Patents Assigned to Board of Trustees of Southern Illinois University
  • Patent number: 11136312
    Abstract: The present disclosure describes novel compounds that are somatostatin receptor type 4 agonists.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: October 5, 2021
    Assignee: Board of Trustees of the Southern Illinois University
    Inventors: Kenneth A. Witt, Albert M. Crider, William Neumann, Audrey Hospital, Karin Sandoval, Maria Kontoyianni
  • Patent number: 11116713
    Abstract: The present disclosure relates to compositions and methods for inhibiting the growth of, decreasing the amount of, and abolishing the growth of mutans streptococci.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: September 14, 2021
    Assignee: The Board of Trustees of Southern Illinois University
    Inventors: Kevin Rowland, Brian Hearring
  • Publication number: 20210252493
    Abstract: The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described.
    Type: Application
    Filed: February 17, 2020
    Publication date: August 19, 2021
    Applicants: Board of Trustees of Southern Illinois University, Vanderbilt University, The Regents of the University of California
    Inventors: Boyd M. Goodson, Eduard Y. Chekmenev, Igor V. Koptyug, Kirill V. Kovtunov, Roman V. Shchepin, Bryce E. Kidd, Jonathan Gesiorski, Max E. Gemeinhardt, Danila A. Barskiy
  • Patent number: 11026793
    Abstract: Systems and methods for magnetic induction of a penile prosthesis are disclosed. The magnetic induction system includes a wand that has a coil arrangement covered with a thermal and electrical insulator sheath operable to generate an alternating magnetic field. The coil arrangement of the sheath is configured to receive the length of the penile prosthesis therein. The penile prosthesis may be made from a shape memory material such that application of alternating magnetic fields generated by the magnetic induction system induces eddy currents that raise the temperature of the penile prosthesis to a temperature above the austenitic transformation temperature that allows the penile prosthesis to achieve an erect state.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: June 8, 2021
    Assignee: The Board of Trustees of Southern Illinois University
    Inventors: Alberto Colombo, Kevin McVary, Brian Le
  • Patent number: 11016152
    Abstract: Provided are methods for nuclear spin polarization enhancement via signal amplification by reversible exchange at very low magnetic fields. The spin polarization is hyperpolarization of isotopically enriched heteronuclei by using a catalyst and parahydrogen to create a complex using iridium and applying magnetic fields in the microtesia range to transfer the spin order from parahydrogen to the complex.
    Type: Grant
    Filed: May 12, 2018
    Date of Patent: May 25, 2021
    Assignees: Vanderbilt University, Duke University, The Board of Trustees of Southern Illinois University
    Inventors: Eduard Y. Chekmenev, Danila A. Barskiy, Roman V. Shchepin, Warren S. Warren, Thomas Theis, Boyd Goodson
  • Patent number: 10887593
    Abstract: A highly parallel bit rate estimator and method for estimating bit rate are provided for high efficiency video coding applications. The electrical hardware architecture groups syntax elements into independent processing groups and utilizes a table-based context-adaptive binary arithmetic coding scheme to more rapidly estimate bit rates and optimize compression of high-definition videos.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: January 5, 2021
    Assignee: Board of Trustees of Southern Illinois University
    Inventors: Yuanzhi Zhang, Chao Lu
  • Publication number: 20200360609
    Abstract: A syringe device and methods for device for separating liquids of different densities are provided where the syringe device includes a hollow syringe barrel, a perforated plunger seal with a seal hole, and a hollow plunging tube with a closed bottom with at least one tube hole.
    Type: Application
    Filed: August 4, 2020
    Publication date: November 19, 2020
    Applicant: Board of Trustees of Southern Illinois University
    Inventors: Ashim Gupta, Michael W. Neumeister, Sohyung Cho, Scott Moore, Robert B. Zajeski, JR.
