Abstract: A device for processing and cataloging of a sample, in a container having a label with identifying data, has a frame; a plurality of cameras mounted to the frame; and a controller system coupled to the cameras, the controller system including a controller and a non-transitory memory storing instructions, which, when executed by the controller, cause carrying out of computer processes that produce a catalog record output characterizing the sample, such record also including the identifying data.
Abstract: Compositions and methods for improving plant growth are provided herein. Polynucleotides encoding thioredoxin proteins, polypeptides encompassing thioredoxin proteins, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided.
Abstract: What is described is a method for treating cancer in a patient in need of such treatment through the use of an antagonist to CXCR1 and/or CXCR2 receptors by administering a therapeutically effective amount of an antagonist of CXCR1 and/or CXCR2, or pharmaceutical compositions thereof, either alone as monotherapy, or in combination with at least one other anticancer therapy.
Type:
Grant
Filed:
February 23, 2018
Date of Patent:
May 26, 2020
Assignee:
Syntrix Biosystems Inc.
Inventors:
John A. Zebala, Dean Y. Maeda, Aaron D. Schuler
Abstract: A device for processing and cataloging of a sample, in a container having a label with identifying data, has a frame; a plurality of cameras mounted to the frame; and a controller system coupled to the cameras, the controller system including a controller and a non-transitory memory storing instructions, which, when executed by the controller, cause carrying out of computer processes that produce a catalog record output characterizing the sample, such record also including the identifying data.
Abstract: A sweat sensing device includes a flexible body having a first, outwardly facing surface and a second, skin facing surface and a sweat channel formed in the body, the sweat channel having a first end defining a fluid inlet and a second end. A biochemical assay well formed in the sweat channel and an assay material is disposed in the biochemical assay well, the assay material positioned to react with sweat traveling through the sweat channel and to provide one of a visual indicator and an indicator detectable by a camera and connected processor of the flow of the sweat in the sweat channel.
Type:
Application
Filed:
July 24, 2018
Publication date:
April 30, 2020
Applicant:
Epicore Biosystems, Inc.
Inventors:
Jeffrey B. Model, Roozbeh Ghaffari, Alexander J. Aranyosi, Stephen P. Lee, Milan S. Raj
Abstract: The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing endotoxi-induced clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the level of endotoxin present in the sample.
Type:
Grant
Filed:
September 20, 2012
Date of Patent:
April 14, 2020
Assignee:
T2 Biosystems, Inc.
Inventors:
Rahul K. Dhanda, Vyacheslav Papkov, Thomas Jay Lowery, Jr.
Abstract: This document provides methods and materials for detecting target nucleic acid. For example, methods and materials for detecting the presence or absence of target nucleic acid, methods and materials for detecting the amount of target nucleic acid present within a sample, kits for detecting the presence or absence of target nucleic acid, kits for detecting the amount of target nucleic acid present within a sample, and methods for making such kits are provided.
Type:
Grant
Filed:
May 5, 2017
Date of Patent:
April 14, 2020
Assignee:
Cascade Biosystems, Inc.
Inventors:
Kenneth D. Smith, Nina Yazvenko, Mariya Smit
Abstract: This document provides methods and materials for detecting genetic and/or epigenetic elements. For example, methods and materials for detecting the presence or absence of target nucleic acid containing a genetic or epigenetic element, methods and materials for detecting the amount of target nucleic acid containing a genetic or epigenetic element within a sample, kits for detecting the presence or absence of target nucleic acid containing a genetic or epigenetic element, kits for detecting the amount of target nucleic acid containing a genetic or epigenetic element present within a sample, and methods for making such kits are provided.
Type:
Application
Filed:
June 21, 2019
Publication date:
February 20, 2020
Applicant:
Cascade Biosystems, Inc.
Inventors:
Kenneth D. Smith, Nina Yazvenko, Mariya Smit
Abstract: The present disclosure relates to automated systems and methods for washing microtiter plates that offer advantages such as increased efficiency and decreased contamination during the washing process. In an exemplary embodiment, an automated system for washing multiwell plates comprises an arm having a metal portion and having a multiwell plate holder for holding a multiwell plate; a first rotational servo configured to rotate the multiwell plate about a first axis; a second rotational servo configured to rotate the arm about a second axis; and a controller configured to operate the system to dispels fluid in the multiwell plate.
Abstract: What is described is a method for treating cancer in a patient in need of such treatment through the use of a dual CXCR1/2 antagonist by administering a therapeutically effective amount of a dual CXCR1/2 antagonist, or pharmaceutical compositions thereof, either alone as monotherapy, or in combination with at least one other anticancer therapy.
Abstract: Disclosed herein are methods, apparatuses, and devices for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, or skin repositioning. Such methods and devices include an ablative apparatus, a removal apparatus, and/or a positioning apparatus.
Type:
Grant
Filed:
August 8, 2014
Date of Patent:
February 11, 2020
Assignee:
Cytrellis Biosystems, Inc.
Inventors:
Alec Ginggen, Douglas Levinson, David Stone
Abstract: The present invention relates to methods and devices for skin tightening after incising or excising tissue portions from a subject. Exemplary methods and devices include tunable dressings having an adhesive layer and a regulatable layer or an un-stretched layer that responds to one or more external stimuli to contract or expand the dressing, where the contraction or expansion can be uniform or non-uniform.
