Patents Assigned to Biotechnology Research and Development Corporation
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Patent number: 6221661Abstract: A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a “hairpin” portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.Type: GrantFiled: June 7, 1995Date of Patent: April 24, 2001Assignees: The of Regents for Northern Illinois University of DeKalb, Biotechnology Research and Development CorporationInventors: Arnold E. Hampel, Richard H. Tritz, Margaret F. Hicks
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Patent number: 6191196Abstract: A polymer composition uncludes a first component being a hydroxy-functional polymer, a second component being a natural polymer and a third component being a thermoplastic polyester. The first component, second component and third component are compounded to form a polymer composition.Type: GrantFiled: April 12, 1999Date of Patent: February 20, 2001Assignees: The United States of America as represented by the Secretary of Agriculture, Biotechnology Research and Development CorporationInventors: Julious L. Willett, William M. Doane
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Patent number: 6054510Abstract: Compositions of the invention include a hydroxy-functional polyester and a natural polymer. Articles can be made from such a composition so as to have sufficiently strong tensile strengths as to form disposable utensils or to have sufficient stretchability so as to form thin wrap films. However, the compositions are more environmentally friendly than commodity plastics such as polyethylene or polystyrene. Granular starches derived from a grain, a root, a legume, or mixtures thereof, are particularly preferred as the natural polymers for inclusion in the compositions.Type: GrantFiled: September 10, 1998Date of Patent: April 25, 2000Assignees: The United States of America as represented by the Secretary of the Agriculture, Biotechnology Research and Development CorporationInventors: Julious L. Willett, William M. Doane, Wayne Xu, Michael N. Mang, Jerry E. White
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Patent number: 5955646Abstract: Chimeric regulatory regions and gene cassettes based upon Agrobacterium tumefaciens opine sythase genes are provided for expressing foreign genes in plants. Various upstream activating sequences from opine synthase genes like the mannopine synthase and the octopine synthase genes are operably linked with promoters (or promoters plus activating sequences), both of which are then operably linked to the foreign gene. These regions and cassettes permit expression levels and patterns that could not be obtained previously.Type: GrantFiled: July 31, 1996Date of Patent: September 21, 1999Assignees: Biotechnology Research And Development Corporation, Purdue Research FoundationInventors: Stanton B. Gelvin, Randal Hauptmann, Min Ni, Decai Cui
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Patent number: 5869339Abstract: A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.Type: GrantFiled: June 7, 1995Date of Patent: February 9, 1999Assignees: The Board of Regents for Northern Illinois University of DeKalb, Biotechnology Research and Development CorporationInventors: Arnold E. Hampel, Richard H. Tritz, Margaret F. Hicks
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Patent number: 5866701Abstract: A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.Type: GrantFiled: June 17, 1993Date of Patent: February 2, 1999Assignees: The Board of Regents for Northern Illinois University of DeKalb, Biotechnology Research and Development CorporationInventors: Arnold E. Hampel, Richard H. Tritz
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Patent number: 5858666Abstract: A transducer for detecting biomolecules comprises a bottom and a top unit. The bottom unit has a set of parallel electrically conductive transmission lines thereon and probes attached to selected locations along each transmission line for binding with the target molecule. The top unit has thereon a second set of parallel transmission lines transverse to those on the bottom unit. By applying AC signals sequentially to the two sets of transmission lines, each of the probe locations at the intersection of the two transmission lines can be addressed and the response of the probe in an unfilled detector location or a complex formed by the probe and the target in a filled detector location can be measured. If the target has been labelled, than the label at each of the locations may also be detected. The device can also be used for measuring binding constants between the probe and the target and concentrations of target solutions.Type: GrantFiled: August 29, 1996Date of Patent: January 12, 1999Assignees: Biotechnology Research and Development Corporation, The Penn State Research FoundationInventor: Paul S. Weiss
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Patent number: 5858785Abstract: A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.Type: GrantFiled: June 7, 1995Date of Patent: January 12, 1999Assignees: The Board of Regents for Northern Illinois University of DeKalb, Biotechnology Research and Development CorporationInventors: Arnold E. Hampel, Richard H. Tritz
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Patent number: 5856188Abstract: A synthetic RNA catalyst capable of cleaving an RNA substrate, the catalyst comprising a substrate binding portion and a "hairpin" portion. The invention also provides an engineered DNA molecule and a vector, each comprising a DNA sequence coding for an RNA catalyst according to the invention. The invention further comprises host cells transformed with the vectors of the invention which are capable of expressing the RNA catalyst. Finally, the invention provides a method of cleaving an RNA substrate which comprises contacting the substrate with a synthetic RNA catalyst according to the invention.Type: GrantFiled: June 7, 1995Date of Patent: January 5, 1999Assignees: The Board of Regents for Northern Illinois University of DeKalb, Biotechnology Research and Development CorporationInventors: Arnold E. Hampel, Richard H. Tritz, Margaret F. Hicks
