Patents Assigned to Board of Trustees of the University of Illinois
  • Patent number: 10276942
    Abstract: A wireless communication device includes an array of helical antennas on a substrate. Each helical antenna comprises a strain-relieved sheet with a conductive strip thereon, where the strain-relieved sheet and the conductive strip are in a rolled configuration about a longitudinal axis. The conductive strip is oriented at an angle ? with respect to a rolling direction so as to comprise a helical configuration about the longitudinal axis with a non-zero helix angle ?. The array exhibits a maximum gain of at least about 10 dB at a working frequency of at least about 0.1 THz.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: April 30, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Xiuling Li, Wen Huang, Paul J. Froeter
  • Patent number: 10272099
    Abstract: The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: April 30, 2019
    Assignees: The Board of Regents of the University of Texas System, The Board of Trustees of the University of Illinois.
    Inventors: Paul J. Hergenrother, David A. Boothman, Joseph S. Bair, Lifen Cao, Jinming Gao, Xiumei Huang, Xiuquan Luo, Xinpeng Ma, Zachary R. Moore, Elizabeth I. Parkinson
  • Publication number: 20190119459
    Abstract: A thermally degradable polymeric sheet, comprising: a poly(hydroxyalkanoate); and a metal selected from the group consisting of an alkali earth metal and a transition metal; where the volume fraction of the metal in the sheet is at least 0.1 vol %.
    Type: Application
    Filed: September 21, 2018
    Publication date: April 25, 2019
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Scott R. WHITE, Nancy R. SOTTOS, Piyush R. THAKRE
  • Patent number: 10266503
    Abstract: The enantioselective synthesis of isochroman motifs has been accomplished via Pd(II)-catalyzed allylic C—H oxidation from terminal olefin precursors. Critical to the success of this goal was the development and utilization of a novel chiral aryl sulfoxide-oxazoline (ArSOX) ligand. The allylic C—H oxidation reaction proceeds with the broadest scope and highest levels asymmetric induction reported to date (avg. 92% ee, 13 examples ?90% ee). Additionally, C(sp3)-N fragment coupling reaction between abundant terminal olefins and N-triflyl protected aliphatic and aromatic amines via Pd(II)/sulfoxide (SOX) catalyzed intermolecular allylic C—H amination is disclosed. A range of 52 allylic amines are furnished in good yields (avg. 76%) and excellent regio- and stereoselectivity (avg. >20:1 linear:branched, >20:1 E:Z).
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: April 23, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: M. Christina White, Stephen E. Ammann, Wei Liu, Rulin Ma
  • Patent number: 10266573
    Abstract: Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death. The present inventors have found that different pathogens produce different cytotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer.
    Type: Grant
    Filed: May 19, 2008
    Date of Patent: April 23, 2019
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Ananda M. Chakrabarty, Tapas K. Das Gupta, Vasu Punji, Olga Zaborina
  • Patent number: 10266520
    Abstract: The invention provides compounds, compositions and therapeutic methods. The compounds and compositions can be used for the treatment of myotonic dystrophy. The compounds can selectively bind to CUG repeats in RNA, or to CTG repeats in DNA, and inhibit replication of the nucleic acids. RNA-targeted therapeutic agents for the treatment of myotonic dystrophy type 1 (DM1) are described. In one embodiment, two bisamidinium ligands are linked using “click” chemistry to form a heterodimer that is a potent inhibitor of the MBNL1-rCUGexp complex (KI=25±8 nM), is relatively non-toxic to HeLa cells, dissolves nuclear foci, corrects >80% of the IR misregulated alternative splicing in DM1 model cells (1 ?M), and shows improvement of disease phenotypes in a DM1 Drosophila model.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: April 23, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Steven C. Zimmerman, Long M. Luu, Lien T. T. Nguyen
  • Patent number: 10266868
    Abstract: The present invention relates to cupredoxin, specifically Pseudomonas aeruginosa azurin, and/or Pseudomonas aeruginosa cytochrome c551 and their use in inhibiting of viral infection, and in particular infection of mammalian cells by the Human Immunodeficiency Virus (HIV). The invention also relates to variants and derivatives of cupredoxin and cytochrome c that retain the ability to inhibit viral infection, and in particular infection by the Human Immunodeficiency Virus (HIV). The invention also relates to research methods for studying viral and bacterial infection in mammalian cells.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: April 23, 2019
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Ananda Chakrabarty, Tapas Das Gupta, Tohru Yamada, Anita Chaudhari, Arsenio Fialho, Chang Soo Hong
  • Patent number: 10266852
