Patents Assigned to Biotechnology Research and Development Corporation
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Publication number: 20080241900Abstract: A new xylose reductase encoding gene from Neurspora crassa was heterologously expressed in E. coli as a His-tag fusion protein and subsequently purified in high yield. This xylose reductase was shown to have a high turnover rate and catalytic efficiency, high stability at room temperature, broad pH profile, and a preference of NADPH over NADH. This enzyme is utilized in production of xylitol and other sugar alcohols such as sorbitol and also in the metabolic enhancement of organisms used for fermentation of plant biomass into ethanol.Type: ApplicationFiled: May 19, 2008Publication date: October 2, 2008Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, BIOTECHNOLOGY RESEARCH AND DEVELOPMENT CORPORATIONInventors: Huimin Zhao, Ryan Woodyer, Michael Simurdiak, Wilfred A. van der Donk
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Patent number: 7402419Abstract: Phosphite dehydrogenase mutant enzymes were generated that provide relaxed cofactor specificity and increased thermostability over the wild type enzyme. The mutant enzymes are useful for nicotinamide cofactor regeneration.Type: GrantFiled: June 10, 2004Date of Patent: July 22, 2008Assignees: Biotechnology Research and Development Corporation, Board of Trustees of the University of IllinoisInventors: Huimin Zhao, William W. Metcalf, Wilfred A. van der Donk, Tyler Johnannes, Ryan Woodyer
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Publication number: 20070077214Abstract: A chemical composition comprising a linker agent and a compound comprising at least one UV-absorbing chromophore, wherein the linker agent is characterized by the general formula: wherein X1 and X2 are the same or different, and at least one of X1 or X2 is a functional group that bonds with the compound comprising at least one UV-absorbing chromophore, and b+f?2, Y comprises an 0, N, or S that is substituted or unsubstituted, each a, b, c, e and f is ?0 and a+b+c+e+f?2, d is 0 or 1, n1 and n2 represent the number of hydrogen atoms required to complete the undesignated valencies, and m ranges from 1 to about 100 and each individual m unit may be the same or different.Type: ApplicationFiled: June 19, 2006Publication date: April 5, 2007Applicants: Biotechnology Research & Development Corporation, United States Department of AgricultureInventors: Joseph Laszlo, David Compton, Louis DeFilippi, Steven Grall
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Publication number: 20070077636Abstract: A method of making a compound having the structural formula: wherein at least two of R1, R2, and R3 are non-fatty acid carboxylates, and the other of R1, R2, and R3 are each either a C2-C24 fatty acid moiety, OH, or a non-fatty acid carboxylate, wherein the first and second non-fatty acid carboxylates, when present, are the same or different, comprising (a) partially deacylating a triacylglycerol so as to provide a mono- or diacylglycerol, (b) reacting in a reaction mixture an acyl ester of the phytochemical with said mono- or diacylglycerol in the presence of a esterase catalyst under conditions that permit transesterification of said ester with said mono- or diacylglycerol, and (c) recovering said compound from said reaction mixture.Type: ApplicationFiled: June 19, 2006Publication date: April 5, 2007Applicants: Biotechnology Research & Development Corporation, United States Department of AgricultureInventors: Joseph Laszlo, David Compton, Louis DeFilippi, Steven Grall
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Patent number: 7193072Abstract: The present invention provides non-invasive methods and compositions to differentiate, with a high level of sensitivity and specificity, swine that are genetically susceptible to diseases associated with F18 E. coli infection, from resistant swine. DNA polymorphisms in the swine alpha (1,2) fucosyltransferase 1 (FUT1) gene were used to differentiate resistant from susceptible swine. The invention includes a polypeptide with amino acid substitutions, encoded by the nucleotide polymorphisms, a molecular diagnostic assay, and a kit for the differentiation, of E. coli F18-adhesion resistant, heterozygous (carrier) and homozygous susceptible pigs. The molecular test identifies susceptibility to oedema disease and postweaning diarrhea with high sensitivity and specificity, therefore, is useful to swine breeder in their effort to enhance for resistance. Information on the polymorphisms of the present invention provides insight into causation and treatment of E. coli associated intestinal disorders.Type: GrantFiled: July 25, 2001Date of Patent: March 20, 2007Assignees: Biotechnology Research and Development Corporation, The United States of America as represented by the Secretary of Agriculture, Swiss Federal Institute of TechnologyInventors: Brad T. Bosworth, Peter Vögeli
