Patents Assigned to Board of Trustees of Southern Illinois University
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Patent number: 12270039Abstract: The present invention is directed to a transgenic soybean plant with increased oleic acid content comprising a polynucleotide encoding a fatty acid desaturase (FAD) related promoter that functions in the soybean plant operably linked to a polynucleotide encoding a polypeptide having FAD activity. The invention is also related to a plant of an agronomically elite soybean variety with increased oleic acid content comprising a polynucleotide encoding a fatty acid desaturase (FAD) related promoter that functions in the soybean plant operably linked to a polynucleotide encoding a polypeptide having FAD activity. The invention is still further directed to a method of increasing the oleic acid content of a soybean plant comprising transforming the soybean plant with a polynucleotide encoding a fatty acid desaturase (FAD) related promoter that functions in the soybean plant operably linked to a polynucleotide encoding a polypeptide having FAD activity.Type: GrantFiled: May 16, 2022Date of Patent: April 8, 2025Assignee: Board of Trustees of Southern Illinois UniversityInventors: Khalid Meksem, Naoufal Lakhssassi, Dounya Knizia
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Patent number: 12270040Abstract: The present invention is directed to a transgenic soybean plant having increased oleic acid content comprising a polynucleotide comprising a fatty acid thioesterase (FAT) related promoter that functions in the soybean plant operably linked to a polynucleotide encoding a polypeptide having FAT activity. The invention is further directed to a method of increasing oleic acid content of a soybean plant comprising transforming a soybean plant with a polynucleotide comprising a fatty acid thioesterase (FAT) related promoter that functions in the soybean plant operably linked to a polynucleotide encoding a polypeptide having FAT activity.Type: GrantFiled: May 27, 2022Date of Patent: April 8, 2025Assignee: Board of Trustees of Southern Illinois UniversityInventors: Khalid Meksem, Naoufal Lakhssassi, Dounya Knizia, Zhou Zhou
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Patent number: 12251537Abstract: A syringe device and methods for device for separating liquids of different densities are provided where the syringe device includes a hollow syringe barrel, a perforated plunger seal with a seal hole, and a hollow plunging tube with a closed bottom with at least one tube hole.Type: GrantFiled: August 4, 2020Date of Patent: March 18, 2025Assignee: Board of Trustees of Southern Illinois UniversityInventors: Ashim Gupta, Michael W. Neumeister, Sohyung Cho, Scott Moore, Robert B. Zajeski, Jr.
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Patent number: 12162935Abstract: Compositions and treatment regimen that includes the compositions, suitable for preventing, treating and restoring hearing acuity in a subject are provided. The treatment regimen includes an amount of capsaicin and an amount of a TNF-? inhibitor (such as etanercept) that are delivered relatively simultaneously to a subject. Methods of providing a pretreatment to a subject suitable for preventing hearing loss are also provided. The capsaicin and TNF? inhibitor may be provided in different delivery forms to the subject. Methods of providing a treatment for hearing loss with a TNF? inhibitor alone, such as entanercept, or with capsaicin alone, are also provided.Type: GrantFiled: February 8, 2021Date of Patent: December 10, 2024Assignee: Board of Trustees of Southern Illinois UniversityInventors: Debashree Mukherjea, Vickram Ramkumar, Leonard Rybak
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Patent number: 12133762Abstract: A system for patient cardiac imaging and tissue modeling. The system includes a patient imaging device that can acquire patient cardiac imaging data. A processor is configured to receive the cardiac imaging data. A user interface and display allow a user to interact with the cardiac imaging data. The processor includes fat identification software conducting operations to interact with a trained learning network to identify fat tissue in the cardiac imaging data and to map fat tissue onto a three-dimensional model of the heart. A preferred system uses an ultrasound imaging device as the patient imaging device. Another preferred system uses an MRI or CT image device as the patient imaging device.Type: GrantFiled: April 27, 2022Date of Patent: November 5, 2024Assignee: Board of Trustees of Southern Illinois UniversityInventors: Jon Klingensmith, Colin Gibbons, Michaela Kulasekara, Vu Quang Dinh