    Abstract: Disclosed herein are methods for the production of fuels, chemicals, or materials from biomass-derived lignin, cellulose, and hemicellulose. Also provided are methods for the production of polyhydroxyalkanoates from lignocellulosic biomass and the subsequent thermal and catalytic conversion of polyhydroxyalkanoates to hydrocarbons. In addition, methods for the production of ethanol from the fermentation of polysaccharides are described.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: April 23, 2019
    Assignees: Alliance for Sustainable Energy, LLC, The Board of Trustees of the University of Illinois
    Inventors: Gregg T. Beckham, Jeffrey G. Linger, Derek R. Vardon, Michael T. Guarnieri, Eric M. Karp, Mary Ann Franden, Christopher W. Johnson, Timothy J. Strathmann, Philip T. Pienkos
  • Patent number: 10258238
    Abstract: Methods and apparatus for ascertaining a relative viscosity characterizing a fluid sample. The fluid sample is illuminated through a scattering membrane adjacent to the fluid with broadband radiation. Scattering from particles within the fluid sample characterized by a distribution of characteristic dimensions spanning at least two orders of magnitude is detected, generating a detector signal as a function of depth relative to a specified surface of the scattering membrane at a plurality of temporal delays. A cross-correlation function of at least one of amplitude, phase and intensity of a scattered optical field is derived for a plurality of depths relative to the specified surface. A mean cross-correlation function is then derived for each depth and fit to obtain a diffusion coefficient, from which a relative viscosity characterizing the fluid is derived.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: April 16, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Stephen A. Boppart, Guillermo Luciano Monroy, Paritosh Pande
  • Patent number: 10261157
    Abstract: Aspects of the subject disclosure include a system that applies magnetic resonance elastography to a sample to obtain uncorrected k-space data where the magnetic resonance elastography utilizes a multi-shot spin-echo sequence with variable density spiral readout gradients, and adjusts the uncorrected k-space data to corrected k-space data by adjusting a k-space trajectory by shifting a center point for each shot to a new center point according to signal intensity and by adjusting a phase for each shot based on a phase offset that is determined according to the signal intensity.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: April 16, 2019
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Bradley Sutton, John G. Georgiadis, Curtis Johnson
  • Publication number: 20190106448
    Abstract: Reactions that directly install nitrogen into C—H bonds of complex molecules are significant because of their potential to change the chemical and biological properties of a given compound. Selective intramolecular C—H amination reactions that achieve high levels of reactivity, while maintaining excellent site-selectivity and functional-group tolerance is a challenging problem. Herein is reported a manganese perchlorophthalocyanine catalyst [MnIII(ClPc)] for intermolecular benzylic C—H amination of bioactive molecules and natural products that proceeds with unprecedented levels of reactivity and site-selectivity. In the presence of Brønsted or Lewis acid, the [MnIII(ClPc)]-catalyzed C—H amination demonstrates unique tolerance for tertiary amine, pyridine and benzimidazole functionalities. Mechanistic studies indicate that C—H amination proceeds through an electrophilic metallonitrene intermediate via a stepwise pathway where C—H cleavage is the rate-determining step of the reaction.
    Type: Application
    Filed: October 5, 2018
    Publication date: April 11, 2019
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: M. Christina WHITE, Joseph R. CLARK, Kaibo FENG, Anasheh SOOKEZIAN
  • Publication number: 20190109290
    Abstract: Provided is a method of detecting the presence of an object in proximity to an optoelectronic device comprising (a) providing an optoelectronic device comprising a light-emitting optoelectronic element and a photocurrent-generating optoelectronic element, (b) imposing an effective forward bias voltage on the light-emitting optoelectronic element and an effective reverse bias voltage on the photocurrent-generating optoelectronic element, (c) bringing an object capable of scattering or reflecting light or a combination thereof to a distance of 0.1 to 5 mm from a point on the surface of the optoelectronic device from which light emerges, causing light that is emitted by the light-emitting optoelectronic element to be reflected or scattered so that the light falls upon the photocurrent-generating optoelectronic element.
    Type: Application
    Filed: March 23, 2017
    Publication date: April 11, 2019
    Applicants: Dow Global Technologies LLC, Rohm And Haas Company, The Board of Trustees of the University of Illinois, Rohm and Haas Electronic Materials
    Inventors: Peter Trefonas, III, Kishori Deshpande, Trevor Ewers, Edward Greer, Jaebum Joo, Bong Hoon Kim, Nuri Oh, John Rogers, Moonsub Shim, Jieqian Zhang
  • Publication number: 20190099419
    Abstract: The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.
