Joseph D. Antocci, Thomas Cygan, William Peine, Uli Thomann, Chris Werner