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Patent number: 5854345Abstract: Expanded articles have a compressible and resilient body including two biodegradable components. One component preferably is starch or a modified starch. Another component is a water insoluble, synthetic polymer, preferably a hydroxy-functional polyester. The article may be thermoformed, and has exterior surfaces with substantial resistance to moisture.Type: GrantFiled: September 4, 1997Date of Patent: December 29, 1998Assignees: The United States of America as represented by the Secretary of Agriculture, Biotechnology Research & Development CorporationInventors: Wayne Xu, William M. Doane
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Patent number: 5852078Abstract: Compositions of the invention include a hydroxy-functional polyester and a natural polymer. Articles can be made from such a composition so as to have sufficiently strong tensile strengths as to form disposable utensils or to have sufficient stretchability so as to form thin wrap films. However, the compositions are more environmentally friendly than commodity plastics such as polyethylene or polystyrene. Granular starches derived from a grain, a root, a legume, or mixtures thereof, are particularly preferred as the natural polymers for inclusion in the compositions.Type: GrantFiled: February 21, 1997Date of Patent: December 22, 1998Assignees: The United States of America as represented by the Secretary of Agriculture, Biotechnology Research and Development CorporationInventors: Julious L. Willett, William M. Doane, Wayne Xu, Michael N. Mang, Jerry E. White
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Patent number: 5849305Abstract: Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.Type: GrantFiled: May 8, 1996Date of Patent: December 15, 1998Assignees: The United States of America as represented by the Secretary of the Department of Agriculture, Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 5840556Abstract: Tools for genetically engineering Pasteurellaceae are provided. Replication-conditional plasmids which are useful for the Pasteurellaceae have been isolated and characterized. The plasmids can be utilized for delivery of DNA segments into the Pasteurellaceae in situations where control of extrachromosomal replication desired, such as in achieving allelic exchange or site-directed mutagenesis.A restriction endonuclease, HsoI, was isolated from a bovine lung isolate of Haemophilus somnus. The enzyme was found to be a true isoschizomer of HinPI, a commercially available enzyme originally isolated from Haemophilus influenzae PI. Commercially available HhaI methyl transferase was found to protect against cleavage by both enzymes. Methylation of foreign plasmid DNA was found to enhance transformation of Haemophilus somnus in excess of four orders of magnitude.Type: GrantFiled: December 19, 1996Date of Patent: November 24, 1998Assignees: The United States of America as represented by the Department of Agriculture, Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 5824525Abstract: Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.Type: GrantFiled: May 8, 1996Date of Patent: October 20, 1998Assignees: Biotechnology Research and Development Corporation, The United States of America as represented by the Department of AgricultureInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 5821286Abstract: Biodegradable films include two biodegradable components. One component preferably is starch while the other component is a water insoluble, synthetic polymer, preferably a hydroxy-functional polyester.Type: GrantFiled: May 24, 1996Date of Patent: October 13, 1998Assignees: The United States of America as represented by the Secretary of the Agriculture, Biotechnology Research & Development CorporationInventors: Wayne Xu, William M. Doane, John W. Lawton, Jr.
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Patent number: 5733780Abstract: Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.Type: GrantFiled: May 8, 1996Date of Patent: March 31, 1998Assignees: The United States of America as represented by the Department of Agriculture, Biotechnology and Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 5693777Abstract: Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.Type: GrantFiled: May 8, 1996Date of Patent: December 2, 1997Assignees: The United States of America as represented by the Secretary of Agriculture, Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 5683900Abstract: Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.Type: GrantFiled: May 8, 1996Date of Patent: November 4, 1997Assignees: The United States of America as represented by the Department of Agriculture, Biotechnology Research and Development CorporationInventors: Robert E. Briggs, Fred M. Tatum
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Patent number: 5674733Abstract: A method of introducing expressible heterologous DNA into Prevotella ruminicola is provided. The method involves conjugal transfer of a shuttle vector comprising the heterologous DNA operatively linked to a promoter functional in P. ruminicola. The invention also provides shuttle vectors for use in the method and P. ruminicola produced by the method. The invention further provides a tetracycline resistance gene of the TetQ class, or fragments thereof that confer tetracycline resistance, and a protein of the TetQ class that provides resistance to tetracycline by protecting ribosomes from tetracycline, or active fragments thereof. Finally, the invention provides a promoter functional in P. ruminicola and an engineered P. ruminicola comprising expressible foreign DNA.Type: GrantFiled: December 2, 1993Date of Patent: October 7, 1997Assignee: Biotechnology Research and Development CorporationInventors: Abigail A. Salyers, Nadja B. Shoemaker, Mikeljon P. Nikolich
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Patent number: 5619035Abstract: A system for transporting in a vacuum chamber sample holders and samples between a holder tray and a location for use with a surface analytical instrument is disclosed. Also provided is a system including a microwave coaxial cable connecting the tip terminal of a scanning tunneling microscope to a microwave signal source and a system for clamping a heater to a sample holder in order to heat the sample.Type: GrantFiled: December 22, 1995Date of Patent: April 8, 1997Assignees: Biotechnology Research & Development Corporation, Penn State Research FoundationInventors: Paul S. Weiss, Stephan J. Stranick