Type:
Grant
Filed:
February 14, 2014
Date of Patent:
January 28, 2020
Assignee:
Cytrellis Biosystems, Inc.
Inventors:
Douglas Levinson, David Stone, Alec Ginggen
Abstract: The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. The flow activator may be actuated in a deployment direction by a deployment actuator, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, an effector may enable fluid communication between the opening and the vacuum source and may do so in response to actuation of the flow activator.
Type:
Grant
Filed:
November 11, 2016
Date of Patent:
January 28, 2020
Assignee:
Seventh Sense Biosystems, Inc.
Inventors:
Howard Bernstein, Donald E. Chickering, III, Ping Gong, Shawn Davis
Abstract: The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus.
Type:
Application
Filed:
December 1, 2017
Publication date:
January 16, 2020
Applicant:
Seventh Sense Biosystems, Inc.
Inventors:
Donald E. Chickering, III, Shawn Davis, Ramin Haghgooie, Howard Bernstein, Douglas A. Levinson, Mark Michelman
Abstract: An integrated sample analysis system is disclosed. The sample analysis system contains (1) a sample preparation/analysis module having sample purification device comprising a monolith that binds specifically to nucleic acids and a sample analysis device comprising a microarray enclosed in a reaction chamber having a hydrophilic interior surface; (2) a temperature control module comprising a thermocycler having a thermally conductive temperature-control bladder; and (3) an imaging device capable of capturing an image of the microarray in the reaction chamber.
Type:
Grant
Filed:
April 3, 2019
Date of Patent:
January 14, 2020
Assignee:
Akonni Biosystems, Inc.
Inventors:
Christopher G. Cooney, Phillip Belgrader, Arial Bueno, Steve Garber, Nitu Harshendu Thakore, Peter Qiang Qu
Abstract: The present invention relates to containers for holding liquid samples. The containers may be useful for mixing a liquid sample or lysing cells in a liquid sample. The invention also relates to methods of using the containers of the invention.
Type:
Grant
Filed:
March 8, 2017
Date of Patent:
November 26, 2019
Assignee:
T2 Biosystems, Inc.
Inventors:
Adam Suchocki, Mark John Audeh, Matthew Blanco, James Franklin Chepin, Vasiliki Demas, Marilyn Lee Fritzemeier, Thomas Jay Lowery, Jr., Michael Min, Lori Anne Neely, Charles William Rittershaus, Hwa-Tang Wang, Parris Wellman
Abstract: Compositions and methods for improving plant growth are provided herein. Compositions comprise promoter sequences that direct expression of an operably linked nucleotide in a developmentally regulated manner. Polynucleotides, polypeptides, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided.
Type:
Application
Filed:
July 26, 2019
Publication date:
November 14, 2019
Applicant:
Benson Hill Biosystems, Inc.
Inventors:
Thomas P. Brutnell, Douglas W. Bryant, Todd Christopher Mockler, Lin Wang
Abstract: In some embodiments, the present invention generally relates to the separation of blood within a device to form plasma or serum. In some embodiments, the present invention generally relates to the removal of fluids, such as blood, contained within a device. In one aspect, the present invention is generally directed to systems and methods for receiving blood from a subject and processing the blood to form plasma or serum. For example, a device may be applied to the skin of a subject to receive blood from the subject and pass the blood through a separation membrane, which separates the blood into plasma and a portion concentrated in blood cells. As another example, blood or plasma may be allowed to clot within the device and serum (the unclotted portion of the blood) may be withdrawn from the device. The device may contain, in some cases, a vacuum source such as a pre-packaged vacuum to facilitate receiving of blood and/or passage of the blood through the separation membrane to produce plasma or serum.
Type:
Application
Filed:
December 12, 2018
Publication date:
November 7, 2019
Applicant:
Seventh Sense Biosystems, Inc.
Inventors:
Ramin Haghgooie, Donald E. Chickering, III, Shawn Davis, Mark Michelman, Howard Bernstein, Kristin Horton
Abstract: The present invention provides improved DNA polymerases, in particular, type A DNA polymerases, that may be better suited for applications in recombinant DNA technologies. Among other things, the present invention provides modified DNA polymerases derived from directed evolution experiments designed to select mutations that confer advantageous phenotypes under conditions used in industrial or research applications.
Type:
Grant
Filed:
November 3, 2009
Date of Patent:
October 29, 2019
Assignee:
Kapa Biosystems, Inc.
Inventors:
William Bourn, Maryke Appel, Gavin Rush, John Foskett, Paul McEwan
Abstract: There is disclosed aminopyridine- and aminopyrimidinecarboxamide aminopyridinecarboxamide compounds useful as pharmaceutical agents, synthesis processes, and pharmaceutical compositions which include aminopyridine- and aminopyrimidinecarboxamides aminopyridinecarboxamide compounds. More specifically, there is disclosed a genus of CXCR2 inhibitor compounds that are useful for treating a variety of inflammatory and neoplastic disorders.
Type:
Grant
Filed:
July 14, 2016
Date of Patent:
November 26, 2019
Assignee:
Syntrix Biosystems Inc.
Inventors:
Dean Y. Maeda, John A. Zebala, Aaron D. Schuler