  • Publication number: 20200315996
    Abstract: Niclosamide is an effective therapeutic medicament for the treatment of endometriosis. Niclosamide treatment can reduce the size of endometriotic lesions and reduce cell proliferation in the lesions. Niclosamide treatment can result in the inhibition of proteins and genes associated with inflammatory signaling, including those associated with NF?B and STAT3 activation, but without altering the expression of steroid hormone receptors. Niclosamide can be effective in reducing the growth of endometriotic lesions in female mice without impairing their ability to become pregnant and without negative effect on gestation and offspring. The invention herein is useful in treating symptoms associated with endometriosis, such as reducing the growth of lesions of the endometrium, without disrupting normal reproductive function in females. The invention also relates to derivatives of niclosamide having improved solubility and enhanced efficacy.
    Type: Application
    Filed: May 26, 2017
    Publication date: October 8, 2020
    Applicant: Board of Trustees, Southern Illinois University
    Inventors: Kanako Hayashi, James MACLEAN, II, Mandy KING
  • Patent number: 10774301
    Abstract: A syringe device for separating liquids of different densities is provided with a hollow syringe barrel, a perforated plunger seal with a seal hole, and a hollow plunging tube with a closed bottom with at least one tube hole. The perforated plunger seal has an outer perimeter that resides flush against an interior surface of the hollow syringe barrel. The tube hole is in operational relationship with the seal hole. Optionally, a relief hole is provided on a top portion of the hollow plunging tube to allow a user to create vacuum pressure as necessary.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: September 15, 2020
    Assignee: Board of Trustees of Southern Illinois University
    Inventors: Ashim Gupta, Michael W. Neumeister, Sohyung Cho
  • Publication number: 20200270628
    Abstract: A transgenic soybean plant resistant to soybean cyst nematode (SCN), or parts thereof, are provided. Also provided are methods of increasing SCN resistance of a soybean plant and associated DNA constructs.
    Type: Application
    Filed: January 10, 2020
    Publication date: August 27, 2020
    Applicants: Board of Trustees of Southern Illinois University, The Curators of the University of Missouri
    Inventors: Khalid Meksem, Henry Nguyen, Naoufal Lakhssassi, Mariola Klepadlo, Gunvant Patil
  • Patent number: 10751123
    Abstract: A thermoablation probe for performing an interstitial thermal therapy (ITT) procedure on a brain lesion generally includes a rigid sheath and a flexible treatment device telescopically slidable within the sheath. The treatment device has a substantially continuous covering and a shape-memory wire enveloped by the covering.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: August 25, 2020
    Assignees: Washington University, Board of Trustees of Southern Illinois University
    Inventors: Eric Leuthardt, Jenna Gorlewicz, Mahmood Rezapour
  • Publication number: 20200172493
    Abstract: The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.
    Type: Application
    Filed: November 27, 2019
    Publication date: June 4, 2020
    Applicants: Board of Trustees of Southern Illinois University, Vanderbilt University
    Inventors: Boyd M. Goodson, Eduard Y. Chekmenev, Bryce E. Kidd, Jamil A. Mashni, Miranda Limbach, Yuqing Hou, Fan Shi
  • Patent number: 10464886
    Abstract: A heavy-atom derivative of CHCA, a primary matrix molecule for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), is synthesized and purified. This new matrix molecule ?-cyano-4-hydroxy-3-iodocinnamic acid (CHICA) is characterized by 1H NMR and mass spectrometry. CHICA is shown to increase MALDI-MS yield for the test analytes human angiotensin II and sex pheromone inhibitor as compared to both CHCA and an alternative heavy-atom CHCA derivative matrix. An optimal CHICA matrix concentration is determined to be 4 mg/mL. Analyte ion yield is shown to be comparable for CHICA and CHCA for analyte concentrations below 0.001 mg/mL. For analyte concentrations above this threshold, use of CHICA resulted in higher analyte yield and significantly lower relative standard deviation.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: November 5, 2019
    Assignee: Board of Trustees of Southern Illinois University
    Inventors: Kristopher M Kirmess, Gary R Kinsel, Kyle Newton Plunkett
  • Publication number: 20190313028
    Abstract: A multifunctional camera system having a bendable arm configured to be inserted into the thoracic cavity of a patient and camera head at a distal end of the bendable arm. The camera head has a high definition video camera and a light source. The camera head has a view adjustment mechanism for changing a view angle of the camera without changing the position of the camera head. A controller controls the view adjustment mechanism under command of a surgeon.
