Abstract: A stent comprising a basic stent body, at least one anchor group on the surface of the basic stent body, and at least one biomolecule which is bound to the at least one anchor group, the anchor group being the same or different and selected from the group of compounds with the general formula (I) (R2O)2(O)P-L-(CH2)x-M-R1 ??(I) in which R1 represents —COOH, —OH, —SH, —NH2, benzophenone or benzophenone derivatives, R2 represents hydrogen, —CH2CH3 or —CH3, L represents a single bond or —O—, M represents a single bond or —(CH2—CH2—O)y, x represents an integer from 1 to 25, y represents an integer from 1 to 25 and the biomolecule or biomolecules are selected as the same or different from the group consisting of compounds which promote the attachment of the endothelial progenitor cells to the stent surface.

Abstract: A multilayered catheter tube element (10), preferably for situating a guide wire, comprising a first layer (11) forming the external layer and a second layer (12) at least partially forming the internal layer. The first layer (11) contains at least one plastic or multiple plastics from the group consisting of PEBA, polyamide, and elastomer-modified polyamide and the second layer (12) contains ethylene tetrafluoroethylene. A cost-effective method for producing a multilayered catheter tube element of this type is also disclosed.

Abstract: A medical implant comprising a composite material which is composed of reinforcement fibers made of a magnesium-containing, bio-corrosive alloy, another bio-corrosive alloy containing a main component that is selected from the group consisting of Mg, Ca, Fe, and Y, or a non-biodegradable fiber material, embedded in a matrix made of crystalline magnesium or magnesium alloys.

Abstract: An implant made of a biocorrodible metallic material and having a coating or cavity filling comprising gelatin.

Abstract: A stent made of a biocorrodible metallic material having a coating or cavity filling comprising a diblock or triblock copolymer made of (i) a poly(D,L-lactide-co-glycolide) block and (ii) a polyethylene glycol block.

Abstract: A stent having a main body made of a biodegradable material and an active coating applied to the main body, which comprises a biodegradable carrier matrix and at least one pharmaceutically active substance embedded in the carrier matrix.

Abstract: An x-ray marker for medical implants made of a biocorrodible metallic material, the x-ray marker comprises a boride or carbide of the elements tantalum or tungsten.

Abstract: A magnesium alloy, comprising: Y: 0.5-10? Zn: 0.5-6?? Ca: 0.05-1?? Mn: ??0-0.5 Ag: 0-1 Ce: 0-1 Zr: 0-1 or Si: 0-0.4, wherein the amounts are based on weight-percent of the alloy and Mg, and manufacturing-related impurities constitute the remainder of the alloy to a total of 100 weight-percent. Also disclosed is a method for manufacturing such an alloy and a biodegradable implant formed therefrom.

Abstract: A biodegradable metallic stent having improved stability properties after implantation of the stent, methods for producing such a stabilized stent, methods for improving the stabilization of a biodegradable metallic stent, and a method for improving the stability of a biodegradable metallic stent by using vasodilator active ingredients.

Abstract: A stent made of a biocorrodible metallic material and having a coating or cavity filling which contains genistein.

Abstract: A method for producing a composite made of oligonucleotides or polynucleotides and hydrophobic biodegradable polymers. The method comprises the following steps: (i) producing an aqueous solution of a polyethylene glycol having a mean molecular weight in the range from 600 to 8,000 g/mole; (ii) adding an aqueous, possibly buffered solution of oligonucleotides or polynucleotides to the aqueous solution from step (i); iii) freezing the aqueous solution from step (ii) and subsequently freeze-drying the frozen solution to obtain a freeze-dried substrate; (iv) providing a solution of the hydrophobic biodegradable polymer in an organic solvent; (v) adding the substrate obtained according to step (iii) to the solution of the polymer; and (vi) removing the organic solvent to obtain the composite. Also disclosed is a composite produced by the method.

Abstract: An implant made of a biocorrodible metallic material having a coating made of an organosilicon compound.

