Patents Assigned to Board of Trustees of the University of Illinois
  • Patent number: 10807964
    Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: October 20, 2020
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Debra A. Tonetti
  • Patent number: 10808260
    Abstract: Methods of increasing the resistance of plants, in particular soybeans, to nematodes, in particular soybean cyst nematodes, are provided herein. The methods include increasing the expression of Glyma18g02580, Glyma18g02590 and/or Glyma18g2610 in cells of a plant and in particular in root cells of a plant to increase the resistance of the plant and plant cells to nematodes. The methods include increasing the expression using constitutive promoters or by increasing the copy number of the polynucleotides. Constructs for expressing these polypeptides, transgenic cells, transgenic plants and methods of generating the same are also provided. Methods of screening plant cells for resistance or susceptibility to nematodes are also provided.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: October 20, 2020
    Assignees: Wisconsin Alumni Research Foundation, The Board of Trustees of the University of Illinois
    Inventors: Andrew Farmer Bent, Matthew Hudson, Brian Diers, Sara Melito, David Edward Cook, Teresa Hughes, Adam Bayless, Jianping Wang, Tong Geon Lee, Xiaoli Guo
  • Patent number: 10800822
    Abstract: Synthetic histatins composed of combinations of functional domains of natural histatins separated by exogenous linkers are described as are methods of using endogenous and synthetic histatins for the treatment of ocular diseases or conditions.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: October 13, 2020
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventor: Vinay Aakalu
  • Patent number: 10800730
    Abstract: The invention provides a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp3 carbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: October 13, 2020
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Paul J. Hergenrother, Robert W. Huigens, III, Karen C. Morrison, Robert W. Hicklin, II, Timothy A. Flood, Jr.
  • Patent number: 10799727
    Abstract: A helmet for anesthesia, adapted to keep confined anesthetic gases and to administer them in a non-invasive fashion to a patient laying on an operating table, allowing to provide oxygen and/or anesthetic gases through tubes and fast access to the patient's head in case of emergency is described. The helmet has a lower half-shell and an upper half-shell, the lower half-shell being anatomically shaped to receive and support the nape and the neck of the laying patient, the upper half-shell and the lower half-shell having fastening means for fastening one to the other and being configured to be fitted one to the other and to the neck or torso of the patient to form a substantially airtight enclosure for enclosing head of the patient, at least one inlet port for gas supply and at least one outlet port for gas evacuation being on the lower half-shell and/or the upper half-shell.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: October 13, 2020
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Pier Giulianotti, Arturo Vittori, Andreas Vogler
  • Patent number: 10804103
    Abstract: A method for microassembly of heterogeneous materials comprises contacting a stamp with an ink disposed on a donor substrate to form an inked stamp, where the ink is reversibly bound to the stamp. The inked stamp is stamped onto a receiving substrate or onto an object on the receiving substrate, and the stamp is removed, thereby transferring the ink to the receiving substrate. The ink and the receiving substrate or the ink and the object are thermally joined, thereby forming a microassembly of heterogeneous materials. The ink may comprise a first material and the receiving substrate or the object may comprise a second material different from the first material.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: October 13, 2020
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Seok Kim, Zining Yang, Hohyun Keum
  • Publication number: 20200315488
    Abstract: Provided herein are skin-mounted biomedical devices and methods of making and using biomedical devices for sensing and actuation applications. For example, flexible and/or stretchable biomedical devices are provided, including electronic devices useful for establishing conformal contact with the skin of a subject. Devices disclosed herein can comprise a plurality of sensing and/or actuating devices provided as part of a skin-mounted flexible or stretchable electronic circuit.
    Type: Application
    Filed: August 27, 2019
    Publication date: October 8, 2020
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: John A. ROGERS, Dae-Hyeong KIM
  • Patent number: 10796831
    Abstract: A magnetically-responsive surface structure comprises an array of hybrid microstructures on a substrate, where each hybrid microstructure comprises an elastomeric micropillar attached to the substrate and a rigid tile attached to the elastomeric micropillar. The rigid tiles collectively define a discontinuous, changeable surface. The hybrid microstructures further comprise a ferromagnetic material. The elastomeric micropillars are deflectable under a magnetic field so as to alter an orientation of the rigid tiles, thereby allowing a characteristic of the discontinuous, changeable surface to be manipulated.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: October 6, 2020
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Seok Kim, Zining Yang, Jun Kyu Park
  • Patent number: 10775337
    Abstract: New approaches for selective detection of chemical agents such as sarin are necessary because of the high toxicity of sarin and related compounds, the potential of these compounds to be used as weapons of mass destruction, and the limitations of current detection methodologies. Herein is described an apparatus and a method for selective and amplified detection of sarin simulants deposited via an aerosol process. The simulant absorbs into a hydrogel, where it hydrolyzes upon contact with water producing elemental ions. The elemental ions are then concentrated via an ionic chemical potential gradient to a sensor, where it is detected. This technique has potential to amplify the capture efficiency of a sensor by a 1000-fold within couple of minutes.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: September 15, 2020
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Paul V. Braun, Mohammad Amdad Ali
  • Publication number: 20200281568
    Abstract: Systems and methods are provided for employing informational models trained using the Autoprogressive Algorithm to learn the mechanical behavior and internal structure of biological materials using a sparse sampling of force and displacement measurements. Forces are applied to the biological material and the force and displacement are measured and applied to the AutoP algorithm. Additionally, a coordinate based scaling factor is applied to the measured displacement.
