Abstract: An implant having a base body comprised entirely or partially of a biocorrodible metallic material and in which at least the parts of the base body comprising the biocorrodible metallic material are covered entirely or partially with a coating which contains or is comprised of the polymer. At least 90% of the total number of polymer units of the polymer comprise polymer units of formula (1) and polymer units of formula (2) wherein R1 is alkyl, hydroxyalkyl, alkoxyalkyl or cycloalkyl; R2 is a silyl radical that is hydrolyzable in artificial plasma; R3 is hydrogen or methyl, and n+m=10 to 20,000, such that the ratio of n to m is in the range of 1:9 to 9:1.
Abstract: An implant having a base body, comprised either entirely or in part of a biocorrodible metallic material wherein at least the parts of the base body having the biocorrodible metallic material are at least partially covered with a coating of a crosslinked CFx layer with an F/C ratio in the range of 0.5 to 1.5.
Type:
Application
Filed:
December 19, 2008
Publication date:
June 25, 2009
Applicant:
BIOTRONIK VI PATENT AG
Inventors:
Baerbel Becher, Carsten Momma, Daniel Lootz, Antje Quade, Andreas Ohl, Karsten Schroeder
Abstract: An implant for implantation in a human or animal body having a structure comprising a) an implant base body; b) a primer layer which is partially or completely applied to the surface of the implant; c) an active ingredient layer consisting of one, two, three or more active ingredients applied entirely or partially to the surface of the primer layer; and d) a diffusion-controlling layer which is applied partially or entirely to the active ingredient layer, and optionally to the primer layer, wherein diffusion of the active ingredients of the active ingredient layer is controlled. Also disclosed is a manufacturing method for an implant.
Type:
Application
Filed:
December 10, 2008
Publication date:
June 11, 2009
Applicants:
BIOTRONIK VI PATENT AG, UNIVERSITAT ROSTOCK, UNIVERSITAT GREIFSWALD
Inventors:
Klaus-Peter Schmitz, Detlef Behrend, Katrin Sternberg, Niels Grabow, Claus Harder, Bjoern Klocke, Heyo K. Kroemer, Werner Weitschies
Abstract: A stent having a base body of a bioinert metallic implant material wherein the base body is covered with an SiC coating. An external surface of the base body has a plurality of cavities which are filled with an antiproliferative active ingredient, A luminal surface of the base body has a coating which contains or comprises attractors for endothelial cells.
Type:
Application
Filed:
October 22, 2008
Publication date:
April 30, 2009
Applicant:
BIOTRONIK VI PATENT AG
Inventors:
Claus Harder, Alexander Borck, Gerd Bayer, Matthias Fringes
Abstract: A stent made of nitinol having improved axial or radial stiffness, the stent having a support structure which comprises peripheral struts around the circumference, wherein the peripheral struts are linked to one another in the axial direction via connection struts. The support structure may assume a first compressed state and a second expanded state. The nitinol is in the support structure in a martensitic microstructure in the compressed state and largely in an austenitic microstructure in the second expanded state. One or more support structure sections, however, are entirely or partially in a martensitic microstructure in the second expanded state.
Abstract: A stent having a coating comprising either L-3,4-dihydroxyphenylalanine (L-DOPA) or a derivative of L-3,4-dihydroxyphenylalanine (L-DOPA), the foregoing obtained by either ionic or covalent bonding of a pharmaceutical active ingredient to either the amino or the acid function of L-3,4-dihydroxyphenylalanine (L-DOPA).
Abstract: A stent comprising a base body consisting at least in part of either an arsenic-containing or selenium-containing biocorrodable alloy of at least one element selected from the group consisting of magnesium, iron, tungsten, zinc and molybdenum. A method for producing a stent with a base body having a core and a diffusion layer covering the core and an arsenic-containing and/or selenium-containing biocorrodable alloy comprising at least one element selected from the group consisting of magnesium, iron, tungsten, zinc and molybdenum.
Abstract: A stent comprising a degradable metal stent main body; a partition layer which is applied to the surface of the stent main body so that at least parts of the surface of the luminal side are not covered; and an agent-containing layer which is applied to the surface of the partition layer at least partially on the abluminal side of the stent main body and comprises one or more agents and possibly one or more polymers.
Abstract: A stent with a basic mesh comprising an at least largely biodegradable material and a coating (30) arranged on the biodegradable material. The basic mesh is covered completely by a coating, except for at least one degradation area (23, 25, 32), whereby the at least one degradation area (23, 25, 32) is designed as a recess in the coating (30).