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Patent number: 11918588Abstract: A method for treating a subject with symptoms of tinnitus and pharmaceutical compositions for treating tinnitus, the pharmaceutical compositions comprising one or more of the following: sazetidine, a pharmaceutically acceptable salt of sazetidine, varenicline, a pharmaceutically acceptable salt of varenicline, or any combination thereof.Type: GrantFiled: February 6, 2020Date of Patent: March 5, 2024Assignee: Board of Trustees of Southern Illinois UniversityInventors: Donald Caspary, Thomas Brozoski, Brandon Cox
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Patent number: 11912687Abstract: The present disclosure describes novel compounds that are somatostatin receptor type 4 agonists.Type: GrantFiled: September 3, 2021Date of Patent: February 27, 2024Assignee: Board of Trustees of the Southern Illinois UniversityInventors: Kenneth A. Witt, Albert M. Crider, William Neumann, Audrey Hospital, Karin Sandoval, Maria Kontoyianni
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Patent number: 11834416Abstract: The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.Type: GrantFiled: November 27, 2019Date of Patent: December 5, 2023Assignees: Board of Trustees of Southern Illinois University, Vanderbilt UniversityInventors: Boyd M. Goodson, Eduard Y. Chekmenev, Bryce E. Kidd, Jamil A. Mashni, Miranda Limbach, Yuqing Hou, Fan Shi
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Patent number: 11707437Abstract: Nanoparticles comprising resiniferatoxin (RTX) encapsulated in a poly(lactic-co-glycolic acid) (PLGA) polymer and compositions, especially topical compositions, comprising the nanoparticles. The compositions can be used as topical formulations for ameliorating pain, including for diabetic patients with peripheral neuropathy.Type: GrantFiled: July 10, 2020Date of Patent: July 25, 2023Assignees: BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY, UNIVERSITY OF WYOMINGInventors: Louis Premkumar, Baskaran Thyagarajan
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Publication number: 20230151378Abstract: The present invention is directed to a transgenic soybean plant having increased seed protein content and/or increased seed oil content comprising a polynucleotide encoding a ?-ConGlycinin soybean seed storage promoter that functions in the soybean plant operably linked to a polynucleotide encoding a soybean seed storage polypeptide having ?-ConGlycinin activity. The invention is further directed to a method of increasing seed protein content and/or increasing seed oil content of a soybean plant comprising transforming the soybean plant with a polynucleotide encoding a ?-ConGlycinin soybean seed storage promoter that functions in the soybean plant operably linked to a polynucleotide encoding a soybean seed storage polypeptide having ?-ConGlycinin activity.Type: ApplicationFiled: October 28, 2022Publication date: May 18, 2023Applicant: Board of Trustees of Southern Illinois UniversityInventors: Khalid Meksem, Naoufal Lakhssassi
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Publication number: 20230150943Abstract: The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.Type: ApplicationFiled: January 4, 2023Publication date: May 18, 2023Applicants: Board of Trustees of Southern Illinois University, Vanderbilt UniversityInventors: Boyd M. Goodson, Eduard Y. Chekmenev, Bryce E. Kidd, Jamil A. Mashni, Miranda Limbach, Yuqing Hou, Fan Shi
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Patent number: 11571686Abstract: The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described.Type: GrantFiled: February 17, 2020Date of Patent: February 7, 2023Assignees: Board of Trustees of Southern Illinois University, Vanderbilt University, The Regents of the University of CaliforniaInventors: Boyd M. Goodson, Eduard Y. Chekmenev, Igor V. Koptyug, Kirill V. Kovtunov, Roman V. Shchepin, Bryce E. Kidd, Jonathan Gesiorski, Max E. Gemeinhardt, Danila A. Barskiy
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Publication number: 20230001400Abstract: The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described.Type: ApplicationFiled: February 17, 2020Publication date: January 5, 2023Applicants: Board of Trustees of Southern Illinois University, Vanderbilt University, The Regents of the University of CaliforniaInventors: Boyd M. Goodson, Eduard Y. Chekmenev, Igor V. Koptyug, Kirill V. Kovtunov, Roman V. Shchepin, Bryce E. Kidd, Jonathan Gesiorski, Max E. Gemeinhardt, Danila A. Barskiy
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Patent number: 11533435Abstract: A multifunctional camera system having a bendable arm configured to be inserted into the thoracic cavity of a patient and camera head at a distal end of the bendable arm. The camera head has a high definition video camera and a light source. The camera head has a view adjustment mechanism for changing a view angle of the camera without changing the position of the camera head. A controller controls the view adjustment mechanism under command of a surgeon.Type: GrantFiled: April 5, 2019Date of Patent: December 20, 2022Assignee: Board of Trustees of Southern Illinois UniversityInventors: Traves Crabtree, Timothy York, Mitch McKay, Mingshao Zhang
