Abstract: In one aspect, the disclosure relates to relates to substituted benzothiophene analogs which are useful as selective degraders of estrogen receptor, methods of making same, pharmaceutical compositions comprising same, and methods of treating one or more clinical conditions associated with estrogen receptor, such as a cancer, including breast cancer, or osteoporosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: An embodiment may involve obtaining an image composed of color channels, wherein each of the color channels represents colors therein with n bits per pixel; quantizing each of the color channels to be represented by m bits per pixel; using a space-filling curve to convert each of the color channels as quantized into respective vectors; generating, for each of the respective vectors, a respective set of m arrays, wherein the m arrays for a particular vector of the respective vectors contain indices of where a fixed value selected from a range of 0 to m?1 is found in the particular vector; applying, to each of the m arrays for each of the respective vectors, differential encoding and compression of the indices therein; mapping each of the m arrays for each of the respective vectors to blocks of nucleotides; synthesizing the blocks; and storing, in a DNA-based storage medium, the blocks.

Abstract: A method for increasing yield or vigor of a plant is provided, which includes the selective removal of the plant's shoot apical meristem at a period between vegetative growth stage 1 and vegetative growth stage 2, or between vegetative growth stage 2 and vegetative growth stage 3.

Abstract: A frontally polymerized polymeric body includes, according to a first embodiment, a deformable polymer comprising polydicyclopentadiene (pDCPD) and/or poly(5-ethylidene-2-norbornene) (pENB), where the deformable polymer has a fracture strain of at least about 0.5 mm mm?1. According to a second embodiment, the frontally polymerized polymeric body includes a first polymer comprising pDCPD and/or pENB, and a second polymer adjacent to the first polymer also comprising the pDCPD and/or the pENB. The second polymer is more or less deformable than the first polymer. Thus, the frontally polymerized polymeric body exhibits spatially varying mechanical and/or other properties.

Abstract: The present disclosure provides systems and methods that can provide portable, real-time accessible DNA memories. An example DNA-based data storage system includes a loading region configured to receive a plurality of DNA-based data storage elements in a suspension fluid and a plurality of microtubes disposed in a capture/release region. The microtubes are configured to capture and release the DNA-based data storage elements. The DNA-based data storage system also includes a linearization region configured to linearize the DNA-based data storage elements and a readout region with a readout device configured to provide information indicative of the respective DNA-based data storage elements.

Abstract: Described herein are PPAR? agonists, including, but not limited to, endocannabinoids that can be used for treatment of a neuropsychiatric disorder and/or symptom thereof. Also described herein are pharmaceutical formulations containing an effective amount of a PPAR? agonists, including but not limited to endocannabinoids, where the effective amount is effective for treating a neuropsychiatric disorder and/or symptom thereof. Also described herein are methods of treating a neuropsychiatric disorder and/or a symptom thereof in a subject in need thereof.

Abstract: A method and microfluidic device for increasing the production of extracellular vesicles are provided which include the use of a cell-adhesive substrate for culturing extracellular-vesicle-producing cells, wherein the cell-adhesive substrate is a hydrogel having a Young's modulus of about 0.1 kPa to about 5 kPa and the hydrogel is functionalized with one or more cell adhesive peptides.

Abstract: Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.

Abstract: Described herein are systems and methods which utilize an array of wells to isolate pathogens and nucleic acid detection techniques to accurately and rapidly detect pathogens in fluid samples, even in very low concentrations, including from solid or semi-solid samples that have been fluidized. The provided systems and methods dry the fluid sample to deposit a fraction of the total volume in a number of wells and perform nucleic acid detection on individual wells to detect even individual pathogens and provide a quantitative analysis of the amount of pathogen within the sample. Also provided are methods and systems for precise delivery of dried materials, including biomolecules that are enzymes of use in the process, to microwells.

Abstract: A nucleic acid-based assay of pancreatic cyst fluid is provided for differentiating between high-grade and low-grade intraductal papillary mucinous neoplasms.

Abstract: A reconfigurable metamaterial is used to enhance the reception field of a radio frequency (“RF”) coil for use in magnetic resonance imaging (“MRI”). In general, the metamaterial can be a metasurface, which may be flexible, having a periodic array of resonators. Each resonator in the periodic array can be defined as a unit cell of the metamaterial and/or metasurface. The unit cells include a first conductor and a second conductor separated by an insulator layer. The first conductor can be a solid conductor and the second conductor can be a conductive fluid (e.g., a liquid metal, a liquid metal alloy) contained within a microfluidic channel. Varying the volume of conductive fluid in each unit cell adjust the signal enhancement ratio of the metamaterial.