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Patent number: 7037959Abstract: A polymer composition includes a first component being a hydroxy-functional polymer, a second component being a natural polymer and a third component being a thermoplastic polyester. The first component, second component and third component are compounded to form a polymer composition.Type: GrantFiled: March 28, 2000Date of Patent: May 2, 2006Assignees: The United States of America as represented by the Secretary of the Agriculture, Biotechnology Research and Development CorporationInventors: Julious L. Willett, William M. Doane, Donald Garlotta
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Patent number: 6936262Abstract: Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.Type: GrantFiled: January 25, 2002Date of Patent: August 30, 2005Assignee: Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Publication number: 20050003549Abstract: Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.Type: ApplicationFiled: February 4, 2004Publication date: January 6, 2005Applicants: The USA as Represented by the Department of Agriculture, Biotechnology and Research and Development CorporationInventors: Robert Briggs, Fred Tatum
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Patent number: 6793927Abstract: Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.Type: GrantFiled: December 15, 1998Date of Patent: September 21, 2004Assignees: The United States of America as represented by the Secretary of the Department of Agriculture, Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 6632862Abstract: A polymer composition includes a first component being a hydroxy-functional polymer, a second component being a natural polymer and a third component being a thermoplastic polyester. The first component, second component and third component are compounded to form a polymer composition.Type: GrantFiled: May 18, 2001Date of Patent: October 14, 2003Assignees: The United States of America as represented by the Secretary of Agriculture, Biotechnology Research and Development CorporationInventors: Julius L. Willett, William M. Doane, Sterling St. Lawrence, Parvinder Walia
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Patent number: 6630543Abstract: A method of making a biodegradable polymer composition including the steps of providing a first component being either one of a thermoplastic poly(hydroxy ester ether) or a synthetic, hydroxy-functional polymer and providing a second component being a natural polymer. The method includes the steps of mixing the first component and second component together to form a mixture, compounding the mixture, and pelletizing the compounded mixture to form pellets of a biodegradable polymer composition.Type: GrantFiled: May 30, 2001Date of Patent: October 7, 2003Assignees: Biotechnology Research and Development Corporation, The United States of America as represented by the Secretary of AgricultureInventors: William M. Doane, Wayne Xu, Michael N. Mang, Jerry E. White, Julious L. Willett
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Patent number: 6573093Abstract: Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.Type: GrantFiled: October 19, 2001Date of Patent: June 3, 2003Assignee: Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 6495145Abstract: Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.Type: GrantFiled: October 19, 2001Date of Patent: December 17, 2002Assignees: The United States of America as represented by the Secretary of Agriculture, Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Publication number: 20020150584Abstract: Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.Type: ApplicationFiled: January 25, 2002Publication date: October 17, 2002Applicant: Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 6423310Abstract: Novel methods and compositions are provided for the biocontrol of plant diseases by use of a biological coating that confers both a protective and a curative effect for the control of postharvest decay. The coating includes chitosan salts, an antagonistic microorganism, and a cation. A composition of chitosan salts, CaCl2 and yeast is effective. The combined fungicidal activities of the chitosan salts and the antagonistic microorganism make the compositions of the present invention superior to previous coatings. When applied to the surface of a harvested plant commodity, the compositions both prevent and cure postharvest decay.Type: GrantFiled: June 2, 1999Date of Patent: July 23, 2002Assignees: Biotechnology Research and Development Corporation, The United States of America as represented by the Secretary of AgricultureInventors: Charles Wilson, Ahmed El Ghaouth