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Publication number: 20220380789Abstract: The present invention is directed to a transgenic soybean plant having increased oleic acid content comprising a polynucleotide comprising a fatty acid thioesterase (FAT) related promoter that functions in the soybean plant operably linked to a polynucleotide encoding a polypeptide having FAT activity. The invention is further directed to a method of increasing oleic acid content of a soybean plant comprising transforming a soybean plant with a polynucleotide comprising a fatty acid thioesterase (FAT) related promoter that functions in the soybean plant operably linked to a polynucleotide encoding a polypeptide having FAT activity.Type: ApplicationFiled: May 27, 2022Publication date: December 1, 2022Applicant: Board of Trustees of Southern Illinois UniversityInventors: Khalid Meksem, Naoufal Lakhssassi, Dounya Knizia, Zhou Zhou
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Publication number: 20220364106Abstract: The present invention is directed to a transgenic soybean plant with increased oleic acid content comprising a polynucleotide encoding a fatty acid desaturase (FAD) related promoter that functions in the soybean plant operably linked to a polynucleotide encoding a polypeptide having FAD activity. The invention is also related to a plant of an agronomically elite soybean variety with increased oleic acid content comprising a polynucleotide encoding a fatty acid desaturase (FAD) related promoter that functions in the soybean plant operably linked to a polynucleotide encoding a polypeptide having FAD activity. The invention is still further directed to a method of increasing the oleic acid content of a soybean plant comprising transforming the soybean plant with a polynucleotide encoding a fatty acid desaturase (FAD) related promoter that functions in the soybean plant operably linked to a polynucleotide encoding a polypeptide having FAD activity.Type: ApplicationFiled: May 16, 2022Publication date: November 17, 2022Applicant: Board of Trustees of Southern Illinois UniversityInventors: Khalid Meksem, Naoufal Lakhssassi, Dounya Knizia
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Patent number: 11480458Abstract: A pathogen transport modelled biomimetic sensor includes a stack of capacitive electrodes with a plurality of gaps therebetween. The gaps and electrodes are structured and arranged to model an outer layer and one or more sublayers of fresh food of interest. The electrodes are arranged to provide multiple measurable impedances that are affected in response to cell or polymeric biofilm presence that affects the electrostatic field around and between the electrodes and consequently changes the measurable impedances.Type: GrantFiled: March 19, 2020Date of Patent: October 25, 2022Assignee: Board of Trustees of Southern Illinois UniversityInventors: Mohammad Shavezipur, Minako Sumita, Roya Mazrouei
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Patent number: 11426448Abstract: Provided herein is technology relating to compositions comprising sonic hedgehog protein and therapeutic uses thereof. In particular, the technology relates to compositions comprising a hedgehog protein and one or more peptide amphiphiles for use in methods of treating or preventing stress urinary incontinence and/or erectile dysfunction in a subject.Type: GrantFiled: May 13, 2019Date of Patent: August 30, 2022Assignees: NORTHWESTERN UNIVERSITY, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY, THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Carol Podlasek, Samuel I. Stupp, Kevin McVary, Dan Harrington
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Patent number: 11306305Abstract: The present disclosure provides CRISPR/Cas9 ribonucleoprotein compositions comprising chemically modified CRISPR RNA (crRNA) guide and trans-acting CRISPR RNA (tracrRNA) components. Methods of using the disclosed CRISPR/Cas9 ribonucleoprotein compositions are also provided.Type: GrantFiled: September 22, 2017Date of Patent: April 19, 2022Assignees: Board of Trustees of Southern Illinois UniversityInventors: Keith Gagnon, Masad Damha, Elise Malek-Adamian, Maryam Habibian, Daniel Timothy O'Reilly, Zachery Kartje
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Publication number: 20220002274Abstract: The present disclosure describes novel compounds that are somatostatin receptor type 4 agonists.Type: ApplicationFiled: September 3, 2021Publication date: January 6, 2022Applicant: Board of Trustees of the Southern Illinois UniversityInventors: Kenneth A. Witt, Albert M. Crider, William Neumann, Audrey Hospital, Karin Sandoval, Maria Kontoyianni