    Type: Application
    Filed: March 6, 2020
    Publication date: September 10, 2020
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Cameron Lee Hoerig, Michael F Insana, Jamshid Ghaboussi
  • Patent number: 10752577
    Abstract: Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: August 25, 2020
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Martin D. Burke, Junqi Li, Eric P. Gillis
  • Patent number: 10752809
    Abstract: A reusable attaching apparatus includes (a) a reversible adhesive comprising a shape memory polymer and (b) a mounting structure bonded to the reversible adhesive. The shape memory polymer has a glass transition temperature (Tg) and comprises a deformable state at temperatures above the Tg and a rigid state at temperatures below the Tg.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: August 25, 2020
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Seok Kim, Jeffrey D. Eisenhaure, Jun Kyu Park
  • Patent number: 10752994
    Abstract: An apparatus for depositing a coating on a substrate at atmospheric pressure comprises (a) a plasma torch comprising a microwave source coupled to an antenna disposed within a chamber having an open end, the chamber comprising a gas inlet for flow of a gas over the antenna to generate a plasma jet; (b) a substrate positioned outside the open end of the chamber a predetermined distance away from a tip of the antenna; and (c) a target material to be coated on the substrate disposed at the tip of the antenna.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: August 25, 2020
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: David N. Ruzic, Yuilun Wu, Ivan Shchelkanov, Jungmi Hong, Zihao Ouyang, Tae Seung Cho
  • Patent number: 10748781
    Abstract: A method of catalyst-assisted chemical etching with a vapor-phase etchant has been developed. In one approach, a semiconductor substrate including a patterned titanium nitride layer thereon is heated, and an oxidant and an acid are evaporated to form a vapor-phase etchant comprising an oxidant vapor and an acid vapor. The semiconductor substrate and the patterned titanium nitride layer are exposed to the vapor-phase etchant during the heating of the semiconductor substrate. The vapor-phase etchant diffuses through the patterned titanium nitride layer, and titanium nitride-covered regions of the semiconductor substrate are etched. Thus, an etched semiconductor structure is formed.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: August 18, 2020
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Xiuling Li, Dane J. Sievers, Lukas Janavicius, Jeong Dong Kim
  • Patent number: 10736551
    Abstract: The invention provides systems and methods for tissue-mounted photonics. Devices of some embodiments implement photonic sensing and actuation in flexible and/stretchable device architectures compatible with achieving long term, mechanically robust conformal integration with a range of tissue classes, including in vivo biometric sensing for internal and external tissues. Tissue-mounted photonic systems of some embodiments include colorimetric, fluorometric and/or spectroscopic photonics sensors provided in pixelated array formats on soft, elastomeric substrates to achieve spatially and/or or temporally resolved sensing of tissue and/or environmental properties, while minimize adverse physical effects to the tissue. Tissue-mounted photonic systems of some embodiments enable flexible passive or active optical sensing modalities, including sensing compatible with optical readout using a mobile electronic devices such as a mobile phone or tablet computer.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: August 11, 2020
    Assignee: The Board of Trustees of the University of Illinois
    Inventor: John A. Rogers
  • Patent number: 10739340
    Abstract: Embodiments of the methods, compositions, and systems provided herein relate to enzymatic enhancement of immunoassays using photonic sensor arrays.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: August 11, 2020
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Ryan C. Bailey, Matthew S. Luchansky, Abraham J. Qavi, Jared T. Kindt
  • Patent number: 10738080
    Abstract: Provided herein are compounds that inhibit a binding interaction between a ? integrin and a G protein subunit, as well as compositions, e.g., pharmaceutical compositions, comprising the same, and related kits. In some embodiments, the compound is an antibody or antibody analog, and, in other embodiments, the compound is a peptide or peptide analog. Also provided are methods of using the compounds, including methods of treating or preventing a medical condition, such as stroke, heart attack, cancer, or inflammation.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: August 11, 2020
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventor: Xiaoping Du
  • Patent number: 10741705
    Abstract: An optoelectronic device with an antireflective surface comprises a semiconductor substrate having a textured surface including a plurality of surface protrusions and/or indentations. A first electrode is in contact with the semiconductor substrate and spaced apart from a second electrode that is also in contact with the semiconductor substrate. The textured surface is fabricated by inverse metal-assisted chemical etching, and thus the semiconductor substrate is substantially devoid of ion-induced defects.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: August 11, 2020
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Xiuling Li, Jeong Dong Kim, Munho Kim
  • Patent number: 10738088
    Abstract: A non-naturally occurring porcine reproductive and respiratory syndrome virus (PRRSV) is provided herein, and methods of making and using the non-naturally occurring PRRSV also are provided.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: August 11, 2020
    Assignees: NUtech Ventures, The Board of Trustees of the University of Illinois
    Inventors: Hiep Lai Xuan Vu, Fernando Osorio, William W. Laegreid, Asit K. Pattnaik, Fangrui Ma
  • Patent number: 10736992
    Abstract: The invention provides methods and compositions for making and using collagen-glycosaminoglycan three-dimensional scaffolds immobilized with biomolecules that are spatially and temporally patterned. The method comprises adding benzophenone to a collagen-glycosaminoglycan three dimensional scaffold in the dark; adding one or more biomolecules to one or more areas of the collagen-glycosaminoglycan three-dimensional scaffold (which can be done optionally in the dark or in the light); and exposing the collagen-2glycosaminoglycan three-dimensional scaffold to light at a wavelength of about 350 to about 365 nm.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: August 11, 2020
    Assignee: BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Ryan C. Bailey, Brendan A. Harley, Teresa A. Martin, Steven R. Caliari