Abstract: One embodiment of the invention concerns a medical implant having a basic body that includes the antioxidative substance squalene incorporated into at least one of the basic body and a coating on at least a portion of the basic body, the incorporated squalene being present in quantities of 0.4 ?g to 2000 ?g.
Abstract: An endoprosthesis includes a carrier structure which contains a metallic material. The metallic material contains a magnesium alloy of the following composition: magnesium: >90%, yttrium: 3.7%-5.5%, rare earths: 1.5%-4.4% and balance: <1%.
Type:
Grant
Filed:
November 11, 2003
Date of Patent:
April 23, 2013
Assignee:
Biotronik VI Patent AG
Inventors:
Claus Harder, Bodo Gerold, Heinz Mueller, Bernd Heublein
Abstract: An implant made in total or in parts of a biodegradable magnesium alloy consisting of Y: 2.0-6.0% by weight, Nd: 1.5-4.5% by weight, Gd: 0-4.0% by weight, Dy: 0-4.0% by weight, Er: 0-4.0% by weight, Zr: 0.1-1.0% by weight, Li:0-0.2% by weight, Al: 0-0.3% by weight, under the condition that a) a total content of Er, Gd and Dy is in the range of 0.5-4.0% by weight and b) a total content of Nd, Er, Gd and Dy is in the range of 2.0-5.5% by weight, the balance being magnesium and incidental impurities up to a total of 0.3% by weight.
Abstract: The present invention relates to a measuring device including a sensor catheter, an evaluation unit, and means for receiving a magnetic field and converting the magnetic field to an electrical measurement signal which are situated in the sensor catheter and connected to the evaluation unit. The evaluation unit is designed to evaluate the electrical measurement signal.
Abstract: A base body for an implant comprising a biocorrodible iron alloy including at least one of the following: (i) a biocorrodible iron alloy of formula Fe—P where P is 0.01-5 wt %, and Fe plus impurities account for the remainder up to 100 wt %; or (ii) a biocorrodible iron alloy of formula Fe—Mn—X where Mn is 5-30 wt %, X is at least one of Pt, Pd, Ir, Rh, Re, Ru and Os, and X is 0-20 wt % and Fe plus impurities account for the remainder up to 100 wt %; or (iii) a biocorrodible iron alloy of formula Fe—Z where Z is at least one of Pt, Ir and Os and Z is 5-30 wt %, and Fe plus impurities account for the remainder up to 100 wt %.
Type:
Grant
Filed:
February 5, 2009
Date of Patent:
February 12, 2013
Assignee:
Biotronik VI Patent AG
Inventors:
Heinz Mueller, Joerg Loeffler, Peter Uggowitzer
Abstract: The invention relates to a catheter, in particular an endovascular catheter, having an applicator device for liquid active substances for applying same to an active substance storage zone mounted on the catheter.
Abstract: The present invention proposes a method for manufacturing an implant, in particular an intraluminal endoprosthesis, having a body such that the body has metallic material. To control the degradation in a desired time window, e.g., between four weeks and six months, the following production method is performed: a) preparing the body of the implant, and b) plasma-chemical treatment of at least a portion of the surface of the body in an aqueous solution by applying a plasma-generating electric alternating voltage to the body (5) of the implant, said voltage having a frequency of at least approximately 1 kHz, to create a first layer. The invention also relates to an implant obtainable by such a method.
Type:
Grant
Filed:
September 22, 2009
Date of Patent:
December 25, 2012
Assignee:
Biotronik VI Patent AG
Inventors:
Ullrich Bayer, Jan Schettler, Guenter Ewert
Abstract: An implant comprising a body (1), at least one active pharmaceutical substance (4) and an element (5, 15, 35, 45, 55) deflectable in relation to the body, serving to release the at least one active pharmaceutical substance (4) during or after an external excitation of the deflection. Also disclosed is a system of such an implant and an excitation device (30, 70).
Type:
Grant
Filed:
July 11, 2008
Date of Patent:
December 25, 2012
Assignee:
Biotronik vi Patent AG
Inventors:
Bjoern Klocke, Matthias Fringes, Eugen Hofmann
Abstract: The invention relates to a fiber strand (10) for an implantable supporting body (100) comprising at least two individual fibers (12). The at least two individual fibers (12) are each shorter in their longitudinal extent than the longitudinal extent (14) of the fiber strand, and in their transverse extent they are each thinner than the transverse extent (16) of the fiber strand.
Abstract: A magnesium alloy, comprising: Y: 0.5-10? Zn: 0.5-6?? Ca: 0.05-1?? Mn: ??0-0.5 Ag: 0-1 Ce: 0-1 Zr: 0-1 or Si: 0-0.4, wherein the amounts are based on weight-percent of the alloy and Mg, and manufacturing-related impurities constitute the remainder of the alloy to a total of 100 weight-percent. Also disclosed is a method for manufacturing such an alloy and a biodegradable implant formed therefrom.
Type:
Grant
Filed:
July 27, 2007
Date of Patent:
October 23, 2012
Assignee:
Biotronik VI Patent AG
Inventors:
Bodo Gerold, Heinz Mueller, Joerg Loeffler, Anja Haenzi, Peter Uggowitzer
Abstract: An implant consisting entirely or in part of a biocorrodible magnesium alloy having the composition Gd: 2.7-15.0 wt %, Zn: 0-0.5 wt %, Zr: 0.2-1.0 wt %, Nd: 0-4.5 wt %, Y: 0-2.0 wt %, where magnesium and impurities due to the production process account for the remainder to a total of 100 wt %.