    Type: Application
    Filed: October 1, 2018
    Publication date: April 4, 2019
    Applicants: The Board of Trustees of the University of Illinois, Vanquish Oncology, Inc., The Johns Hopkins University
    Inventors: Paul J. HERGENROTHER, Rachel C. BOTHAM, Timothy M. FAN, Mark J. GILBERT, Michael K. HANDLEY, Avadhut JOSHI, Gregory J. RIGGINS, Theodore M. TARASOW
  • Publication number: 20190099418
    Abstract: The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.
    Type: Application
    Filed: October 1, 2018
    Publication date: April 4, 2019
    Applicants: The Board of Trustees of the University of Illinois, Vanquish Oncology, Inc.
    Inventors: Paul J. HERGENROTHER, Rachel C. BOTHAM, Timothy M. FAN, Mark J. GILBERT, Michael K. HANDLEY, Howard S. ROTH, Theodore M. TARASOW
  • Publication number: 20190090801
    Abstract: Provided are implantable, injectable and/or surface mounted biomedical devices and related methods for interfacing with a target tissue. The devices have a substrate, one or more microfluidic channels embedded in or supported by the substrate and a fluid actuator in operational communication with one or more reservoirs and responsive to a wireless control signal. The components of the device are specially configured and packaged to be ultra-thin and mechanically compliant. In some embodiments, the devices are self-powered and fully implantable. The devices can be shaped to provide injection in a minimally invasive manner, thereby avoiding unnecessary tissue damage and providing a platform for long-term implantation for interfacing with biological tissue.
    Type: Application
    Filed: July 1, 2016
    Publication date: March 28, 2019
    Applicants: WASHINGTON UNIVERSITY IN ST. LOUIS, The Board of Trustee of the University of Illinois
    Inventors: John A. ROGERS, Michael Raymond BRUCHAS, Jaewoong JEONG, Jordan Gary MCCALL
  • Publication number: 20190093229
    Abstract: An apparatus for depositing a coating on a substrate at atmospheric pressure comprises (a) a plasma torch comprising a microwave source coupled to an antenna disposed within a chamber having an open end, the chamber comprising a gas inlet for flow of a gas over the antenna to generate a plasma jet; (b) a substrate positioned outside the open end of the chamber a predetermined distance away from a tip of the antenna; and (c) a target material to be coated on the substrate disposed at the tip of the antenna.
    Type: Application
    Filed: November 21, 2018
    Publication date: March 28, 2019
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: David N. Ruzic, Yuilun Wu, Ivan Shchelkanov, Jungmi Hong, Zihao Ouyang, Tae Seung Cho
  • Patent number: 10239920
    Abstract: The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The invention further discloses methods for treating cancer and diagnosing cancer.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: March 26, 2019
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Ananda Chakrabarty, Tapas Das Gupta, Tohru Yamada, Arsenio Fialho
  • Patent number: 10239978
    Abstract: The invention provides a redox flow battery comprising a microporous or nanoporous size-exclusion membrane, wherein one cell of the battery contains a redox-active colloidal particle dispersed in a non-aqueous solvent. The redox flow battery provides enhanced ionic conductivity across the electrolyte separator and reduced redox-active species crossover, thereby improving the performance and enabling widespread utilization of the battery. Redox active colloidal particles (RACs) were prepared, analyzed, and were found to be highly effective redox species for use in redox flow batteries.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: March 26, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Jeffrey S. Moore, Joaquin Rodriguez-Lopez, Nagarjuna Gavvalapalli, Elena Montoto, Jingshu Hui
  • Patent number: 10239824
    Abstract: Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: March 26, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Martin D. Burke, Junqi Li, Eric P. Gillis
  • Patent number: 10243057
    Abstract: Representative embodiments provide an InAlN/GaN MISHFET having a predetermined breakdown voltage, calibrated to a permittivity-thickness parameter and selectable before or during transistor fabrication, which can be greater than 700 V for a normally-off InAlN/GaN MISHFET. Representative embodiments include a first dielectric layer coupled to a gate and to an InAlN barrier layer, a second dielectric layer, and an optional third dielectric layer. The first dielectric layer comprises a first dielectric material having a first predetermined thickness and a first relative permittivity.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: March 26, 2019
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventor: Junxia Shi