    Type: Application
    Filed: April 5, 2019
    Publication date: October 10, 2019
    Applicant: Board of Trustees of Southern Illinois University
    Inventors: Traves Crabtree, Timothy York, Mitch McKay, Mingshao Zhang
  • Patent number: 10400389
    Abstract: A textile-reinforced composite friction material is provided by the present invention that includes a nonwoven needlepunched fiber mat, a resin matrix impregnated within and onto the fiber mat, and a carbon nanomaterial dispersed within the resin matrix. The carbon nanomaterial is preferably carbon nanotubes and/or carbon nanofibers.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: September 3, 2019
    Assignees: BOARD OF TRUSTEES AT SOUTHERN ILLINOIS UNIVERSITY, TRIBCO INC.
    Inventors: Peter Filip, David N. Bortz, Brian Howells, Ashley R. Kelm, Tod Policandriotes
  • Patent number: 10312888
    Abstract: Various embodiments of a robust double node upset tolerant latch in which all internal and external nodes are capable of recovering the previous value after a single event upset are disclosed.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: June 4, 2019
    Assignee: Board of Trustees of Southern Illinois University on Behalf of Southern Illinois University Carbondale
    Inventors: Adam Watkins, Spyros Tragoudas
  • Patent number: 10294489
    Abstract: A transgenic soybean plant or parts thereof, resistant to soybean cyst nematodes, transformed to express Glyma18g02570, Glyma18g02580, or Glyma18g02590, or a variant thereof. Also provided is a method of making such a plant. Also provided is an artificial DNA construct encoding Glyma18g02570, Glyma18g02580, or Glyma18g02590, or a variant thereof.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: May 21, 2019
    Assignees: BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY, THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Khalid Meksem, Shiming Liu, Pramod Kaitheri Kandoth, Melissa G. Mitchum, David Lightfoot
  • Patent number: 10287601
    Abstract: Among the various aspects of the present disclosure is the provision of a transgenic organism, an artificial DNA construct, and methods for producing a transgenic organism for indigo, indirubin, and other indole-derived compound production. Another aspect of the present disclosure is the provision of a transgenic organism wherein the indole-derived compound imparts color to the transgenic organism or to a portion of the transgenic organism.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: May 14, 2019
    Assignee: BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY
    Inventor: Aldwin Anterola
  • Patent number: 10240910
    Abstract: Systems and methods for compressive image sensor techniques based on sparse measurement matrices are disclosed. A method to perform compressive sensing (CS) measurement operations for image sensors limits pixel summation to be within neighboring pixels and hence dramatically simplifies CS image sensor circuits and reduces their power consumption while providing better image quality compared to conventional random measurement matrix based methods. A sparse measurement matrix is applied to pixel data to generate a desired number of summation groups, each summation group consisting of outputs from an equal number of pixel cells. Each pair of summation groups contains the same number of shared outputs from pixel cells. From the summation groups, an image captured by the pixel cells is recovered.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: March 26, 2019
    Assignee: Board of Trustees of Southern Illinois University on Behalf of Southern Illinois University Carbondale
    Inventors: Stefan Leitner, Haibo Wang, Spyros Tragoudas
  • Publication number: 20190037795
    Abstract: A transgenic soybean resistant to soybean cyst nematode (SCN), or parts thereof, including an artificial DNA construct encoding a serine hydroxymethyltransferase protein (e.g., GmSHMT).
    Type: Application
    Filed: August 9, 2018
    Publication date: February 7, 2019
    Applicants: Board of Trustees of Southern Illinois University, The Curators of the University of Missouri
    Inventors: Khalid Meksem, Shiming Liu, Pramod Kaitheri Kandoth, Melissa G. Mitchum