Abstract: A method for producing an agent depot for mechanical connection to a surface of an endovascular implantable body, comprising a) providing one or more polymers; b) providing one or more agents; and c) producing an agent depot from said polymers and said agents, the agent depot being mechanically connectable to the surface of the body using force action or adhesive.
Abstract: An implant comprising a body (1), at least one active pharmaceutical substance (4) and an element (5, 15, 35, 45, 55) deflectable in relation to the body, serving to release the at least one active pharmaceutical substance (4) during or after an external excitation of the deflection. Also disclosed is a system of such an implant and an excitation device (30, 70).
Type:
Application
Filed:
July 11, 2008
Publication date:
January 15, 2009
Applicant:
BIOTRONIK VI PATENT AG
Inventors:
Bjoern Klocke, Matthias Fringes, Eugen Hofmann
Abstract: An implant comprising an implant material forming a base made of one or more metallic elements; a diffusion layer covering the base made of at least one of the metallic elements of the implant material and at least magnesium; and, optionally, a metal layer covering the diffusion layer made of magnesium or a biocorrodible magnesium alloy.
Type:
Application
Filed:
June 13, 2008
Publication date:
December 18, 2008
Applicant:
BIOTRONIK VI PATENT AG
Inventors:
Heinz Mueller, Peter Uggowitzer, Joerg Loeffler
Abstract: A medical implantable stent comprising a main structure (1) composed of deformable struts (2), which are preferably machined from a tubular blank (3) by laser cutting. A fine structure (4) made of a wire-like or thread-like material attached to the struts (2) of the main structure (1).
Abstract: A medical implant, in particular a stent for insertion in a bodily lumen, having a base structure (2, 3), wherein a passive electronic oscillating circuit configuration (4), comprising at least one inductor (L) and at least one capacitor (C1 through C4), is integrated in the base structure (2, 3), whose natural frequency (fres0) in the implanted state of the implant (1) is externally detectable by exciting the oscillating circuit configuration (4) using electromagnetic radiation such that a significant identification feature or a change of the base structure (2, 3) is detectable by the value or a change of the natural frequency (fres0) of the oscillating circuit configuration (4).
Abstract: A stent comprising an essentially tubular open supporting structure (4) of interconnected trusses (9), whereby the supporting structure (4) can be widened radially with deformation of the trusses (9) for application of the stent, and predetermined breaking points (14) in the supporting structure (4) for fragmentation of the stent after application, and the ends (10, 11) of the trusses (9) that are adjacent to the respective predetermined breaking point (14) having a joint design and which are provided in the area of the predetermined breaking point (14), such that the ends (10, 11) of the trusses (9) are held together with articulation under an applied pressure with the predetermined breaking point (14) broken.
Type:
Application
Filed:
April 24, 2008
Publication date:
October 30, 2008
Applicant:
BIOTRONIK VI PATENT AG
Inventors:
Daniel Lootz, Bettina Surber, Mathias Haussmann
Abstract: A stent made of a material having a low strength and having a main body circumscribing a cylindrical shape and radially expandable from a contracted starting position into a dilated support position, comprising a) a plurality of support segments disposed around the circumference and arrayed on one another in the axial direction each segment being formed by a strut meandering in its coarse structure in its contracted starting position and having alternately opposing meandering curves expandable into the support position made of flexible material; b) a plurality of axial connectors connecting between zenith points of at least a part of the meandering curves in the axial-parallel direction of the support segments; and c) at least one means for stabilizing the strut coarse structure in its contracted starting position against radial expansion and being automatically detachable upon a radial expansion of the stent.
Type:
Application
Filed:
March 28, 2008
Publication date:
October 2, 2008
Applicant:
BIOTRONIK VI PATENT AG
Inventors:
Daniel Lootz, Bettina Surber, Daniel Wintsch, Johannes Riedmueller
Abstract: A method for producing a corrosion-inhibiting coating on an implant made of a biocorrodible magnesium alloy, the method comprising providing the implant; and treating the implant surface using an aqueous or alcoholic conversion solution containing one or more ions selected from the group consisting of K+, Na+, NH4+, Ca2+, Mg2+, Zn2+, Ti4+, Zr4+, Ce3+, Ce4+, PO43?, HPO42?, H2PO4?, OH?, B33?, B4O72?, SiO32?, MnO42?, MnO4?, VO3?, WO42?, MoO42?, TiO32?, Se2?, ZrO32?, and NbO4?, wherein the concentration of the ion or ions is in the range of from 0.01 mol/l to 2 mol/l. An implant produced by this method is also disclosed.
Type:
Application
Filed:
December 17, 2007
Publication date:
October 2, 2008
Applicant:
BIOTRONIK VI PATENT AG
Inventors:
Gerhard Kappelt, Peter Kurze, Dora Banerjee