Abstract: An endoprosthesis, in particular an intraluminal endoprosthesis, for example a stent, having a base body composed at least partially of a metallic material, and having a functional element which is attached to the base body or imbedded therein and which contains material that is radiopaque and/or X-ray opaque and has a different material composition, at least in a portion of its volume, compared to the material of the base body. To avoid contact corrosion and undesired corrosion, the functional element is provided with a barrier layer which electrically insulates the radiopaque and/or X-ray opaque material from the base body.
Abstract: An implant for implantation in a human or animal body having a structure comprising a) an implant base body; b) a primer layer which is partially or completely applied to the surface of the implant; c) an active ingredient layer consisting of one, two, three or more active ingredients applied entirely or partially to the surface of the primer layer; and d) a diffusion-controlling layer which is applied partially or entirely to the active ingredient layer, and optionally to the primer layer, wherein diffusion of the active ingredients of the active ingredient layer is controlled. Also disclosed is a manufacturing method for an implant.
Type:
Grant
Filed:
December 10, 2008
Date of Patent:
September 4, 2012
Assignees:
Biotronik VI Patent AG, Universitaet Rostock, Universitaet Greifswald
Inventors:
Klaus-Peter Schmitz, Detlef Behrend, Katrin Sternberg, Niels Grabow, Claus Harder, Bjoern Klocke, Heyo K. Kroemer, Werner Weitschies
Abstract: Stent, as well as a method and device for fabricating the stent, wherein the stent has a tubular lattice structure comprising individual struts and at least one strut of which at least one longitudinal section runs with at least one directional component in the radial circumferential direction of the stent, wherein the surface of the longitudinal section facing the outside of the stent is curved only about the longitudinal axis of the stent. According to the invention, the surface of longitudinal section of the strut, which surface faces the inside of the stent, has such a curvature that the strut cross section is fluidically optimized.
Abstract: A medical supporting implant, in particular a stent, comprises a tubular base body which is made up of bendable struts (2), such that at node points (4) of at least two struts (2), the bendable struts (2) form an acute angle (W) to one another which angle becomes larger on dilatation of the implant with plastic deformation of the struts (2) at the node point (4). At least a portion of the struts (2) between the plastic deformation areas (4) is provided with a telescoping ratchet mechanism (R) for irreversible lengthening of the respective struts (2) on dilatation.
Abstract: A catheter (10) having an internal tube (13) and an external tube (14) which at least sectionally encloses the internal tube (13). The external tube (14) is connected to a balloon (16) having an endoprosthesis section (18) which positions an intraluminal endoprosthesis (20). The catheter (10) has stiffening means (31, 33, 34, 35) located in the area of at least one end of the endoprosthesis section (18) in its longitudinal direction on the internal tube (13). Also disclosed is a system comprising an intraluminal endoprosthesis (20) and a catheter (10) used for introducing an intraluminal endoprosthesis (20), preferably a stent, into a body cavity.
Abstract: A multi-membrane balloon (10) for a catheter having an at least double membrane sleeve (20, 40) comprising at least one fillable and emptiable expansion space (46) between a proximal end (12) and a distal end (14), wherein a stiff supporting element (60) surrounds the at least double membrane sleeve (20, 40) and the outer membrane sleeve (20) surrounds one or more inner membrane sleeves (40). The supporting element (60) at least partially takes hold with the outer membrane sleeve (20).
Abstract: The invention relates to an implantable drug reservoir (10) having a cavity (28) enclosed by a sheathing (12) and arranged between a proximal end (14) and a distal end (16) for storing one or more drugs (50), having an outlet opening (24) for the drug(s) (50). The drug(s) (50) can be delivered to a delivery region (70) through a puncture device (20) at one end (16). The invention also relates to a device (100) having a drug reservoir (10).
Type:
Grant
Filed:
June 3, 2009
Date of Patent:
May 1, 2012
Assignee:
Biotronik VI Patent AG
Inventors:
Amir Fargahi, Michael Tittelbach, Claus Harder
Abstract: A stent is provided having a base body circumscribing a cylindrical shape and radially expandable from a contracted starting position into a dilated support position, including a plurality of meander-shaped struts disposed in the circumferential direction and arrayed on one another in the axial direction, each strut being meander-shaped in its coarse structure and made of a flexible material, and at least one axial connector in the axial direction, connecting the meander-shaped struts of two axially adjacent meandering curves, wherein the at least one axial connector connects the inside radius of a zenith point of a first meandering curve with a second meandering curve, characterized in that the at least one axial connector at the inside radius of the zenith point of the first meandering curve has an at least double-arm structure.
Abstract: A stent made of nitinol having improved axial or radial stiffness, the stent having a support structure which comprises peripheral struts around the circumference, wherein the peripheral struts are linked to one another in the axial direction via connection struts. The support structure may assume a first compressed state and a second expanded state. The nitinol is in the support structure in a martensitic microstructure in the compressed state and largely in an austenitic microstructure in the second expanded state. One or more support structure sections, however, are entirely or partially in a martensitic microstructure in the second expanded state.