Abstract: An atomically dispersed precursor (ADP) for preparing a non-platinum group metal electrocatalyst includes: sacrificial metal centers comprising a sacrificial metal selected from Cd and Zn; metal active sites comprising a transition metal; and first and second ligands linking the sacrificial metal centers and the metal active sites into a network. The ADP may be immobilized on a carbon support. The first and second ligands may comprise N-containing ligands of different carbon chain lengths. Alternatively, the first and second ligands may comprise N-containing ligands and O-containing ligands, respectively.

Abstract: A method to form a three-dimensional photonic crystal template with a gradient structure involves irradiating a photoresist composition of a thickness of at least 15 ?m from at least four laser beams to yield a periodic patterned with a percolating matrix of mass in constructive volumes of a cured photoresist composition and destructive volumes of voids free of condensed matter where the proportion of constructive volume displays a gradient from the irradiated surface to the substrate after development. For a given light intensity, photoinitiator concentration in the photoresist composition, and a given thickness, by irradiating for a relatively short period, a three-dimensional photonic crystal template displaying a gradient having greater constructive volume proximal the air interface forms and a relatively long irradiation period results in a gradient having greater constructive volume proximal the substrate.

Abstract: A method of compositional feature representation learning for video understanding is described. The method includes individually processing a sequence of video frames received as an input of a feature map network to generate a plurality of feature maps. The method also includes binding the plurality of feature maps to a fixed set of slot variables using an attention model according to a motion segmentation signal. The method further includes combining slot states corresponding to the fixed set of slot variables into a combined feature map. The method also includes decoding the combined feature map to form a reconstructed sequence of video frames, in which objects discovered in the reconstructed sequence of video frames are identified.

Abstract: An apparatus includes a piezoelectric thin film suspended above a carrier substrate, where the piezoelectric thin film is of one of lithium niobate (LiNbO3) or lithium tantalate (LiTaO3) adapted to propagate an acoustic wave in a Lamb wave mode excited by a component of an electric field that is oriented in a longitudinal direction along a length of the piezoelectric thin film. A signal electrode is disposed on, and in physical contact with, the piezoelectric thin film and oriented perpendicular to the longitudinal direction. A ground electrode disposed on, and in physical contact with, the piezoelectric thin film and oriented perpendicular to the longitudinal direction, where the ground electrode is separated from the signal electrode by a gap comprising a longitudinal distance and in which the acoustic wave resonates. A release window is formed within the piezoelectric thin film adjacent to the ground electrode.

Abstract: A method of light-promoted frontal ring-opening metathesis polymerization includes providing a monomer solution including dicyclopentadiene, a ruthenium-based catalyst and a phosphite inhibitor, and exposing the monomer solution to ultraviolet light having a wavelength in a range from 315 nm to 400 nm, thereby initiating an exothermic polymerization reaction and generating a self-propagating polymerization front. The polymerization front moves through the monomer solution and polymerizes the dicyclopentadiene.

Abstract: A passive thermal regulation system includes a substrate and a coating. The coating is positioned to encapsulate at least a portion of the substrate. The coating includes a first hydrogel layer and a second hydrogel layer. The first hydrogel layer has a plurality of carbon materials configured to absorb a solar radiation. The second hydrogel layer includes a hydrogel that is different from the first hydrogel layer. The coating, at a first temperature, causes the passive thermal regulation system to passively switch from a solar reflective state to solar absorber state to permit the plurality of carbon materials to absorb the solar radiation. At a second temperature, the coating causes the system to passively switch from the solar absorber state to the solar reflective state where the hydrogel of the second hydrogel layer inhibits the solar radiation from absorption. The second temperature is greater than the first temperature.

Abstract: Aspects of the subject disclosure may include, for example, performing, by a processing system, image fusion using two or more groups of images to generate predicted images, wherein each group of the two or more groups has one of a different resolution, a different frequency temporal pattern or a combination thereof than another of the two or more groups. Gap filling can be performed by the processing system to correct images of the two or more groups. Additional embodiments are disclosed.

Abstract: Methods and diagnostic tools are provided for assessing contrast sensitivity in a subject in the presence and absence of luminance noise by: i) presenting to the subject a series of scenes, each scene comprising at least a first target having a preselected level of contrast superimposed on a uniform background and a second target having a preselected level of contrast superimposed on a luminance noise background, wherein in each successively presented scene the first and second targets that are superimposed on the uniform background and on the luminance noise background, respectively, have contrast levels that are different from the contrast levels of the first and second targets superimposed on the uniform background and on the luminance noise background, respectively, in the previously presented scene; ii) monitoring responses by the subject to step i); and iii) evaluating the contrast sensitivity of the subject based on the monitored responses.

Abstract: Methods of RNA-guided DNA endonuclease-mediated genome editing in Bacteria and Archaea are provided.