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Patent number: 6419922Abstract: Novel methods and compositions are provided for the biocontrol of plant diseases, in particular diseases causing plant postharvest decay. The novel compositions are “biocontrol cocktails” that are combinations of antagonistic microorganisms and antifungal agents. Suitable microorganisms include yeasts such as Candida spp. Suitable antifungal agents include enzymes or combinations of enzymes such as lysozyme or lyticase. The compositions are applied to the plants either to prevent or cure infections caused by microorganisms such as fungi. Synergistic effects occur. The methods and compositions are comparable to or better than synthetic fungicides or to either agent alone.Type: GrantFiled: June 2, 1999Date of Patent: July 16, 2002Assignees: Biotechnology Research and Development Corporation, The United States of America as represented by the Secretary of AgricultureInventors: Ahmed El Ghaouth, Charles Wilson
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Patent number: 6362256Abstract: A polymer composition includes a first component being a hydroxy-functional polymer, a second component being a natural polymer and a third component being a thermoplastic polyester. The first component, second component and third component are compounded to form a polymer composition.Type: GrantFiled: February 15, 2001Date of Patent: March 26, 2002Assignees: The United States of America as represented by the Secretary of Agriculture, Biotechnology Research and Development CorporationInventors: Julious L. Willett, William M. Doane
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Patent number: 6355859Abstract: The present invention relates interactions between genotype and diet that are useful in the dietary control of intestinal disease. Compositions are related that are useful to differentiate, with a high level of sensitivity and specificity, swine that are genetically resistant to a reduced rate of weight gain when fed diets containing high levels of SBM. The reduced rate of gain can be prevented by reducing the levels of SBM in nursery diets and replacing a majority of the soy bean meal with animal-based protein sources, fish meal, plasma or milk. Genetically resistant swine fed either the diet low in SBM, or a diet high in SBM, and susceptible swine fed a diet low in SBM, were not colonized by F18+E. coli and gained weight at an acceptable rate.Type: GrantFiled: September 18, 1998Date of Patent: March 12, 2002Assignees: Biotechnology Research and Development Corporation, The United States of America as represented by the Department of AgricultureInventors: Brad Bosworth, Julia Ridpath, Barry Wiseman
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Patent number: 6331303Abstract: Mutants of P. haemolytica provide excellent safety and efficacy when used as vaccines in ruminants, for example cattle, sheep, and goats, subject to pneumonic pasteurellosis. They can be administered by a variety of routes. Especially preferred is the use in animal feeds. The mutants are not reverting and contain no foreign DNA and no introduced antibiotic resistance genes.Type: GrantFiled: September 25, 1998Date of Patent: December 18, 2001Assignee: Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: RE38028Abstract: Tools for genetically engineering Pasteurellaceae are provided. Replication-conditional plasmids which are useful for the Pasteurellaceae have been isolated and characterized. The plasmids can be utilized for delivery of DNA segments into the Pasteurellaceae in situations where control of extra-chromosomal replication desired, such as in achieving allelic exchange or site-directed mutagenesis. A restriction endonuclease, HsoI, was isolated from a bovine lung isolate of Haemophilus somnus. The enzyme was found to be a true isoschizomer of HinPI, a commercially available enzyme originally isolated from Haemophilus influenzae PI. Commercially available HhaI methyl transferase was found to protect against cleavage by both enzymes. Methylation of foreign plasmid DNA was found to enhance transformation of Haemophilus somnus in excess of four orders of magnitude.Type: GrantFiled: November 21, 2000Date of Patent: March 11, 2003Assignees: Biotechnology Research and Development Corporation, The United States of America as represented by the Department of AgricultureInventors: Robert E. Briggs, Fred M. Tatum