Abstract: A stent having a structure made of a biocorrodible metallic material, having multiple web sections connected to one another, with a support structure made of a number of first web sections connected to one another, designed to assume a function supporting the vascular wall or preserving the mechanical integrity of the stent for a predefinable time after expansion; and at least one second web section electrically connected directly to a first web section of the support structure, which does not assume a function supporting the vascular wall or preserving the mechanical integrity of the stent for the predefined time after the expansion, and whose electrode potential E2 is reduced by a mechanical strain of the second web section during or before the expansion so it is lower than an electrode potential E1 of the first web section after the expansion.

Abstract: An x-ray marker for medical implants made of a biocorrodible metallic material, wherein the x-ray marker composite comprises 1-40 weight parts of a carrier matrix having a melting point greater than or equal to 43° C., which comprises 90 weight-percent or more triglycerides; and 60-99 weight parts of a radiopaque marker component, which is embedded in the carrier matrix.

Abstract: An endoprosthesis, in particular, an intraluminal endoprosthesis, e.g., a stent, having a basic mesh and a functional element attached to a carrier structure, the functional element having a different material composition than the material of the basic mesh in at least a portion of its volume. The carrier structure is arranged on the basic mesh in the first essentially finger-shaped end and protrudes away from the mesh essentially like a projection. The functional element is arranged on an area of the carrier structure protruding away from the base body and at least partially surrounds the area of the carrier structure.

Abstract: A marker alloy foreign implant made of a biodegradable metallic material and having the composition MgxYbyMz wherein x is equal to 10-60 atomic percent; y is equal to 40-90 atomic percent; z is equal to 0-10 atomic percent; M is one or more element selected from the group consisting of Ag, Zn, Au, Ga, Pd, Pt, Al, Sn, Ca, Nd, Ba, Si, and Ge; and wherein x, y, and z, together, and including contaminants caused by production, result in 100 atomic percent.

Abstract: A device to produce strand-shaped products from thermoplastic or elastomer materials comprising a paste extruder having a specially implemented internal volume defined by a cylindrical internal mandrel (2) and an external cylinder mantle (1). The polymer material is charged in the internal volume. The polymer raw material may be provided as a powder or granulate or as material cores produced in a separate precursor process using the same device. The polymer mass is melted by heating and discharged using an expulsion piston (3). A static mixing line (5) is provided in the outlet area, in which penetration of the melt flow occurs due to special shaping and uniform mixing of the molten material. A homogeneous material flow is achieved, which is supplied via a melt duct to a conventional longitudinal or transverse extrusion head (4).

Abstract: A coated implant and a method of use of cholesterol or a cholesterol ester. The implant has a coating which contains one or more components selected from the group of cholesterol and cholesterol esters.

Abstract: A system for treating extensive obliterative vascular diseases, in which the severity of the disease is different in different vascular sections, comprises: one or more biocorrodible stents arranged with a distance between them in sections of the diseased vessel that have been dilated by transluminal angioplasty, and a device adapted for release of an active ingredient in the lumen or in the vascular tissue, designed (i) to release the active ingredient in the lumen of the diseased vessel, whereby the active ingredient is released in a vascular section at the greatest distance proximally in the direction of blood flow in the vessel; or (ii) to release the active ingredient in the vascular tissue whereby the active ingredient is released in one or more vascular sections of the vessel to be treated so that the active ingredient can spread throughout the area of the diseased vessel through diffusion.

Abstract: The invention concerns an endovascular implant comprising a biodegradable material and having a tubular main body which is open at the ends and which is dilatable from an unexpanded condition into an expanded condition. The implant is so designed that when the implant in the expanded condition is subjected to a radially acting compression pressure in the range of between 5 and 30 kPa (0.05-0.3 bar) a cross-sectional area of the implant is reduced to 70% or less of the original cross-sectional area, or an internal volume of the implant is reduced to 70% or less of the original internal volume.